Sarcoplasmic Reticulum Ca2+ Dysregulation in the Pathophysiology of Inherited Arrhythmia: An Update
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Title
Sarcoplasmic Reticulum Ca2+ Dysregulation in the Pathophysiology of Inherited Arrhythmia: An Update
Authors
Keywords
Sarcoplasmic reticulum, Calcium, Ryanodine receptor, Inherited arrhythmias, CPVT, LQTS
Journal
BIOCHEMICAL PHARMACOLOGY
Volume 200, Issue -, Pages 115059
Publisher
Elsevier BV
Online
2022-04-29
DOI
10.1016/j.bcp.2022.115059
References
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Note: Only part of the references are listed.- The role of calcium homeostasis remodeling in inherited cardiac arrhythmia syndromes
- (2021) Shanna Hamilton et al. PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY
- Mitochondria Associated Membranes (MAMs): Architecture and physiopathological role
- (2021) Lucia Barazzuol et al. CELL CALCIUM
- ER stress in Cardiometabolic Diseases: from Molecular Mechanisms to Therapeutics
- (2021) Amir Ajoolabady et al. ENDOCRINE REVIEWS
- The transmembrane peptide DWORF activates SERCA2a via dual mechanisms
- (2021) Ang Li et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Endoplasmic reticulum stress and unfolded protein response in cardiovascular diseases
- (2021) Jun Ren et al. Nature Reviews Cardiology
- The mechanosensitive Piezo1 channel mediates heart mechano-chemo transduction
- (2021) Fan Jiang et al. Nature Communications
- Identification of loss-of-function RyR2 mutations associated with idiopathic ventricular fibrillation and sudden death
- (2021) Xiaowei Zhong et al. BIOSCIENCE REPORTS
- Short-coupled ventricular fibrillation represents a distinct phenotype among latent causes of unexplained cardiac arrest: a report from the CASPER registry
- (2021) Christian Steinberg et al. EUROPEAN HEART JOURNAL
- Precision Medicine in Catecholaminergic Polymorphic Ventricular Tachycardia
- (2021) Silvia G. Priori et al. JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
- TRPC7 regulates the electrophysiological functions of embryonic stem cell-derived cardiomyocytes
- (2021) Xianji Liu et al. Stem Cell Research & Therapy
- Abnormal Calcium Handling in Duchenne Muscular Dystrophy: Mechanisms and Potential Therapies
- (2021) Satvik Mareedu et al. Frontiers in Physiology
- An International Evidence Based Reappraisal of Genes Associated with Arrhythmogenic Right Ventricular Cardiomyopathy (ARVC) using the ClinGen Framework
- (2021) Cynthia A. James et al. Circulation-Genomic and Precision Medicine
- The multifaceted view of heart problem in Duchenne muscular dystrophy
- (2021) Urszula Florczyk-Soluch et al. CELLULAR AND MOLECULAR LIFE SCIENCES
- Impaired Binding to Junctophilin2 and Nanostructural Alteration in CPVT Mutation
- (2021) liheng yin et al. CIRCULATION RESEARCH
- Proline hydroxylase domain-containing enzymes regulate calcium levels in cardiomyocytes by TRPA1 ion channel
- (2021) Lan Liu et al. EXPERIMENTAL CELL RESEARCH
- Diagnosis, management and therapeutic strategies for congenital long QT syndrome
- (2021) Arthur A M Wilde et al. HEART
- The effect of statins on RyR and RyR-associated disease
- (2021) Mohsin Haseeb et al. JOURNAL OF APPLIED PHYSIOLOGY
- Sarcoplasmic reticulum-mitochondria communication; implications for cardiac arrhythmia
- (2021) Shanna Hamilton et al. JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY
