High resolution structural evidence suggests the Sarcoplasmic Reticulum forms microdomains with Acidic Stores (lysosomes) in the heart

Danon disease: a phenotypic expression of LAMP-2 deficiency

(2015) Yukari Endo et al.   ACTA NEUROPATHOLOGICA

Inhibition of NAADP signalling on reperfusion protects the heart by preventing lethal calcium oscillations via two-pore channel 1 and opening of the mitochondrial permeability transition pore

(2015) Sean M. Davidson et al.   CARDIOVASCULAR RESEARCH

Coupling acidic organelles with the ER through Ca2+ microdomains at membrane contact sites

(2015) Christopher J. Penny et al.   CELL CALCIUM

Two-pore Channels (TPC2s) and Nicotinic Acid Adenine Dinucleotide Phosphate (NAADP) at Lysosomal-Sarcoplasmic Reticular Junctions Contribute to Acute and Chronic β-Adrenoceptor Signaling in the Heart

(2015) Rebecca A. Capel et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Nicotinic Acid Adenine Dinucleotide Phosphate Analogues Substituted on the Nicotinic Acid and Adenine Ribosides. Effects on ReceptorMediated Ca2+ Release

(2015) Christopher J. Trabbic et al.   JOURNAL OF MEDICINAL CHEMISTRY

The mitochondrial permeability transition pore and its role in myocardial ischemia reperfusion injury

(2015) Sang-Bing Ong et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Lysosomal calcium signalling regulates autophagy through calcineurin and TFEB

(2015) Diego L. Medina et al.   NATURE CELL BIOLOGY

Two-pore channels control Ebola virus host cell entry and are drug targets for disease treatment

(2015) Yasuteru Sakurai et al.   SCIENCE

Frontrunners of T cell activation: Initial, localized Ca2+signals mediated by NAADP and the type 1 ryanodine receptor

(2015) Insa M. A. Wolf et al.   Science Signaling

Optimal microdomain crosstalk between endoplasmic reticulum and mitochondria for Ca2+ oscillations

(2015) Hong Qi et al.   Scientific Reports

Ca2+ Channel Re-localization to Plasma-Membrane Microdomains Strengthens Activation of Ca2+-Dependent Nuclear Gene Expression

(2015) Krishna Samanta et al.   Cell Reports

Frontrunners of T cell activation: Initial, localized Ca2+signals mediated by NAADP and the type 1 ryanodine receptor

(2015) Insa M. A. Wolf et al.   Science Signaling

Teaching the basics of autophagy and mitophagy to redox biologists—Mechanisms and experimental approaches

(2015) Jianhua Zhang   Redox Biology

Autophagosomes, phagosomes, autolysosomes, phagolysosomes, autophagolysosomes… Wait, I’m confused

(2014) Daniel J Klionsky et al.   Autophagy

NAADP-sensitive two-pore channels are present and functional in gastric smooth muscle cells

(2014) Gustavo J.S. Pereira et al.   CELL CALCIUM

A computational model of lysosome-ER Ca2+ microdomains

(2014) C. J. Penny et al.   JOURNAL OF CELL SCIENCE

High susceptibility to fatty liver disease in two-pore channel 2-deficient mice

(2014) Christian Grimm et al.   Nature Communications

The endoplasmic reticulum and junctional membrane communication during calcium signaling

(2013) Andy K.M. Lam et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Organization and function of membrane contact sites

(2013) Sebastian C.J. Helle et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Microarchitecture of the dyad

(2013) David R.L. Scriven et al.   CARDIOVASCULAR RESEARCH

Fast Measurement of Sarcomere Length and Cell Orientation in Langendorff-Perfused Hearts Using Remote Focusing Microscopy

(2013) Edward J. Botcherby et al.   CIRCULATION RESEARCH

Nicotinic Acid Adenine Dinucleotide Phosphate (NAADP)-mediated Calcium Signaling and Arrhythmias in the Heart Evoked by β-Adrenergic Stimulation

