Calcium Handling Defects and Cardiac Arrhythmia Syndromes

CaMKII signaling in heart diseases: Emerging role in diabetic cardiomyopathy

(2019) Bence Hegyi et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Efficacy of Flecainide in Catecholaminergic Polymorphic Ventricular Tachycardia Is Mutation-Independent but Reduced by Calcium Overload

(2019) Hyun Seok Hwang et al.   Frontiers in Physiology

Genetic Mosaicism in Calmodulinopathy

(2019) Lisa M. Wren et al.   Circulation-Genomic and Precision Medicine

Human Calmodulin Mutations

(2018) Helene H. Jensen et al.   Frontiers in Molecular Neuroscience

Calcium in the Pathophysiology of Atrial Fibrillation and Heart Failure

(2018) Nathan C. Denham et al.   Frontiers in Physiology

Altered Ca2+ and Na+ Homeostasis in Human Hypertrophic Cardiomyopathy: Implications for Arrhythmogenesis

(2018) Raffaele Coppini et al.   Frontiers in Physiology

Arrhythmogenic Mechanisms in Heart Failure: Linking β-Adrenergic Stimulation, Stretch, and Calcium

(2018) Daniel M. Johnson et al.   Frontiers in Physiology

Calcium signalling silencing in atrial fibrillation

(2017) Maura Greiser   JOURNAL OF PHYSIOLOGY-LONDON

Potassium currents in the heart: functional roles in repolarization, arrhythmia and therapeutics

(2017) Nipavan Chiamvimonvat et al.   JOURNAL OF PHYSIOLOGY-LONDON

Ups and downs of calcium in the heart

(2017) David A. Eisner   JOURNAL OF PHYSIOLOGY-LONDON

Enhanced Late Na and Ca Currents as Effective Antiarrhythmic Drug Targets

(2017) Hrayr S. Karagueuzian et al.   Frontiers in Pharmacology

New Insights Into the Genetic Basis of Inherited Arrhythmia Syndromes

(2016) Belinda Gray et al.   Circulation-Cardiovascular Genetics

TECRL , a new life‐threatening inherited arrhythmia gene associated with overlapping clinical features of both LQTS and CPVT

(2016) Harsha D Devalla et al.   EMBO Molecular Medicine

2016 ESC Guidelines for the management of atrial fibrillation developed in collaboration with EACTS

(2016) Paulus Kirchhof et al.   EUROPEAN JOURNAL OF CARDIO-THORACIC SURGERY

Novel long QT syndrome-associated missense mutation, L762F, in CACNA1C-encoded L-type calcium channel imparts a slower inactivation tau and increased sustained and window current

(2016) Andrew P. Landstrom et al.   INTERNATIONAL JOURNAL OF CARDIOLOGY

The Arrhythmogenic Calmodulin p.Phe142Leu Mutation Impairs C-domain Ca2+Binding but Not Calmodulin-dependent Inhibition of the Cardiac Ryanodine Receptor

(2016) Mads Toft Søndergaard et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Current controversies in determining the main mechanisms of atrial fibrillation

(2016) U. Schotten et al.   JOURNAL OF INTERNAL MEDICINE

Electrophysiological and molecular mechanisms of paroxysmal atrial fibrillation

(2016) Stanley Nattel et al.   Nature Reviews Cardiology

New Insights Into the Genetic Basis of Inherited Arrhythmia Syndromes

(2016) Belinda Gray et al.   Circulation-Cardiovascular Genetics

Mechanisms of Ventricular Arrhythmias: From Molecular Fluctuations to Electrical Turbulence

(2015) Zhilin Qu et al.   Annual Review of Physiology

Oxidative shift in tissue redox potential increases beat-to-beat variability of action potential duration

(2015) Kornél Kistamás et al.   CANADIAN JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY

Cytosolic calcium changes affect the incidence of early afterdepolarizations in canine ventricular myocytes

(2015) Balázs Horváth et al.   CANADIAN JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY

Homozygous/Compound Heterozygous Triadin Mutations Associated With Autosomal-Recessive Long-QT Syndrome and Pediatric Sudden Cardiac Arrest: Elucidation of the Triadin Knockout Syndrome

(2015) H. M. Altmann et al.   CIRCULATION

The Mechanism of Flecainide Action in CPVT Does Not Involve a Direct Effect on RyR2

