Modulating biomolecular condensates: a novel approach to drug discovery
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Title
Modulating biomolecular condensates: a novel approach to drug discovery
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Journal
NATURE REVIEWS DRUG DISCOVERY
Volume -, Issue -, Pages -
Publisher
Springer Science and Business Media LLC
Online
2022-08-16
DOI
10.1038/s41573-022-00505-4
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Note: Only part of the references are listed.- Biomolecular condensates and cancer
- (2021) Ann Boija et al. CANCER CELL
- Deciphering molecular interactions by proximity labeling
- (2021) Wei Qin et al. NATURE METHODS
- Biomolecular condensation of NUP98 fusion proteins drives leukemogenic gene expression
- (2021) Stefan Terlecki-Zaniewicz et al. NATURE STRUCTURAL & MOLECULAR BIOLOGY
- FUS and TDP-43 Phases in Health and Disease
- (2021) Bede Portz et al. TRENDS IN BIOCHEMICAL SCIENCES
- Formation and Function of Liquid-Like Viral Factories in Negative-Sense Single-Stranded RNA Virus Infections
- (2021) Justin M. Su et al. Viruses-Basel
- Phase separation and DAXX redistribution contribute to LANA nuclear body and KSHV genome dynamics during latency and reactivation
- (2021) Olga Vladimirova et al. PLoS Pathogens
- High-fidelity reconstitution of stress granules and nucleoli in mammalian cellular lysate
- (2021) Brian D. Freibaum et al. JOURNAL OF CELL BIOLOGY
- An intrinsically disordered region-mediated confinement state contributes to the dynamics and function of transcription factors
- (2021) David A. Garcia et al. MOLECULAR CELL
- Stress-induced nuclear condensation of NELF drives transcriptional downregulation
- (2021) Prashant Rawat et al. MOLECULAR CELL
- Biomolecular condensates at the nexus of cellular stress, protein aggregation disease and ageing
- (2021) Simon Alberti et al. NATURE REVIEWS MOLECULAR CELL BIOLOGY
- Local translation in nuclear condensate amyloid bodies
- (2021) Phaedra R. Theodoridis et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Ligand effects on phase separation of multivalent macromolecules
- (2021) Kiersten M. Ruff et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Liquid Biomolecular Condensates and Viral Lifecycles: Review and Perspectives
- (2021) Temitope Etibor et al. Viruses-Basel
- Targeting NSD2-mediated SRC-3 liquid–liquid phase separation sensitizes bortezomib treatment in multiple myeloma
- (2021) Jing Liu et al. Nature Communications
- Nanoscopic subcellular imaging enabled by ion beam tomography
- (2021) Ahmet F. Coskun et al. Nature Communications
- Reentrant liquid condensate phase of proteins is stabilized by hydrophobic and non-ionic interactions
- (2021) Georg Krainer et al. Nature Communications
- Computational Screening of Biological Phase-separating Proteins
- (2021) Boyan Shen et al. GENOMICS PROTEOMICS & BIOINFORMATICS
- The role of liquid–liquid phase separation in regulating enzyme activity
- (2021) Brian G. O'Flynn et al. CURRENT OPINION IN CELL BIOLOGY
- Modern optical microscopy methods to study biomolecular condensates
- (2021) Anisha Shakya et al. CURRENT OPINION IN COLLOID & INTERFACE SCIENCE
- Paraspeckles are constructed as block copolymer micelles
- (2021) Tomohiro Yamazaki et al. EMBO JOURNAL
- Biomolecular condensates amplify mRNA decapping by biasing enzyme conformation
- (2021) Ryan W. Tibble et al. Nature Chemical Biology
- Human centrosome organization and function in interphase and mitosis
- (2021) Alejandra Vasquez-Limeta et al. SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY
- A modular tool to query and inducibly disrupt biomolecular condensates
- (2021) Carmen N. Hernández-Candia et al. Nature Communications
- The Integral Role of RNA in Stress Granule Formation and Function
- (2021) Danae Campos-Melo et al. Frontiers in Cell and Developmental Biology
- Finding functions of phase separation in the presynapse
- (2021) Nathan A. McDonald et al. CURRENT OPINION IN NEUROBIOLOGY
- The evolving complexity of DNA damage foci: RNA, condensates and chromatin in DNA double-strand break repair
- (2021) Carel Fijen et al. DNA REPAIR
- Small Molecule Sequestration of the Intrinsically Disordered Protein, p27Kip1, Within Soluble Oligomers
- (2021) Luigi I. Iconaru et al. JOURNAL OF MOLECULAR BIOLOGY
