Targeting liquid–liquid phase separation of SARS-CoV-2 nucleocapsid protein promotes innate antiviral immunity by elevating MAVS activity
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Title
Targeting liquid–liquid phase separation of SARS-CoV-2 nucleocapsid protein promotes innate antiviral immunity by elevating MAVS activity
Authors
Keywords
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Journal
NATURE CELL BIOLOGY
Volume 23, Issue 7, Pages 718-732
Publisher
Springer Science and Business Media LLC
Online
2021-07-09
DOI
10.1038/s41556-021-00710-0
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Note: Only part of the references are listed.- The SARS-CoV-2 nucleocapsid protein is dynamic, disordered, and phase separates with RNA
- (2021) Jasmine Cubuk et al. Nature Communications
- Genome Composition and Divergence of the Novel Coronavirus (2019-nCoV) Originating in China
- (2020) Aiping Wu et al. Cell Host & Microbe
- Coronavirus infections and immune responses
- (2020) Geng Li et al. JOURNAL OF MEDICAL VIROLOGY
- Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China
- (2020) Chaolin Huang et al. LANCET
- Comparative therapeutic efficacy of remdesivir and combination lopinavir, ritonavir, and interferon beta against MERS-CoV
- (2020) Timothy P. Sheahan et al. Nature Communications
- Genomic characterization of the 2019 novel human-pathogenic coronavirus isolated from a patient with atypical pneumonia after visiting Wuhan
- (2020) Jasper Fuk-Woo Chan et al. Emerging Microbes & Infections
- Imbalanced Host Response to SARS-CoV-2 Drives Development of COVID-19
- (2020) Daniel Blanco-Melo et al. CELL
- The Innate Immune System: Fighting on the Front Lines or Fanning the Flames of COVID-19?
- (2020) Julia L. McKechnie et al. Cell Host & Microbe
- Comparative replication and immune activation profiles of SARS-CoV-2 and SARS-CoV in human lungs: an ex vivo study with implications for the pathogenesis of COVID-19
- (2020) Hin Chu et al. CLINICAL INFECTIOUS DISEASES
- A SARS-CoV-2 protein interaction map reveals targets for drug repurposing
- (2020) David E. Gordon et al. NATURE
- COVID-19 and the Immune System
- (2020) J PACES et al. PHYSIOLOGICAL RESEARCH
- Architecture and self‐assembly of the SARS‐CoV ‐2 nucleocapsid protein
- (2020) Qiaozhen Ye et al. PROTEIN SCIENCE
- Impaired type I interferon activity and inflammatory responses in severe COVID-19 patients
- (2020) Jérôme Hadjadj et al. SCIENCE
- Liquid–liquid phase separation by SARS-CoV-2 nucleocapsid protein and RNA
- (2020) Hui Chen et al. CELL RESEARCH
- Structures of the SARS ‐CoV‐2 nucleocapsid and their perspectives for drug design
- (2020) Ya Peng et al. EMBO JOURNAL
- Type I interferon susceptibility distinguishes SARS-CoV-2 from SARS-CoV.
- (2020) Kumari G. Lokugamage et al. JOURNAL OF VIROLOGY
- SARS‐CoV‐2 nucleocapsid protein phase‐separates with RNA and with human hnRNPs
- (2020) Theodora Myrto Perdikari et al. EMBO JOURNAL
- Phosphoregulation of Phase Separation by the SARS-CoV-2 N Protein Suggests a Biophysical Basis for its Dual Functions
- (2020) Christopher R. Carlson et al. MOLECULAR CELL
- Genomic RNA Elements Drive Phase Separation of the SARS-CoV-2 Nucleocapsid
- (2020) Christiane Iserman et al. MOLECULAR CELL
- Nucleocapsid protein of SARS-CoV-2 phase separates into RNA-rich polymerase-containing condensates
- (2020) Adriana Savastano et al. Nature Communications
- Targeting UBE4A Revives Viperin Protein in Epithelium to Enhance Host Antiviral Defense
- (2019) Yukang Yuan et al. MOLECULAR CELL
- Protein Phase Separation: A New Phase in Cell Biology
- (2018) Steven Boeynaems et al. TRENDS IN CELL BIOLOGY
- FAF1 Regulates Antiviral Immunity by Inhibiting MAVS but Is Antagonized by Phosphorylation upon Viral Infection
- (2018) Tong Dai et al. Cell Host & Microbe
- The ubiquitin E3 ligase TRIM31 promotes aggregation and activation of the signaling adaptor MAVS through Lys63-linked polyubiquitination
- (2016) Bingyu Liu et al. NATURE IMMUNOLOGY
- SARS and MERS: recent insights into emerging coronaviruses
