Overview of how N32 and N34 elovanoids sustain sight by protecting retinal pigment epithelial cells and photoreceptors

Membrane‐type frizzled‐related protein regulates lipidome and transcription for photoreceptor function

(2019) Marie‐Audrey I. Kautzmann et al.   FASEB JOURNAL

Elovanoids counteract oligomeric β-amyloid-induced gene expression and protect photoreceptors

(2019) Khanh V. Do et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Docosahexaenoic acid regulates the formation of lipid rafts: A unified view from experiment and simulation

(2018) Stephen R. Wassall et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

ADIPOR1 is essential for vision and its RPE expression is lost in the Mfrprd6 mouse

(2018) Valentin M. Sluch et al.   Scientific Reports

Docosanoids and elovanoids from omega-3 fatty acids are pro-homeostatic modulators of inflammatory responses, cell damage and neuroprotection

(2018) Nicolas G. Bazan   MOLECULAR ASPECTS OF MEDICINE

ELOVL4: Very long-chain fatty acids serve an eclectic role in mammalian health and function

(2018) Blake R. Hopiavuori et al.   PROGRESS IN RETINAL AND EYE RESEARCH

DHA Cycling Halves the DHA Supplementation Needed to Maintain Blood and Tissue Concentrations via Higher Synthesis from ALA in Long–Evans Rats

(2018) Adam H Metherel et al.   JOURNAL OF NUTRITION

Treating inflammation and infection in the 21st century: new hints from decoding resolution mediators and mechanisms

(2017) Charles N. Serhan   FASEB JOURNAL

Role of NAD+ and mitochondrial sirtuins in cardiac and renal diseases

(2017) Kathleen A. Hershberger et al.   Nature Reviews Nephrology

Mitochondrial Sirtuins and Molecular Mechanisms of Aging

(2017) Robert A.H. van de Ven et al.   TRENDS IN MOLECULAR MEDICINE

Adipose tissue NAD + -homeostasis, sirtuins and poly(ADP-ribose) polymerases -important players in mitochondrial metabolism and metabolic health

(2017) Riikka Jokinen et al.   Redox Biology

Elovanoids are novel cell-specific lipid mediators necessary for neuroprotective signaling for photoreceptor cell integrity

(2017) Bokkyoo Jun et al.   Scientific Reports

Gene Therapy Restores Mfrp and Corrects Axial Eye Length

(2017) Gabriel Velez et al.   Scientific Reports

A mutation in ADIPOR1 causes nonsyndromic autosomal dominant retinitis pigmentosa

(2016) Jinlu Zhang et al.   HUMAN GENETICS

ADIPOR1Is Mutated in Syndromic Retinitis Pigmentosa

(2016) Mingchu Xu et al.   HUMAN MUTATION

Augmentation of poly(ADP-ribose) polymerase-dependent neuronal cell death by acidosis

(2016) Jian Zhang et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Altered Cytoskeleton as a Mitochondrial Decay Signature in the Retinal Pigment Epithelium

(2016) Srinivas R. Sripathi et al.   PROTEIN JOURNAL

Prohibitin 1 gene delivery promotes functional recovery in rats with spinal cord injury

(2015) L. Li et al.   NEUROSCIENCE

Prohibitin as the Molecular Binding Switch in the Retinal Pigment Epithelium

(2015) Srinivas R. Sripathi et al.   PROTEIN JOURNAL

Adiponectin receptor 1 conserves docosahexaenoic acid and promotes photoreceptor cell survival

(2015) Dennis S. Rice et al.   Nature Communications

A NewELOVL4Mutation in a Case of Spinocerebellar Ataxia With Erythrokeratodermia

(2015) Cynthia V. Bourassa et al.   JAMA Neurology

Improved Conformational Stability of the Visual G Protein-Coupled Receptor Rhodopsin by Specific Interaction with Docosahexaenoic Acid Phospholipid

(2013) Maria Jesús Sánchez-Martín et al.   CHEMBIOCHEM

Parthanatos mediates AIMP2-activated age-dependent dopaminergic neuronal loss

(2013) Yunjong Lee et al.   NATURE NEUROSCIENCE

Reprogramming cellular events by poly(ADP-ribose)-binding proteins

(2012) Jana Krietsch et al.   MOLECULAR ASPECTS OF MEDICINE

Adiponectin receptor 1 gene (ADIPOR1) variant is associated with advanced age-related macular degeneration in Finnish population

(2012) Kai Kaarniranta et al.   NEUROSCIENCE LETTERS

Docosahexaenoic Acid Signalolipidomics in Nutrition: Significance in Aging, Neuroinflammation, Macular Degeneration, Alzheimer's, and Other Neurodegenerative Diseases

(2011) Nicolas G. Bazan et al.   Annual Review of Nutrition

ELOVL4 protein preferentially elongates 20:5n3 to very long chain PUFAs over 20:4n6 and 22:6n3

(2011) Man Yu et al.   JOURNAL OF LIPID RESEARCH

Iduna protects the brain from glutamate excitotoxicity and stroke by interfering with poly(ADP-ribose) polymer-induced cell death

(2011) Shaida A Andrabi et al.   NATURE MEDICINE

Iduna is a poly(ADP-ribose) (PAR)-dependent E3 ubiquitin ligase that regulates DNA damage

(2011) H. C. Kang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Expression and role of Elovl4 elongases in biosynthesis of very long-chain fatty acids during zebrafish Danio rerio early embryonic development

(2010) Óscar Monroig et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Sequential depletion of rat testicular lipids with long-chain and very long-chain polyenoic fatty acids after X-ray-induced interruption of spermatogenesis

(2010) Gerardo M. Oresti et al.   JOURNAL OF LIPID RESEARCH

Retinal very long-chain PUFAs: new insights from studies on ELOVL4 protein

(2010) Martin-Paul Agbaga et al.   JOURNAL OF LIPID RESEARCH

Cellular and molecular events mediated by docosahexaenoic acid-derived neuroprotectin D1 signaling in photoreceptor cell survival and brain protection

(2009) Nicolas G. Bazan   PROSTAGLANDINS LEUKOTRIENES AND ESSENTIAL FATTY ACIDS

Oxidative damage–induced inflammation initiates age-related macular degeneration

(2008) Joe G Hollyfield et al.   NATURE MEDICINE