- A condensate-hardening drug blocks RSV replication in vivo
- (2021) Jennifer Risso-Ballester et al. NATURE
- Highly accurate protein structure prediction with AlphaFold
- (2021) John Jumper et al. NATURE
- Phase separation drives aberrant chromatin looping and cancer development
- (2021) Jeong Hyun Ahn et al. NATURE
- Targeting liquid–liquid phase separation of SARS-CoV-2 nucleocapsid protein promotes innate antiviral immunity by elevating MAVS activity
- (2021) Shuai Wang et al. NATURE CELL BIOLOGY
- Mechanistic dissection of increased enzymatic rate in a phase-separated compartment
- (2021) William Peeples et al. Nature Chemical Biology
- p62-containing, proteolytically active nuclear condensates, increase the efficiency of the ubiquitin–proteasome system
- (2021) Afu Fu et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Local thermodynamics govern formation and dissolution of Caenorhabditis elegans P granule condensates
- (2021) Anatol W. Fritsch et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Subcellular localization of biomolecules and drug distribution by high-definition ion beam imaging
- (2021) Xavier Rovira-Clavé et al. Nature Communications
- Higher-order organization of biomolecular condensates
- (2021) Charlotte M. Fare et al. Open Biology
- Emerging Roles of Liquid–Liquid Phase Separation in Cancer: From Protein Aggregation to Immune-Associated Signaling
- (2021) Jiahua Lu et al. Frontiers in Cell and Developmental Biology
- Chemical-Mediated Targeted Protein Degradation in Neurodegenerative Diseases
- (2021) Soonsil Hyun et al. Life-Basel
- Hybridization-proximity labeling reveals spatially ordered interactions of nuclear RNA compartments
- (2021) Karen Yap et al. MOLECULAR CELL
- ALS-linked cytoplasmic FUS assemblies are compositionally different from physiological stress granules and sequester hnRNPA3, a novel modifier of FUS toxicity
- (2021) Haiyan An et al. NEUROBIOLOGY OF DISEASE
- Phase Separation mediates NUP98 Fusion Oncoprotein Leukemic Transformation
- (2021) Bappaditya Chandra et al. Cancer Discovery
- Physical Principles Underlying the Complex Biology of Intracellular Phase Transitions
- (2020) Jeong-Mo Choi et al. Annual Review of Biophysics
- Regulated changes in material properties underlie centrosome disassembly during mitotic exit
- (2020) Matthäus Mittasch et al. JOURNAL OF CELL BIOLOGY
- Mouse Heterochromatin Adopts Digital Compaction States without Showing Hallmarks of HP1-Driven Liquid-Liquid Phase Separation
- (2020) Fabian Erdel et al. MOLECULAR CELL
- Stress- and ubiquitylation-dependent phase separation of the proteasome
- (2020) Sayaka Yasuda et al. NATURE
- HSF1 phase transition mediates stress adaptation and cell fate decisions
- (2020) Giorgio Gaglia et al. NATURE CELL BIOLOGY
- Phase separation at the synapse
- (2020) Xudong Chen et al. NATURE NEUROSCIENCE
- TDP-43 α-helical structure tunes liquid–liquid phase separation and function
- (2020) Alexander E. Conicella et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Phase separation provides a mechanism to reduce noise in cells
- (2020) A. Klosin et al. SCIENCE
- SPLIT: Stable Protein Coacervation Using a Light Induced Transition
- (2020) Ellen H. Reed et al. ACS Synthetic Biology
- Live-Cell Imaging and Quantification of PolyQ Aggregates by Stimulated Raman Scattering of Selective Deuterium Labeling
- (2020) Kun Miao et al. ACS Central Science
- Competing Protein-RNA Interaction Networks Control Multiphase Intracellular Organization
- (2020) David W. Sanders et al. CELL
- G3BP1 Is a Tunable Switch that Triggers Phase Separation to Assemble Stress Granules
- (2020) Peiguo Yang et al. CELL
- RNA-Induced Conformational Switching and Clustering of G3BP Drive Stress Granule Assembly by Condensation
- (2020) Jordina Guillén-Boixet et al. CELL
- Phase-separated condensate-aided enrichment of biomolecular interactions for high-throughput drug screening in test tubes
- (2020) Min Zhou et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- BR-Bodies Provide Selectively Permeable Condensates that Stimulate mRNA Decay and Prevent Release of Decay Intermediates
- (2020) Nadra Al-Husini et al. MOLECULAR CELL
- Phase separation directs ubiquitination of gene-body nucleosomes
