Immune resolution mechanisms in inflammatory arthritis

Divergent shifts in lipid mediator profile following supplementation with n-3 docosapentaenoic acid and eicosapentaenoic acid

(2016) James F. Markworth et al.   FASEB JOURNAL

Proresolving Actions of Synthetic and Natural Protease Inhibitors Are Mediated by Annexin A1

(2016) Juliana P. Vago et al.   JOURNAL OF IMMUNOLOGY

Specialised pro-resolving mediators of inflammation in inflammatory arthritis

(2016) Anne E. Barden et al.   PROSTAGLANDINS LEUKOTRIENES AND ESSENTIAL FATTY ACIDS

Adenosine as a Multi-Signalling Guardian Angel in Human Diseases: When, Where and How Does it Exert its Protective Effects?

(2016) Pier Andrea Borea et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Identification and Actions of a Novel Third Maresin Conjugate in Tissue Regeneration: MCTR3

(2016) Jesmond Dalli et al.   PLoS One

Proresolving actions of a new resolvin D1 analog mimetic qualifies as an immunoresolvent

(2015) Sarah K. Orr et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Determination of ω-6 and ω-3 PUFA metabolites in human urine samples using UPLC/MS/MS

(2015) Ai Sasaki et al.   ANALYTICAL AND BIOANALYTICAL CHEMISTRY

Alpha-1-anti-trypsin-Fc fusion protein ameliorates gouty arthritis by reducing release and extracellular processing of IL-1β and by the induction of endogenous IL-1Ra

(2015) Leo A B Joosten et al.   ANNALS OF THE RHEUMATIC DISEASES

Comparison of lipid and lipid-associated cardiovascular risk marker changes after treatment with tocilizumab or adalimumab in patients with rheumatoid arthritis

(2015) Cem Gabay et al.   ANNALS OF THE RHEUMATIC DISEASES

Galectin-1 Regulates Tissue Exit of Specific Dendritic Cell Populations

(2015) Sandra Thiemann et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Annexin A1–containing extracellular vesicles and polymeric nanoparticles promote epithelial wound repair

(2015) Giovanna Leoni et al.   JOURNAL OF CLINICAL INVESTIGATION

Biased Agonism as a Novel Strategy To Harness the Proresolving Properties of Melanocortin Receptors without Eliciting Melanogenic Effects

(2015) Trinidad Montero-Melendez et al.   JOURNAL OF IMMUNOLOGY

Human milk proresolving mediators stimulate resolution of acute inflammation

(2015) H Arnardottir et al.   Mucosal Immunology

Elucidation of novel 13-series resolvins that increase with atorvastatin and clear infections

(2015) Jesmond Dalli et al.   NATURE MEDICINE

Hydrogen sulfide-based therapeutics: exploiting a unique but ubiquitous gasotransmitter

(2015) John L. Wallace et al.   NATURE REVIEWS DRUG DISCOVERY

Resolvin Infectious Inflammation by Targeting the Host Response

(2015) Craig R. Lee et al.   NEW ENGLAND JOURNAL OF MEDICINE

Low expression of CD39 on regulatory T cells as a biomarker for resistance to methotrexate therapy in rheumatoid arthritis

(2015) Raphael Sanches Peres et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Targeted nanoparticles containing the proresolving peptide Ac2-26 protect against advanced atherosclerosis in hypercholesterolemic mice

(2015) Gabrielle Fredman et al.   Science Translational Medicine

Neutrophil-derived microvesicles enter cartilage and protect the joint in inflammatory arthritis

(2015) Sarah E. Headland et al.   Science Translational Medicine

Gaseous mediators in resolution of inflammation

(2015) John L. Wallace et al.   SEMINARS IN IMMUNOLOGY

New insights into the resolution of inflammation

(2015) Derek Gilroy et al.   SEMINARS IN IMMUNOLOGY

The resolution code of acute inflammation: Novel pro-resolving lipid mediators in resolution

(2015) Charles N. Serhan et al.   SEMINARS IN IMMUNOLOGY

ACTH: The forgotten therapy

(2015) Trinidad Montero-Melendez   SEMINARS IN IMMUNOLOGY

Resolution Pharmacology: Opportunities for Therapeutic Innovation in Inflammation

(2015) Mauro Perretti et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Simvastatin and Benznidazole-Mediated Prevention of Trypanosoma cruzi-Induced Endothelial Activation: Role of 15-epi-lipoxin A4 in the Action of Simvastatin

