Unbalance Between Sarcoplasmic Reticulum Ca2 + Uptake and Release: A First Step Toward Ca2 + Triggered Arrhythmias and Cardiac Damage

Cardiomyocyte mitochondrial dysfunction in diabetes and its contribution in cardiac arrhythmogenesis

(2019) Hamza El Hadi et al.   MITOCHONDRION

CaMKII does not control mitochondrial Ca 2+ uptake in cardiac myocytes

(2019) Alexander G. Nickel et al.   JOURNAL OF PHYSIOLOGY-LONDON

Role of SIRT1 in Modulating Acetylation of the Sarco-Endoplasmic Reticulum Ca 2+ -ATPase in Heart Failure

(2019) Przemyslaw A Gorski et al.   CIRCULATION RESEARCH

The Cardiac Ryanodine Receptor Phosphorylation Hotspot Embraces PKA in a Phosphorylation-Dependent Manner

(2019) Omid Haji-Ghassemi et al.   MOLECULAR CELL

Modulation of cardiac ryanodine receptor 2 by calmodulin

(2019) Deshun Gong et al.   NATURE

Slaying a giant: Structures of calmodulin and protein kinase a bound to the cardiac ryanodine receptor

(2019) Filip Van Petegem   CELL CALCIUM

Sorcin ablation plus β-adrenergic stimulation generate an arrhythmogenic substrate in mouse ventricular myocytes

(2018) Xi Chen et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Endoplasmic Reticulum–Mitochondrial Contactology: Structure and Signaling Functions

(2018) György Csordás et al.   TRENDS IN CELL BIOLOGY

Clinical Use of Digitalis: A State of the Art Review

(2018) Thomas F. Whayne   American Journal of Cardiovascular Drugs

Ablation of phospholamban rescues reperfusion arrhythmias but exacerbates myocardium infarction in hearts with Ca2+/calmodulin kinase II constitutive phosphorylation of ryanodine receptors

(2018) Carlos A Valverde et al.   CARDIOVASCULAR RESEARCH

Activation of protein phosphatase 1 by a selective phosphatase disrupting peptide reduces sarcoplasmic reticulum Ca2+ leak in human heart failure

(2018) Thomas H. Fischer et al.   EUROPEAN JOURNAL OF HEART FAILURE

The Histidine-Rich Calcium Binding Protein in Regulation of Cardiac Rhythmicity

(2018) Demetrios A. Arvanitis et al.   Frontiers in Physiology

Phosphorylation of the ryanodine receptor 2 at serine 2030 is required for a complete β-adrenergic response

(2018) Duilio M. Potenza et al.   JOURNAL OF GENERAL PHYSIOLOGY

The structural basis of ryanodine receptor ion channel function

(2017) Gerhard Meissner   JOURNAL OF GENERAL PHYSIOLOGY

Physiology and pathophysiology of excitation–contraction coupling: the functional role of ryanodine receptor

(2017) Gaetano Santulli et al.   JOURNAL OF MUSCLE RESEARCH AND CELL MOTILITY

Calcium-calmodulin-dependent protein kinase mediates the intracellular signalling pathways of cardiac apoptosis in mice with impaired glucose tolerance

(2017) Marilen Federico et al.   JOURNAL OF PHYSIOLOGY-LONDON

Intracellular calcium release channels: an update

(2017) Gaetano Santulli et al.   JOURNAL OF PHYSIOLOGY-LONDON

Reversible redox modifications of ryanodine receptor ameliorate ventricular arrhythmias in the ischemic-reperfused heart

(2016) Romina Becerra et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Animal models for diabetes: Understanding the pathogenesis and finding new treatments

(2016) Aileen King et al.   BIOCHEMICAL PHARMACOLOGY

Ryanodine receptor phosphorylation by CaMKII promotes spontaneous Ca2+ release events in a rodent model of early stage diabetes: The arrhythmogenic substrate

(2016) Leandro Sommese et al.   INTERNATIONAL JOURNAL OF CARDIOLOGY

The Arrhythmogenic Calmodulin p.Phe142Leu Mutation Impairs C-domain Ca2+Binding but Not Calmodulin-dependent Inhibition of the Cardiac Ryanodine Receptor

(2016) Mads Toft Søndergaard et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Phospholamban ablation rescues the enhanced propensity to arrhythmias of mice with CaMKII-constitutive phosphorylation of RyR2 at site S2814

(2016) G. Mazzocchi et al.   JOURNAL OF PHYSIOLOGY-LONDON

Reactive oxygen species-mediated cardiac-reperfusion injury: Mechanisms and therapies

