Biomolecular condensates and cancer

Physical Principles Underlying the Complex Biology of Intracellular Phase Transitions

(2020) Jeong-Mo Choi et al.   Annual Review of Biophysics

Arginine-Enriched Mixed-Charge Domains Provide Cohesion for Nuclear Speckle Condensation

(2020) Jamie A. Greig et al.   MOLECULAR CELL

Stress- and ubiquitylation-dependent phase separation of the proteasome

(2020) Sayaka Yasuda et al.   NATURE

Phase separation organizes the site of autophagosome formation

(2020) Yuko Fujioka et al.   NATURE

HSF1 phase transition mediates stress adaptation and cell fate decisions

(2020) Giorgio Gaglia et al.   NATURE CELL BIOLOGY

Phase separation provides a mechanism to reduce noise in cells

(2020) A. Klosin et al.   SCIENCE

Poly(ADP-ribose): A Dynamic Trigger for Biomolecular Condensate Formation

(2020) Anthony K.L. Leung   TRENDS IN CELL BIOLOGY

DNA repair by Rad52 liquid droplets

(2020) Roxanne Oshidari et al.   Nature Communications

Liquid-liquid phase separation and extracellular multivalent interactions in the tale of galectin-3

(2020) Yi-Ping Chiu et al.   Nature Communications

Liquid-like droplet formation by tumor suppressor p53 induced by multivalent electrostatic interactions between two disordered domains

(2020) Kiyoto Kamagata et al.   Scientific Reports

Competing Protein-RNA Interaction Networks Control Multiphase Intracellular Organization

(2020) David W. Sanders et al.   CELL

G3BP1 Is a Tunable Switch that Triggers Phase Separation to Assemble Stress Granules

(2020) Peiguo Yang et al.   CELL

RNA-Induced Conformational Switching and Clustering of G3BP Drive Stress Granule Assembly by Condensation

(2020) Jordina Guillén-Boixet et al.   CELL

A separation that’s for the best: coming together at the PAS

(2020) Wayne D. Hawkins et al.   CELL RESEARCH

Biomarker-Guided Development of DNA Repair Inhibitors

(2020) James M. Cleary et al.   MOLECULAR CELL

Composition-dependent thermodynamics of intracellular phase separation

(2020) Joshua A. Riback et al.   NATURE

The SWI/SNF complex in cancer — biology, biomarkers and therapy

(2020) Priya Mittal et al.   Nature Reviews Clinical Oncology

Nuclear body phase separation drives telomere clustering in ALT cancer cells

(2020) Huaiying Zhang et al.   MOLECULAR BIOLOGY OF THE CELL

MeCP2 links heterochromatin condensates and neurodevelopmental disease

(2020) Charles H. Li et al.   NATURE

RNA contributions to the form and function of biomolecular condensates

(2020) Christine Roden et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Epigenetic Therapies for Cancer

(2020) Susan E. Bates   NEW ENGLAND JOURNAL OF MEDICINE

Partitioning of cancer therapeutics in nuclear condensates

(2020) Isaac A. Klein et al.   SCIENCE

Biomolecular Condensates in the Nucleus

(2020) Benjamin R. Sabari et al.   TRENDS IN BIOCHEMICAL SCIENCES

Head-to-Tail Polymerization in the Assembly of Biomolecular Condensates

(2020) Mariann Bienz   CELL

Phase Separation of a PKA Regulatory Subunit Controls cAMP Compartmentation and Oncogenic Signaling

(2020) Jason Z. Zhang et al.   CELL

Phase Separation of Disease-Associated SHP2 Mutants Underlies MAPK Hyperactivation

(2020) Guangya Zhu et al.   CELL

Biomolecular Condensates and Gene Activation in Development and Disease

(2020) Benjamin R. Sabari   DEVELOPMENTAL CELL

Enzymatic Reactions inside Biological Condensates

(2020) Yi Zhang et al.   JOURNAL OF MOLECULAR BIOLOGY

Nucleated transcriptional condensates amplify gene expression

(2020) Ming-Tzo Wei et al.   NATURE CELL BIOLOGY

lncRNA DIGIT and BRD3 protein form phase-separated condensates to regulate endoderm differentiation