- (2020) Laura D. Gallego et al. NATURE
- Composition-dependent thermodynamics of intracellular phase separation
- (2020) Joshua A. Riback et al. NATURE
- TiPARP forms nuclear condensates to degrade HIF-1α and suppress tumorigenesis
- (2020) Lu Zhang et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Combined Selective Plane Illumination Microscopy and FRAP Maps Intranuclear Diffusion of NLS-GFP
- (2020) Chad M. Hobson et al. BIOPHYSICAL JOURNAL
- Mechanistic insights and potential therapeutic targets for NUP98-rearranged hematologic malignancies
- (2020) Nicole L. Michmerhuizen et al. BLOOD
- Stress granule subtypes: an emerging link to neurodegeneration
- (2020) Vivek M. Advani et al. CELLULAR AND MOLECULAR LIFE SCIENCES
- Karyopherins and condensates
- (2020) Charis E. Springhower et al. CURRENT OPINION IN CELL BIOLOGY
- Designer protein assemblies with tunable phase diagrams in living cells
- (2020) Meta Heidenreich et al. Nature Chemical Biology
- RNA contributions to the form and function of biomolecular condensates
- (2020) Christine Roden et al. NATURE REVIEWS MOLECULAR CELL BIOLOGY
- Partitioning of cancer therapeutics in nuclear condensates
- (2020) Isaac A. Klein et al. SCIENCE
- Biomolecular Condensates in the Nucleus
- (2020) Benjamin R. Sabari et al. TRENDS IN BIOCHEMICAL SCIENCES
- A quantitative inventory of yeast P body proteins reveals principles of composition and specificity
- (2020) Wenmin Xing et al. eLife
- Disclosing the Interactome of Leukemogenic NUP98-HOXA9 and SET-NUP214 Fusion Proteins Using a Proteomic Approach
- (2020) Adélia Mendes et al. Cells
- Protein Databases Related to Liquid–Liquid Phase Separation
- (2020) Qian Li et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- AggFluor: Fluorogenic Toolbox Enables Direct Visualization of the Multi-Step Protein Aggregation Process in Live Cells
- (2020) Charles H. Wolstenholme et al. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
- Nucleated transcriptional condensates amplify gene expression
- (2020) Ming-Tzo Wei et al. NATURE CELL BIOLOGY
- The nucleolus as a multiphase liquid condensate
- (2020) Denis L. J. Lafontaine et al. NATURE REVIEWS MOLECULAR CELL BIOLOGY
- Identification of Small Molecules that Modulate Mutant p53 Condensation
- (2020) Clara Lemos et al. iScience
- Negri bodies and other virus membrane-less replication compartments
- (2020) Quentin Nevers et al. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH
- Nucleophosmin, a multifunctional nucleolar organizer with a role in DNA repair
- (2020) David J. López et al. BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS
- RNA-Mediated Feedback Control of Transcriptional Condensates
- (2020) Jonathan E. Henninger et al. CELL
- SARS‐CoV‐2 nucleocapsid protein phase‐separates with RNA and with human hnRNPs
- (2020) Theodora Myrto Perdikari et al. EMBO JOURNAL
- Structure and function of p62/SQSTM1 in the emerging framework of phase separation
- (2020) Sabrina Berkamp et al. FEBS Journal
- Genomic RNA Elements Drive Phase Separation of the SARS-CoV-2 Nucleocapsid
- (2020) Christiane Iserman et al. MOLECULAR CELL
- Image-based profiling for drug discovery: due for a machine-learning upgrade?
- (2020) Srinivas Niranj Chandrasekaran et al. NATURE REVIEWS DRUG DISCOVERY
- The functional organization of axonal mRNA transport and translation
- (2020) Irene Dalla Costa et al. NATURE REVIEWS NEUROSCIENCE
- Optogenetic TDP-43 nucleation induces persistent insoluble species and progressive motor dysfunction in vivo
- (2020) Charlton G. Otte et al. NEUROBIOLOGY OF DISEASE
- Double-edged Role of PML Nuclear Bodies during Human Adenovirus Infection
- (2020) Samuel Hofmann et al. VIRUS RESEARCH
- ALS-implicated protein TDP-43 sustains levels of STMN2, a mediator of motor neuron growth and repair
- (2019) Joseph R. Klim et al. NATURE NEUROSCIENCE
- Principles of Stress Granules Revealed by Imaging Approaches
- (2019) Briana Van Treeck et al. Cold Spring Harbor Perspectives in Biology
- RNA Binding Antagonizes Neurotoxic Phase Transitions of TDP-43
- (2019) Jacob R. Mann et al. NEURON
- A gel phase promotes condensation of liquid P granules in Caenorhabditis elegans embryos
- (2019) Andrea Putnam et al. NATURE STRUCTURAL & MOLECULAR BIOLOGY
- Cellular sensing by phase separation: Using the process, not just the products