(2016) Fereshte Bagheri et al.   LIFE SCIENCES

Structural basis for the gating mechanism of the type 2 ryanodine receptor RyR2

(2016) Wei Peng et al.   SCIENCE

Targeting metabolic disturbance in the diabetic heart

(2015) Jesús Fuentes-Antrás et al.   Cardiovascular Diabetology

S-Nitrosylation of Calcium-Handling Proteins in Cardiac Adrenergic Signaling and HypertrophyNovelty and Significance

(2015) Tomoya Irie et al.   CIRCULATION RESEARCH

Validity of animal models of type 1 diabetes, and strategies to enhance their utility in translational research

(2015) Melanie L. Graham et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

The role of CaMKII in diabetic heart dysfunction

(2015) Lorna Daniels et al.   HEART FAILURE REVIEWS

Ca2+ Sparks and Ca2+ waves are the subcellular events underlying Ca2+ overload during ischemia and reperfusion in perfused intact hearts

(2015) Alicia Mattiazzi et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

The mitochondrial permeability transition pore: Molecular nature and role as a target in cardioprotection

(2015) Paolo Bernardi et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Human G109E-inhibitor-1 impairs cardiac function and promotes arrhythmias

(2015) Kobra Haghighi et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Ryanodine Receptors: Allosteric Ion Channel Giants

(2015) Filip Van Petegem   JOURNAL OF MOLECULAR BIOLOGY

Enhanced oxidative stress sensitizes the mitochondrial permeability transition pore to opening in heart from Zucker Fa/fa rats with type 2 diabetes

(2015) Adriana Riojas-Hernández et al.   LIFE SCIENCES

Updating Experimental Models of Diabetic Cardiomyopathy

(2015) J. Fuentes-Antrás et al.   Journal of Diabetes Research

Calcium signaling in diabetic cardiomyocytes

(2014) Laetitia Pereira et al.   CELL CALCIUM

Molecular mechanisms of diabetic cardiomyopathy

(2014) Heiko Bugger et al.   DIABETOLOGIA

Altered RyR2 regulation by the calmodulin F90L mutation associated with idiopathic ventricular fibrillation and early sudden cardiac death

(2014) Michail Nomikos et al.   FEBS LETTERS

CaMKII-dependent phosphorylation of cardiac ryanodine receptors regulates cell death in cardiac ischemia/reperfusion injury

(2014) Mariano N. Di Carlo et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Phospholamban interactome in cardiac contractility and survival: A new vision of an old friend

(2014) Kobra Haghighi et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

The ryanodine receptor store-sensing gate controls Ca2+ waves and Ca2+-triggered arrhythmias

(2014) Wenqian Chen et al.   NATURE MEDICINE

A Systematic Review of Fetal Genes as Biomarkers of Cardiac Hypertrophy in Rodent Models of Diabetes

(2014) Emily J. Cox et al.   PLoS One

The role of CaMKII regulation of phospholamban activity in heart disease

(2014) Alicia Mattiazzi et al.   Frontiers in Pharmacology

CaMKII regulation of cardiac ryanodine receptors and inositol triphosphate receptors

(2014) Emmanuel Camors et al.   Frontiers in Pharmacology

Oxidative stress in cardiomyocytes contributes to decreased SERCA2a activity in rats with metabolic syndrome

(2013) Jaime Balderas-Villalobos et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

HNO Enhances SERCA2a Activity and Cardiomyocyte Function by Promoting Redox-Dependent Phospholamban Oligomerization

(2013) Vidhya Sivakumaran et al.   ANTIOXIDANTS & REDOX SIGNALING

Ryanodine receptor phosphorylation by oxidized CaMKII contributes to the cardiotoxic effects of cardiac glycosides

(2013) Hsiang-Ting Ho et al.   CARDIOVASCULAR RESEARCH

Ca 2+ /Calmodulin-Dependent Protein Kinase II and Protein Kinase A Differentially Regulate Sarcoplasmic Reticulum Ca 2+ Leak in Human Cardiac Pathology

(2013) Thomas H. Fischer et al.   CIRCULATION

Ca 2+ /Calmodulin-Dependent Protein Kinase II δ Mediates Myocardial Ischemia/Reperfusion Injury Through Nuclear Factor-κB

(2013) Haiyun Ling et al.   CIRCULATION RESEARCH

Dynamics of the late Na+ current during cardiac action potential and its contribution to afterdepolarizations