(2015) M. L. Bannister et al.   CIRCULATION RESEARCH

Novel Timothy syndrome mutation leading to increase in CACNA1C window current

(2015) Nicole J. Boczek et al.   HEART RHYTHM

Delayed afterdepolarizations generate both triggers and a vulnerable substrate promoting reentry in cardiac tissue

(2015) Michael B. Liu et al.   HEART RHYTHM

Short-coupled polymorphic ventricular tachycardia at rest linked to a novel ryanodine receptor (RyR2) mutation: Leaky RyR2 channels under non-stress conditions

(2015) Jim W. Cheung et al.   INTERNATIONAL JOURNAL OF CARDIOLOGY

Arrhythmogenic Calmodulin Mutations Affect the Activation and Termination of Cardiac Ryanodine Receptor-mediated Ca2+Release

(2015) Mads T. Søndergaard et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Mechanism of Reflection Type Reentry: A Simulation Study

(2015) SUNIL M. KANDEL et al.   JOURNAL OF CARDIOVASCULAR ELECTROPHYSIOLOGY

Perspective: A dynamics-based classification of ventricular arrhythmias

(2015) James N. Weiss et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Role of Gap Junction Channel in the Development of Beat-to-Beat Action Potential Repolarization Variability and Arrhythmias

(2015) Janos Magyar et al.   CURRENT PHARMACEUTICAL DESIGN

Single Delivery of an Adeno-Associated Viral Construct to Transfer the CASQ2 Gene to Knock-In Mice Affected by Catecholaminergic Polymorphic Ventricular Tachycardia Is Able to Cure the Disease From Birth to Advanced Age

(2014) Marco Denegri et al.   CIRCULATION

Screening for Acute I Kr Block Is Insufficient to Detect Torsades de Pointes Liability

(2014) Tao Yang et al.   CIRCULATION

Cellular and Molecular Electrophysiology of Atrial Fibrillation Initiation, Maintenance, and Progression

(2014) Jordi Heijman et al.   CIRCULATION RESEARCH

Tachycardia-induced silencing of subcellular Ca2+ signaling in atrial myocytes

(2014) Maura Greiser et al.   JOURNAL OF CLINICAL INVESTIGATION

Calmodulin mutations associated with long QT syndrome prevent inactivation of cardiac L-type Ca2+ currents and promote proarrhythmic behavior in ventricular myocytes

(2014) Worawan B. Limpitikul et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

KCNE2 modulates cardiac L-type Ca2+ channel

(2014) Wenjuan Liu et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Contribution of ion currents to beat-to-beat variability of action potential duration in canine ventricular myocytes

(2014) Norbert Szentandrássy et al.   PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY

EAD and DAD mechanisms analyzed by developing a new human ventricular cell model

(2014) K. Asakura et al.   PROGRESS IN BIOPHYSICS & MOLECULAR BIOLOGY

Calmodulin Mutations Associated With Recurrent Cardiac Arrest in Infants

(2013) Lia Crotti et al.   CIRCULATION

Executive Summary: HRS/EHRA/APHRS Expert Consensus Statement on the Diagnosis and Management of Patients with Inherited Primary Arrhythmia Syndromes

(2013) Silvia G. Priori et al.   HEART RHYTHM

An LQTS6 MiRP1 Mutation Suppresses Pacemaker Current and is Associated with Sinus Bradycardia

(2013) POOJA A. NAWATHE et al.   JOURNAL OF CARDIOVASCULAR ELECTROPHYSIOLOGY

The TRPM4 non-selective cation channel contributes to the mammalian atrial action potential

(2013) Christophe Simard et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Dynamics of the late Na+ current during cardiac action potential and its contribution to afterdepolarizations

(2013) Balazs Horvath et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

A Mutation in CALM1 Encoding Calmodulin in Familial Idiopathic Ventricular Fibrillation in Childhood and Adolescence

(2013) Roos F. Marsman et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Effects of tacrolimus on action potential configuration and transmembrane ion currents in canine ventricular cells

(2013) László Szabó et al.   NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY

Molecular Genetics and Functional Anomalies in a Series of 248 Brugada Cases with 11 Mutations in the TRPM4 Channel