- (2019) Haneul Yoo et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Considerations and Challenges in Studying Liquid-Liquid Phase Separation and Biomolecular Condensates
- (2019) Simon Alberti et al. CELL
- C9orf72 Poly(PR) Dipeptide Repeats Disturb Biomolecular Phase Separation and Disrupt Nucleolar Function
- (2019) Michael R. White et al. MOLECULAR CELL
- Epi-illumination SPIM for volumetric imaging with high spatial-temporal resolution
- (2019) Bin Yang et al. NATURE METHODS
- Spontaneous driving forces give rise to protein−RNA condensates with coexisting phases and complex material properties
- (2019) Steven Boeynaems et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- A first order phase transition mechanism underlies protein aggregation in mammalian cells
- (2019) Arjun Narayanan et al. eLife
- Chronic optogenetic induction of stress granules is cytotoxic and reveals the evolution of ALS-FTD pathology
- (2019) Peipei Zhang et al. eLife
- Viral Regulation of RNA Granules in Infected Cells
- (2019) Qiang Zhang et al. VIROLOGICA SINICA
- Fast Fluorescence Lifetime Imaging Reveals the Aggregation Processes of α-Synuclein and Polyglutamine in Aging Caenorhabditis elegans
- (2019) Romain F. Laine et al. ACS Chemical Biology
- Genome organization around nuclear speckles
- (2019) Yu Chen et al. CURRENT OPINION IN GENETICS & DEVELOPMENT
- Heterochromatin drives compartmentalization of inverted and conventional nuclei
- (2019) Martin Falk et al. NATURE
- m6A enhances the phase separation potential of mRNA
- (2019) Ryan J. Ries et al. NATURE
- Small-Molecule Modulation of TDP-43 Recruitment to Stress Granules Prevents Persistent TDP-43 Accumulation in ALS/FTD
- (2019) Mark Y. Fang et al. NEURON
- The nucleolus functions as a phase-separated protein quality control compartment
- (2019) F. Frottin et al. SCIENCE
- Automated detection of the HER2 gene amplification status in Fluorescence in situ hybridization images for the diagnostics of cancer tissues
- (2019) Falk Zakrzewski et al. Scientific Reports
- Liquid–Liquid Phase Separation in Disease
- (2019) Simon Alberti et al. Annual Review of Genetics
- Mediator Condensates Localize Signaling Factors to Key Cell Identity Genes
- (2019) Alicia V. Zamudio et al. MOLECULAR CELL
- DEAD-box ATPases are global regulators of phase-separated organelles
- (2019) Maria Hondele et al. NATURE
- Functional transcription promoters at DNA double-strand breaks mediate RNA-driven phase separation of damage-response factors
- (2019) Fabio Pessina et al. NATURE CELL BIOLOGY
- Quantifying Dynamics in Phase-Separated Condensates Using Fluorescence Recovery after Photobleaching
- (2019) Nicole O. Taylor et al. BIOPHYSICAL JOURNAL
- Organization of Chromatin by Intrinsic and Regulated Phase Separation
- (2019) Bryan A. Gibson et al. CELL
- Lnc RNA ‐dependent nuclear stress bodies promote intron retention through SR protein phosphorylation
- (2019) Kensuke Ninomiya et al. EMBO JOURNAL
- Evaluating phase separation in live cells: diagnosis, caveats, and functional consequences
- (2019) David T. McSwiggen et al. GENES & DEVELOPMENT
- The Control Centers of Biomolecular Phase Separation: How Membrane Surfaces, PTMs, and Active Processes Regulate Condensation
- (2019) Wilton T. Snead et al. MOLECULAR CELL
- Allele-selective lowering of mutant HTT protein by HTT–LC3 linker compounds
- (2019) Zhaoyang Li et al. NATURE
- Biomolecular condensates in neurodegeneration and cancer
- (2019) Stephanie Spannl et al. TRAFFIC
- Chromatin-bound CRM1 recruits SET-Nup214 and NPM1c onto HOX clusters causing aberrant HOX expression in leukemia cells
- (2019) Masahiro Oka et al. eLife
- Nucleolar Sequestration: Remodeling Nucleoli Into Amyloid Bodies
- (2019) Miling Wang et al. Frontiers in Genetics
- HIV-1 Gag specifically restricts PI(4,5)P2 and cholesterol mobility in living cells creating a nanodomain platform for virus assembly
- (2019) C. Favard et al. Science Advances
- Utilizing Stimulated Raman Scattering Microscopy To Study Intracellular Distribution of Label-Free Ponatinib in Live Cells
- (2019) Kristel Sepp et al. JOURNAL OF MEDICINAL CHEMISTRY
- Direct visualization of degradation microcompartments at the ER membrane
