Phenytoin Reduces Activity of Cardiac Ryanodine Receptor 2; A Potential Mechanism for Its Cardioprotective Action

Calmodulin inhibition of human RyR2 channels requires phosphorylation of RyR2-S2808 or RyR2-S2814

(2019) Kafa Walweel et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Antiarrhythmic Effects of Carvedilol and Flecainide in Cardiomyocytes Derived from Catecholaminergic Polymorphic Ventricular Tachycardia Patients

(2018) R. P. Pölönen et al.   Stem Cells International

Ryanodine receptor modification and regulation by intracellular Ca2+ and Mg2+ in healthy and failing human hearts

(2017) K. Walweel et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Prediction of the permeability of neutral drugs inferred from their solvation properties

(2015) Edoardo Milanetti et al.   BIOINFORMATICS

Crystal structures of ryanodine receptor SPRY1 and tandem-repeat domains reveal a critical FKBP12 binding determinant

(2015) Zhiguang Yuchi et al.   Nature Communications

Dantrolene Suppresses Ventricular Ectopy and Arrhythmogenicity with Acute Myocardial Infarction in a Langendorff-Perfused Pacing-Induced Heart Failure Rabbit Model

(2013) CHUNG-CHUAN CHOU et al.   JOURNAL OF CARDIOVASCULAR ELECTROPHYSIOLOGY

Termination of calcium-induced calcium release by induction decay: An emergent property of stochastic channel gating and molecular scale architecture

(2012) D.R. Laver et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Dantrolene prevents arrhythmogenic Ca2+ release in heart failure

(2011) Joshua T. Maxwell et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Inhibition of Cardiac Ca 2+ Release Channels (RyR2) Determines Efficacy of Class I Antiarrhythmic Drugs in Catecholaminergic Polymorphic Ventricular Tachycardia

(2011) Hyun Seok Hwang et al.   Circulation-Arrhythmia and Electrophysiology

Localization of the Dantrolene-binding Sequence near the FK506-binding Protein-binding Site in the Three-dimensional Structure of the Ryanodine Receptor

(2011) Ruiwu Wang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Flecainide inhibits arrhythmogenic Ca2+ waves by open state block of ryanodine receptor Ca2+ release channels and reduction of Ca2+ spark mass

(2009) Fredrick A. Hilliard et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Dantrolene, a Therapeutic Agent for Malignant Hyperthermia, Markedly Improves the Function of Failing Cardiomyocytes by Stabilizing Interdomain Interactions Within the Ryanodine Receptor

(2009) Shigeki Kobayashi et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Termination of Cardiac Ca 2+ Sparks

(2008) Aleksey V. Zima et al.   CIRCULATION RESEARCH

Dantrolene: Mechanisms of Neuroprotection and Possible Clinical Applications in the Neurointensive Care Unit

(2008) Susanne Muehlschlegel et al.   Neurocritical Care