(2013) Balazs Horvath et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Diabetic hyperglycaemia activates CaMKII and arrhythmias by O-linked glycosylation

(2013) Jeffrey R. Erickson et al.   NATURE

The physiological role of mitochondrial calcium revealed by mice lacking the mitochondrial calcium uniporter

(2013) Xin Pan et al.   NATURE CELL BIOLOGY

The use of animal models in diabetes research

(2012) Aileen JF King   BRITISH JOURNAL OF PHARMACOLOGY

Calcium-mediated cell death during myocardial reperfusion

(2012) D. Garcia-Dorado et al.   CARDIOVASCULAR RESEARCH

Ryanodine Receptor S2808 Phosphorylation in Heart Failure

(2012) Donald M. Bers   CIRCULATION RESEARCH

Shortened Ca 2+ Signaling Refractoriness Underlies Cellular Arrhythmogenesis in a Postinfarction Model of Sudden Cardiac Death

(2012) Andriy E. Belevych et al.   CIRCULATION RESEARCH

Role of RyR2 Phosphorylation at S2814 During Heart Failure Progression

(2012) Jonathan L. Respress et al.   CIRCULATION RESEARCH

Modulation of Cardiac Contractility by the Phopholamban/SERCA2a Regulatome

(2012) Evangelia G. Kranias et al.   CIRCULATION RESEARCH

SR and mitochondria: Calcium cross-talk between kissing cousins

(2012) Gerald W. Dorn et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

CaMKII determines mitochondrial stress responses in heart

(2012) Mei-ling A. Joiner et al.   NATURE

FKBP12 Activates the Cardiac Ryanodine Receptor Ca2+-Release Channel and Is Antagonised by FKBP12.6

(2012) Elena Galfré et al.   PLoS One

Small Heat Shock Protein 20 Interacts With Protein Phosphatase-1 and Enhances Sarcoplasmic Reticulum Calcium Cycling

(2011) Jiang Qian et al.   CIRCULATION RESEARCH

Alternans and Arrhythmias

(2011) James N. Weiss et al.   CIRCULATION RESEARCH

Calcium-Calmodulin Kinase II Mediates Digitalis-Induced Arrhythmias

(2011) Luis A. Gonano et al.   Circulation-Arrhythmia and Electrophysiology

Calcium-calmodulin dependent protein kinase II (CaMKII): A main signal responsible for early reperfusion arrhythmias

(2011) M. Said et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Arrhythmogenic adverse effects of cardiac glycosides are mediated by redox modification of ryanodine receptors

(2011) Hsiang-Ting Ho et al.   JOURNAL OF PHYSIOLOGY-LONDON

Overexpression of CaMKIIδc in RyR2R4496C+/− Knock-In Mice Leads to Altered Intracellular Ca2+ Handling and Increased Mortality

(2011) Nataliya Dybkova et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

SUMO1-dependent modulation of SERCA2a in heart failure

(2011) Changwon Kho et al.   NATURE

Lethal Arg9Cys phospholamban mutation hinders Ca2+-ATPase regulation and phosphorylation by protein kinase A

(2011) K. N. Ha et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Ryanodine receptors

(2011) E Michelle Capes et al.   Skeletal Muscle

So Little Source, So Much Sink: Requirements for Afterdepolarizations to Propagate in Tissue

(2010) Yuanfang Xie et al.   BIOPHYSICAL JOURNAL

Ryanodine Receptor Phosphorylation by Calcium/Calmodulin-Dependent Protein Kinase II Promotes Life-Threatening Ventricular Arrhythmias in Mice With Heart Failure

(2010) Ralph J. van Oort et al.   CIRCULATION

Kinetics of FKBP12.6 Binding to Ryanodine Receptors in Permeabilized Cardiac Myocytes and Effects on Ca Sparks

(2010) Tao Guo et al.   CIRCULATION RESEARCH

Redox-mediated reciprocal regulation of SERCA and Na+–Ca2+ exchanger contributes to sarcoplasmic reticulum Ca2+ depletion in cardiac myocytes

(2010) Gabriela M. Kuster et al.   FREE RADICAL BIOLOGY AND MEDICINE

Early afterdepolarizations and cardiac arrhythmias

(2010) James N. Weiss et al.   HEART RHYTHM

S100A1: A Regulator of Striated Muscle Sarcoplasmic Reticulum Ca2+Handling, Sarcomeric, and Mitochondrial Function