- Structure and Function of Mitochondria-Associated Endoplasmic Reticulum Membranes (MAMs) and Their Role in Cardiovascular Diseases
- (2021) Yi Luan et al. Oxidative Medicine and Cellular Longevity
- Advances in the Molecular Genetics of Catecholaminergic Polymorphic Ventricular Tachycardia
- (2021) Junxia Song et al. Frontiers in Pharmacology
- Presenilin 1 is a direct regulator of the cardiac sarco/endoplasmic reticulum calcium pump
- (2021) Elisa Bovo et al. CELL CALCIUM
- Loss-of-function mutations in cardiac ryanodine receptor channel cause various types of arrhythmias including long QT syndrome
- (2021) Sayako Hirose et al. EUROPACE
- Evaluation of gene validity for CPVT and short QT syndrome in sudden arrhythmic death
- (2021) Roddy Walsh et al. EUROPEAN HEART JOURNAL
- CPVT-associated calmodulin variants N53I and A102V dysregulate Ca2+ signalling via different mechanisms
- (2021) Ohm Prakash et al. JOURNAL OF CELL SCIENCE
- The interplay between mitochondria and store‐operated Ca 2+ entry: Emerging insights into cardiac diseases
- (2021) Jinliang Nan et al. JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
- Clinical and Functional Characterization of Ryanodine Receptor 2 Variants Implicated in Calcium-Release Deficiency Syndrome
- (2021) Thomas M. Roston et al. JAMA Cardiology
- Orai1 Channel Inhibition Preserves Left Ventricular Systolic Function and Normal Ca 2+ Handling After Pressure Overload
- (2020) Fiona Bartoli et al. CIRCULATION
- An International, Multicentered, Evidence-Based Reappraisal of Genes Reported to Cause Congenital Long QT Syndrome
- (2020) Arnon Adler et al. CIRCULATION
- Phenytoin Reduces Activity of Cardiac Ryanodine Receptor 2; A Potential Mechanism for Its Cardioprotective Action
- (2020) A. Ashna et al. MOLECULAR PHARMACOLOGY
- Single SERCA2a Therapy Ameliorated Dilated Cardiomyopathy for 18 Months in a Mouse Model of Duchenne Muscular Dystrophy
- (2020) Nalinda B. Wasala et al. MOLECULAR THERAPY
- Calcium Handling Defects and Cardiac Arrhythmia Syndromes
- (2020) Kornél Kistamás et al. Frontiers in Pharmacology
- Unbalance Between Sarcoplasmic Reticulum Ca2 + Uptake and Release: A First Step Toward Ca2 + Triggered Arrhythmias and Cardiac Damage
- (2020) Marilén Federico et al. Frontiers in Physiology
- Integrin β1D Deficiency–Mediated RyR2 Dysfunction Contributes to Catecholamine-Sensitive Ventricular Tachycardia in Arrhythmogenic Right Ventricular Cardiomyopathy
- (2020) Yihui Wang et al. CIRCULATION
- The arrhythmogenic N53I variant subtly changes the structure and dynamics in the calmodulin N-terminal domain, altering its interaction with the cardiac ryanodine receptor
- (2020) Christian Holt et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Novel Variants in TECRL Cause Recessive Inherited CPVT Type 3 with Severe and Variable Clinical Symptoms
- (2020) Alexander Moscu‐Gregor et al. JOURNAL OF CARDIOVASCULAR ELECTROPHYSIOLOGY
- TRIC-A shapes oscillatory Ca2+ signals by interaction with STIM1/Orai1 complexes
- (2020) Niroj Shrestha et al. PLOS BIOLOGY
- Mitochondrial Ca2+ regulation in the etiology of heart failure: physiological and pathophysiological implications
- (2020) Hai-xia Xu et al. ACTA PHARMACOLOGICA SINICA
- Increased RyR2 activity is exacerbated by calcium leak-induced mitochondrial ROS
- (2020) Shanna Hamilton et al. BASIC RESEARCH IN CARDIOLOGY
- SARS-CoV-2 and cardiovascular complications: From molecular mechanisms to pharmaceutical management
