mTORC1 controls lysosomal Ca2+release through the two-pore channel TPC2

Patch-clamp technique to characterize ion channels in enlarged individual endolysosomes

(2017) Cheng-Chang Chen et al.   Nature Protocols

Tuning the ion selectivity of two-pore channels

(2017) Jiangtao Guo et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Tetrandrine, an Activator of Autophagy, Induces Autophagic Cell Death via PKC-α Inhibition and mTOR-Dependent Mechanisms

(2017) Vincent Kam Wai Wong et al.   Frontiers in Pharmacology

Endolysosomal two-pore channels regulate autophagy in cardiomyocytes

(2016) Vanessa García-Rúa et al.   JOURNAL OF PHYSIOLOGY-LONDON

Expression of Ca2+-permeable two-pore channels rescues NAADP signalling in TPC-deficient cells

(2015) M. Ruas et al.   EMBO JOURNAL

Two-pore channels control Ebola virus host cell entry and are drug targets for disease treatment

(2015) Yasuteru Sakurai et al.   SCIENCE

Differential mechanisms of action of the mucolipin synthetic agonist, ML-SA1, on insect TRPML and mammalian TRPML1

(2014) Xinghua Feng et al.   CELL CALCIUM

Lysosomal Two-pore Channel Subtype 2 (TPC2) Regulates Skeletal Muscle Autophagic Signaling

(2014) Pei-Hui Lin et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

mTOR Regulates Lysosomal ATP-Sensitive Two-Pore Na+ Channels to Adapt to Metabolic State

(2013) Chunlei Cang et al.   CELL

Mammalian Target of Rapamycin Complex 2 (mTORC2) Coordinates Pulmonary Artery Smooth Muscle Cell Metabolism, Proliferation, and Survival in Pulmonary Arterial Hypertension

(2013) Dmitry A. Goncharov et al.   CIRCULATION

Bidirectional Ca2+signaling occurs between the endoplasmic reticulum and acidic organelles

(2013) Anthony J. Morgan et al.   JOURNAL OF CELL BIOLOGY

TPC Proteins Are Phosphoinositide- Activated Sodium-Selective Ion Channels in Endosomes and Lysosomes

(2012) Xiang Wang et al.   CELL

Membrane Potential Regulates Nicotinic Acid Adenine Dinucleotide Phosphate (NAADP) Dependence of the pH- and Ca2+-sensitive Organellar Two-pore Channel TPC1

(2012) Volodymyr Rybalchenko et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Cyclic Adenosine Diphosphate Ribose Activates Ryanodine Receptors, whereas NAADP Activates Two-pore Domain Channels

(2011) Oluseye A. Ogunbayo et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Photoaffinity Labeling of Nicotinic Acid Adenine Dinucleotide Phosphate (NAADP) Targets in Mammalian Cells

(2011) Yaping Lin-Moshier et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Purified TPC Isoforms Form NAADP Receptors with Distinct Roles for Ca2+ Signaling and Endolysosomal Trafficking

(2010) Margarida Ruas et al.   CURRENT BIOLOGY

Phosphatidylinositol 3,5-Bisphosphate (PI(3,5)P2) Potentiates Cardiac Contractility via Activation of the Ryanodine Receptor

(2010) Chad D. Touchberry et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

TPC2 Is a Novel NAADP-sensitive Ca2+Release Channel, Operating as a Dual Sensor of Luminal pH and Ca2+

(2010) Samantha J. Pitt et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Characterization of Two-pore Channel 2 (TPCN2)-mediated Ca2+Currents in Isolated Lysosomes

(2010) Michael Schieder et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Calcium signaling via two-pore channels: local or global, that is the question

(2009) Michael X. Zhu et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

NAADP mobilizes calcium from acidic organelles through two-pore channels

(2009) Peter J. Calcraft et al.   NATURE

The two-pore channel TPCN2 mediates NAADP-dependent Ca2+-release from lysosomal stores

(2009) Xiangang Zong et al.   PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY

Lysosomes co-localize with ryanodine receptor subtype 3 to form a trigger zone for calcium signalling by NAADP in rat pulmonary arterial smooth muscle

(2008) Nicholas P. Kinnear et al.   CELL CALCIUM

The type IV mucolipidosis-associated protein TRPML1 is an endolysosomal iron release channel

(2008) Xian-Ping Dong et al.   NATURE