- (2019) Sahradha Albert et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- The Role of Phase Separation in Heterochromatin Formation, Function, and Regulation
- (2018) Adam G. Larson et al. BIOCHEMISTRY
- Functional Implications of Intracellular Phase Transitions
- (2018) Alex S. Holehouse et al. BIOCHEMISTRY
- P-Bodies: Composition, Properties, and Functions
- (2018) Yang Luo et al. BIOCHEMISTRY
- Nuclear Import Receptor Inhibits Phase Separation of FUS through Binding to Multiple Sites
- (2018) Takuya Yoshizawa et al. CELL
- Context-Dependent and Disease-Specific Diversity in Protein Interactions within Stress Granules
- (2018) Sebastian Markmiller et al. CELL
- A Molecular Grammar Governing the Driving Forces for Phase Separation of Prion-like RNA Binding Proteins
- (2018) Jie Wang et al. CELL
- Nuclear-Import Receptors Reverse Aberrant Phase Transitions of RNA-Binding Proteins with Prion-like Domains
- (2018) Lin Guo et al. CELL
- Ubiquitin Modulates Liquid-Liquid Phase Separation of UBQLN2 via Disruption of Multivalent Interactions
- (2018) Thuy P. Dao et al. MOLECULAR CELL
- Non-invasive perturbations of intracellular flow reveal physical principles of cell organization
- (2018) Matthäus Mittasch et al. NATURE CELL BIOLOGY
- RNA–protein interaction detection in living cells
- (2018) Muthukumar Ramanathan et al. NATURE METHODS
- TDP-43 pathology disrupts nuclear pore complexes and nucleocytoplasmic transport in ALS/FTD
- (2018) Ching-Chieh Chou et al. NATURE NEUROSCIENCE
- Principles for targeting RNA with drug-like small molecules
- (2018) Katherine Deigan Warner et al. NATURE REVIEWS DRUG DISCOVERY
- RNA buffers the phase separation behavior of prion-like RNA binding proteins
- (2018) Shovamayee Maharana et al. SCIENCE
- mRNA structure determines specificity of a polyQ-driven phase separation
- (2018) Erin M. Langdon et al. SCIENCE
- Imaging dynamic and selective low-complexity domain interactions that control gene transcription
- (2018) Shasha Chong et al. SCIENCE
- DNA-induced liquid phase condensation of cGAS activates innate immune signaling
- (2018) Mingjian Du et al. SCIENCE
- Coactivator condensation at super-enhancers links phase separation and gene control
- (2018) Benjamin R. Sabari et al. SCIENCE
- Mediator and RNA polymerase II clusters associate in transcription-dependent condensates
- (2018) Won-Ki Cho et al. SCIENCE
- Organization and Function of Non-dynamic Biomolecular Condensates
- (2018) Jeffrey B. Woodruff et al. TRENDS IN BIOCHEMICAL SCIENCES
- Paraspeckles: Where Long Noncoding RNA Meets Phase Separation
- (2018) Archa H. Fox et al. TRENDS IN BIOCHEMICAL SCIENCES
- P-Bodies: Cytosolic Droplets for Coordinated mRNA Storage
- (2018) Nancy Standart et al. TRENDS IN GENETICS
- Self-interaction of NPM1 modulates multiple mechanisms of liquid–liquid phase separation
- (2018) Diana M. Mitrea et al. Nature Communications
- PML: Regulation and multifaceted function beyond tumor suppression
- (2018) Kuo-Sheng Hsu et al. Cell and Bioscience
- Pi-Pi contacts are an overlooked protein feature relevant to phase separation
- (2018) Robert McCoy Vernon et al. eLife
- Who's In and Who's Out—Compositional Control of Biomolecular Condensates
- (2018) Jonathon A. Ditlev et al. JOURNAL OF MOLECULAR BIOLOGY
- Methods for Physical Characterization of Phase-Separated Bodies and Membrane-less Organelles
- (2018) Diana M. Mitrea et al. JOURNAL OF MOLECULAR BIOLOGY
- Poly(ADP-Ribose) Prevents Pathological Phase Separation of TDP-43 by Promoting Liquid Demixing and Stress Granule Localization
- (2018) Leeanne McGurk et al. MOLECULAR CELL
- Efficient proximity labeling in living cells and organisms with TurboID
- (2018) Tess C Branon et al. NATURE BIOTECHNOLOGY
- Sulforaphane inhibits growth and blocks Wnt/β-catenin signaling of colorectal cancer cells
- (2018) Dominic B. Bernkopf et al. Oncotarget
- Tissue degeneration in ALS affected spinal cord evaluated by Raman spectroscopy
- (2018) Gennaro Picardi et al. Scientific Reports
- Transcription Factors Activate Genes through the Phase-Separation Capacity of Their Activation Domains
- (2018) Ann Boija et al. CELL
- A Membraneless Organelle Associated with the Endoplasmic Reticulum Enables 3′UTR-Mediated Protein-Protein Interactions
- (2018) Weirui Ma et al. CELL
- Mapping Local and Global Liquid Phase Behavior in Living Cells Using Photo-Oligomerizable Seeds