- (2020) Lin Wu et al. BIOCHEMICAL PHARMACOLOGY
- Intracellular calcium leak in heart failure and atrial fibrillation: a unifying mechanism and therapeutic target
- (2020) Haikel Dridi et al. Nature Reviews Cardiology
- Arrhythmogenic cardiomyopathy: An in-depth look at molecular mechanisms and clinical correlates
- (2020) Sarah Costa et al. TRENDS IN CARDIOVASCULAR MEDICINE
- Inherited cardiac arrhythmias
- (2020) Peter J. Schwartz et al. Nature Reviews Disease Primers
- Molecular characterization of the calcium release channel deficiency syndrome
- (2020) David J. Tester et al. JCI Insight
- Calsequestrin. Structure, function, and evolution
- (2020) Qian Wang et al. CELL CALCIUM
- Interaction of the Joining Region in Junctophilin-2 with the L-type Ca 2+ Channel Is Pivotal for Cardiac Dyad Assembly and Intracellular Ca 2+ Dynamics
- (2020) Polina Gross et al. CIRCULATION RESEARCH
- Idiopathic ventricular fibrillation: the ongoing quest for diagnostic refinement
- (2020) Giulio Conte et al. EUROPACE
- The structure of a calsequestrin filament reveals mechanisms of familial arrhythmia
- (2020) Erron W. Titus et al. NATURE STRUCTURAL & MOLECULAR BIOLOGY
- Phylogenetic and biochemical analysis of calsequestrin structure and association of its variants with cardiac disorders
- (2020) Qian Wang et al. Scientific Reports
- Sarcolipin haploinsufficiency prevents dystrophic cardiomyopathy in mdx mice
- (2020) Satvik Mareedu et al. AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
- RYR2 Channel Inhibition Is the Principal Mechanism 0f Flecainide Action in CPVT
- (2020) Dmytro O Kryshtal et al. CIRCULATION RESEARCH
- Life-threatening arrhythmias with autosomal recessive TECRL variants
- (2020) Gregory Webster et al. EUROPACE
- Ventricular arrhythmia burden during the coronavirus disease 2019 (COVID-19) pandemic
- (2020) Catherine J O’Shea et al. EUROPEAN HEART JOURNAL
- Genealogy and clinical course of catecholaminergic polymorphic ventricular tachycardia caused by the ryanodine receptor type 2 P2328S mutation
- (2020) Mikael Koponen et al. PLoS One
- Cardiac transmembrane ion channels and action potentials: cellular physiology and arrhythmogenic behavior
- (2020) András Varró et al. PHYSIOLOGICAL REVIEWS
- Calmodulin inhibition of human RyR2 channels requires phosphorylation of RyR2-S2808 or RyR2-S2814
- (2019) Kafa Walweel et al. JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY
- A compound heterozygosity of Tecrl gene confirmed in a catecholaminergic polymorphic ventricular tachycardia family
- (2019) Lijian Xie et al. European Journal of Medical Genetics
- Structures of the heart specific SERCA2a Ca2+‐ATPase
- (2019) Aljona Sitsel et al. EMBO JOURNAL
- Role of SIRT1 in Modulating Acetylation of the Sarco-Endoplasmic Reticulum Ca 2+ -ATPase in Heart Failure
- (2019) Przemyslaw A Gorski et al. CIRCULATION RESEARCH
- Disruption of Ca 2+ i Homeostasis and Cx43 Hemichannel Function in the Right Ventricle Precedes Overt Arrhythmogenic Cardiomyopathy in PKP2-Deficient Mice
- (2019) Joon-Chul Kim et al. CIRCULATION
- Modulation of cardiac ryanodine receptor 2 by calmodulin
- (2019) Deshun Gong et al. NATURE
- MURC/CAVIN-4 facilitates store-operated calcium entry in neonatal cardiomyocytes
- (2019) Julien Malette et al. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH
- Cardiac Pathophysiology and the Future of Cardiac Therapies in Duchenne Muscular Dystrophy
