NUP98 gene fusions and hematopoietic malignancies: common themes and new biologic insights

Hallmarks of Cancer: The Next Generation

(2011) Douglas Hanahan et al.   CELL

RNA export factor RAE1 contributes to NUP98-HOXA9-mediated leukemogenesis

(2011) Tatsuyoshi Funasaka et al.   CELL CYCLE

Mutant nucleophosmin and cooperating pathways drive leukemia initiation and progression in mice

(2011) George S Vassiliou et al.   NATURE GENETICS

NUP98-MLL fusion in human acute myeloblastic leukemia

(2010) S. Kaltenbach et al.   BLOOD

A novel NUP98/RARG gene fusion in acute myeloid leukemia resembling acute promyelocytic leukemia

(2010) E. Such et al.   BLOOD

Genome-wide identification of human microRNAs located in leukemia-associated genomic alterations

(2010) D. T. Starczynowski et al.   BLOOD

MicroRNAs expression signatures are associated with lineage and survival in acute leukemias

(2010) Yungui Wang et al.   BLOOD CELLS MOLECULES AND DISEASES

Chromatin-Bound Nuclear Pore Components Regulate Gene Expression in Higher Eukaryotes

(2010) Maya Capelson et al.   CELL

Nucleoporins Directly Stimulate Expression of Developmental and Cell-Cycle Genes Inside the Nucleoplasm

(2010) Bernike Kalverda et al.   CELL

Role of the polycomb group proteins in hematopoietic stem cells

(2010) Takaaki Konuma et al.   DEVELOPMENT GROWTH & DIFFERENTIATION

HoxA cluster is haploinsufficient for activity of hematopoietic stem and progenitor cells

(2010) Charles-Etienne Lebert-Ghali et al.   EXPERIMENTAL HEMATOLOGY

Nucleoporin Nup98: a gatekeeper in the eukaryotic kingdoms

(2010) Masaaki Iwamoto et al.   GENES TO CELLS

Expression of miR-196b is not exclusively MLL-driven but is especially linked to activation of HOXA genes in pediatric acute lymphoblastic leukemia

(2010) D. Schotte et al.   HAEMATOLOGICA

Effects of the NUP98–DDX10 oncogene on primary human CD34+ cells: role of a conserved helicase motif

(2010) E R Yassin et al.   LEUKEMIA

High frequencies of simultaneous FLT3-ITD, WT1 and KIT mutations in hematological malignancies with NUP98-fusion genes

(2010) T Taketani et al.   LEUKEMIA

Regulation of differentiation by a PHD domain in the NUP98-PHF23 fusion protein

(2010) Jocelyn C. Reader et al.   LEUKEMIA RESEARCH

Delineating domains and functions of NUP98 contributing to the leukemogenic activity of NUP98-HOX fusions

(2010) Eric Yung et al.   LEUKEMIA RESEARCH

The role of microRNA-196a and microRNA-196b as ERG regulators in acute myeloid leukemia and acute T-lymphoblastic leukemia

(2010) Ebru Coskun et al.   LEUKEMIA RESEARCH

The Mobile FG Nucleoporin Nup98 Is a Cofactor for Crm1-dependent Protein Export

(2010) Masahiro Oka et al.   MOLECULAR BIOLOGY OF THE CELL

The reduced and altered activities of PAX5 are linked to the protein–protein interaction motif (coiled-coil domain) of the PAX5–PML fusion protein in t(9;15)-associated acute lymphocytic leukemia

(2010) J J Qiu et al.   ONCOGENE

Structural and functional analysis of the interaction between the nucleoporin Nup98 and the mRNA export factor Rae1

(2010) Y. Ren et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Chromosomes in Leukemia and Beyond: From Irrelevant to Central Players

(2009) Janet D. Rowley   Annual Review of Genomics and Human Genetics

Regulation of mir-196b by MLL and its overexpression by MLL fusions contributes to immortalization

(2009) R. Popovic et al.   BLOOD

Chromatin Signatures in Multipotent Human Hematopoietic Stem Cells Indicate the Fate of Bivalent Genes during Differentiation

(2009) Kairong Cui et al.   Cell Stem Cell

MicroRNA and leukemia: Tiny molecule, great function

(2009) Haifeng Zhao et al.   CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY

A NUP98-HOXD13 Fusion Gene Impairs Differentiation of B and T Lymphocytes and Leads to Expansion of Thymocytes with Partial TCRB Gene Rearrangement

(2009) C. W. Choi et al.   JOURNAL OF IMMUNOLOGY

Non-coding RNAs: regulators of disease

(2009) Ryan J Taft et al.   JOURNAL OF PATHOLOGY

Acute myeloid leukemia bearing t(7;11)(p15;p15) is a distinct cytogenetic entity with poor outcome and a distinct mutation profile: comparative analysis of 493 adult patients

(2009) W-C Chou et al.   LEUKEMIA

NUP98–HMGB3: a novel oncogenic fusion

(2009) A Petit et al.   LEUKEMIA

Haematopoietic malignancies caused by dysregulation of a chromatin-binding PHD finger

(2009) Gang G. Wang et al.   NATURE

Leukemogenic mechanisms and targets of a NUP98/HHEX fusion in acute myeloid leukemia

(2008) D. Jankovic et al.   BLOOD

Leukemic transformation in mice expressing a NUP98-HOXD13 transgene is accompanied by spontaneous mutations in Nras, Kras, and Cbl

(2008) C. Slape et al.   BLOOD

MicroRNA expression profiling in relation to the genetic heterogeneity of acute myeloid leukemia

(2008) M. Jongen-Lavrencic et al.   BLOOD

Impaired differentiation and apoptosis of hematopoietic precursors in a mouse model of myelodysplastic syndrome

(2008) C. W. Choi et al.   HAEMATOLOGICA

t(3;11)(q12;p15)/NUP98-LOC348801 fusion transcript in acute myeloid leukemia

(2008) P. Gorello et al.   HAEMATOLOGICA

Prognostic Significance of, and Gene and MicroRNA Expression Signatures Associated With,CEBPAMutations in Cytogenetically Normal Acute Myeloid Leukemia With High-Risk Molecular Features: A Cancer and Leukemia Group B Study

(2008) Guido Marcucci et al.   JOURNAL OF CLINICAL ONCOLOGY

HOX expression patterns identify a common signature for favorable AML

(2008) M Andreeff et al.   LEUKEMIA

MicroRNA Expression in Cytogenetically Normal Acute Myeloid Leukemia

(2008) Guido Marcucci et al.   NEW ENGLAND JOURNAL OF MEDICINE

Leukemogenic properties of NUP98-PMX1 are linked to NUP98 and homeodomain sequence functions but not to binding properties of PMX1 to serum response factor

(2008) K Hirose et al.   ONCOGENE

Transplantation of a myelodysplastic syndrome by a long-term repopulating hematopoietic cell

(2008) Y. J. Chung et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Distinct microRNA expression profiles in acute myeloid leukemia with common translocations

(2008) Z. Li et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA