The role of calcium homeostasis remodeling in inherited cardiac arrhythmia syndromes

Molecular and tissue mechanisms of catecholaminergic polymorphic ventricular tachycardia

(2020) Matthew J. Wleklinski et al.   JOURNAL OF PHYSIOLOGY-LONDON

Calcium Handling Defects and Cardiac Arrhythmia Syndromes

(2020) Kornél Kistamás et al.   Frontiers in Pharmacology

Novel Variants in TECRL Cause Recessive Inherited CPVT Type 3 with Severe and Variable Clinical Symptoms

(2020) Alexander Moscu‐Gregor et al.   JOURNAL OF CARDIOVASCULAR ELECTROPHYSIOLOGY

Increased RyR2 activity is exacerbated by calcium leak-induced mitochondrial ROS

(2020) Shanna Hamilton et al.   BASIC RESEARCH IN CARDIOLOGY

Late I Na blocker GS967 Suppress Polymorphic VT in a Transgenic Rabbit Model of Long QT Type 2

(2020) Jungmin Hwang et al.   Circulation-Arrhythmia and Electrophysiology

Transgenic Rabbit Models in Proarrhythmia Research

(2020) István Baczkó et al.   Frontiers in Pharmacology

Calcium signaling consequences of RyR2 mutations associated with CPVT1 introduced via CRISPR/Cas9 gene editing in human-induced pluripotent stem cell–derived cardiomyocytes: Comparison of RyR2-R420Q, F2483I, and Q4201R

(2020) Xiao-Hua Zhang et al.   HEART RHYTHM

The molecular complexity of the Mitochondrial Calcium Uniporter

(2020) Simona Feno et al.   CELL CALCIUM

Altered Intracellular Calcium Homeostasis and Arrhythmogenesis in the Aged Heart

(2019) Shanna Hamilton et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Gene Therapy for Catecholaminergic Polymorphic Ventricular Tachycardia by Inhibition of Ca 2+ /Calmodulin-Dependent Kinase II

(2019) Vassilios J. Bezzerides et al.   CIRCULATION

Insights Into the Pathogenesis of Catecholaminergic Polymorphic Ventricular Tachycardia From Engineered Human Heart Tissue

(2019) Sung-Jin Park et al.   CIRCULATION

Interplay between triadin and calsequestrin in the pathogenesis of CPVT in mouse

(2019) Marine Cacheux et al.   MOLECULAR THERAPY

Gene Transfer of Engineered Calmodulin Alleviates Ventricular Arrhythmias in a Calsequestrin‐Associated Mouse Model of Catecholaminergic Polymorphic Ventricular Tachycardia

(2018) Bin Liu et al.   Journal of the American Heart Association

In Vivo Ryr 2 Editing Corrects Catecholaminergic Polymorphic Ventricular Tachycardia

(2018) Xiaolu Pan et al.   CIRCULATION RESEARCH

Arrhythmias precede cardiomyopathy and remodeling of Ca2+ handling proteins in a novel model of long QT syndrome

(2018) Jérôme Montnach et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Calcium in Brugada Syndrome: Questions for Future Research

(2018) Michelle M. Monasky et al.   Frontiers in Physiology

Proarrhythmic Remodeling of Calcium Homeostasis in Cardiac Disease; Implications for Diabetes and Obesity

(2018) Shanna Hamilton et al.   Frontiers in Physiology

Pharmacological Modulation of Mitochondrial Ca2+ Content Regulates Sarcoplasmic Reticulum Ca2+ Release via Oxidation of the Ryanodine Receptor by Mitochondria-Derived Reactive Oxygen Species

(2018) Shanna Hamilton et al.   Frontiers in Physiology

Dynamical effects of calcium-sensitive potassium currents on voltage and calcium alternans

(2017) Matthew Kennedy et al.   JOURNAL OF PHYSIOLOGY-LONDON

Increased mitochondrial nanotunneling activity, induced by calcium imbalance, affects intermitochondrial matrix exchanges

(2017) Manuela Lavorato et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

TECRL , a new life‐threatening inherited arrhythmia gene associated with overlapping clinical features of both LQTS and CPVT

(2016) Harsha D Devalla et al.   EMBO Molecular Medicine

Mitochondrial generation of superoxide and hydrogen peroxide as the source of mitochondrial redox signaling

(2016) Martin D. Brand   FREE RADICAL BIOLOGY AND MEDICINE

Calcium-activated chloride current determines action potential morphology during calcium alternans in atrial myocytes

(2016) Giedrius Kanaporis et al.   JOURNAL OF PHYSIOLOGY-LONDON

Mitofusins, from Mitochondria to Metabolism

(2016) Emilie Schrepfer et al.   MOLECULAR CELL

Adeno-associated virus-mediated CASQ2 delivery rescues phenotypic alterations in a patient-specific model of recessive catecholaminergic polymorphic ventricular tachycardia

(2016) Francesco Lodola et al.   Cell Death & Disease

Homozygous/Compound Heterozygous Triadin Mutations Associated With Autosomal-Recessive Long-QT Syndrome and Pediatric Sudden Cardiac Arrest: Elucidation of the Triadin Knockout Syndrome

(2015) H. M. Altmann et al.   CIRCULATION

Altered distribution of ICa impairs Ca release at the t-tubules of ventricular myocytes from failing hearts

(2015) Simon M. Bryant et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Protein phosphatase 2A regulatory subunit B56α limits phosphatase activity in the heart

(2015) Sean C. Little et al.   Science Signaling

Protein phosphatase 2A regulatory subunit B56α limits phosphatase activity in the heart