(2020) Kaveh Daneshvar et al.   NATURE CELL BIOLOGY

Concepts of extracellular matrix remodelling in tumour progression and metastasis

(2020) Juliane Winkler et al.   Nature Communications

Identification of Small Molecules that Modulate Mutant p53 Condensation

(2020) Clara Lemos et al.   iScience

RNA-Mediated Feedback Control of Transcriptional Condensates

(2020) Jonathan E. Henninger et al.   CELL

Biological Functions of Autophagy Genes: A Disease Perspective

(2019) Beth Levine et al.   CELL

Identification and characterization of oncogenic SOS1 mutations in lung adenocarcinoma

(2019) Diana Cai et al.   MOLECULAR CANCER RESEARCH

Long non-coding RNA NEAT1 confers oncogenic role in triple-negative breast cancer through modulating chemoresistance and cancer stemness

(2019) Vivian Yvonne Shin et al.   Cell Death & Disease

A molecular assembly phase transition and kinetic proofreading modulate Ras activation by SOS

(2019) William Y. C. Huang et al.   SCIENCE

Stoichiometry controls activity of phase-separated clusters of actin signaling proteins

(2019) Lindsay B. Case et al.   SCIENCE

Phase separation of ligand-activated enhancers licenses cooperative chromosomal enhancer assembly

(2019) Sreejith J. Nair et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Cellular sensing by phase separation: Using the process, not just the products

(2019) Haneul Yoo et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Regulation of Transmembrane Signaling by Phase Separation

(2019) Lindsay B. Case et al.   Annual Review of Biophysics

Redox State Controls Phase Separation of the Yeast Ataxin-2 Protein via Reversible Oxidation of Its Methionine-Rich Low-Complexity Domain

(2019) Masato Kato et al.   CELL

PARP-1 Activation Directs FUS to DNA Damage Sites to Form PARG-Reversible Compartments Enriched in Damaged DNA

(2019) Anastasia S. Singatulina et al.   Cell Reports

Phase separation of 53 BP 1 determines liquid‐like behavior of DNA repair compartments

(2019) Sinan Kilic et al.   EMBO JOURNAL

Phase separation of Polycomb-repressive complex 1 is governed by a charged disordered region of CBX2

(2019) Aaron J. Plys et al.   GENES & DEVELOPMENT

Clustered telomeres in phase-separated nuclear condensates engage mitotic DNA synthesis through BLM and RAD52

(2019) Jaewon Min et al.   GENES & DEVELOPMENT

m6A enhances the phase separation potential of mRNA

(2019) Ryan J. Ries et al.   NATURE

Enhancer Features that Drive Formation of Transcriptional Condensates

(2019) Krishna Shrinivas et al.   MOLECULAR CELL

Mediator Condensates Localize Signaling Factors to Key Cell Identity Genes

(2019) Alicia V. Zamudio et al.   MOLECULAR CELL

Pol II phosphorylation regulates a switch between transcriptional and splicing condensates

(2019) Yang Eric Guo et al.   NATURE

Functional transcription promoters at DNA double-strand breaks mediate RNA-driven phase separation of damage-response factors

(2019) Fabio Pessina et al.   NATURE CELL BIOLOGY

A new class of disordered elements controls DNA replication through initiator self-assembly

(2019) Matthew W Parker et al.   eLife

Organization of Chromatin by Intrinsic and Regulated Phase Separation

(2019) Bryan A. Gibson et al.   CELL

The liquid nucleome – phase transitions in the nucleus at a glance

(2019) Amy R. Strom et al.   JOURNAL OF CELL SCIENCE

Androgen Receptor Interaction with Mediator Complex Is Enhanced in Castration-Resistant Prostate Cancer by CDK7 Phosphorylation of MED1