(2013) Hui Liu et al.   PLoS One

Congenital Long QT Syndrome: An Update and Present Perspective in Saudi Arabia

(2013) Zahurul A. Bhuiyan et al.   Frontiers in Pediatrics

Mutations in Calmodulin Cause Ventricular Tachycardia and Sudden Cardiac Death

(2012) Mette Nyegaard et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Refractoriness of sarcoplasmic reticulum Ca2+ release determines Ca2+ alternans in atrial myocytes

(2012) Vyacheslav M. Shkryl et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Enhanced Sarcoplasmic Reticulum Ca 2+ Leak and Increased Na + -Ca 2+ Exchanger Function Underlie Delayed Afterdepolarizations in Patients With Chronic Atrial Fibrillation

(2012) Niels Voigt et al.   CIRCULATION

Calcium Leak Through Ryanodine Receptors Leads to Atrial Fibrillation in 3 Mouse Models of Catecholaminergic Polymorphic Ventricular Tachycardia

(2012) Jian Shan et al.   CIRCULATION RESEARCH

Viral Gene Transfer Rescues Arrhythmogenic Phenotype and Ultrastructural Abnormalities in Adult Calsequestrin-Null Mice With Inherited Arrhythmias

(2012) Marco Denegri et al.   CIRCULATION RESEARCH

Long-QT Syndrome

(2012) Peter J. Schwartz et al.   Circulation-Arrhythmia and Electrophysiology

Pro- and antiarrhythmic effects of ATP-sensitive potassium current activation on reentry during early afterdepolarization-mediated arrhythmias

(2012) Marvin G. Chang et al.   HEART RHYTHM

Sodium-channel blockers might contribute to the prevention of ventricular tachycardia in patients with long QT syndrome type 2: a description of 4 cases

(2012) Rukijat Ildarova et al.   JOURNAL OF ELECTROCARDIOLOGY

Not All Beta-Blockers Are Equal in the Management of Long QT Syndrome Types 1 and 2

(2012) Priya Chockalingam et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Inherited calcium channelopathies in the pathophysiology of arrhythmias

(2012) Luigi Venetucci et al.   Nature Reviews Cardiology

Calsequestrin Mutations and Catecholaminergic Polymorphic Ventricular Tachycardia

(2012) Michela Faggioni et al.   PEDIATRIC CARDIOLOGY

Mutation-Linked Defective Interdomain Interactions Within Ryanodine Receptor Cause Aberrant Ca 2+ Release Leading to Catecholaminergic Polymorphic Ventricular Tachycardia

(2011) Takeshi Suetomi et al.   CIRCULATION

Short Communication: Flecainide Exerts an Antiarrhythmic Effect in a Mouse Model of Catecholaminergic Polymorphic Ventricular Tachycardia by Increasing the Threshold for Triggered Activity

(2011) Nian Liu et al.   CIRCULATION RESEARCH

Inhibition of Cardiac Ca 2+ Release Channels (RyR2) Determines Efficacy of Class I Antiarrhythmic Drugs in Catecholaminergic Polymorphic Ventricular Tachycardia

(2011) Hyun Seok Hwang et al.   Circulation-Arrhythmia and Electrophysiology

A rare association of long QT syndrome and syndactyly: Timothy Syndrome (LQT 8)

(2011) U. Krause et al.   Clinical Research in Cardiology

Successful treatment of catecholaminergic polymorphic ventricular tachycardia with flecainide: a case report and review of the current literature

(2011) C. Pott et al.   EUROPACE

Guidelines for the diagnosis and management of Catecholaminergic Polymorphic Ventricular Tachycardia

(2011) Andreas Pflaumer et al.   Heart Lung and Circulation

Bi-stable wave propagation and early afterdepolarization–mediated cardiac arrhythmias

(2011) Marvin G. Chang et al.   HEART RHYTHM

Microvolt T-Wave Alternans

(2011) Richard L. Verrier et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Flecainide Therapy Reduces Exercise-Induced Ventricular Arrhythmias in Patients With Catecholaminergic Polymorphic Ventricular Tachycardia

(2011) Christian van der Werf et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Using induced pluripotent stem cells to investigate cardiac phenotypes in Timothy syndrome

(2011) Masayuki Yazawa et al.   NATURE

Carvedilol and its new analogs suppress arrhythmogenic store overload–induced Ca2+ release