(2015) Carolina Campos-Estrada et al.   PLoS Neglected Tropical Diseases

Association between Periodontal Disease and Inflammatory Arthritis Reveals Modulatory Functions by Melanocortin Receptor Type 3

(2014) Trinidad Montero-Melendez et al.   AMERICAN JOURNAL OF PATHOLOGY

Identification and signature profiles for pro-resolving and inflammatory lipid mediators in human tissue

(2014) Romain A. Colas et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Cell-cell interactions and bronchoconstrictor eicosanoid reduction with inhaled carbon monoxide and resolvin D1

(2014) Masakazu Shinohara et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Melanocortin peptides protect chondrocytes from mechanically induced cartilage injury

(2014) Magdalena K. Kaneva et al.   BIOCHEMICAL PHARMACOLOGY

Resolution of acute inflammation bridges the gap between innate and adaptive immunity

(2014) J. Newson et al.   BLOOD

Endogenous annexin A1 is a novel protective determinant in nonalcoholic steatohepatitis in mice

(2014) Irene Locatelli et al.   HEPATOLOGY

Proresolving Lipid Mediators and Mechanisms in the Resolution of Acute Inflammation

(2014) Christopher D. Buckley et al.   IMMUNITY

Galectin-9-CD44 Interaction Enhances Stability and Function of Adaptive Regulatory T Cells

(2014) Chuan Wu et al.   IMMUNITY

Leukocyte Migration into Inflamed Tissues

(2014) Sussan Nourshargh et al.   IMMUNITY

Proresolving Nanomedicines Activate Bone Regeneration in Periodontitis

(2014) T.E. Van Dyke et al.   JOURNAL OF DENTAL RESEARCH

Pro-resolving lipid mediators are leads for resolution physiology

(2014) Charles N. Serhan   NATURE

Effect of hydrogen sulfide sources on inflammation and catabolic markers on interleukin 1β-stimulated human articular chondrocytes

(2014) E.F. Burguera et al.   OSTEOARTHRITIS AND CARTILAGE

Maresin 1 biosynthesis during platelet–neutrophil interactions is organ-protective

(2014) Raja-Elie E. Abdulnour et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A vasculo-protective circuit centered on lipoxin A4 and aspirin-triggered 15-epi-lipoxin A4 operative in murine microcirculation

(2013) V. Brancaleone et al.   BLOOD

The Lipid Mediator Protectin D1 Inhibits Influenza Virus Replication and Improves Severe Influenza

(2013) Masayuki Morita et al.   CELL

Investigational Analysis Reveals a Potential Role for Neutrophils in Giant-Cell Arteritis Disease Progression

(2013) Suchita Nadkarni et al.   CIRCULATION RESEARCH

Connections in pharmacology: innovation serving translational medicine

(2013) Trinidad Montero-Melendez et al.   DRUG DISCOVERY TODAY

Microparticle alpha-2-macroglobulin enhances pro-resolving responses and promotes survival in sepsis

(2013) Jesmond Dalli et al.   EMBO Molecular Medicine

Resolution of inflammation: an integrated view

(2013) Almudena Ortega-Gómez et al.   EMBO Molecular Medicine

Inhaled Carbon Monoxide Accelerates Resolution of Inflammation via Unique Proresolving Mediator-Heme Oxygenase-1 Circuits

(2013) N. Chiang et al.   JOURNAL OF IMMUNOLOGY

Endogenous Galectin-1 Exerts Tonic Inhibition on Experimental Arthritis

(2013) A. J. Iqbal et al.   JOURNAL OF IMMUNOLOGY

Control of Myeloid Cell Trafficking in Resolution

(2013) Lucy V. Norling et al.   Journal of Innate Immunity

Maternal dietary omega-3 fatty acid intake increases resolvin and protectin levels in the rat placenta

(2013) Megan L. Jones et al.   JOURNAL OF LIPID RESEARCH

High levels of anti-inflammatory and pro-resolving lipid mediators lipoxins and resolvins and declining docosahexaenoic acid levels in human milk during the first month of lactation

(2013) Gisela Adrienne Weiss et al.   Lipids in Health and Disease

Changes in lipid levels with inflammation and therapy in RA: a maturing paradigm

(2013) Jamie Robertson et al.   Nature Reviews Rheumatology

Ligand-specific conformational change of the G-protein-coupled receptor ALX/FPR2 determines proresolving functional responses