(2015) Sean C. Little et al.   Science Signaling

Calcium Movement in Cardiac Mitochondria

(2014) Liron Boyman et al.   BIOPHYSICAL JOURNAL

Neuronal Na+ channel blockade suppresses arrhythmogenic diastolic Ca2+ release

(2014) Przemysław B. Radwański et al.   CARDIOVASCULAR RESEARCH

Hyperphosphorylation of RyRs Underlies Triggered Activity in Transgenic Rabbit Model of LQT2 Syndrome

(2014) Dmitry Terentyev et al.   CIRCULATION RESEARCH

Cardiac alternans and intracellular calcium cycling

(2014) Joshua N Edwards et al.   CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY

Intracellular Na+ overload causes oxidation of CaMKII and leads to Ca2+ mishandling in isolated ventricular myocytes

(2014) Serge Viatchenko-Karpinski et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Ca handling during excitation–contraction coupling in heart failure

(2014) Aleksey V. Zima et al.   PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY

Induced Pluripotent Stem Cell–Derived Cardiomyocytes

(2013) Björn C. Knollmann   CIRCULATION RESEARCH

Na+ transport in the normal and failing heart — Remember the balance

(2013) Sanda Despa et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Cellular mechanisms of ventricular arrhythmias in a mouse model of Timothy syndrome (long QT syndrome 8)

(2013) Benjamin M.L. Drum et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Redox modification of ryanodine receptors by mitochondria-derived reactive oxygen species contributes to aberrant Ca2+handling in ageing rabbit hearts

(2013) Leroy L. Cooper et al.   JOURNAL OF PHYSIOLOGY-LONDON

CaMKII inhibition rectifies arrhythmic phenotype in a patient-specific model of catecholaminergic polymorphic ventricular tachycardia

(2013) E Di Pasquale et al.   Cell Death & Disease

Posttranslational modifications of cardiac ryanodine receptors: Ca2+ signaling and EC-coupling

(2012) Ernst Niggli et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Ryanodine Receptor Current Amplitude Controls Ca 2+ Sparks in Cardiac Muscle

(2012) Tao Guo et al.   CIRCULATION RESEARCH

Measuring Local Gradients of Intramitochondrial [Ca 2+ ] in Cardiac Myocytes During Sarcoplasmic Reticulum Ca 2+ Release

(2012) Xiyuan Lu et al.   CIRCULATION RESEARCH

Heterogeneity of Ryanodine Receptor Dysfunction in a Mouse Model of Catecholaminergic Polymorphic Ventricular Tachycardia

(2012) Randall Loaiza et al.   CIRCULATION RESEARCH

Long-QT Syndrome

(2012) Peter J. Schwartz et al.   Circulation-Arrhythmia and Electrophysiology

Proteomic analyses of transgenic LQT1 and LQT2 rabbit hearts elucidate an increase in expression and activity of energy producing enzymes

(2012) Hitesh K. Jindal et al.   Journal of Proteomics

Arrhythmogenic left atrial cellular electrophysiology in a murine genetic long QT syndrome model

(2011) Marc D. Lemoine et al.   CARDIOVASCULAR RESEARCH

MicroRNA-1 and -133 Increase Arrhythmogenesis in Heart Failure by Dissociating Phosphatase Activity from RyR2 Complex

(2011) Andriy E. Belevych et al.   PLoS One

β1-Adrenergic receptor activation induces mouse cardiac myocyte death through both L-type calcium channel-dependent and -independent pathways

(2010) Wei Wang et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Does Cellular Hydrogen Peroxide Diffuse or Act Locally?

(2010) Natalia M. Mishina et al.   ANTIOXIDANTS & REDOX SIGNALING

Dantrolene, a Therapeutic Agent for Malignant Hyperthermia, Inhibits Catecholaminergic Polymorphic Ventricular Tachycardia in a RyR2R2474S/+ Knock-In Mouse Model

(2010) Shigeki Kobayashi et al.   CIRCULATION JOURNAL

The Cardiac Desmosome and Arrhythmogenic Cardiomyopathies

(2010) Mario Delmar et al.   CIRCULATION RESEARCH

Calmodulin kinase II inhibition prevents arrhythmias in RyR2R4496C+/− mice with catecholaminergic polymorphic ventricular tachycardia

(2010) Nian Liu et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

The Calcium/Calmodulin/Kinase System and Arrhythmogenic Afterdepolarizations in Bradycardia-Related Acquired Long-QT Syndrome

(2009) XiaoYan Qi et al.   Circulation-Arrhythmia and Electrophysiology

Catecholaminergic polymorphic ventricular tachycardia: A paradigm to understand mechanisms of arrhythmias associated to impaired Ca2+ regulation

(2009) Marina Cerrone et al.   HEART RHYTHM

Mitochondrial Ca2+ uptake: Tortoise or hare?

(2009) Brian O'Rourke et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Ablation of triadin causes loss of cardiac Ca2+ release units, impaired excitation-contraction coupling, and cardiac arrhythmias

(2009) N. Chopra et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Redox Modification of Ryanodine Receptors Contributes to Sarcoplasmic Reticulum Ca 2+ Leak in Chronic Heart Failure

(2008) Dmitry Terentyev et al.   CIRCULATION RESEARCH

Inhibition of the Na+/Ca2+ exchanger suppresses torsades de pointes in an intact heart model of long QT syndrome-2 and long QT syndrome-3

(2008) Peter Milberg et al.   HEART RHYTHM

Mechanisms of cardiac arrhythmias and sudden death in transgenic rabbits with long QT syndrome

(2008) Michael Brunner et al.   JOURNAL OF CLINICAL INVESTIGATION