- (2018) Dan Bracha et al. CELL
- Friend or foe — post-translational modifications as regulators of phase separation and RNP granule dynamics
- (2018) Mario Hofweber et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Content-aware image restoration: pushing the limits of fluorescence microscopy
- (2018) Martin Weigert et al. NATURE METHODS
- Deep learning enables cross-modality super-resolution in fluorescence microscopy
- (2018) Hongda Wang et al. NATURE METHODS
- Compositional adaptability in NPM1-SURF6 scaffolding networks enabled by dynamic switching of phase separation mechanisms
- (2018) Mylene C. Ferrolino et al. Nature Communications
- Getting to know the neighborhood: using proximity-dependent biotinylation to characterize protein complexes and map organelles
- (2018) Anne-Claude Gingras et al. CURRENT OPINION IN CHEMICAL BIOLOGY
- P-Body Purification Reveals the Condensation of Repressed mRNA Regulons
- (2017) Arnaud Hubstenberger et al. MOLECULAR CELL
- The Stress Granule Transcriptome Reveals Principles of mRNA Accumulation in Stress Granules
- (2017) Anthony Khong et al. MOLECULAR CELL
- Phase separation drives heterochromatin domain formation
- (2017) Amy R. Strom et al. NATURE
- RNA phase transitions in repeat expansion disorders
- (2017) Ankur Jain et al. NATURE
- Liquid droplet formation by HP1α suggests a role for phase separation in heterochromatin
- (2017) Adam G. Larson et al. NATURE
- MobiDB 3.0: more annotations for intrinsic disorder, conformational diversity and interactions in proteins
- (2017) Damiano Piovesan et al. NUCLEIC ACIDS RESEARCH
- Nuclear speckles: molecular organization, biological function and role in disease
- (2017) Lukasz Galganski et al. NUCLEIC ACIDS RESEARCH
- Amyotrophic lateral sclerosis-linked mutations increase the viscosity of liquid-like TDP-43 RNP granules in neurons
- (2017) Pallavi P. Gopal et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Coordinating cell cycle-regulated histone gene expression through assembly and function of the Histone Locus Body
- (2017) Robert J. Duronio et al. RNA Biology
- ATP as a biological hydrotrope
- (2017) Avinash Patel et al. SCIENCE
- Liquid phase condensation in cell physiology and disease
- (2017) Yongdae Shin et al. SCIENCE
- Negri bodies are viral factories with properties of liquid organelles
- (2017) Jovan Nikolic et al. Nature Communications
- Sulforaphane for the chemoprevention of bladder cancer: molecular mechanism targeted approach
- (2017) Andrew Leone et al. Oncotarget
- The Role of Dipeptide Repeats in C9ORF72-Related ALS-FTD
- (2017) Brian D. Freibaum et al. Frontiers in Molecular Neuroscience
- EPI-001, A Compound Active against Castration-Resistant Prostate Cancer, Targets Transactivation Unit 5 of the Androgen Receptor
- (2016) Eva De Mol et al. ACS Chemical Biology
- Characterization and prediction of the mechanism of action of antibiotics through NMR metabolomics
- (2016) Verena Hoerr et al. BMC MICROBIOLOGY
- NUP98 Fusion Proteins Interact with the NSL and MLL1 Complexes to Drive Leukemogenesis
- (2016) Haiming Xu et al. CANCER CELL
- Amyloid-like Self-Assembly of a Cellular Compartment
- (2016) Elvan Boke et al. CELL
- ATPase-Modulated Stress Granules Contain a Diverse Proteome and Substructure
- (2016) Saumya Jain et al. CELL
- C9orf72 Dipeptide Repeats Impair the Assembly, Dynamics, and Function of Membrane-Less Organelles
- (2016) Kyung-Ha Lee et al. CELL
- Compositional Control of Phase-Separated Cellular Bodies
- (2016) Salman F. Banani et al. CELL
- Coexisting Liquid Phases Underlie Nucleolar Subcompartments
- (2016) Marina Feric et al. CELL
- Phase separation in biology; functional organization of a higher order
- (2016) Diana M. Mitrea et al. Cell Communication and Signaling
- Stimulated Raman scattering microscopy: an emerging tool for drug discovery
- (2016) W. J. Tipping et al. CHEMICAL SOCIETY REVIEWS
- Adaptation to Stressors by Systemic Protein Amyloidogenesis
- (2016) Timothy E. Audas et al. DEVELOPMENTAL CELL
- Modulation of Intrinsically Disordered Protein Function by Post-translational Modifications
- (2016) Alaji Bah et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- An improved smaller biotin ligase for BioID proximity labeling
