Polyunsaturated fatty acids and fatty acid-derived lipid mediators: Recent advances in the understanding of their biosynthesis, structures, and functions

Lipid mediator n‐3 docosapentaenoic acid‐derived protectin D1 enhances synaptic inhibition of hippocampal principal neurons by interaction with a G‐protein‐coupled receptor

(2022) Apostolos Mikroulis et al.   FASEB JOURNAL

Ferroptosis: mechanisms, biology and role in disease

(2021) Xuejun Jiang et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Trimethylornithine Membrane Lipids: Discovered in Planctomycetes and Identified in Diverse Environments

(2021) Eli K. Moore   Metabolites

PCTR1 enhances repair and bacterial clearance in skin wounds.

(2021) Brian E. Sansbury et al.   AMERICAN JOURNAL OF PATHOLOGY

Potential physio-pathological effects of branched fatty acid esters of hydroxy fatty acids

(2021) Melha Benlebna et al.   BIOCHIMIE

Food Lipidomics for 155 Agricultural Plant Products

(2021) Yuki Matsuzawa et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Very long-chain fatty acid-containing lipids: a decade of novel insights from the study of ELOVL4

(2021) Gyening Kofi Yeboah et al.   JOURNAL OF LIPID RESEARCH

Cysteinyl-specialized proresolving mediators link resolution of infectious inflammation and tissue regeneration via TRAF3 activation

(2021) Nan Chiang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Lipidomics Revealed Aberrant Metabolism of Lipids Including FAHFAs in Renal Tissue in the Progression of Lupus Nephritis in a Murine Model

(2021) Changfeng Hu et al.   Metabolites

Fish oil replacement prevents, while docosahexaenoic acid‐derived protectin DX mitigates end‐stage‐renal‐disease in atherosclerotic diabetic mice

(2021) Laís R. Perazza et al.   FASEB JOURNAL

Resolvin D1 and D2 reduce SARS‐CoV‐2‐induced inflammatory responses in cystic fibrosis macrophages

(2021) Antonio Recchiuti et al.   FASEB JOURNAL

Regression of human coronary artery plaque is associated with a high ratio of (18‐hydroxy‐eicosapentaenoic acid + resolvin E1) to leukotriene B 4

(2021) Francine K. Welty et al.   FASEB JOURNAL

Activation of GPR37 in macrophages confers protection against infection-induced sepsis and pain-like behaviour in mice

(2021) Sangsu Bang et al.   Nature Communications

Agonist anti-ChemR23 mAb reduces tissue neutrophil accumulation and triggers chronic inflammation resolution

(2021) C. Trilleaud et al.   Science Advances

Loss of 15-lipoxygenase disrupts Treg differentiation altering their pro-resolving functions

(2021) Raquel M. Marques et al.   CELL DEATH AND DIFFERENTIATION

Disrupted Resolution Mechanisms Favor Altered Phagocyte Responses in COVID-19

(2021) Duco Steven Koenis et al.   CIRCULATION RESEARCH

Quantitative profiling of inflammatory and pro-resolving lipid mediators in human adolescents and mouse plasma using UHPLC-MS/MS

(2021) Ivan Hartling et al.   CLINICAL CHEMISTRY AND LABORATORY MEDICINE

Metabolomics and lipid profile analysis of Coccomyxa melkonianii SCCA 048

(2021) Giacomo Fais et al.   EXTREMOPHILES

Maresin 1 activates LGR6 signaling to inhibit smooth muscle cell activation and attenuate murine abdominal aortic aneurysm formation

(2021) Craig T. Elder et al.   FASEB JOURNAL

High levels of eicosanoids and docosanoids in the lungs of intubated COVID‐19 patients

(2021) Anne‐Sophie Archambault et al.   FASEB JOURNAL

Inflammation resolution circuits are uncoupled in acute sepsis and correlate with clinical severity

(2021) Bakr Jundi et al.   JCI Insight

Lipidomic Analysis to Assess Oxidative Stress in Acute Coronary Syndrome and Acute Stroke Patients

(2021) Martin Malý et al.   Metabolites

Specialized Proresolving Mediators in Symptomatic Women With Coronary Microvascular Dysfunction (from the Women's Ischemia Trial to Reduce Events in Nonobstructive CAD [WARRIOR] Trial)

(2021) Ellen C. Keeley et al.   AMERICAN JOURNAL OF CARDIOLOGY

Mouse LGR6 regulates osteogenesis in vitro and in vivo through differential ligand use

(2021) Vikram Khedgikar et al.   BONE

New understandings of the pathway of long-chain polyunsaturated fatty acid biosynthesis

(2021) J. Thomas Brenna et al.   CURRENT OPINION IN CLINICAL NUTRITION AND METABOLIC CARE

Long-term high intake of 9-PAHPA or 9-OAHPA increases basal metabolism and insulin sensitivity but disrupts liver homeostasis in healthy mice

(2020) Melha Benlebna et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

Identification of Polymethylene-Interrupted Polyunsaturated Fatty Acids (PMI–PUFA) by Solvent-Mediated Covalent Adduct Chemical Ionization Triple Quadrupole Tandem Mass Spectrometry