(2013) S. N. Cooray et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Galectin-1 induces 12/15-lipoxygenase expression in murine macrophages and favors their conversion toward a pro-resolving phenotype

(2013) Ran Rostoker et al.   PROSTAGLANDINS & OTHER LIPID MEDIATORS

ACTH as a treatment for acute crystal-induced arthritis: Update on clinical evidence and mechanisms of action

(2013) Dimitrios Daoussis et al.   SEMINARS IN ARTHRITIS AND RHEUMATISM

The impact of endogenous annexin A1 on glucocorticoid control of inflammatory arthritis

(2012) Hetal B Patel et al.   ANNALS OF THE RHEUMATIC DISEASES

Lipid and lipid mediator profiling of human synovial fluid in rheumatoid arthritis patients by means of LC–MS/MS

(2012) Martin Giera et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Specific lipid mediator signatures of human phagocytes: microparticles stimulate macrophage efferocytosis and pro-resolving mediators

(2012) J. Dalli et al.   BLOOD

Influence of marine n-3 polyunsaturated fatty acids on immune function and a systematic review of their effects on clinical outcomes in rheumatoid arthritis

(2012) Elizabeth A. Miles et al.   BRITISH JOURNAL OF NUTRITION

Gene expression signature-based approach identifies a pro-resolving mechanism of action for histone deacetylase inhibitors

(2012) T Montero-Melendez et al.   CELL DEATH AND DIFFERENTIATION

The role of stromal cells in the persistence of chronic inflammation

(2012) A. J. Naylor et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

Role of Proopiomelanocortin-Derived Peptides and Their Receptors in the Osteoarticular System: From Basic to Translational Research

(2012) Markus Böhm et al.   ENDOCRINE REVIEWS

Infection regulates pro-resolving mediators that lower antibiotic requirements

(2012) Nan Chiang et al.   NATURE

Resolvin E1 promotes phagocytosis-induced neutrophil apoptosis and accelerates resolution of pulmonary inflammation

(2012) D. El Kebir et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Serum amyloid A opposes lipoxin A4 to mediate glucocorticoid refractory lung inflammation in chronic obstructive pulmonary disease

(2012) S. Bozinovski et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A decrease in galectin-1 (Gal-1) levels correlates with an increase in anti-Gal-1 antibodies at the synovial level in patients with rheumatoid arthritis

(2012) D Xibillé-Friedmann et al.   SCANDINAVIAN JOURNAL OF RHEUMATOLOGY

Adenosine A2A Receptor Activation Prevents Wear Particle-Induced Osteolysis

(2012) A. Mediero et al.   Science Translational Medicine

Selective Activation of Adenosine A2A Receptors on Immune Cells by a CD73-Dependent Prodrug Suppresses Joint Inflammation in Experimental Rheumatoid Arthritis

(2012) U. Flogel et al.   Science Translational Medicine

Endogenous Galectin-1 and Acute Inflammation

(2011) Asif J. Iqbal et al.   AMERICAN JOURNAL OF PATHOLOGY

Molecular engineering of short half-life small peptides (VIP, αMSH and γ3MSH) fused to latency-associated peptide results in improved anti-inflammatory therapeutics

(2011) Sandrine Vessillier et al.   ANNALS OF THE RHEUMATIC DISEASES

The precursor of resolvin D series and aspirin-triggered resolvin D1 display anti-hyperalgesic properties in adjuvant-induced arthritis in rats

(2011) JF Lima-Garcia et al.   BRITISH JOURNAL OF PHARMACOLOGY

Regulatory T-cells in systemic lupus erythematosus and rheumatoid arthritis

(2011) Konstantia-Maria Chavele et al.   FEBS LETTERS

Spatial and Temporal Localization of the Melanocortin 1 Receptor and Its Ligand α–Melanocyte-Stimulating Hormone during Cutaneous Wound Repair

(2011) Lara A. Muffley et al.   JOURNAL OF HISTOCHEMISTRY & CYTOCHEMISTRY

5-Lipoxygenase-Deficient Mice Infected with Borrelia burgdorferi Develop Persistent Arthritis

(2011) V. A. Blaho et al.   JOURNAL OF IMMUNOLOGY

Evidence for an Anti-Inflammatory Loop Centered on Polymorphonuclear Leukocyte Formyl Peptide Receptor 2/Lipoxin A4 Receptor and Operative in the Inflamed Microvasculature

(2011) V. Brancaleone et al.   JOURNAL OF IMMUNOLOGY

Cutting Edge: Humanized Nano-Proresolving Medicines Mimic Inflammation-Resolution and Enhance Wound Healing

