Ca2+-dependent calmodulin binding to cardiac ryanodine receptor (RyR2) calmodulin-binding domains

Ryanodine receptors under the magnifying lens: Insights and limitations of cryo-electron microscopy and X-ray crystallography studies

(2016) Zhiguang Yuchi et al.   CELL CALCIUM

Structural insights into Ca2+-activated long-range allosteric channel gating of RyR1

(2016) Risheng Wei et al.   CELL RESEARCH

The Central domain of RyR1 is the transducer for long-range allosteric gating of channel opening

(2016) Xiao-Chen Bai et al.   CELL RESEARCH

The emerging role of calmodulin regulation of RyR2 in controlling heart rhythm, the progression of heart failure and the antiarrhythmic action of dantrolene

(2016) Kafa Walweel et al.   CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY

The Arrhythmogenic Calmodulin p.Phe142Leu Mutation Impairs C-domain Ca2+Binding but Not Calmodulin-dependent Inhibition of the Cardiac Ryanodine Receptor

(2016) Mads Toft Søndergaard et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Current view on regulation of voltage-gated sodium channels by calcium and auxiliary proteins

(2016) Geoffrey S. Pitt et al.   PROTEIN SCIENCE

Structural basis for the gating mechanism of the type 2 ryanodine receptor RyR2

(2016) Wei Peng et al.   SCIENCE

Arrhythmogenic Calmodulin Mutations Affect the Activation and Termination of Cardiac Ryanodine Receptor-mediated Ca2+Release

(2015) Mads T. Søndergaard et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Ryanodine Receptors: Allosteric Ion Channel Giants

(2015) Filip Van Petegem   JOURNAL OF MOLECULAR BIOLOGY

Lobe-Specific Calmodulin Binding to Different Ryanodine Receptor Isoforms

(2014) Kelvin Lau et al.   BIOCHEMISTRY

Junctional Cleft [Ca 2+ ] i Measurements Using Novel Cleft-Targeted Ca 2+ Sensors

(2014) Sanda Despa et al.   CIRCULATION RESEARCH

Calmodulin regulation (calmodulation) of voltage-gated calcium channels

(2014) Manu Ben-Johny et al.   JOURNAL OF GENERAL PHYSIOLOGY

Structure of a mammalian ryanodine receptor

(2014) Ran Zalk et al.   NATURE

Structure of the rabbit ryanodine receptor RyR1 at near-atomic resolution

(2014) Zhen Yan et al.   NATURE

Architecture and conformational switch mechanism of the ryanodine receptor

(2014) Rouslan G. Efremov et al.   NATURE

Cardiac hypertrophy associated with impaired regulation of cardiac ryanodine receptor by calmodulin and S100A1

(2013) Naohiro Yamaguchi et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Calmodulin modulates the termination threshold for cardiac ryanodine receptor-mediated Ca2+release

(2013) Xixi Tian et al.   BIOCHEMICAL JOURNAL

Imaging Ca 2+ Nanosparks in Heart With a New Targeted Biosensor

(2013) Wei Shang et al.   CIRCULATION RESEARCH

Cardiac Myocyte Z-Line Calmodulin Is Mainly RyR2-Bound, and Reduction Is Arrhythmogenic and Occurs in Heart Failure

(2013) Yi Yang et al.   CIRCULATION RESEARCH

Calmodulin in a Heartbeat

(2013) Anders B. Sorensen et al.   FEBS Journal

Two potential calmodulin-binding sequences in the ryanodine receptor contribute to a mobile, intra-subunit calmodulin-binding domain

(2013) X. Huang et al.   JOURNAL OF CELL SCIENCE

Cardiac calcium signalling pathologies associated with defective calmodulin regulation of type 2 ryanodine receptor

(2013) Juan José Arnáiz-Cot et al.   JOURNAL OF PHYSIOLOGY-LONDON

Mutations in Calmodulin Cause Ventricular Tachycardia and Sudden Cardiac Death

(2012) Mette Nyegaard et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Seeing the Forest through the Trees: towards a Unified View on Physiological Calcium Regulation of Voltage-Gated Sodium Channels

(2012) Filip Van Petegem et al.   BIOPHYSICAL JOURNAL

Calmodulin-binding Locations on the Skeletal and Cardiac Ryanodine Receptors

(2012) Xiaojun Huang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Cardiac Sarcoplasmic Reticulum Calcium Leak: Basis and Roles in Cardiac Dysfunction

(2011) Donald M. Bers   Annual Review of Physiology

FRET Detection of Calmodulin Binding to the Cardiac RyR2 Calcium Release Channel

(2011) Tao Guo et al.   BIOPHYSICAL JOURNAL

Analysis of protein-ligand interactions by fluorescence polarization

(2011) Ana M Rossi et al.   Nature Protocols

Calcium Signaling in Cardiac Myocytes

(2011) C. J. Fearnley et al.   Cold Spring Harbor Perspectives in Biology

Site-specific modification of calmodulin Ca2+affinity tunes the skeletal muscle ryanodine receptor activation profile

(2010) Jie Jiang et al.   BIOCHEMICAL JOURNAL

A general strategy to characterize calmodulin–calcium complexes involved in CaM–target recognition: DAPK and EGFR calmodulin binding domains interact with different calmodulin–calcium complexes

(2010) Rania Dagher et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Intermolecular tuning of calmodulin by target peptides and proteins: Differential effects on Ca2+ binding and implications for kinase activation

(2010) Olve B. Peersen et al.   PROTEIN SCIENCE

FRET-based mapping of calmodulin bound to the RyR1 Ca2+ release channel

(2009) R. L. Cornea et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Calcium Cycling and Signaling in Cardiac Myocytes

(2007) Donald M. Bers   Annual Review of Physiology