(2020) Dong Hao Wang et al.   ANALYTICAL CHEMISTRY

Nonenzymatic oxygenated metabolite of docosahexaenoic acid, 4(RS )-4-F4t -neuroprostane, acts as a bioactive lipid molecule in neuronal cells

(2020) Yiu Yiu Lee et al.   FEBS LETTERS

AIG1 and ADTRP are endogenous hydrolases of fatty acid esters of hydroxy fatty acids (FAHFAs) in mice

(2020) Meric Erikci Ertunc et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Triacylglycerol‐Rich Oils of Marine Origin are Optimal Nutrients for Induction of Polyunsaturated Docosahexaenoic Acid Ester of Hydroxy Linoleic Acid (13‐DHAHLA) with Anti‐Inflammatory Properties in Mice

(2020) Veronika Paluchova et al.   MOLECULAR NUTRITION & FOOD RESEARCH

Pulmonary Vascular Endothelialitis, Thrombosis, and Angiogenesis in Covid-19

(2020) Maximilian Ackermann et al.   NEW ENGLAND JOURNAL OF MEDICINE

Identification of short chain fatty acid esters of hydroxy fatty acids (SFAHFAs) in murine model by nontargeted analysis using ultra‐high‐performance liquid chromatography/linear trap quadrupole‐Orbitrap mass spectrometry

(2020) Siddabasave Gowda B. Gowda et al.   RAPID COMMUNICATIONS IN MASS SPECTROMETRY

Cyclopentenone Prostaglandins and Structurally Related Oxidized Lipid Species Instigate and Share Distinct Pro- and Anti-inflammatory Pathways

(2020) Jonathan Muri et al.   Cell Reports

Lipid polarity gradient formed by ω-hydroxy lipids in tear film prevents dry eye disease

(2020) Masatoshi Miyamoto et al.   eLife

Resolvin D1 Reduces Lung Infection and Inflammation Activating Resolution in Cystic Fibrosis

(2020) Elisa Isopi et al.   Frontiers in Immunology

Omega-3 Polyunsaturated Fatty Acids Decrease Aortic Valve Disease through the Resolvin E1 and ChemR23 Axis

(2020) Gonzalo Artiach et al.   CIRCULATION

Oxidation of polyunsaturated fatty acids to produce lipid mediators

(2020) William W. Christie et al.   Essays in Biochemistry

Moving forward with isoprostanes, neuroprostanes and phytoprostanes: where are we now?

(2020) Omar S. Ahmed et al.   Essays in Biochemistry

Role of bioactive sphingolipids in physiology and pathology

(2020) Ana Gomez-Larrauri et al.   Essays in Biochemistry

Neutrophils and COVID-19: Nots, NETs, and knots

(2020) Carl Nathan   JOURNAL OF EXPERIMENTAL MEDICINE

Understanding FAHFAs: From structure to metabolic regulation

(2020) Kristyna Brejchova et al.   PROGRESS IN LIPID RESEARCH

Effects of antiemetic doses of dexamethasone on plasma mediators of inflammation resolution and pain after surgery in women

(2020) Anne Barden et al.   PROSTAGLANDINS & OTHER LIPID MEDIATORS

Treatment With a Marine Oil Supplement Alters Lipid Mediators and Leukocyte Phenotype in Healthy Patients and Those With Peripheral Artery Disease

(2020) Melinda S. Schaller et al.   Journal of the American Heart Association

Specialized pro-resolving mediator network: an update on production and actions

(2020) Nan Chiang et al.   Essays in Biochemistry

Eicosanoids

(2020) Philip C. Calder   Essays in Biochemistry

Long-term intake of 9-PAHPA or 9-OAHPA modulates favorably the basal metabolism and exerts an insulin sensitizing effect in obesogenic diet-fed mice

(2020) Melha Benlebna et al.   EUROPEAN JOURNAL OF NUTRITION

Updating Phospholipase A2 Biology

(2020) Makoto Murakami et al.   Biomolecules

Chemical Labeling Assisted Detection and Identification of Short Chain Fatty Acid Esters of Hydroxy Fatty Acid in Rat Colon and Cecum Contents

(2020) Siddabasave Gowda B. Gowda et al.   Metabolites

EPA and DHA differentially modulate monocyte inflammatory response in subjects with chronic inflammation in part via plasma specialized pro-resolving lipid mediators: A randomized, double-blind, crossover study

(2020) Jisun So et al.   ATHEROSCLEROSIS

Ferroptosis: molecular mechanisms and health implications

(2020) Daolin Tang et al.   CELL RESEARCH

Increased inspired oxygen concentration does not adversely affect oxidative stress and the resolution of inflammation during reperfusion in patients undergoing knee replacement surgery

(2020) Anne Barden et al.   FREE RADICAL RESEARCH

Cutting Edge: Severe SARS-CoV-2 Infection in Humans Is Defined by a Shift in the Serum Lipidome, Resulting in Dysregulation of Eicosanoid Immune Mediators

(2020) Benjamin Schwarz et al.   JOURNAL OF IMMUNOLOGY

Cytochrome P450-derived linoleic acid metabolites EpOMEs and DiHOMEs: a review of recent studies