(2011) Qiang Zhou et al.   NATURE MEDICINE

The Role of the Calcium and the Voltage Clocks in Sinoatrial Node Dysfunction

(2011) Boyoung Joung et al.   YONSEI MEDICAL JOURNAL

Identification of a Kir3.4 Mutation in Congenital Long QT Syndrome

(2010) Yanzong Yang et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Pharmacodynamic Effects in the Cardiovascular System: The Modeller’s View

(2010) Martin Fink et al.   BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY

Catecholaminergic Polymorphic Ventricular Tachycardia Is Caused by Mutation-Linked Defective Conformational Regulation of the Ryanodine Receptor

(2010) Hitoshi Uchinoumi et al.   CIRCULATION RESEARCH

In the RyR2 R4496C Mouse Model of CPVT, β-Adrenergic Stimulation Induces Ca Waves by Increasing SR Ca Content and Not by Decreasing the Threshold for Ca Waves

(2010) Takeshi Kashimura et al.   CIRCULATION RESEARCH

A Coupled SYSTEM of Intracellular Ca 2+ Clocks and Surface Membrane Voltage Clocks Controls the Timekeeping Mechanism of the Heart’s Pacemaker

(2010) Edward G. Lakatta et al.   CIRCULATION RESEARCH

CaMKII-Dependent Diastolic SR Ca 2+ Leak and Elevated Diastolic Ca 2+ Levels in Right Atrial Myocardium of Patients With Atrial Fibrillation

(2010) Stefan Neef et al.   CIRCULATION RESEARCH

Efficacy of flecainide in a patient with catecholaminergic polymorphic ventricular tachycardia

(2010) E. K. Biernacka et al.   EUROPACE

Clinical effectiveness of pulmonary vein isolation for arrhythmic events in a patient with catecholaminergic polymorphic ventricular tachycardia

(2010) Naokata Sumitomo et al.   HEART AND VESSELS

Trigger-specific risk factors and response to therapy in long QT syndrome type 2

(2010) James A. Kim et al.   HEART RHYTHM

Mutations in the cardiac L-type calcium channel associated with inherited J-wave syndromes and sudden cardiac death

(2010) Elena Burashnikov et al.   HEART RHYTHM

The Catecholaminergic Polymorphic Ventricular Tachycardia Mutation R33Q Disrupts the N-terminal Structural Motif That Regulates Reversible Calsequestrin Polymerization

(2010) Naresh C. Bal et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Role of the Transient Outward Current in Regulating Mechanical Properties of Canine Ventricular Myocytes

(2010) MIN DONG et al.   JOURNAL OF CARDIOVASCULAR ELECTROPHYSIOLOGY

Short QT interval in clinical practice

(2010) Preben Bjerregaard et al.   JOURNAL OF ELECTROCARDIOLOGY

Calmodulin kinase II inhibition prevents arrhythmias in RyR2R4496C+/− mice with catecholaminergic polymorphic ventricular tachycardia

(2010) Nian Liu et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Histidine-rich calcium binding protein: The new regulator of sarcoplasmic reticulum calcium cycling

(2010) Demetrios A. Arvanitis et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Ranolazine Safely Decreases Ventricular and Atrial Fibrillation in Timothy Syndrome (LQT8)

(2010) DIPAK P. SHAH et al.   PACE-PACING AND CLINICAL ELECTROPHYSIOLOGY

Phase-2 reentry in cardiac tissue: Role of the slow calcium pulse

(2010) Inma R. Cantalapiedra et al.   PHYSICAL REVIEW E

Dog left ventricular midmyocardial myocytes for assessment of drug-induced delayed repolarization: short-term variability and proarrhythmic potential

(2009) Najah Abi-Gerges et al.   BRITISH JOURNAL OF PHARMACOLOGY

Incidence and Risk Factors of Arrhythmic Events in Catecholaminergic Polymorphic Ventricular Tachycardia

(2009) Meiso Hayashi et al.   CIRCULATION

Diastolic Intracellular Calcium-Membrane Voltage Coupling Gain and Postshock Arrhythmias

(2009) Mitsunori Maruyama et al.   CIRCULATION RESEARCH

Protein Kinase A-Dependent Biophysical Phenotype for V227F-KCNJ2 Mutation in Catecholaminergic Polymorphic Ventricular Tachycardia

(2009) Amanda L. Vega et al.   Circulation-Arrhythmia and Electrophysiology

A paradigm shift for the heart's pacemaker

(2009) Edward G. Lakatta   HEART RHYTHM

J wave syndromes

(2009) Charles Antzelevitch et al.   HEART RHYTHM

Roscovitine Binds to Novel L-channel (CaV1.2) Sites That Separately Affect Activation and Inactivation

(2009) Viktor Yarotskyy et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

What keeps us ticking: a funny current, a calcium clock, or both?