(2019) Joshua W. Russo et al.   Cancer Discovery

Autophagy in cancer: moving from understanding mechanism to improving therapy responses in patients

(2019) Jean M. Mulcahy Levy et al.   CELL DEATH AND DIFFERENTIATION

Molecular structure in biomolecular condensates

(2019) Ivan Peran et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

Functions of N6-methyladenosine and its role in cancer

(2019) Liuer He et al.   Molecular Cancer

Impaired cell fate through gain-of-function mutations in a chromatin reader

(2019) Liling Wan et al.   NATURE

Phase separation of YAP reorganizes genome topology for long-term YAP target gene expression

(2019) Danfeng Cai et al.   NATURE CELL BIOLOGY

The Cytosolic DNA-Sensing cGAS–STING Pathway in Cancer

(2019) John Kwon et al.   Cancer Discovery

Neuronal Synapses: Microscale Signal Processing Machineries Formed by Phase Separation?

(2018) Zhe Feng et al.   BIOCHEMISTRY

Non-coding RNAs in the reprogramming of glucose metabolism in cancer

(2018) Ram C. Shankaraiah et al.   CANCER LETTERS

Phase Transitions in the Assembly and Function of Human miRISC

(2018) Jessica Sheu-Gruttadauria et al.   CELL

A Molecular Grammar Governing the Driving Forces for Phase Separation of Prion-like RNA Binding Proteins

(2018) Jie Wang et al.   CELL

Oncogenic Signaling Pathways in The Cancer Genome Atlas

(2018) Francisco Sanchez-Vega et al.   CELL

Polyubiquitin chain-induced p62 phase separation drives autophagic cargo segregation

(2018) Daxiao Sun et al.   CELL RESEARCH

Cytosolic sensing of immuno-stimulatory DNA, the enemy within

(2018) Rekha Dhanwani et al.   CURRENT OPINION IN IMMUNOLOGY

Cancer-Cell-Intrinsic Mechanisms Shaping the Tumor Immune Landscape

(2018) Max D. Wellenstein et al.   IMMUNITY

The Role of RNA in Biological Phase Separations

(2018) Marta M. Fay et al.   JOURNAL OF MOLECULAR BIOLOGY

Role of Liquid–Liquid Phase Separation in Assembly of Elastin and Other Extracellular Matrix Proteins

(2018) Lisa D. Muiznieks et al.   JOURNAL OF MOLECULAR BIOLOGY

Intrinsically Disordered Proteins: Structure, Function and Therapeutics

(2018) Jianhan Chen et al.   JOURNAL OF MOLECULAR BIOLOGY

Functional Domains of NEAT1 Architectural lncRNA Induce Paraspeckle Assembly through Phase Separation

(2018) Tomohiro Yamazaki et al.   MOLECULAR CELL

Mechanism and medical implications of mammalian autophagy

(2018) Ivan Dikic et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

RNA buffers the phase separation behavior of prion-like RNA binding proteins

(2018) Shovamayee Maharana et al.   SCIENCE

Imaging dynamic and selective low-complexity domain interactions that control gene transcription

(2018) Shasha Chong et al.   SCIENCE

DNA-induced liquid phase condensation of cGAS activates innate immune signaling

(2018) Mingjian Du et al.   SCIENCE

Coactivator condensation at super-enhancers links phase separation and gene control

(2018) Benjamin R. Sabari et al.   SCIENCE

Mediator and RNA polymerase II clusters associate in transcription-dependent condensates

(2018) Won-Ki Cho et al.   SCIENCE

CAR T cell immunotherapy for human cancer

(2018) Carl H. June et al.   SCIENCE

Phase separation of a yeast prion protein promotes cellular fitness

(2018) Titus M. Franzmann et al.   SCIENCE

Organization and Function of Non-dynamic Biomolecular Condensates

(2018) Jeffrey B. Woodruff et al.   TRENDS IN BIOCHEMICAL SCIENCES

Self-interaction of NPM1 modulates multiple mechanisms of liquid–liquid phase separation