(2020) Kelsey Hildreth et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

Distinct roles of adipose triglyceride lipase and hormone-sensitive lipase in the catabolism of triacylglycerol estolides

(2020) Kristyna Brejchova et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Altered tissue specialized pro-resolving mediators in chronic rhinosinusitis

(2020) Thad W. Vickery et al.   PROSTAGLANDINS LEUKOTRIENES AND ESSENTIAL FATTY ACIDS

Dose- and time-dependent increase in circulating anti-inflammatory and pro-resolving lipid mediators following eicosapentaenoic acid supplementation in patients with major depressive disorder and chronic inflammation

(2020) Stefania Lamon-Fava et al.   PROSTAGLANDINS LEUKOTRIENES AND ESSENTIAL FATTY ACIDS

The relationship between specialized pro-resolving lipid mediators, morbid obesity and weight loss after bariatric surgery

(2020) Fabian Schulte et al.   Scientific Reports

The Biosynthesis of Enzymatically Oxidized Lipids

(2020) Ali A. Hajeyah et al.   Frontiers in Endocrinology

Determination of Major Endogenous FAHFAs in Healthy Human Circulation: The Correlations with Several Circulating Cardiovascular-Related Biomarkers and Anti-Inflammatory Effects on RAW 264.7 Cells

(2020) Rachmad Anres Dongoran et al.   Biomolecules

Fatty Acyl Esters of Hydroxy Fatty Acid (FAHFA) Lipid Families

(2020) Paul L. Wood   Metabolites

Overview of how N32 and N34 elovanoids sustain sight by protecting retinal pigment epithelial cells and photoreceptors

(2020) Nicolas G. Bazan   JOURNAL OF LIPID RESEARCH

Moose and Caribou as Novel Sources of Functional Lipids: Fatty Acid Esters of Hydroxy Fatty Acids, Diglycerides and Monoacetyldiglycerides

(2019) Thu Pham et al.   MOLECULES

Effects of sex (or lack thereof) on meibogenesis in mice (Mus musculus): Comparative evaluation of lipidomes and transcriptomes of male and female tarsal plates

(2019) Igor A. Butovich et al.   Ocular Surface

Evidence for an alternative fatty acid desaturation pathway increasing cancer plasticity

(2019) Kim Vriens et al.   NATURE

Tumours use a metabolic twist to make lipids

(2019) Marteinn Thor Snaebjornsson et al.   NATURE

A maresin 1/RORα/12-lipoxygenase autoregulatory circuit prevents inflammation and progression of nonalcoholic steatohepatitis

(2019) Yong-Hyun Han et al.   JOURNAL OF CLINICAL INVESTIGATION

Dynamic changes to lipid mediators support transitions among macrophage subtypes during muscle regeneration

(2019) Nikolas Giannakis et al.   NATURE IMMUNOLOGY

Analysis of Fatty Acid Esters of Hydroxyl Fatty Acid in Selected Plant Food

(2019) Ana-Marija Liberati-Čizmek et al.   PLANT FOODS FOR HUMAN NUTRITION

Resolvin D4 attenuates the severity of pathological thrombosis in mice

(2019) Deya Cherpokova et al.   BLOOD

Linoleic acid esters of hydroxy linoleic acids are anti-inflammatory lipids found in plants and mammals

(2019) Matthew J. Kolar et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Brain tissue saving effects by single-dose intralesional administration of Neuroprotectin D1 on experimental focal penetrating brain injury in rats

(2019) Rand Wilcox Vanden Berg et al.   JOURNAL OF CLINICAL NEUROSCIENCE

Linoleic acid‐derived metabolites constitute the majority of oxylipins in the rat pup brain and stimulate axonal growth in primary rat cortical neuron‐glia co‐cultures in a sex‐dependent manner

(2019) Marie Hennebelle et al.   JOURNAL OF NEUROCHEMISTRY

Fish Oil Increases Specialized Pro-resolving Lipid Mediators in PAD (The OMEGA-PAD II Trial)

(2019) Joel L. Ramirez et al.   JOURNAL OF SURGICAL RESEARCH

From discoveries in ageing research to therapeutics for healthy ageing

(2019) Judith Campisi et al.   NATURE

Resolvin D5 Inhibits Neuropathic and Inflammatory Pain in Male But Not Female Mice: Distinct Actions of D-Series Resolvins in Chemotherapy-Induced Peripheral Neuropathy

(2019) Xin Luo et al.   Frontiers in Pharmacology

Proresolving mediator profiles in cerebrospinal fluid are linked with disease severity and outcome in adults with tuberculous meningitis

(2019) Romain A. Colas et al.   FASEB JOURNAL

Specialized pro-resolving lipid mediators are differentially altered in peripheral blood of patients with multiple sclerosis and attenuate monocyte and blood-brain barrier dysfunction

(2019) Gijs Kooij et al.   HAEMATOLOGICA

Maresin 1 activates LGR6 receptor promoting phagocyte immunoresolvent functions

(2019) Nan Chiang et al.   JOURNAL OF CLINICAL INVESTIGATION

Anti-Bacterial Effect and Cytotoxicity Assessment of Lipid 430 Isolated from Algibacter sp.