- (2019) Tatyana A. Meyers et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- Interplay between triadin and calsequestrin in the pathogenesis of CPVT in mouse
- (2019) Marine Cacheux et al. MOLECULAR THERAPY
- CASQ2 variants in Chinese children with catecholaminergic polymorphic ventricular tachycardia
- (2019) Qirui Li et al. Molecular Genetics & Genomic Medicine
- SERCA2a: a key protein in the Ca2+ cycle of the heart failure
- (2019) Liu Zhihao et al. HEART FAILURE REVIEWS
- Epidemiology of inherited arrhythmias
- (2019) Joost A. Offerhaus et al. Nature Reviews Cardiology
- DJ-1 regulates the integrity and function of ER-mitochondria association through interaction with IP3R3-Grp75-VDAC1
- (2019) Yi Liu et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Lysosomal Ca2+ Homeostasis and Signaling in Health and Disease
- (2019) Emyr Lloyd-Evans et al. Cold Spring Harbor Perspectives in Biology
- Targeting pathological leak of ryanodine receptors: preclinical progress and the potential impact on treatments for cardiac arrhythmias and heart failure
- (2019) Patrick Connell et al. EXPERT OPINION ON THERAPEUTIC TARGETS
- Ryanodine-receptor inhibition by dantrolene effectively suppresses ventricular arrhythmias in an ex vivo model of long-QT syndrome
- (2018) Gerrit Frommeyer et al. JOURNAL OF CARDIOVASCULAR ELECTROPHYSIOLOGY
- A delayed diagnosis of catecholaminergic polymorphic ventricular tachycardia with a mutant of RYR2 at c.7580T>G for 6 years in a 9-year-old child
- (2018) Hongyu Duan et al. MEDICINE
- mTORC1 controls lysosomal Ca2+release through the two-pore channel TPC2
- (2018) Oluseye A. Ogunbayo et al. Science Signaling
- mTORC1 controls lysosomal Ca2+release through the two-pore channel TPC2
- (2018) Oluseye A. Ogunbayo et al. Science Signaling
- Clinical Diagnosis, Imaging, and Genetics of Arrhythmogenic Right Ventricular Cardiomyopathy/Dysplasia
- (2018) Estelle Gandjbakhch et al. JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
- Ca2+-dependent calmodulin binding to cardiac ryanodine receptor (RyR2) calmodulin-binding domains
- (2018) Malene Brohus et al. BIOCHEMICAL JOURNAL
- SOCE and STIM1 signaling in the heart: Timing and location matter
- (2018) Paul Rosenberg et al. CELL CALCIUM
- SPEG Controls Calcium Re-Uptake into the Sarcoplasmic Reticulum Through Regulating SERCA2a by Its Second Kinase-Domain
- (2018) Chao Quan et al. CIRCULATION RESEARCH
- Cardiac Phenotypes in Hereditary Muscle Disorders
- (2018) Eloisa Arbustini et al. JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
- IP3 Receptors Preferentially Associate with ER-Lysosome Contact Sites and Selectively Deliver Ca2+ to Lysosomes
- (2018) Peace Atakpa et al. Cell Reports
- Potential Arrhythmogenic Role of TRPC Channels and Store-Operated Calcium Entry Mechanism in Mouse Ventricular Myocytes
- (2018) Hairuo Wen et al. Frontiers in Physiology
- A type 2 ryanodine receptor variant associated with reduced Ca2+ release and short-coupled torsades de pointes ventricular arrhythmia
- (2017) Yusuke Fujii et al. HEART RHYTHM
- Calcium Dynamics Mediated by the Endoplasmic/Sarcoplasmic Reticulum and Related Diseases
- (2017) et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- Interaction of Mitochondria with the Endoplasmic Reticulum and Plasma Membrane in Calcium Homeostasis, Lipid Trafficking and Mitochondrial Structure