(2009) Edward G. Lakatta et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

L-type Ca2+ current in ventricular cardiomyocytes

(2009) Jean-Pierre Benitah et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Flecainide inhibits arrhythmogenic Ca2+ waves by open state block of ryanodine receptor Ca2+ release channels and reduction of Ca2+ spark mass

(2009) Fredrick A. Hilliard et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

The effects of membrane potential, SR Ca2+content and RyR responsiveness on systolic Ca2+alternans in rat ventricular myocytes

(2009) Yatong Li et al.   JOURNAL OF PHYSIOLOGY-LONDON

Reexcitation mechanisms in epicardial tissue: Role of Ito density heterogeneities and INa inactivation kinetics

(2009) Inma R. Cantalapiedra et al.   JOURNAL OF THEORETICAL BIOLOGY

Flecainide prevents catecholaminergic polymorphic ventricular tachycardia in mice and humans

(2009) Hiroshi Watanabe et al.   NATURE MEDICINE

Ablation of triadin causes loss of cardiac Ca2+ release units, impaired excitation-contraction coupling, and cardiac arrhythmias

(2009) N. Chopra et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Endoplasmic reticulum Ca2+measurements reveal that the cardiac ryanodine receptor mutations linked to cardiac arrhythmia and sudden death alter the threshold for store-overload-induced Ca2+release

(2008) Peter P. Jones et al.   BIOCHEMICAL JOURNAL

Intracellular Ca Alternans: Coordinated Regulation by Sarcoplasmic Reticulum Release, Uptake, and Leak

(2008) Lai-Hua Xie et al.   BIOPHYSICAL JOURNAL

Identification of Target Domains of the Cardiac Ryanodine Receptor to Correct Channel Disorder in Failing Hearts

(2008) Takeshi Yamamoto et al.   CIRCULATION

Proarrhythmic Defects in Timothy Syndrome Require Calmodulin Kinase II

(2008) William H. Thiel et al.   CIRCULATION

Unexpected Structural and Functional Consequences of the R33Q Homozygous Mutation in Cardiac Calsequestrin

(2008) Nicoletta Rizzi et al.   CIRCULATION RESEARCH

Cellular Signaling Underlying Atrial Tachycardia Remodeling of L-type Calcium Current

(2008) Xiao Yan Qi et al.   CIRCULATION RESEARCH

Oxidative Stress–Induced Afterdepolarizations and Calmodulin Kinase II Signaling

(2008) Lai-Hua Xie et al.   CIRCULATION RESEARCH

α-1-Syntrophin Mutation and the Long-QT Syndrome

(2008) Geru Wu et al.   Circulation-Arrhythmia and Electrophysiology

Intracellular calcium leak due to FKBP12.6 deficiency in mice facilitates the inducibility of atrial fibrillation

(2008) Subeena Sood et al.   HEART RHYTHM

Role of ryanodine receptor as a Ca2+ regulatory center in normal and failing hearts

(2008) Masafumi Yano et al.   Journal of Cardiology

Ranolazine Shortens Repolarization in Patients with Sustained Inward Sodium Current Due to Type-3 Long-QT Syndrome

(2008) ARTHUR J. MOSS et al.   JOURNAL OF CARDIOVASCULAR ELECTROPHYSIOLOGY

Ryanodine receptor and calsequestrin in arrhythmogenesis: What we have learnt from genetic diseases and transgenic mice

(2008) Nian Liu et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

J-Point Elevation in Survivors of Primary Ventricular Fibrillation and Matched Control Subjects

(2008) Raphael Rosso et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Sudden Cardiac Arrest Associated with Early Repolarization

(2008) Michel Haïssaguerre et al.   NEW ENGLAND JOURNAL OF MEDICINE

Pathophysiology and pharmacology of the cardiac “late sodium current”

(2008) Antonio Zaza et al.   PHARMACOLOGY & THERAPEUTICS

A Rabbit Ventricular Action Potential Model Replicating Cardiac Dynamics at Rapid Heart Rates

(2007) Aman Mahajan et al.   BIOPHYSICAL JOURNAL