(2019) Yannik K.-H. Schneider et al.   MOLECULES

Elovanoids counteract oligomeric β-amyloid-induced gene expression and protect photoreceptors

(2019) Khanh V. Do et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Fibrinogen-like protein 2 controls sepsis catabasis by interacting with resolvin Dp5

(2019) Yu Zhou et al.   Science Advances

Enriched Marine Oil Supplements Increase Peripheral Blood Specialized Pro-Resolving Mediators Concentrations and Reprogram Host Immune Responses

(2019) Patricia R. Souza et al.   CIRCULATION RESEARCH

Lipokine 5-PAHSA Is Regulated by Adipose Triglyceride Lipase and Primes Adipocytes for De Novo Lipogenesis in Mice

(2019) Veronika Paluchova et al.   DIABETES

FADS3 is a Δ14Z sphingoid base desaturase that contributes to gender differences in the human plasma sphingolipidome

(2019) Gergely Karsai et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

GPR101 mediates the pro-resolving actions of RvD5n-3 DPA in arthritis and infections

(2019) Magdalena B. Flak et al.   JOURNAL OF CLINICAL INVESTIGATION

Identification and Complete Stereochemical Assignments of the New Resolvin Conjugates in Tissue Regeneration in Human Tissues that Stimulate Proresolving Phagocyte Functions and Tissue Regeneration

(2018) Xavier de la Rosa et al.   AMERICAN JOURNAL OF PATHOLOGY

Levels of palmitic acid ester of hydroxystearic acid (PAHSA) are reduced in the breast milk of obese mothers

(2018) Marie Brezinova et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Branched Fatty Acyl Esters of Hydroxyl Fatty Acids (FAHFAs), Appealing Beneficial Endogenous Fat against Obesity and Type-2 Diabetes

(2018) Laurence Balas et al.   CHEMISTRY-A EUROPEAN JOURNAL

ERV1/ChemR23 Signaling Protects from Atherosclerosis by Modifying oxLDL Uptake and Phagocytosis in Macrophages

(2018) Andres Laguna-Fernandez et al.   CIRCULATION

Impaired Production and Diurnal Regulation of Vascular RvDn-3 DPAIncrease Systemic Inflammation and Cardiovascular DiseaseNovelty and Significance

(2018) Romain A. Colas et al.   CIRCULATION RESEARCH

Nrf2-Mediated Antioxidant Defense and Peroxiredoxin 6 Are Linked to Biosynthesis of Palmitic Acid Ester of 9-Hydroxystearic Acid

(2018) Ondrej Kuda et al.   DIABETES

GPR37 regulates macrophage phagocytosis and resolution of inflammatory pain

(2018) Sangsu Bang et al.   JOURNAL OF CLINICAL INVESTIGATION

Biosynthesis of D-Series Resolvins in Skin Provides Insights into their Role in Tissue Repair

(2018) Jason Hellmann et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Biological activities of non-enzymatic oxygenated metabolites of polyunsaturated fatty acids (NEO-PUFAs) derived from EPA and DHA: New anti-arrhythmic compounds?

(2018) Jean-Marie Galano et al.   MOLECULAR ASPECTS OF MEDICINE

The effect of n-3 fatty acids and coenzyme Q10 supplementation on neutrophil leukotrienes, mediators of inflammation resolution and myeloperoxidase in chronic kidney disease

(2018) Anne E. Barden et al.   PROSTAGLANDINS & OTHER LIPID MEDIATORS

The role of fatty acid desaturase (FADS) genes in oleic acid metabolism: FADS1 Δ7 desaturates 11-20:1 to 7,11-20:2

(2018) Hui Gyu Park et al.   PROSTAGLANDINS LEUKOTRIENES AND ESSENTIAL FATTY ACIDS

A rare eicosanoid precursor analogue, sciadonic acid (5Z,11Z,14Z–20:3), detected in vivo in hormone positive breast cancer tissue

(2018) H.G. Park et al.   PROSTAGLANDINS LEUKOTRIENES AND ESSENTIAL FATTY ACIDS

Lipidomics of equine amniotic fluid: Identification of amphiphilic (O-acyl)-ω-hydroxy-fatty acids

(2018) Paul L. Wood et al.   THERIOGENOLOGY

Resolving the Role of Lipoxygenases in the Initiation and Execution of Ferroptosis

(2018) Ron Shah et al.   ACS Central Science

Tau protein aggregation is associated with cellular senescence in the brain

(2018) Nicolas Musi et al.   AGING CELL

Conversion of dietary trans-vaccenic acid to trans11,cis13-conjugated linoleic acid in the rat lactating mammary gland by Fatty Acid Desaturase 3-catalyzed methyl-end Δ13-desaturation

(2018) Cyrielle Garcia et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Adipose tissue dysfunction is associated with low levels of the novel Palmitic Acid Hydroxystearic Acids

(2018) Ann Hammarstedt et al.   Scientific Reports

The glycine lipids of Bacteroides thetaiotaomicron are important for fitness during growth in vivo and in vitro