(2018) Diana M. Mitrea et al.   Nature Communications

Transcriptional Regulation in Prostate Cancer

(2018) David P. Labbé et al.   Cold Spring Harbor Perspectives in Medicine

Pi-Pi contacts are an overlooked protein feature relevant to phase separation

(2018) Robert McCoy Vernon et al.   eLife

Deciphering the Dichotomous Effects of PGC-1α on Tumorigenesis and Metastasis

(2018) Simon-Pierre Gravel   Frontiers in Oncology

Reconstituted Postsynaptic Density as a Molecular Platform for Understanding Synapse Formation and Plasticity

(2018) Menglong Zeng et al.   CELL

cGAS activation in phased droplets

(2018) Yongbo Liu et al.   CELL RESEARCH

The molecular language of membraneless organelles

(2018) Edward Gomes et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Phase Separation in Biology and Disease

(2018) Julie D. Forman-Kay et al.   JOURNAL OF MOLECULAR BIOLOGY

Cancer Mutations of the Tumor Suppressor SPOP Disrupt the Formation of Active, Phase-Separated Compartments

(2018) Jill J. Bouchard et al.   MOLECULAR CELL

Kinase-controlled phase transition of membraneless organelles in mitosis

(2018) Arpan Kumar Rai et al.   NATURE

Transcriptional addiction in cancer cells is mediated by YAP/TAZ through BRD4

(2018) Francesca Zanconato et al.   NATURE MEDICINE

BRD4 amplification facilitates an oncogenic gene expression program in high-grade serous ovarian cancer and confers sensitivity to BET inhibitors

(2018) Garrett W. Rhyasen et al.   PLoS One

Histone H3.3 K27M Accelerates Spontaneous Brainstem Glioma and Drives Restricted Changes in Bivalent Gene Expression

(2018) Jon D. Larson et al.   CANCER CELL

Transcription Factors Activate Genes through the Phase-Separation Capacity of Their Activation Domains

(2018) Ann Boija et al.   CELL

Liquid Nuclear Condensates Mechanically Sense and Restructure the Genome

(2018) Yongdae Shin et al.   CELL

HSF1 as a Cancer Biomarker and Therapeutic Target

(2018) Richard L. Carpenter et al.   CURRENT CANCER DRUG TARGETS

53BP1: A key player of DNA damage response with critical functions in cancer

(2018) Mohammad Mirza-Aghazadeh-Attari et al.   DNA REPAIR

Therapeutic Inhibition of Myc in Cancer. Structural Bases and Computer-Aided Drug Discovery Approaches

(2018) Lavinia Carabet et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Nuclear condensates of the Polycomb protein chromobox 2 (CBX2) assemble through phase separation

(2018) Roubina Tatavosian et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Chromatin regulatory mechanisms and therapeutic opportunities in cancer

(2018) Alfredo M. Valencia et al.   NATURE CELL BIOLOGY

MALAT1: a potential biomarker in cancer

(2018) Zhi-Xing Li et al.   Cancer Management and Research

Intrinsically disordered sequences enable modulation of protein phase separation through distributed tyrosine motifs

(2017) Yuan Lin et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The wisdom of crowds: regulating cell function through condensed states of living matter

(2017) Simon Alberti   JOURNAL OF CELL SCIENCE

A Small Molecule Causes a Population Shift in the Conformational Landscape of an Intrinsically Disordered Protein

(2017) David Ban et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

TORC1 organized in inhibited domains (TOROIDs) regulate TORC1 activity

(2017) Manoël Prouteau et al.   NATURE

Phase separation drives heterochromatin domain formation

(2017) Amy R. Strom et al.   NATURE

ENL links histone acetylation to oncogenic gene expression in acute myeloid leukaemia

(2017) Liling Wan et al.   NATURE

RNA phase transitions in repeat expansion disorders

(2017) Ankur Jain et al.   NATURE

Liquid droplet formation by HP1α suggests a role for phase separation in heterochromatin

