Multi-organ system for the evaluation of efficacy and off-target toxicity of anticancer therapeutics

Human-on-a-Chip Systems: Long-Term Electrical and Mechanical Function Monitoring of a Human-on-a-Chip System (Adv. Funct. Mater. 8/2019)

(2019) Carlota Oleaga et al.   ADVANCED FUNCTIONAL MATERIALS

Investigation of the effect of hepatic metabolism on off-target cardiotoxicity in a multi-organ human-on-a-chip system

(2018) Carlota Oleaga et al.   BIOMATERIALS

Interconnected Microphysiological Systems for Quantitative Biology and Pharmacology Studies

(2018) Collin D. Edington et al.   Scientific Reports

Simultaneous electrical recording of cardiac electrophysiology and contraction on chip

(2017) Fang Qian et al.   LAB ON A CHIP

An impedance-based approach using human iPSC-derived cardiomyocytes significantly improves in vitro prediction of in vivo cardiotox liabilities

(2017) Bryan Koci et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Design and demonstration of a pumpless 14 compartment microphysiological system

(2016) Paula G. Miller et al.   BIOTECHNOLOGY AND BIOENGINEERING

Key cost drivers of pharmaceutical clinical trials in the United States

(2016) Aylin Sertkaya et al.   Clinical Trials

From the Cover: High-Throughput Imaging of Cardiac Microtissues for the Assessment of Cardiac Contraction during Drug Discovery

(2016) Amy Pointon et al.   TOXICOLOGICAL SCIENCES

Multi-Organ toxicity demonstration in a functional human in vitro system composed of four organs

(2016) Carlota Oleaga et al.   Scientific Reports

Therapeutic options for chronic myeloid leukemia: focus on imatinib (Glivec®, Gleevec™)

(2016) Heiko Kuip   Therapeutics and Clinical Risk Management

A phenotypic in vitro model for the main determinants of human whole heart function

(2015) Maria Stancescu et al.   BIOMATERIALS

Functional myotube formation from adult rat satellite cells in a defined serum-free system

(2015) Christopher W. McAleer et al.   BIOTECHNOLOGY PROGRESS

Human-on-a-chip design strategies and principles for physiologically based pharmacokinetics/pharmacodynamics modeling

(2015) Hasan Erbil Abaci et al.   Integrative Biology

Tamoxifen for prevention of breast cancer: extended long-term follow-up of the IBIS-I breast cancer prevention trial

(2015) Jack Cuzick et al.   LANCET ONCOLOGY

Human iPSC-based Cardiac Microphysiological System For Drug Screening Applications

(2015) Anurag Mathur et al.   Scientific Reports

Intraoperative use of ketorolac or diclofenac is associated with improved disease-free survival and overall survival in conservative breast cancer surgery

(2014) P. Forget et al.   BRITISH JOURNAL OF ANAESTHESIA

Mechanistic investigation of adult myotube response to exercise and drug treatment in vitro using a multiplexed functional assay system

(2014) C. W. McAleer et al.   JOURNAL OF APPLIED PHYSIOLOGY

Lessons learned from the fate of AstraZeneca's drug pipeline: a five-dimensional framework

(2014) David Cook et al.   NATURE REVIEWS DRUG DISCOVERY

Cardiac Cell Culture Model As a Left Ventricle Mimic for Cardiac Tissue Generation

(2013) Mai-Dung Nguyen et al.   ANALYTICAL CHEMISTRY

Correlation of embryonic skeletal muscle myotube physical characteristics with contractile force generation on an atomic force microscope-based bio-microelectromechanical systems device

(2013) K. L. Pirozzi et al.   APPLIED PHYSICS LETTERS

Effects of adjuvant tamoxifen therapy on cardiac disease: results from a randomized trial with long-term follow-up

(2013) Johan Rosell et al.   BREAST CANCER RESEARCH AND TREATMENT

Direct, Differential Effects of Tamoxifen, 4-Hydroxytamoxifen, and Raloxifene on Cardiac Myocyte Contractility and Calcium Handling

(2013) Michelle L. Asp et al.   PLoS One

Markers of mitochondrial dysfunction during the diclofenac-induced apoptosis in melanoma cell lines

(2012) Francesco Albano et al.   BIOCHIMIE

NIH Image to ImageJ: 25 years of image analysis

(2012) Caroline A Schneider et al.   NATURE METHODS

Patterned cardiomyocytes on microelectrode arrays as a functional, high information content drug screening platform

(2011) Anupama Natarajan et al.   BIOMATERIALS

A Multifaceted Evaluation of Imatinib-induced Cardiotoxicity in the Rat

(2011) Eugene H. Herman et al.   TOXICOLOGIC PATHOLOGY

A microfluidic device for a pharmacokinetic–pharmacodynamic (PK–PD) model on a chip

(2010) Jong Hwan Sung et al.   LAB ON A CHIP

Measurement of Contractile Stress Generated by Cultured Rat Muscle on Silicon Cantilevers for Toxin Detection and Muscle Performance Enhancement

(2010) Kerry Wilson et al.   PLoS One

Rapidly rising clinical trial costs worry researchers

(2009) R. Collier   CANADIAN MEDICAL ASSOCIATION JOURNAL

Cardiotoxicity of Anticancer Drugs: The Need for Cardio-Oncology and Cardio-Oncological Prevention

(2009) Adriana Albini et al.   JNCI-Journal of the National Cancer Institute