(2018) Alli Lynch et al.   APPLIED AND ENVIRONMENTAL MICROBIOLOGY

Cutting Edge: Human Vagus Produces Specialized Proresolving Mediators of Inflammation with Electrical Stimulation Reducing Proinflammatory Eicosanoids

(2018) Charles N. Serhan et al.   JOURNAL OF IMMUNOLOGY

Docosahexaenoic acid is both a product of and a precursor to tetracosahexaenoic acid in the rat

(2018) Adam H Metherel et al.   JOURNAL OF LIPID RESEARCH

Brain oxylipin concentrations following hypercapnia / ischemia: effects of brain dissection and dissection time

(2018) Marie Hennebelle et al.   JOURNAL OF LIPID RESEARCH

GPR18 expression on PMNs as biomarker for outcome in patient with sepsis

(2018) Lanqiu Zhang et al.   LIFE SCIENCES

Docosanoids and elovanoids from omega-3 fatty acids are pro-homeostatic modulators of inflammatory responses, cell damage and neuroprotection

(2018) Nicolas G. Bazan   MOLECULAR ASPECTS OF MEDICINE

Soluble Epoxide Hydrolase-Derived Linoleic Acid Oxylipins in Serum Are Associated with Periventricular White Matter Hyperintensities and Vascular Cognitive Impairment

(2018) Di Yu et al.   Translational Stroke Research

Meibomian glands, meibum, and meibogenesis

(2017) Igor A. Butovich   EXPERIMENTAL EYE RESEARCH

13-Series resolvins mediate the leukocyte-platelet actions of atorvastatin and pravastatin in inflammatory arthritis

(2017) Mary E. Walker et al.   FASEB JOURNAL

Highly sensitive determination of fatty acid esters of hydroxyl fatty acids by liquid chromatography-mass spectrometry

(2017) Quan-Fei Zhu et al.   JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES

Resolvins suppress tumor growth and enhance cancer therapy

(2017) Megan L. Sulciner et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Cholesteryl esters of ω-( O -acyl)-hydroxy fatty acids in vernix caseosa

(2017) Aneta Kalužíková et al.   JOURNAL OF LIPID RESEARCH

Deposition and hydrolysis of serine dipeptide lipids of Bacteroidetes bacteria in human arteries: relationship to atherosclerosis

(2017) Reza Nemati et al.   JOURNAL OF LIPID RESEARCH

Interplay Between n-3 and n-6 Long-Chain Polyunsaturated Fatty Acids and the Endocannabinoid System in Brain Protection and Repair

(2017) Simon C. Dyall   LIPIDS

Specialized pro-resolving mediators in cardiovascular diseases

(2017) Gabrielle Fredman et al.   MOLECULAR ASPECTS OF MEDICINE

The role of pro-resolving lipid mediators in ocular diseases

(2017) Jessica Wei et al.   MOLECULAR ASPECTS OF MEDICINE

Discovery of specialized pro-resolving mediators marks the dawn of resolution physiology and pharmacology

(2017) Charles N. Serhan   MOLECULAR ASPECTS OF MEDICINE

Structural elucidation and physiologic functions of specialized pro-resolving mediators and their receptors

(2017) Nan Chiang et al.   MOLECULAR ASPECTS OF MEDICINE

New pro-resolving n-3 mediators bridge resolution of infectious inflammation to tissue regeneration

(2017) Charles N. Serhan et al.   MOLECULAR ASPECTS OF MEDICINE

Immune resolution mechanisms in inflammatory arthritis

(2017) Mauro Perretti et al.   Nature Reviews Rheumatology

Cytochrome P450 eicosanoids in cerebrovascular function and disease

(2017) Catherine M. Davis et al.   PHARMACOLOGY & THERAPEUTICS

Isoprostanes, neuroprostanes and phytoprostanes: An overview of 25 years of research in chemistry and biology

(2017) Jean-Marie Galano et al.   PROGRESS IN LIPID RESEARCH

Fads3 modulates docosahexaenoic acid in liver and brain

(2017) Ji Yao Zhang et al.   PROSTAGLANDINS LEUKOTRIENES AND ESSENTIAL FATTY ACIDS

Circulating inflammation-resolving lipid mediators RvD1 and DHA are decreased in patients with acutely symptomatic carotid disease

(2017) Hernan A. Bazan et al.   PROSTAGLANDINS LEUKOTRIENES AND ESSENTIAL FATTY ACIDS

PNPLA1 has a crucial role in skin barrier function by directing acylceramide biosynthesis

(2017) Tetsuya Hirabayashi et al.   Nature Communications

Distribution of ELOVL4 in the Developing and Adult Mouse Brain

(2017) David M. Sherry et al.   Frontiers in Neuroanatomy

Absence of Carbohydrate Response Element Binding Protein in Adipocytes Causes Systemic Insulin Resistance and Impairs Glucose Transport

(2017) Archana Vijayakumar et al.   Cell Reports

Mesenchymal Stem Cells Secretory Responses: Senescence Messaging Secretome and Immunomodulation Perspective

(2017) Victoria V. Lunyak et al.   Frontiers in Genetics

Elovanoids are a novel class of homeostatic lipid mediators that protect neural cell integrity upon injury