- (2016) Emmie de Wit et al. NATURE REVIEWS MICROBIOLOGY
- Innate Immune Pattern Recognition: A Cell Biological Perspective
- (2015) Sky W. Brubaker et al. Annual Review of Immunology
- Real-time characterization of risks of death associated with the Middle East respiratory syndrome (MERS) in the Republic of Korea, 2015
- (2015) Kenji Mizumoto et al. BMC Medicine
- Treatment With Lopinavir/Ritonavir or Interferon-β1b Improves Outcome of MERS-CoV Infection in a Nonhuman Primate Model of Common Marmoset
- (2015) Jasper Fuk-Woo Chan et al. JOURNAL OF INFECTIOUS DISEASES
- Subconjunctival Injection of XG-102, a JNK Inhibitor Peptide, in Patients with Intraocular Inflammation: A Safety and Tolerability Study
- (2015) Talal Beydoun et al. JOURNAL OF OCULAR PHARMACOLOGY AND THERAPEUTICS
- MDA5 Is Critical to Host Defense during Infection with Murine Coronavirus
- (2015) Zachary B. Zalinger et al. JOURNAL OF VIROLOGY
- Liquid-Liquid Phase Separation in Biology
- (2014) Anthony A. Hyman et al. Annual Review of Cell and Developmental Biology
- Efficacy and Safety of AM-111 in the Treatment of Acute Sensorineural Hearing Loss
- (2014) Markus Suckfuell et al. OTOLOGY & NEUROTOLOGY
- Nuclear receptor NR4A1 promotes breast cancer invasion and metastasis by activating TGF-β signalling
- (2014) FangFang Zhou et al. Nature Communications
- A first-in-class, first-in-human, phase I trial of p28, a non-HDM2-mediated peptide inhibitor of p53 ubiquitination in patients with advanced solid tumours
- (2013) M A Warso et al. BRITISH JOURNAL OF CANCER
- MERS-coronavirus replication induces severe in vitro cytopathology and is strongly inhibited by cyclosporin A or interferon- treatment
- (2013) A. H. de Wilde et al. JOURNAL OF GENERAL VIROLOGY
- Tropism of and Innate Immune Responses to the Novel Human Betacoronavirus Lineage C Virus in Human Ex Vivo Respiratory Organ Cultures
- (2013) R. W. Y. Chan et al. JOURNAL OF VIROLOGY
- TRAF4 Promotes TGF-β Receptor Signaling and Drives Breast Cancer Metastasis
- (2013) Long Zhang et al. MOLECULAR CELL
- Inhibition of novel β coronavirus replication by a combination of interferon-α2b and ribavirin
- (2013) Darryl Falzarano et al. Scientific Reports
- The tip of the iceberg: RNA-binding proteins with prion-like domains in neurodegenerative disease
- (2012) Oliver D. King et al. BRAIN RESEARCH
- Novel Therapeutic Approaches in Limiting Oxidative Stress and Inflammation
- (2012) Agnieszka Spychalowicz et al. CURRENT PHARMACEUTICAL BIOTECHNOLOGY
- A Human Coronavirus Responsible for the Common Cold Massively Kills Dendritic Cells but Not Monocytes
- (2012) M. Mesel-Lemoine et al. JOURNAL OF VIROLOGY
- MAVS Forms Functional Prion-like Aggregates to Activate and Propagate Antiviral Innate Immune Response
- (2011) Fajian Hou et al. CELL
- Pattern Recognition Receptors and Inflammation
- (2010) Osamu Takeuchi et al. CELL
- An Interaction between the Nucleocapsid Protein and a Component of the Replicase-Transcriptase Complex Is Crucial for the Infectivity of Coronavirus Genomic RNA
- (2010) K. R. Hurst et al. JOURNAL OF VIROLOGY
- Murine Coronavirus Induces Type I Interferon in Oligodendrocytes through Recognition by RIG-I and MDA5
- (2010) J. Li et al. JOURNAL OF VIROLOGY
- The role of pattern-recognition receptors in innate immunity: update on Toll-like receptors
- (2010) Taro Kawai et al. NATURE IMMUNOLOGY
- Multiple Nucleic Acid Binding Sites and Intrinsic Disorder of Severe Acute Respiratory Syndrome Coronavirus Nucleocapsid Protein: Implications for Ribonucleocapsid Protein Packaging
- (2008) C.-K. Chang et al. JOURNAL OF VIROLOGY
- Murine Coronavirus Mouse Hepatitis Virus Is Recognized by MDA5 and Induces Type I Interferon in Brain Macrophages/Microglia
- (2008) J. K. Roth-Cross et al. JOURNAL OF VIROLOGY
- Characterizing proteins and their interactions in cells and tissues using the in situ proximity ligation assay
- (2008) Ola Söderberg et al. METHODS
- Genetically encoding Nε-acetyllysine in recombinant proteins
- (2008) Heinz Neumann et al. Nature Chemical Biology
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