(2017) Adam G. Larson et al.   NATURE

Proteasome inhibitors in cancer therapy

(2017) Elisabet E. Manasanch et al.   Nature Reviews Clinical Oncology

Biomolecular condensates: organizers of cellular biochemistry

(2017) Salman F. Banani et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Direct observation of structure and dynamics during phase separation of an elastomeric protein

(2017) Sean E. Reichheld et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

ATP as a biological hydrotrope

(2017) Avinash Patel et al.   SCIENCE

Liquid phase condensation in cell physiology and disease

(2017) Yongdae Shin et al.   SCIENCE

Glycolytic Enzymes Coalesce in G Bodies under Hypoxic Stress

(2017) Meiyan Jin et al.   Cell Reports

Intrinsically disordered linkers determine the interplay between phase separation and gelation in multivalent proteins

(2017) Tyler S Harmon et al.   eLife

MLL-Rearranged Leukemias—An Update on Science and Clinical Approaches

(2017) Amanda C. Winters et al.   Frontiers in Pediatrics

Mammalian Autophagy: How Does It Work?

(2016) Carla F. Bento et al.   Annual Review of Biochemistry

Compositional Control of Phase-Separated Cellular Bodies

(2016) Salman F. Banani et al.   CELL

Coexisting Liquid Phases Underlie Nucleolar Subcompartments

(2016) Marina Feric et al.   CELL

The Emerging Hallmarks of Cancer Metabolism

(2016) Natalya N. Pavlova et al.   Cell Metabolism

Innate immune signaling and regulation in cancer immunotherapy

(2016) Leticia Corrales et al.   CELL RESEARCH

Dynamic Protein Interaction Networks and New Structural Paradigms in Signaling

(2016) Veronika Csizmok et al.   CHEMICAL REVIEWS

Progress and Paradigms in Multiple Myeloma

(2016) Kenneth C. Anderson   CLINICAL CANCER RESEARCH

Liquid–liquid phase separation in cellular signaling systems

(2016) P Andrew Chong et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

The Intrinsically Disordered Protein Atg13 Mediates Supramolecular Assembly of Autophagy Initiation Complexes

(2016) Hayashi Yamamoto et al.   DEVELOPMENTAL CELL

PKM2, cancer metabolism, and the road ahead

(2016) Talya L Dayton et al.   EMBO REPORTS

Epigenetic regulators and their impact on therapy in acute myeloid leukemia

(2016) F. Pastore et al.   HAEMATOLOGICA

Obesity and Cancer Mechanisms: Cancer Metabolism

(2016) Benjamin D. Hopkins et al.   JOURNAL OF CLINICAL ONCOLOGY

Sequence Determinants of Intracellular Phase Separation by Complex Coacervation of a Disordered Protein

(2016) Chi W. Pak et al.   MOLECULAR CELL

Cancer metabolism: a therapeutic perspective

(2016) Ubaldo E. Martinez-Outschoorn et al.   Nature Reviews Clinical Oncology

Wnt signaling in cancer

(2016) T Zhan et al.   ONCOGENE

DNA repair targeted therapy: The past or future of cancer treatment?

(2016) Navnath S. Gavande et al.   PHARMACOLOGY & THERAPEUTICS

Histone H3K36 mutations promote sarcomagenesis through altered histone methylation landscape

(2016) C. Lu et al.   SCIENCE

Phase separation of signaling molecules promotes T cell receptor signal transduction

(2016) Xiaolei Su et al.   SCIENCE

The Warburg Effect: How Does it Benefit Cancer Cells?