(2017) Surjyadipta Bhattacharjee et al.   Science Advances

Linoleic acid participates in the response to ischemic brain injury through oxidized metabolites that regulate neurotransmission

(2017) Marie Hennebelle et al.   Scientific Reports

Two alternative pathways for docosahexaenoic acid (DHA, 22:6n-3) biosynthesis are widespread among teleost fish

(2017) Angela Oboh et al.   Scientific Reports

Elovanoids are novel cell-specific lipid mediators necessary for neuroprotective signaling for photoreceptor cell integrity

(2017) Bokkyoo Jun et al.   Scientific Reports

Palmitic acid (16:0) competes with omega-6 linoleic and omega-3 ɑ-linolenic acids for FADS2 mediated Δ6-desaturation

(2016) Hui Gyu Park et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Divergent shifts in lipid mediator profile following supplementation with n-3 docosapentaenoic acid and eicosapentaenoic acid

(2016) James F. Markworth et al.   FASEB JOURNAL

Adipose tissue regulates insulin sensitivity: role of adipogenesis,de novolipogenesis and novel lipids

(2016) U. Smith et al.   JOURNAL OF INTERNAL MEDICINE

Naturally occurring p16Ink4a-positive cells shorten healthy lifespan

(2016) Darren J. Baker et al.   NATURE

Resolution of inflammation: a new therapeutic frontier

(2016) James N. Fullerton et al.   NATURE REVIEWS DRUG DISCOVERY

Regulation of rat plasma and cerebral cortex oxylipin concentrations with increasing levels of dietary linoleic acid

(2016) Ameer Y. Taha et al.   PROSTAGLANDINS LEUKOTRIENES AND ESSENTIAL FATTY ACIDS

Elucidation and identification of amino acid containing membrane lipids using liquid chromatography/high-resolution mass spectrometry

(2016) Eli K. Moore et al.   RAPID COMMUNICATIONS IN MASS SPECTROMETRY

The role of neutrophils in inflammation resolution

(2016) Hefin R. Jones et al.   SEMINARS IN IMMUNOLOGY

Lipidomics of equine sperm and seminal plasma: Identification of amphiphilic (O-acyl)-ω-hydroxy-fatty acids

(2016) Paul L. Wood et al.   THERIOGENOLOGY

Pathway Markers for Pro-resolving Lipid Mediators in Maternal and Umbilical Cord Blood: A Secondary Analysis of the Mothers, Omega-3, and Mental Health Study

(2016) Ellen L. Mozurkewich et al.   Frontiers in Pharmacology

15-Lipoxygenase metabolites of α-linolenic acid, [13-(S)-HPOTrE and 13-(S)-HOTrE], mediate anti-inflammatory effects by inactivating NLRP3 inflammasome

(2016) Naresh Kumar et al.   Scientific Reports

Role of omega-3 PUFA-derived mediators, the protectins, in influenza virus infection

(2015) Yumiko Imai   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Protectins and maresins: New pro-resolving families of mediators in acute inflammation and resolution bioactive metabolome

(2015) Charles N. Serhan et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Phospholipid oxidation generates potent anti-inflammatory lipid mediators that mimic structurally related pro-resolving eicosanoids by activating Nrf2

(2015) P. Bretscher et al.   EMBO Molecular Medicine

The fatty acid desaturase 2 (FADS2) gene product catalyzes Δ4 desaturation to yield n-3 docosahexaenoic acid and n-6 docosapentaenoic acid in human cells

(2015) Hui Gyu Park et al.   FASEB JOURNAL

Nonenzymatic lipid mediators, neuroprostanes, exert the antiarrhythmic properties of docosahexaenoic acid

(2015) Jérôme Roy et al.   FREE RADICAL BIOLOGY AND MEDICINE

15-Hydroxyprostaglandin Dehydrogenase Generation of Electrophilic Lipid Signaling Mediators from Hydroxy Ω-3 Fatty Acids

(2015) Stacy Gelhaus Wendell et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Elucidation of novel 13-series resolvins that increase with atorvastatin and clear infections

(2015) Jesmond Dalli et al.   NATURE MEDICINE

Astrocytes show reduced support of motor neurons with aging that is accelerated in a rodent model of ALS

(2015) Melanie M. Das et al.   NEUROBIOLOGY OF AGING

Resolvin Infectious Inflammation by Targeting the Host Response

(2015) Craig R. Lee et al.   NEW ENGLAND JOURNAL OF MEDICINE

Systematic study of constitutive cyclooxygenase-2 expression: Role of NF-κB and NFAT transcriptional pathways

(2015) Nicholas S. Kirkby et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Adiponectin receptor 1 conserves docosahexaenoic acid and promotes photoreceptor cell survival

(2015) Dennis S. Rice et al.   Nature Communications

Advances in Our Understanding of Oxylipins Derived from Dietary PUFAs

(2015) Melissa Gabbs et al.   Advances in Nutrition

Identification and signature profiles for pro-resolving and inflammatory lipid mediators in human tissue

(2014) Romain A. Colas et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Pathophysiology of isoprostanes in the cardiovascular system: implications of isoprostane-mediated thromboxane A2receptor activation