(2013) Merle Nebel et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Hypoxic pulmonary vasoconstriction in the absence of pretone: essential role for intracellular Ca2+release

(2013) Michelle J. Connolly et al.   JOURNAL OF PHYSIOLOGY-LONDON

ß-Adrenergic receptor signaling increases NAADP and cADPR levels in the heart

(2012) Alexander M. Lewis et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

NAADP Activates Two-Pore Channels on T Cell Cytolytic Granules to Stimulate Exocytosis and Killing

(2012) Lianne C. Davis et al.   CURRENT BIOLOGY

A Vesicular Transport Pathway Shuttles Cargo from Mitochondria to Lysosomes

(2012) Vincent Soubannier et al.   CURRENT BIOLOGY

Direct mobilisation of lysosomal Ca 2+ triggers complex Ca 2+ signals

(2012) Bethan S. Kilpatrick et al.   JOURNAL OF CELL SCIENCE

Lysosomes shape Ins(1,4,5) P 3 -evoked Ca 2+ signals by selectively sequestering Ca 2+ released from the endoplasmic reticulum

(2012) Cristina I. López-Sanjurjo et al.   JOURNAL OF CELL SCIENCE

Molecular mechanisms of endolysosomal Ca2+signalling in health and disease

(2011) Anthony J. Morgan et al.   BIOCHEMICAL JOURNAL

NAADP influences excitation–contraction coupling by releasing calcium from lysosomes in atrial myocytes

(2011) Thomas P. Collins et al.   CELL CALCIUM

NAADP mediates ATP-induced Ca2+signals in astrocytes

(2011) Miquel Barceló-Torns et al.   FEBS LETTERS

Transient Receptor Potential Mucolipin 1 (TRPML1) and Two-pore Channels Are Functionally Independent Organellar Ion Channels

(2011) Soichiro Yamaguchi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Nicotinic acid adenine dinucleotide phosphate-mediated calcium signalling in effector T cells regulates autoimmunity of the central nervous system

(2010) Chiara Cordiglieri et al.   BRAIN

An NAADP-gated Two-pore Channel Targeted to the Plasma Membrane Uncouples Triggering from Amplifying Ca2+Signals

(2010) Eugen Brailoiu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

TPC2 Is a Novel NAADP-sensitive Ca2+Release Channel, Operating as a Dual Sensor of Luminal pH and Ca2+

(2010) Samantha J. Pitt et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Characterization of Two-pore Channel 2 (TPCN2)-mediated Ca2+Currents in Isolated Lysosomes

(2010) Michael Schieder et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Calcium signaling via two-pore channels: local or global, that is the question

(2009) Michael X. Zhu et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Mitochondrial calcium and the permeability transition in cell death

(2009) John J. Lemasters et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

Analogues of the Nicotinic Acid Adenine Dinucleotide Phosphate (NAADP) Antagonist Ned-19 Indicate Two Binding Sites on the NAADP Receptor

(2009) Daniel Rosen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

NAADP mobilizes calcium from acidic organelles through two-pore channels

(2009) Peter J. Calcraft et al.   NATURE

Identification of a chemical probe for NAADP by virtual screening

(2009) Edmund Naylor et al.   Nature Chemical Biology

The two-pore channel TPCN2 mediates NAADP-dependent Ca2+-release from lysosomal stores

(2009) Xiangang Zong et al.   PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY

NAADP-mediated Ca2+ signaling via type 1 ryanodine receptor in T cells revealed by a synthetic NAADP antagonist

(2009) W. Dammermann et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Lysosomes co-localize with ryanodine receptor subtype 3 to form a trigger zone for calcium signalling by NAADP in rat pulmonary arterial smooth muscle

(2008) Nicholas P. Kinnear et al.   CELL CALCIUM

Fluorescent probes for super-resolution imaging in living cells

(2008) Marta Fernández-Suárez et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY