Chromatin-bound CRM1 recruits SET-Nup214 and NPM1c onto HOX clusters causing aberrant HOX expression in leukemia cells

NUP214 in Leukemia: It’s More than Transport

(2019) Adélia Mendes et al.   Cells

Mutant NPM1 Maintains the Leukemic State through HOX Expression

(2018) Lorenzo Brunetti et al.   CANCER CELL

Leukemogenic nucleophosmin mutation disrupts the transcription factor hub that regulates granulomonocytic fates

(2018) Xiaorong Gu et al.   JOURNAL OF CLINICAL INVESTIGATION

NPM1 directs PIDDosome-dependent caspase-2 activation in the nucleolus

(2017) Kiyohiro Ando et al.   JOURNAL OF CELL BIOLOGY

MLL is essential for NUP98-HOXA9-induced leukemia

(2017) Y Shima et al.   LEUKEMIA

NPM1 Mutant Mediated PML Delocalization and Stabilization Enhances Autophagy and Cell Survival in Leukemic Cells

(2017) Qin Zou et al.   Theranostics

NUP98 Fusion Proteins Interact with the NSL and MLL1 Complexes to Drive Leukemogenesis

(2016) Haiming Xu et al.   CANCER CELL

The Oncogenic Fusion Proteins SET-Nup214 and Sequestosome-1 (SQSTM1)-Nup214 Form Dynamic Nuclear Bodies and Differentially Affect Nuclear Protein and Poly(A)+RNA Export

(2016) Sarah A. Port et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Leukemia-Associated Nup214 Fusion Proteins Disturb the XPO1-Mediated Nuclear-Cytoplasmic Transport Pathway and Thereby the NF-κB Signaling Pathway

(2016) Shoko Saito et al.   MOLECULAR AND CELLULAR BIOLOGY

CRISPaint allows modular base-specific gene tagging using a ligase-4-dependent mechanism

(2016) Jonathan L. Schmid-Burgk et al.   Nature Communications

Chromatin-prebound Crm1 recruits Nup98-HoxA9 fusion to induce aberrant expression of Hox cluster genes

(2016) Masahiro Oka et al.   eLife

Epigenomic analysis of the HOX gene loci reveals mechanisms that may control canonical expression patterns in AML and normal hematopoietic cells

(2015) D H Spencer et al.   LEUKEMIA

HISAT: a fast spliced aligner with low memory requirements

(2015) Daehwan Kim et al.   NATURE METHODS

Structural and Functional Characterization of CRM1-Nup214 Interactions Reveals Multiple FG-Binding Sites Involved in Nuclear Export

(2015) Sarah A. Port et al.   Cell Reports

The Nuclear Oncogene SET Controls DNA Repair by KAP1 and HP1 Retention to Chromatin

(2015) Alkmini Kalousi et al.   Cell Reports

A deep proteomics perspective on CRM1-mediated nuclear export and nucleocytoplasmic partitioning

(2015) Koray Kırlı et al.   eLife

Selective inhibitors of nuclear export (SINE) as novel therapeutics for prostate cancer

(2015) Janet Mendonca et al.   Oncotarget

A critical role for CRM1 in regulating HOXA gene transcription in CALM-AF10 leukemias

(2014) A E Conway et al.   LEUKEMIA

deepTools: a flexible platform for exploring deep-sequencing data

(2014) Fidel Ramírez et al.   NUCLEIC ACIDS RESEARCH

NUP214 fusion genes in acute leukemia (Review)

(2014) MIN-HANG ZHOU et al.   Oncology Letters

KPT-330 inhibitor of CRM1 (XPO1)-mediated nuclear export has selective anti-leukaemic activity in preclinical models of T-cell acute lymphoblastic leukaemia and acute myeloid leukaemia

(2013) Julia Etchin et al.   BRITISH JOURNAL OF HAEMATOLOGY

Differential Role for Transcription Factor Oct4 Nucleocytoplasmic Dynamics in Somatic Cell Reprogramming and Self-renewal of Embryonic Stem Cells