(2016) Maria V. Liberti et al.   TRENDS IN BIOCHEMICAL SCIENCES

Transport Selectivity of Nuclear Pores, Phase Separation, and Membraneless Organelles

(2016) H. Broder Schmidt et al.   TRENDS IN BIOCHEMICAL SCIENCES

Principles and Properties of Stress Granules

(2016) David S.W. Protter et al.   TRENDS IN CELL BIOLOGY

Targeting DNA Repair in Cancer: Beyond PARP Inhibitors

(2016) Jessica S. Brown et al.   Cancer Discovery

Estrogen receptor alpha somatic mutations Y537S and D538G confer breast cancer endocrine resistance by stabilizing the activating function-2 binding conformation

(2016) Sean W Fanning et al.   eLife

Nucleophosmin integrates within the nucleolus via multi-modal interactions with proteins displaying R-rich linear motifs and rRNA

(2016) Diana M Mitrea et al.   eLife

Epigenetic regulators and their impact on therapy in acute myeloid leukemia

(2016) F. Pastore et al.   HAEMATOLOGICA

Innate Immune Recognition of Cancer

(2015) Seng-Ryong Woo et al.   Annual Review of Immunology

Stress granules, P-bodies and cancer

(2015) Paul Anderson et al.   Biochimica et Biophysica Acta-Gene Regulatory Mechanisms

Beyond the histone tale: HP1α deregulation in breast cancer epigenetics

(2015) Johan Vad-Nielsen et al.   CANCER BIOLOGY & THERAPY

Phase Separation by Low Complexity Domains Promotes Stress Granule Assembly and Drives Pathological Fibrillization

(2015) Amandine Molliex et al.   CELL

A Liquid-to-Solid Phase Transition of the ALS Protein FUS Accelerated by Disease Mutation

(2015) Avinash Patel et al.   CELL

CDK7-Dependent Transcriptional Addiction in Triple-Negative Breast Cancer

(2015) Yubao Wang et al.   CELL

Chromatin signatures of cancer

(2015) Marc A. Morgan et al.   GENES & DEVELOPMENT

RNA Controls PolyQ Protein Phase Transitions

(2015) Huaiying Zhang et al.   MOLECULAR CELL

Polymer physics of intracellular phase transitions

(2015) Clifford P. Brangwynne et al.   Nature Physics

Intrinsically disordered proteins in cellular signalling and regulation

(2015) Peter E. Wright et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

The disordered P granule protein LAF-1 drives phase separation into droplets with tunable viscosity and dynamics

(2015) Shana Elbaum-Garfinkle et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Liquid demixing of intrinsically disordered proteins is seeded by poly(ADP-ribose)

(2015) Matthias Altmeyer et al.   Nature Communications

MECP2 Is a Frequently Amplified Oncogene with a Novel Epigenetic Mechanism That Mimics the Role of Activated RAS in Malignancy

(2015) M. Neupane et al.   Cancer Discovery

Discovery of Small Molecules that Inhibit the Disordered Protein, p27 Kip1

(2015) Luigi I. Iconaru et al.   Scientific Reports

Signal Transduction in Cancer

(2015) R. Sever et al.   Cold Spring Harbor Perspectives in Medicine

Landscape of gene fusions in epithelial cancers: seq and ye shall find

(2015) Chandan Kumar-Sinha et al.   Genome Medicine

Chemical perturbation of an intrinsically disordered region of TFIID distinguishes two modes of transcription initiation

(2015) Zhengjian Zhang et al.   eLife

Nup98 FG domains from diverse species spontaneously phase-separate into particles with nuclear pore-like permselectivity

(2015) Hermann Broder Schmidt et al.   eLife

Liquid-Liquid Phase Separation in Biology

(2014) Anthony A. Hyman et al.   Annual Review of Cell and Developmental Biology

Targeting Transcriptional Addictions in Small Cell Lung Cancer with a Covalent CDK7 Inhibitor

(2014) Camilla L. Christensen et al.   CANCER CELL

CDK7 Inhibition Suppresses Super-Enhancer-Linked Oncogenic Transcription in MYCN-Driven Cancer

(2014) Edmond Chipumuro et al.   CELL

Classification of Intrinsically Disordered Regions and Proteins

(2014) Robin van der Lee et al.   CHEMICAL REVIEWS

Targeting transcription regulation in cancer with a covalent CDK7 inhibitor

(2014) Nicholas Kwiatkowski et al.   NATURE

The genomic landscape of diffuse intrinsic pontine glioma and pediatric non-brainstem high-grade glioma