(2011) L. V. Norling et al.   JOURNAL OF IMMUNOLOGY

A2A and A3 adenosine receptor expression in rheumatoid arthritis: upregulation, inverse correlation with disease activity score and suppression of inflammatory cytokine and metalloproteinase release

(2011) Katia Varani et al.   ARTHRITIS RESEARCH & THERAPY

Galectin 3 aggravates joint inflammation and destruction in antigen-induced arthritis

(2010) Huamei Forsman et al.   ARTHRITIS AND RHEUMATISM

H2S transiently blocks IL-6 expression in rheumatoid arthritic fibroblast-like synoviocytes and deactivates p44/42 mitogen-activated protein kinase

(2010) Burkhard Kloesch et al.   CELL BIOLOGY INTERNATIONAL

Anti-inflammatory and antiosteoclastogenesis properties of endogenous melanocortin receptor type 3 in experimental arthritis

(2010) Hetal B. Patel et al.   FASEB JOURNAL

Development of a Nascent Galectin-1 Chimeric Molecule for Studying the Role of Leukocyte Galectin-1 Ligands and Immune Disease Modulation

(2010) F. Cedeno-Laurent et al.   JOURNAL OF IMMUNOLOGY

Anti-Inflammatory Role of the Murine Formyl-Peptide Receptor 2: Ligand-Specific Effects on Leukocyte Responses and Experimental Inflammation

(2010) Neil Dufton et al.   JOURNAL OF IMMUNOLOGY

Resolution of Inflammation in Murine Autoimmune Arthritis Is Disrupted by Cyclooxygenase-2 Inhibition and Restored by Prostaglandin E2-Mediated Lipoxin A4 Production

(2010) M. M. Y. Chan et al.   JOURNAL OF IMMUNOLOGY

Lovastatin decreases acute mucosal inflammation via 15-epi-lipoxin A4

(2010) A Planagumà et al.   Mucosal Immunology

Methotrexate—how does it really work?

(2010) Edwin S. L. Chan et al.   Nature Reviews Rheumatology

The melanocortin system in articular chondrocytes: Melanocortin receptors, pro-opiomelanocortin, precursor proteases, and a regulatory effect of α-melanocyte-stimulating hormone on proinflammatory cytokines and extracellular matrix components

(2009) Susanne Grässel et al.   ARTHRITIS AND RHEUMATISM

Sulphasalazine accelerates apoptosis in neutrophils exposed to immune complex: Role of caspase pathway

(2009) M Bertolotto et al.   CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY

Galectin-9 ameliorates immune complex-induced arthritis by regulating FcγR expression on macrophages

(2009) Tomohiro Arikawa et al.   CLINICAL IMMUNOLOGY

12/15-Lipoxygenase Counteracts Inflammation and Tissue Damage in Arthritis

(2009) G. Kronke et al.   JOURNAL OF IMMUNOLOGY

Tolerogenic signals delivered by dendritic cells to T cells through a galectin-1-driven immunoregulatory circuit involving interleukin 27 and interleukin 10

(2009) Juan M Ilarregui et al.   NATURE IMMUNOLOGY

Human articular chondrocytes express 15-lipoxygenase-1 and -2: potential role in osteoarthritis

(2009) Nadir Chabane et al.   ARTHRITIS RESEARCH & THERAPY

Expression of 5-lipoxygenase and 15-lipoxygenase in rheumatoid arthritis synovium and effects of intraarticular glucocorticoids

(2009) Karina Roxana Gheorghe et al.   ARTHRITIS RESEARCH & THERAPY

Annexin 1 mediates the rapid anti-inflammatory effects of neutrophil-derived microparticles

(2008) J. Dalli et al.   BLOOD

Galectin-9 suppresses the generation of Th17, promotes the induction of regulatory T cells, and regulates experimental autoimmune arthritis

(2008) Masako Seki et al.   CLINICAL IMMUNOLOGY

Novel insights into the inhibitory effects of Galectin-1 on neutrophil recruitment under flow

(2008) D. Cooper et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Origin and physiological roles of inflammation

(2008) Ruslan Medzhitov   NATURE

Anesthetics Impact the Resolution of Inflammation

(2008) Nan Chiang et al.   PLoS One

Inhibitory control of endothelial galectin-1 on in vitro and in vivo lymphocyte trafficking

(2007) Lucy V. Norling et al.   FASEB JOURNAL