- (2017) Jędrzej Szymański et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- The structural basis of ryanodine receptor ion channel function
- (2017) Gerhard Meissner JOURNAL OF GENERAL PHYSIOLOGY
- Potassium currents in the heart: functional roles in repolarization, arrhythmia and therapeutics
- (2017) Nipavan Chiamvimonvat et al. JOURNAL OF PHYSIOLOGY-LONDON
- Intracellular calcium release channels: an update
- (2017) Gaetano Santulli et al. JOURNAL OF PHYSIOLOGY-LONDON
- Drug-induced fatal arrhythmias: Acquired long QT and Brugada syndromes
- (2017) Isik Turker et al. PHARMACOLOGY & THERAPEUTICS
- Cardiac T-Tubule Microanatomy and Function
- (2017) TingTing Hong et al. PHYSIOLOGICAL REVIEWS
- Molecular Pathophysiology of Congenital Long QT Syndrome
- (2017) M. S. Bohnen et al. PHYSIOLOGICAL REVIEWS
- Reducing sarcolipin expression mitigates Duchenne muscular dystrophy and associated cardiomyopathy in mice
- (2017) Antanina Voit et al. Nature Communications
- Plakophilin-2 is required for transcription of genes that control calcium cycling and cardiac rhythm
- (2017) Marina Cerrone et al. Nature Communications
- High resolution structural evidence suggests the Sarcoplasmic Reticulum forms microdomains with Acidic Stores (lysosomes) in the heart
- (2017) Daniel Aston et al. Scientific Reports
- Association of cardiac injury with iron-increased oxidative and nitrative modifications of the SERCA2a isoform of sarcoplasmic reticulum Ca2+-ATPase in diabetic rats
- (2016) Xueli Li et al. BIOCHIMIE
- SPEG (Striated Muscle Preferentially Expressed Protein Kinase) Is Essential for Cardiac Function by Regulating Junctional Membrane Complex ActivityNovelty and Significance
- (2016) Ann P. Quick et al. CIRCULATION RESEARCH
- Calcium Revisited
- (2016) John R. Giudicessi et al. Circulation-Arrhythmia and Electrophysiology
- TECRL , a new life‐threatening inherited arrhythmia gene associated with overlapping clinical features of both LQTS and CPVT
- (2016) Harsha D Devalla et al. EMBO Molecular Medicine
- Structural basis for the gating mechanism of the type 2 ryanodine receptor RyR2
- (2016) Wei Peng et al. SCIENCE
- A peptide encoded by a transcript annotated as long noncoding RNA enhances SERCA activity in muscle
- (2016) B. R. Nelson et al. SCIENCE
- Dynamic interaction of SARAF with STIM1 and Orai1 to modulate store-operated calcium entry
- (2016) Letizia Albarran et al. Scientific Reports
- A primer of NAADP-mediated Ca2+ signalling: From sea urchin eggs to mammalian cells
- (2015) Antony Galione CELL CALCIUM
- Proteomic mapping of ER–PM junctions identifies STIMATE as a regulator of Ca2+ influx
- (2015) Ji Jing et al. NATURE CELL BIOLOGY
- Arrhythmogenesis in a catecholaminergic polymorphic ventricular tachycardia mutation that depresses ryanodine receptor function
- (2015) Yan-Ting Zhao et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Progesterone modulates SERCA2a expression and function in rabbit cardiomyocytes
- (2014) Karni S. Moshal et al. AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY
- Single Delivery of an Adeno-Associated Viral Construct to Transfer the CASQ2 Gene to Knock-In Mice Affected by Catecholaminergic Polymorphic Ventricular Tachycardia Is Able to Cure the Disease From Birth to Advanced Age
- (2014) Marco Denegri et al. CIRCULATION
- Prevalence and significance of rare RYR2 variants in arrhythmogenic right ventricular cardiomyopathy/dysplasia: Results of a systematic screening