(2014) Gang Wu et al.   NATURE GENETICS

5-Fluorouracil affects assembly of stress granules based on RNA incorporation

(2014) Christian Kaehler et al.   NUCLEIC ACIDS RESEARCH

An oncogenic super-enhancer formed through somatic mutation of a noncoding intergenic element

(2014) M. R. Mansour et al.   SCIENCE

Hypoxia, lipids, and cancer: surviving the harsh tumor microenvironment

(2014) Daniel Ackerman et al.   TRENDS IN CELL BIOLOGY

Phase transitions of multivalent proteins can promote clustering of membrane receptors

(2014) Sudeep Banjade et al.   eLife

DNA Sequencing of Cancer: What Have We Learned?

(2013) Juliann Chmielecki et al.   Annual Review of Medicine

Selective Inhibition of Tumor Oncogenes by Disruption of Super-Enhancers

(2013) Jakob Lovén et al.   CELL

Phosphorylation-Regulated Binding of RNA Polymerase II to Fibrous Polymers of Low-Complexity Domains

(2013) Ilmin Kwon et al.   CELL

Super-Enhancers in the Control of Cell Identity and Disease

(2013) Denes Hnisz et al.   CELL

Inhibition of mTORC1 by Astrin and Stress Granules Prevents Apoptosis in Cancer Cells

(2013) Kathrin Thedieck et al.   CELL

Immune Sensing of DNA

(2013) Søren R. Paludan et al.   IMMUNITY

Innate and adaptive immune cells in the tumor microenvironment

(2013) Thomas F Gajewski et al.   NATURE IMMUNOLOGY

Real-Time Dynamics of RNA Polymerase II Clustering in Live Human Cells

(2013) I. I. Cisse et al.   SCIENCE

Cancer Genome Landscapes

(2013) B. Vogelstein et al.   SCIENCE

Dynamic Reorganization of Metabolic Enzymes into Intracellular Bodies

(2012) Jeremy D. O'Connell et al.   Annual Review of Cell and Developmental Biology

Mutational and expressional analyses ofSPOP, a candidate tumor suppressor gene, in prostate, gastric and colorectal cancers

(2012) Min S. Kim et al.   APMIS

A Comprehensive Survey of Ras Mutations in Cancer

(2012) I. A. Prior et al.   CANCER RESEARCH

Med1 plays a critical role in the development of tamoxifen resistance

(2012) Arumugam Nagalingam et al.   CARCINOGENESIS

Cell-free Formation of RNA Granules: Low Complexity Sequence Domains Form Dynamic Fibers within Hydrogels

(2012) Masato Kato et al.   CELL

c-Myc Is a Universal Amplifier of Expressed Genes in Lymphocytes and Embryonic Stem Cells

(2012) Zuqin Nie et al.   CELL

Transcriptional Amplification in Tumor Cells with Elevated c-Myc

(2012) Charles Y. Lin et al.   CELL

MYC on the Path to Cancer

(2012) Chi V. Dang   CELL

Phase transitions in the assembly of multivalent signalling proteins

(2012) Pilong Li et al.   NATURE

How cancer metabolism is tuned for proliferation and vulnerable to disruption

(2012) Almut Schulze et al.   NATURE

Driver mutations in histone H3.3 and chromatin remodelling genes in paediatric glioblastoma

(2012) Jeremy Schwartzentruber et al.   NATURE

Cyclic GMP-AMP Is an Endogenous Second Messenger in Innate Immune Signaling by Cytosolic DNA

(2012) J. Wu et al.   SCIENCE

Cyclic GMP-AMP Synthase Is a Cytosolic DNA Sensor That Activates the Type I Interferon Pathway

(2012) L. Sun et al.   SCIENCE

Mitosis-targeted anti-cancer therapies: where they stand

(2012) K-S Chan et al.   Cell Death & Disease

Translocation-Capture Sequencing Reveals the Extent and Nature of Chromosomal Rearrangements in B Lymphocytes