(2014) Jochen Bauer et al.   BRITISH JOURNAL OF PHARMACOLOGY

Discovery of a Class of Endogenous Mammalian Lipids with Anti-Diabetic and Anti-inflammatory Effects

(2014) Mark M. Yore et al.   CELL

Pro-resolving lipid mediators are leads for resolution physiology

(2014) Charles N. Serhan   NATURE

Protectin DX alleviates insulin resistance by activating a myokine-liver glucoregulatory axis

(2014) Phillip J White et al.   NATURE MEDICINE

Role of the Non-enzymatic Metabolite of Eicosapentaenoic Acid, 5-epi-5-F3t-Isoprostane in the Regulation of [3H]d-Aspartate Release in Isolated Bovine Retina

(2014) Jamal Jamil et al.   NEUROCHEMICAL RESEARCH

Cytochrome P450–dependent metabolism of ω-6 and ω-3 long-chain polyunsaturated fatty acids

(2014) Cosima Arnold et al.   Pharmacological Reports

Lipid Profiling following Intake of the Omega 3 Fatty Acid DHA Identifies the Peroxidized Metabolites F4-Neuroprostanes as the Best Predictors of Atherosclerosis Prevention

(2014) Cécile Gladine et al.   PLoS One

Generation and Dietary Modulation of Anti-Inflammatory Electrophilic Omega-3 Fatty Acid Derivatives

(2014) Chiara Cipollina et al.   PLoS One

Maresin Biosynthesis and Identification of Maresin 2, a New Anti-Inflammatory and Pro-Resolving Mediator from Human Macrophages

(2014) Bin Deng et al.   PLoS One

Identification of 14-series sulfido-conjugated mediators that promote resolution of infection and organ protection

(2014) J. Dalli et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

COX-2-derived endocannabinoid metabolites as novel inflammatory mediators

(2014) Mireille Alhouayek et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Protection after stroke: cellular effectors of neurovascular unit integrity

(2014) Rafael Andres Posada-Duque et al.   Frontiers in Cellular Neuroscience

The Lipid Mediator Protectin D1 Inhibits Influenza Virus Replication and Improves Severe Influenza

(2013) Masayuki Morita et al.   CELL

Fatty acid analysis by high resolution gas chromatography and mass spectrometry for clinical and experimental applications

(2013) J. Thomas Brenna   CURRENT OPINION IN CLINICAL NUTRITION AND METABOLIC CARE

Novel n-3 Immunoresolvents: Structures and Actions

(2013) Jesmond Dalli et al.   Scientific Reports

The contribution of the endogenous TRPV1 ligands 9-HODE and 13-HODE to nociceptive processing and their role in peripheral inflammatory pain mechanisms

(2012) Mohammad Alsalem et al.   BRITISH JOURNAL OF PHARMACOLOGY

Novel aspirin-triggered neuroprotectin D1 attenuates cerebral ischemic injury after experimental stroke

(2012) Nicolas G. Bazan et al.   EXPERIMENTAL NEUROLOGY

Maintenance of Arachidonic Acid and Evidence of Δ5 Desaturation in Cats Fed γ-Linolenic and Linoleic Acid Enriched Diets

(2012) Luciano Trevizan et al.   LIPIDS

Expanding the horizons of lipidomics. Towards fluxolipidomics

(2012) Michel Lagarde et al.   MOLECULAR MEMBRANE BIOLOGY

Infection regulates pro-resolving mediators that lower antibiotic requirements

(2012) Nan Chiang et al.   NATURE

Lowering dietary linoleic acid reduces bioactive oxidized linoleic acid metabolites in humans

(2012) Christopher E. Ramsden et al.   PROSTAGLANDINS LEUKOTRIENES AND ESSENTIAL FATTY ACIDS

Changes in consumption of omega-3 and omega-6 fatty acids in the United States during the 20th century

(2011) Tanya L Blasbalg et al.   AMERICAN JOURNAL OF CLINICAL NUTRITION

Recessive Mutations in ELOVL4 Cause Ichthyosis, Intellectual Disability, and Spastic Quadriplegia

(2011) Mohammed A. Aldahmesh et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Docosahexaenoic Acid Signalolipidomics in Nutrition: Significance in Aging, Neuroinflammation, Macular Degeneration, Alzheimer's, and Other Neurodegenerative Diseases

(2011) Nicolas G. Bazan et al.   Annual Review of Nutrition

Lipoxygenase and Leukotriene Pathways: Biochemistry, Biology, and Roles in Disease

(2011) Jesper Z. Haeggström et al.   CHEMICAL REVIEWS

Free Radical Lipid Peroxidation: Mechanisms and Analysis

(2011) Huiyong Yin et al.   CHEMICAL REVIEWS

Novel Proresolving Aspirin-Triggered DHA Pathway

(2011) Charles N. Serhan et al.   CHEMISTRY & BIOLOGY

Lipoxygenases Mediate the Effect of Essential Fatty Acid in Skin Barrier Formation

(2011) Yuxiang Zheng et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The fatty acid oxidation product 15-A3t-Isoprostane is a potent inhibitor of NFκB transcription and macrophage transformation