(2010) Mirko Völkers et al.   JOURNAL OF BIOMEDICINE AND BIOTECHNOLOGY

Role of mitochondrial dysfunction in cardiac glycoside toxicity

(2010) Ting Liu et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Activation of the cardiac Na+–Ca2+ exchanger by sorcin via the interaction of the respective Ca2+-binding domains

(2010) Carlotta Zamparelli et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

The signalling pathway of CaMKII-mediated apoptosis and necrosis in the ischemia/reperfusion injury

(2010) Margarita A. Salas et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Regulation of mitochondrial dehydrogenases by calcium ions

(2009) Richard M. Denton   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

Calpains and proteasomes mediate degradation of ryanodine receptors in a model of cardiac ischemic reperfusion

(2009) Zully Pedrozo et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Transient Ca2+ depletion of the sarcoplasmic reticulum at the onset of reperfusion

(2009) Carlos A. Valverde et al.   CARDIOVASCULAR RESEARCH

Angiotensin II–Induced Oxidative Stress Resets the Ca 2+ Dependence of Ca 2+ –Calmodulin Protein Kinase II and Promotes a Death Pathway Conserved Across Different Species

(2009) Julieta Palomeque et al.   CIRCULATION RESEARCH

Nitroxyl Activates SERCA in Cardiac Myocytes via Glutathiolation of Cysteine 674

(2009) Steve Lancel et al.   CIRCULATION RESEARCH

Inducible Expression of Active Protein Phosphatase-1 Inhibitor-1 Enhances Basal Cardiac Function and Protects Against Ischemia/Reperfusion Injury

(2009) Persoulla Nicolaou et al.   CIRCULATION RESEARCH

S-Nitrosylation of Cardiac Ion Channels

(2009) Daniel R Gonzalez et al.   JOURNAL OF CARDIOVASCULAR PHARMACOLOGY

Role of protein phosphatase-1 inhibitor-1 in cardiac physiology and pathophysiology

(2009) Persoulla Nicolaou et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Coordinated Movement of Cytoplasmic and Transmembrane Domains of RyR1 upon Gating

(2009) Montserrat Samsó et al.   PLOS BIOLOGY

Diabetic Cardiomyopathy: Insights into Pathogenesis, Diagnostic Challenges, and Therapeutic Options

(2008) Ashish Aneja et al.   AMERICAN JOURNAL OF MEDICINE

Increased intracellular Ca2+ and SR Ca2+ load contribute to arrhythmias after acidosis in rat heart. Role of Ca2+/calmodulin-dependent protein kinase II

(2008) M. Said et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Is reduced SERCA2a expression detrimental or beneficial to postischemic cardiac function and injury? Evidence from heterozygous SERCA2a knockout mice

(2008) M. A. Hassan Talukder et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Ryanodine receptor phosphorylation at Serine 2030, 2808 and 2814 in rat cardiomyocytes

(2008) Sabine Huke et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Phospholamban Thiols Play a Central Role in Activation of the Cardiac Muscle Sarcoplasmic Reticulum Calcium Pump by Nitroxyl†

(2008) Jeffrey P. Froehlich et al.   BIOCHEMISTRY

Regulation of the Cardiac Muscle Ryanodine Receptor by O2Tension andS-Nitrosoglutathione†

(2008) Junhui Sun et al.   BIOCHEMISTRY

Adrenergic Regulation of Cardiac Contractility Does Not Involve Phosphorylation of the Cardiac Ryanodine Receptor at Serine 2808

(2008) Scott M. MacDonnell et al.   CIRCULATION RESEARCH

Burst Emergence of Intracellular Ca 2+ Waves Evokes Arrhythmogenic Oscillatory Depolarization via the Na + –Ca 2+ Exchanger

(2008) Katsuji Fujiwara et al.   CIRCULATION RESEARCH

Redox Modification of Ryanodine Receptors Contributes to Sarcoplasmic Reticulum Ca 2+ Leak in Chronic Heart Failure

(2008) Dmitry Terentyev et al.   CIRCULATION RESEARCH

Sorcin modulates cardiac L-type Ca2+current by functional interaction with the α1Csubunit in rabbits

(2008) Mark R. Fowler et al.   EXPERIMENTAL PHYSIOLOGY

What role does modulation of the ryanodine receptor play in cardiac inotropy and arrhythmogenesis?

(2008) D.A. Eisner et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Ion Transport and Energetics During Cell Death and Protection

(2008) Elizabeth Murphy et al.   PHYSIOLOGY

Interplay between impaired calcium regulation and insulin signaling abnormalities in diabetic cardiomyopathy

(2008) Djamel Lebeche et al.   Nature clinical practice. Cardiovascular medicine