(2011) Isaac A. Klein et al.   CELL

Hallmarks of Cancer: The Next Generation

(2011) Douglas Hanahan et al.   CELL

Principles and Current Strategies for Targeting Autophagy for Cancer Treatment

(2011) R. K. Amaravadi et al.   CLINICAL CANCER RESEARCH

An extended Myc network contributes to glucose homeostasis in cancer and diabetes

(2011) Christopher et al.   Frontiers in Bioscience-Landmark

Intrinsically disordered proteins from A to Z

(2011) Vladimir N. Uversky   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Targeting cancer metabolism: a therapeutic window opens

(2011) Matthew G. Vander Heiden   NATURE REVIEWS DRUG DISCOVERY

p21WAF1/CIP1 Upregulation through the Stress Granule-Associated Protein CUGBP1 Confers Resistance to Bortezomib-Mediated Apoptosis

(2011) Cristina Gareau et al.   PLoS One

Extracellular Matrix Degradation and Remodeling in Development and Disease

(2011) P. Lu et al.   Cold Spring Harbor Perspectives in Biology

Elastin-like polypeptides: Biomedical applications of tunable biopolymers

(2010) Sarah R. MacEwan et al.   BIOPOLYMERS

The chemotherapeutic agent bortezomib induces the formation of stress granules

(2010) Marie-Josée Fournier et al.   Cancer Cell International

Intrinsically disordered proteins are potential drug targets

(2010) Steven J Metallo   CURRENT OPINION IN CHEMICAL BIOLOGY

Autophagy: cellular and molecular mechanisms

(2010) Danielle Glick et al.   JOURNAL OF PATHOLOGY

The Nuclear-Retained Noncoding RNA MALAT1 Regulates Alternative Splicing by Modulating SR Splicing Factor Phosphorylation

(2010) Vidisha Tripathi et al.   MOLECULAR CELL

Selective inhibition of BET bromodomains

(2010) Panagis Filippakopoulos et al.   NATURE

Genomic instability — an evolving hallmark of cancer

(2010) Simona Negrini et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

PML Nuclear Bodies

(2010) V. Lallemand-Breitenbach et al.   Cold Spring Harbor Perspectives in Biology

The Role of Myc-Induced Protein Synthesis in Cancer

(2009) D. Ruggero   CANCER RESEARCH

The Cell Cycle and Myc Intersect with Mechanisms that Regulate Pluripotency and Reprogramming

(2009) Amar M. Singh et al.   Cell Stem Cell

Targeting the PI3K signaling pathway in cancer

(2009) Kwok-Kin Wong et al.   CURRENT OPINION IN GENETICS & DEVELOPMENT

An Architectural Role for a Nuclear Noncoding RNA: NEAT1 RNA Is Essential for the Structure of Paraspeckles

(2009) Christine M. Clemson et al.   MOLECULAR CELL

Eukaryotic Stress Granules: The Ins and Outs of Translation

(2009) J. Ross Buchan et al.   MOLECULAR CELL

Gene Regulation and Epigenetic Remodeling in Murine Embryonic Stem Cells by c-Myc

(2009) Chin-Hsing Lin et al.   PLoS One

P-TEFb- the final frontier

(2009) Jiri Kohoutek   Cell Division

Cancer Cell Metabolism: Warburg and Beyond

(2008) Peggy P. Hsu et al.   CELL

Myc's broad reach

(2008) M. Eilers et al.   GENES & DEVELOPMENT

Crosstalk between c-Myc and ribosome in ribosomal biogenesis and cancer

(2008) Mu-Shui Dai et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Formation of stress granules inhibits apoptosis by suppressing stress-responsive MAPK pathways

(2008) Kyoko Arimoto et al.   NATURE CELL BIOLOGY

Transcription-independent functions of MYC: regulation of translation and DNA replication

(2008) Michael D. Cole et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Apoptotic signaling by c-MYC

(2008) B Hoffman et al.   ONCOGENE

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