- (2016) Dae In Kim et al. MOLECULAR BIOLOGY OF THE CELL
- Systemic Delivery and Biodistribution of Cisplatin in Vivo
- (2016) Yu-Hsuan Chu et al. MOLECULAR PHARMACEUTICS
- Decoding ALS: from genes to mechanism
- (2016) J. Paul Taylor et al. NATURE
- Phase separation of signaling molecules promotes T cell receptor signal transduction
- (2016) Xiaolei Su et al. SCIENCE
- Transport Selectivity of Nuclear Pores, Phase Separation, and Membraneless Organelles
- (2016) H. Broder Schmidt et al. TRENDS IN BIOCHEMICAL SCIENCES
- Anti-proliferative activity of the NPM1 interacting natural product avrainvillamide in acute myeloid leukemia
- (2016) Vibeke Andresen et al. Cell Death & Disease
- Monitoring peripheral nerve degeneration in ALS by label-free stimulated Raman scattering imaging
- (2016) Feng Tian et al. Nature Communications
- Molecules that target nucleophosmin for cancer treatment: an update
- (2016) Adele Di Matteo et al. Oncotarget
- A Concentration-Dependent Liquid Phase Separation Can Cause Toxicity upon Increased Protein Expression
- (2016) Benedetta Bolognesi et al. Cell Reports
- Chromatin-prebound Crm1 recruits Nup98-HoxA9 fusion to induce aberrant expression of Hox cluster genes
- (2016) Masahiro Oka et al. eLife
- Nucleophosmin integrates within the nucleolus via multi-modal interactions with proteins displaying R-rich linear motifs and rRNA
- (2016) Diana M Mitrea et al. eLife
- Distinct stages in stress granule assembly and disassembly
- (2016) Joshua R Wheeler et al. eLife
- Interactions of the Natural Product (+)-Avrainvillamide with Nucleophosmin and Exportin-1 Mediate the Cellular Localization of Nucleophosmin and its AML-Associated Mutants
- (2015) Herschel Mukherjee et al. ACS Chemical Biology
- Phase Separation by Low Complexity Domains Promotes Stress Granule Assembly and Drives Pathological Fibrillization
- (2015) Amandine Molliex et al. CELL
- A Liquid-to-Solid Phase Transition of the ALS Protein FUS Accelerated by Disease Mutation
- (2015) Avinash Patel et al. CELL
- Standards and guidelines for the interpretation of sequence variants: a joint consensus recommendation of the American College of Medical Genetics and Genomics and the Association for Molecular Pathology
- (2015) Sue Richards et al. GENETICS IN MEDICINE
- BioID identifies novel c-MYC interacting partners in cultured cells and xenograft tumors
- (2015) Dharmendra Dingar et al. Journal of Proteomics
- RNA Controls PolyQ Protein Phase Transitions
- (2015) Huaiying Zhang et al. MOLECULAR CELL
- Residue-by-Residue View of In Vitro FUS Granules that Bind the C-Terminal Domain of RNA Polymerase II
- (2015) Kathleen A. Burke et al. MOLECULAR CELL
- Phase Transition of a Disordered Nuage Protein Generates Environmentally Responsive Membraneless Organelles
- (2015) Timothy J. Nott et al. MOLECULAR CELL
- The Airyscan detector from ZEISS: confocal imaging with improved signal-to-noise ratio and super-resolution
- (2015) Joseph Huff NATURE METHODS
- Super-resolution spinning-disk confocal microscopy using optical photon reassignment
- (2015) Takuya Azuma et al. OPTICS EXPRESS
- The disordered P granule protein LAF-1 drives phase separation into droplets with tunable viscosity and dynamics
- (2015) Shana Elbaum-Garfinkle et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Liquid demixing of intrinsically disordered proteins is seeded by poly(ADP-ribose)
- (2015) Matthias Altmeyer et al. Nature Communications
- Discovery of Small Molecules that Inhibit the Disordered Protein, p27 Kip1
- (2015) Luigi I. Iconaru et al. Scientific Reports
- Nup98 FG domains from diverse species spontaneously phase-separate into particles with nuclear pore-like permselectivity
- (2015) Hermann Broder Schmidt et al. eLife
- Promiscuous interactions and protein disaggregases determine the material state of stress-inducible RNP granules
- (2015) Sonja Kroschwald et al. eLife
- Liquid-Liquid Phase Separation in Biology
- (2014) Anthony A. Hyman et al. Annual Review of Cell and Developmental Biology
- PLAAC: a web and command-line application to identify proteins with prion-like amino acid composition
- (2014) A. K. Lancaster et al. BIOINFORMATICS
- Directed evolution of APEX2 for electron microscopy and proximity labeling
- (2014) Stephanie S Lam et al. NATURE METHODS