(2013) Masahiro Oka et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

CRM1 inhibition induces tumor cell cytotoxicity and impairs osteoclastogenesis in multiple myeloma: molecular mechanisms and therapeutic implications

(2013) Y-T Tai et al.   LEUKEMIA

Nuclear export inhibition through covalent conjugation and hydrolysis of Leptomycin B by CRM1

(2013) Qingxiang Sun et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

CRM1 Inhibition Sensitizes Drug Resistant Human Myeloma Cells to Topoisomerase II and Proteasome Inhibitors both In Vitro and Ex Vivo

(2013) Joel G. Turner et al.   Journal of Cancer

Selective inhibitors of nuclear export show that CRM1/XPO1 is a target in chronic lymphocytic leukemia

(2012) R. Lapalombella et al.   BLOOD

Novel selective inhibitors of nuclear export CRM1 antagonists for therapy in mantle cell lymphoma

(2012) Kejie Zhang et al.   EXPERIMENTAL HEMATOLOGY

Several Phenylalanine-Glycine Motives in the Nucleoporin Nup214 Are Essential for Binding of the Nuclear Export Receptor CRM1

(2012) Stephanie Roloff et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A 2.1-Å-Resolution Crystal Structure of Unliganded CRM1 Reveals the Mechanism of Autoinhibition

(2012) Natsumi Saito et al.   JOURNAL OF MOLECULAR BIOLOGY

Nucleophosmin/B26 regulates PTEN through interaction with HAUSP in acute myeloid leukemia

(2012) N I Noguera et al.   LEUKEMIA

The role of HOX genes in normal hematopoiesis and acute leukemia

(2012) R A Alharbi et al.   LEUKEMIA

Identification of CRM1-dependent Nuclear Export Cargos Using Quantitative Mass Spectrometry

(2012) Ketan Thakar et al.   MOLECULAR & CELLULAR PROTEOMICS

NUP98 gene fusions and hematopoietic malignancies: common themes and new biologic insights

(2011) S. M. Gough et al.   BLOOD

NUP98/NSD1 characterizes a novel poor prognostic group in acute myeloid leukemia with a distinct HOX gene expression pattern

(2011) I. H. I. M. Hollink et al.   BLOOD

The classification of mRNA expression levels by the phosphorylation state of RNAPII CTD based on a combined genome-wide approach

(2011) Jun Odawara et al.   BMC GENOMICS

Electrostatic Interactions Involving the Extreme C Terminus of Nuclear Export Factor CRM1 Modulate Its Affinity for Cargo

(2011) Abigail M. Fox et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Hox genes and regional patterning of the vertebrate body plan

(2010) Moises Mallo et al.   DEVELOPMENTAL BIOLOGY

Inhibition of CRM1-mediated Nuclear Export of Transcription Factors by Leukemogenic NUP98 Fusion Proteins

(2010) Akiko Takeda et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Mobile FG Nucleoporin Nup98 Is a Cofactor for Crm1-dependent Protein Export

(2010) Masahiro Oka et al.   MOLECULAR BIOLOGY OF THE CELL

Structural basis for leucine-rich nuclear export signal recognition by CRM1

(2009) Xiuhua Dong et al.   NATURE

Nuclear pore proteins and cancer

(2009) Songli Xu et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

The recurrent SET-NUP214 fusion as a new HOXA activation mechanism in pediatric T-cell acute lymphoblastic leukemia

(2008) P. Van Vlierberghe et al.   BLOOD

Nucleophosmin and its AML-associated mutant regulate c-Myc turnover through Fbw7γ

(2008) Paola Bonetti et al.   JOURNAL OF CELL BIOLOGY

Transcription Regulation of the rRNA Gene by a Multifunctional Nucleolar Protein, B23/Nucleophosmin, through Its Histone Chaperone Activity

(2008) K. Murano et al.   MOLECULAR AND CELLULAR BIOLOGY

Nucleophosmin Serves as a Rate-Limiting Nuclear Export Chaperone for the Mammalian Ribosome

(2008) L. B. Maggi et al.   MOLECULAR AND CELLULAR BIOLOGY