Targeting NSD2-mediated SRC-3 liquid–liquid phase separation sensitizes bortezomib treatment in multiple myeloma

Partitioning of cancer therapeutics in nuclear condensates

(2020) Isaac A. Klein et al.   SCIENCE

Liquid-liquid phase separation in biology: mechanisms, physiological functions and human diseases

(2020) Hong Zhang et al.   Science China-Life Sciences

Multiple Myeloma: Current Advances and Future Directions

(2019) Thomas Martin et al.   Clinical Lymphoma Myeloma & Leukemia

A comparative safety review of histone deacetylase inhibitors for the treatment of myeloma

(2019) Guldane Cengiz Seval et al.   Expert Opinion On Drug Safety

Proteasome inhibitor induced SIRT1 deacetylates GLI2 to enhance hedgehog signaling activity and drug resistance in multiple myeloma

(2019) Ying Xie et al.   ONCOGENE

The liquid nucleome – phase transitions in the nucleus at a glance

(2019) Amy R. Strom et al.   JOURNAL OF CELL SCIENCE

Cancer statistics, 2018

(2018) Rebecca L. Siegel et al.   CA-A CANCER JOURNAL FOR CLINICIANS

The RNA-binding Protein MEX3B Mediates Resistance to Cancer Immunotherapy by Downregulating HLA-A Expression

(2018) Lu Huang et al.   CLINICAL CANCER RESEARCH

The Multiple Myeloma Drug Pipeline—2018: A Review of Small Molecules and Their Therapeutic Targets

(2018) Hanley N. Abramson   Clinical Lymphoma Myeloma & Leukemia

Methylation of Aurora kinase A by MMSET reduces p53 stability and regulates cell proliferation and apoptosis

(2018) Jin Woo Park et al.   ONCOGENE

Protein Phase Separation: A New Phase in Cell Biology

(2018) Steven Boeynaems et al.   TRENDS IN CELL BIOLOGY

MMSET I acts as an oncoprotein and regulates GLO1 expression in t(4;14) multiple myeloma cells

(2018) Zhigang Xie et al.   LEUKEMIA

The Epigenome in Multiple Myeloma: Impact on Tumor Cell Plasticity and Drug Response

(2018) Eva De Smedt et al.   Frontiers in Oncology

Liquid phase condensation in cell physiology and disease

(2017) Yongdae Shin et al.   SCIENCE

Epigenetics in multiple myeloma: From mechanisms to therapy

(2017) Mohammad Alzrigat et al.   SEMINARS IN CANCER BIOLOGY

Multiple myeloma

(2017) Shaji K. Kumar et al.   Nature Reviews Disease Primers

Development of a DNA-Templated Peptide Probe for Photoaffinity Labeling and Enrichment of the Histone Modification Reader Proteins

(2016) Xue Bai et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

The Spectrum and Clinical Impact of Epigenetic Modifier Mutations in Myeloma

(2016) C. Pawlyn et al.   CLINICAL CANCER RESEARCH

Development of potent small-molecule inhibitors to drug the undruggable steroid receptor coactivator-3

(2016) Xianzhou Song et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Thymidine phosphorylase exerts complex effects on bone resorption and formation in myeloma

(2016) Huan Liu et al.   Science Translational Medicine

Revised International Staging System for Multiple Myeloma: A Report From International Myeloma Working Group

(2015) Antonio Palumbo et al.   JOURNAL OF CLINICAL ONCOLOGY

A critical role of autocrine sonic hedgehog signaling in human CD138+ myeloma cell survival and drug resistance

(2014) Z. Liu et al.   BLOOD

International Myeloma Working Group updated criteria for the diagnosis of multiple myeloma

(2014) S Vincent Rajkumar et al.   LANCET ONCOLOGY

Histone Methyltransferase MMSET/NSD2 Alters EZH2 Binding and Reprograms the Myeloma Epigenome through Global and Focal Changes in H3K36 and H3K27 Methylation

(2014) Relja Popovic et al.   PLoS Genetics

Expression of steroid receptor coactivator 3 in ovarian epithelial cancer is a poor prognostic factor and a marker for platinum resistance

(2013) C Palmieri et al.   BRITISH JOURNAL OF CANCER

SRC-3 coactivator regulates cell resistance to cytotoxic stress via TRAF4-mediated p53 destabilization

(2013) P. Yi et al.   GENES & DEVELOPMENT

MMSET is the key molecular target in t(4;14) myeloma

(2013) F Mirabella et al.   Blood Cancer Journal

Stemness of B-cell Progenitors in Multiple Myeloma Bone Marrow

(2012) K. Boucher et al.   CLINICAL CANCER RESEARCH

Steroid receptor coactivator-3 as a potential molecular target for cancer therapy

(2012) Jean Ching-Yi Tien et al.   EXPERT OPINION ON THERAPEUTIC TARGETS

MMSET regulates histone H4K20 methylation and 53BP1 accumulation at DNA damage sites

(2011) Huadong Pei et al.   NATURE

Multiple Myeloma

(2011) Antonio Palumbo et al.   NEW ENGLAND JOURNAL OF MEDICINE

Lenalidomide, bortezomib, and dexamethasone combination therapy in patients with newly diagnosed multiple myeloma

(2010) P. G. Richardson et al.   BLOOD

The MMSET histone methyl transferase switches global histone methylation and alters gene expression in t(4;14) multiple myeloma cells

(2010) E. Martinez-Garcia et al.   BLOOD

Integrated Genome-Wide DNA Copy Number and Expression Analysis Identifies Distinct Mechanisms of Primary Chemoresistance in Ovarian Carcinomas

(2009) D. Etemadmoghadam et al.   CLINICAL CANCER RESEARCH

Involvement of SRC-3 in deguelin-induced apoptosis in Jurkat cells

(2009) Rui Li et al.   INTERNATIONAL JOURNAL OF HEMATOLOGY

The role of SRC-3 in human breast cancer

(2009) Ondrej Gojis et al.   Nature Reviews Clinical Oncology

Genistein and resveratrol, alone and in combination, suppress prostate cancer in SV-40 tag rats

(2009) Curt E. Harper et al.   PROSTATE