- Lattice light-sheet microscopy: Imaging molecules to embryos at high spatiotemporal resolution
- (2014) Bi-Chang Chen et al. SCIENCE
- Regulation of RNA granule dynamics by phosphorylation of serine-rich, intrinsically disordered proteins in C. elegans
- (2014) Jennifer T Wang et al. eLife
- Selective Inhibition of Tumor Oncogenes by Disruption of Super-Enhancers
- (2013) Jakob Lovén et al. CELL
- Master Transcription Factors and Mediator Establish Super-Enhancers at Key Cell Identity Genes
- (2013) Warren A. Whyte et al. CELL
- Super-Enhancers in the Control of Cell Identity and Disease
- (2013) Denes Hnisz et al. CELL
- Unique SERM-like properties of the novel fluorescent tamoxifen derivative FLTX1
- (2013) Jorge Marrero-Alonso et al. EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS
- Phase transitions and size scaling of membrane-less organelles
- (2013) Clifford P. Brangwynne JOURNAL OF CELL BIOLOGY
- Stress granules as crucibles of ALS pathogenesis
- (2013) Yun R. Li et al. JOURNAL OF CELL BIOLOGY
- A Comprehensive Mathematical Model for Three-Body Binding Equilibria
- (2013) Eugene F. Douglass et al. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
- Validating therapeutic targets through human genetics
- (2013) Robert M. Plenge et al. NATURE REVIEWS DRUG DISCOVERY
- Aqueous Phase Separation as a Possible Route to Compartmentalization of Biological Molecules
- (2012) Christine D. Keating ACCOUNTS OF CHEMICAL RESEARCH
- Cell-free Formation of RNA Granules: Low Complexity Sequence Domains Form Dynamic Fibers within Hydrogels
- (2012) Masato Kato et al. CELL
- Cell-free Formation of RNA Granules: Bound RNAs Identify Features and Components of Cellular Assemblies
- (2012) Tina W. Han et al. CELL
- Both G3BP1 and G3BP2 contribute to stress granule formation
- (2012) Hideaki Matsuki et al. GENES TO CELLS
- Phase transitions in the assembly of multivalent signalling proteins
- (2012) Pilong Li et al. NATURE
- D2P2: database of disordered protein predictions
- (2012) Matt E. Oates et al. NUCLEIC ACIDS RESEARCH
- Affinity-purification coupled to mass spectrometry: Basic principles and strategies
- (2012) Wade H. Dunham et al. PROTEOMICS
- Beyond Oil and Water--Phase Transitions in Cells
- (2012) A. A. Hyman et al. SCIENCE
- Regulation of stress granules in virus systems
- (2012) James P. White et al. TRENDS IN MICROBIOLOGY
- Cajal bodies: where form meets function
- (2012) Martin Machyna et al. Wiley Interdisciplinary Reviews-RNA
- NUP98 gene fusions and hematopoietic malignancies: common themes and new biologic insights
- (2011) S. M. Gough et al. BLOOD
- Beyond Stereospecificity: Liquids and Mesoscale Organization of Cytoplasm
- (2011) Anthony A. Hyman et al. DEVELOPMENTAL CELL
- PGL proteins self associate and bind RNPs to mediate germ granule assembly inC. elegans
- (2011) Momoyo Hanazawa et al. JOURNAL OF CELL BIOLOGY
- Active liquid-like behavior of nucleoli determines their size and shape in Xenopus laevis oocytes
- (2011) C. P. Brangwynne et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Nonlinear structured-illumination microscopy with a photoswitchable protein reveals cellular structures at 50-nm resolution
- (2011) E. H. Rego et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Assembly and function of DNA double-strand break repair foci in mammalian cells
- (2010) Simon Bekker-Jensen et al. DNA REPAIR
- P Granule Assembly and Function in Caenorhabditis elegans Germ Cells
- (2010) D. Updike et al. JOURNAL OF ANDROLOGY
- Nuclear Stress Bodies
- (2010) G. Biamonti et al. Cold Spring Harbor Perspectives in Biology
- Nuclear Speckles
- (2010) D. L. Spector et al. Cold Spring Harbor Perspectives in Biology
- NLStradamus: a simple Hidden Markov Model for nuclear localization signal prediction
- (2009) Alex N Nguyen Ba et al. BMC BIOINFORMATICS
- Germline P Granules Are Liquid Droplets That Localize by Controlled Dissolution/Condensation
- (2009) C. P. Brangwynne et al. SCIENCE
- Biochemical visualization of cell surface molecular clustering in living cells
- (2008) N. Kotani et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Promiscuous protein biotinylation by Escherichia coli biotin protein ligase
- (2004) Eunjoo Choi-Rhee et al. PROTEIN SCIENCE
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