- (2014) Nathalie Roux-Buisson et al. HEART RHYTHM
- A Protease-Independent Function for SPPL3 in NFAT Activation
- (2014) Stefanie L. Makowski et al. MOLECULAR AND CELLULAR BIOLOGY
- Ryanodine Receptor Mutations Presenting as Idiopathic Ventricular Fibrillation: A Report on Two Novel Familial Compound Mutations, c.6224T>C and c.13781A>G, With the Clinical Presentation of Idiopathic Ventricular Fibrillation
- (2014) Christian Paech et al. PEDIATRIC CARDIOLOGY
- HRS/EHRA/APHRS Expert Consensus Statement on the Diagnosis and Management of Patients with Inherited Primary Arrhythmia Syndromes
- (2013) Silvia G. Priori et al. HEART RHYTHM
- Stroke and ventricular arrhythmias
- (2013) Sahil Koppikar et al. INTERNATIONAL JOURNAL OF CARDIOLOGY
- A Mutation in CALM1 Encoding Calmodulin in Familial Idiopathic Ventricular Fibrillation in Childhood and Adolescence
- (2013) Roos F. Marsman et al. JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
- Crystal structures of the calcium pump and sarcolipin in the Mg2+-bound E1 state
- (2013) Chikashi Toyoshima et al. NATURE
- The sarcolipin-bound calcium pump stabilizes calcium sites exposed to the cytoplasm
- (2013) Anne-Marie L. Winther et al. NATURE
- Genetically encoded fluorescent probe to visualize intracellular phosphatidylinositol 3,5-bisphosphate localization and dynamics
- (2013) X. Li et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Phospholamban R14del mutation in patients diagnosed with dilated cardiomyopathy or arrhythmogenic right ventricular cardiomyopathy: evidence supporting the concept of arrhythmogenic cardiomyopathy
- (2012) Paul A. van der Zwaag et al. EUROPEAN JOURNAL OF HEART FAILURE
- Inherited calcium channelopathies in the pathophysiology of arrhythmias
- (2012) Luigi Venetucci et al. Nature Reviews Cardiology
- Crystal Structure of the Calcium Release-Activated Calcium Channel Orai
- (2012) X. Hou et al. SCIENCE
- β1 integrin
- (2012) Grant A. Howe et al. Cell Adhesion & Migration
- Inhibition of Cardiac Ca 2+ Release Channels (RyR2) Determines Efficacy of Class I Antiarrhythmic Drugs in Catecholaminergic Polymorphic Ventricular Tachycardia
- (2011) Hyun Seok Hwang et al. Circulation-Arrhythmia and Electrophysiology
- SUMO1-dependent modulation of SERCA2a in heart failure
- (2011) Changwon Kho et al. NATURE
- Resting State Orai1 Diffuses as Homotetramer in the Plasma Membrane of Live Mammalian Cells
- (2010) Josef Madl et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Leaky RyR2 trigger ventricular arrhythmias in Duchenne muscular dystrophy
- (2010) J. Fauconnier et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Activation of STIM1-Orai1 Involves an Intramolecular Switching Mechanism
- (2010) M. K. Korzeniowski et al. Science Signaling
- Calcium-binding proteins in skeletal muscles of the mdx mice: potential role in the pathogenesis of Duchenne muscular dystrophy
- (2009) Adriana Pertille et al. INTERNATIONAL JOURNAL OF EXPERIMENTAL PATHOLOGY
- Metallothionein alleviates oxidative stress-induced endoplasmic reticulum stress and myocardial dysfunction
- (2009) Rui Guo et al. JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY
- Flecainide prevents catecholaminergic polymorphic ventricular tachycardia in mice and humans
- (2009) Hiroshi Watanabe et al. NATURE MEDICINE
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