(2011) Joshua D. Brooks et al.   JOURNAL OF NEUROCHEMISTRY

Differential effect of amyloid beta on the cytochrome P450 epoxygenase activity in rat brain

(2011) P. Sarkar et al.   NEUROSCIENCE

Docosahexaenoic Acid-Derived Neuroprotectin D1 Induces Neuronal Survival via Secretase- and PPARγ-Mediated Mechanisms in Alzheimer's Disease Models

(2011) Yuhai Zhao et al.   PLoS One

FADS2 Function Loss at the Cancer Hotspot 11q13 Locus Diverts Lipid Signaling Precursor Synthesis to Unusual Eicosanoid Fatty Acids

(2011) Woo Jung Park et al.   PLoS One

Genetic Loci Associated with Plasma Phospholipid n-3 Fatty Acids: A Meta-Analysis of Genome-Wide Association Studies from the CHARGE Consortium

(2011) Rozenn N. Lemaitre et al.   PLoS Genetics

Poxytrins, a class of oxygenated products from polyunsaturated fatty acids, potently inhibit blood platelet aggregation

(2010) Ping Chen et al.   FASEB JOURNAL

Structural Basis of Fatty Acid Substrate Binding to Cyclooxygenase-2

(2010) Alex J. Vecchio et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Controlling Herpes Simplex Virus-Induced Ocular Inflammatory Lesions with the Lipid-Derived Mediator Resolvin E1

(2010) N. K. Rajasagi et al.   JOURNAL OF IMMUNOLOGY

Retinal very long-chain PUFAs: new insights from studies on ELOVL4 protein

(2010) Martin-Paul Agbaga et al.   JOURNAL OF LIPID RESEARCH

Nonenzymatic free radical-catalyzed generation of 15-deoxy-Δ12,14-prostaglandin J2-like compounds (deoxy-J2-isoprostanes) in vivo

(2010) Klarissa D. Hardy et al.   JOURNAL OF LIPID RESEARCH

Cyclooxygenase-2 generates anti-inflammatory mediators from omega-3 fatty acids

(2010) Alison L Groeger et al.   Nature Chemical Biology

The Science of Stroke: Mechanisms in Search of Treatments

(2010) Michael A. Moskowitz et al.   NEURON

Omega-3 fatty acid oxidation products prevent vascular endothelial cell activation by coplanar polychlorinated biphenyls

(2010) Zuzana Majkova et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

ω–3 Long-chain polyunsaturated fatty acid intake and 12-y incidence of neovascular age-related macular degeneration and central geographic atrophy: AREDS report 30, a prospective cohort study from the Age-Related Eye Disease Study

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Very long chain sphingolipids: Tissue expression, function and synthesis

(2009) Roger Sandhoff   FEBS LETTERS

Human tear film and meibum. Very long chain wax esters and (O-acyl)-omega-hydroxy fatty acids of meibum

(2009) Igor A. Butovich et al.   JOURNAL OF LIPID RESEARCH

An alternate pathway to long-chain polyunsaturates: theFADS2gene product Δ8-desaturates 20:2n-6 and 20:3n-3

(2009) Woo Jung Park et al.   JOURNAL OF LIPID RESEARCH

Amino acid-containing membrane lipids in bacteria

(2009) Otto Geiger et al.   PROGRESS IN LIPID RESEARCH

Beyond Prostaglandins-Chemistry and Biology of Cyclic Oxygenated Metabolites Formed by Free-Radical Pathways from Polyunsaturated Fatty Acids

(2008) Ullrich Jahn et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Lipid Mediators in Health and Disease: Enzymes and Receptors as Therapeutic Targets for the Regulation of Immunity and Inflammation

(2008) Takao Shimizu   Annual Review of Pharmacology and Toxicology

Electrophilic Cyclopentenone Neuroprostanes Are Anti-inflammatory Mediators Formed from the Peroxidation of the ω-3 Polyunsaturated Fatty Acid Docosahexaenoic Acid

(2008) Erik S. Musiek et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Maresins: novel macrophage mediators with potent antiinflammatory and proresolving actions

(2008) Charles N. Serhan et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Cyclooxygenases: structural and functional insights

(2008) Carol A. Rouzer et al.   JOURNAL OF LIPID RESEARCH

The Identification of Mono-, Di-, Tri-, and Tetragalactosyl-diacylglycerols and their Natural Estolides in Oat Kernels

(2008) Robert A. Moreau et al.   LIPIDS

Principles of bioactive lipid signalling: lessons from sphingolipids

(2008) Yusuf A. Hannun et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

General Detoxification and Stress Responses Are Mediated by Oxidized Lipids through TGA Transcription Factors in Arabidopsis

(2008) S. Mueller et al.   PLANT CELL

Role of Stargardt-3 macular dystrophy protein (ELOVL4) in the biosynthesis of very long chain fatty acids

(2008) M.-P. Agbaga et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Endogenous pro-resolving and anti-inflammatory lipid mediators: a new pharmacologic genus

(2007) C N Serhan et al.   BRITISH JOURNAL OF PHARMACOLOGY