Intracellular calcium release channels: an update

Physiology and pathophysiology of excitation–contraction coupling: the functional role of ryanodine receptor

(2017) Gaetano Santulli et al.   JOURNAL OF MUSCLE RESEARCH AND CELL MOTILITY

IP3-mediated gating mechanism of the IP3receptor revealed by mutagenesis and X-ray crystallography

(2017) Kozo Hamada et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Modeling analysis of inositol 1,4,5-trisphosphate receptor-mediated Ca2+ mobilization under the control of glucagon-like peptide-1 in mouse pancreatic β-cells

(2016) Yukari Takeda et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Structural Basis for Gating and Activation of RyR1

(2016) Amédée des Georges et al.   CELL

Leaky ryanodine receptors contribute to diaphragmatic weakness during mechanical ventilation

(2016) Stefan Matecki et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Maintenance of normal blood pressure is dependent on IP3R1-mediated regulation of eNOS

(2016) Qi Yuan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Junctophilin 3 expresses in pancreatic beta cells and is required for glucose-stimulated insulin secretion

(2016) L Li et al.   Cell Death & Disease

Novel Observations From Next-Generation RNA Sequencing of Highly Purified Human Adult and Fetal Islet Cell Subsets

(2015) David M. Blodgett et al.   DIABETES

Calcium release channel RyR2 regulates insulin release and glucose homeostasis

(2015) Gaetano Santulli et al.   JOURNAL OF CLINICAL INVESTIGATION

R4496C RyR2 mutation impairs atrial and ventricular contractility

(2015) Cecilia Ferrantini et al.   JOURNAL OF GENERAL PHYSIOLOGY

Gating machinery of InsP3R channels revealed by electron cryomicroscopy

(2015) Guizhen Fan et al.   NATURE

Glucose-Dependent Insulin Secretion in Pancreatic β-Cell Islets from Male Rats Requires Ca2+ Release via ROS-Stimulated Ryanodine Receptors

(2015) Paola Llanos et al.   PLoS One

Mitochondrial calcium overload is a key determinant in heart failure

(2015) Gaetano Santulli et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mitochondrial oxidative stress promotes atrial fibrillation

(2015) Wenjun Xie et al.   Scientific Reports

Essential Roles of Intracellular Calcium Release Channels in Muscle, Brain, Metabolism, and Aging

(2015) Gaetano Santulli et al.   Current Molecular Pharmacology

Abolished InsP3R2 function inhibits sweat secretion in both humans and mice

(2014) Joakim Klar et al.   JOURNAL OF CLINICAL INVESTIGATION

Impact of detubulation on force and kinetics of cardiac muscle contraction

(2014) Cecilia Ferrantini et al.   JOURNAL OF GENERAL PHYSIOLOGY

Structure of a mammalian ryanodine receptor

(2014) Ran Zalk et al.   NATURE

The ryanodine receptor store-sensing gate controls Ca2+ waves and Ca2+-triggered arrhythmias

(2014) Wenqian Chen et al.   NATURE MEDICINE

Calcineurin inhibitors and hypertension: a role for pharmacogenetics?

(2014) Arthur D Moes et al.   PHARMACOGENOMICS

Genetically enhancing mitochondrial antioxidant activity improves muscle function in aging

(2014) Alisa Umanskaya et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Functional Role of Calstabin2 in Age-related Cardiac Alterations

(2014) Qi Yuan et al.   Scientific Reports

Phospholipase Cε Hydrolyzes Perinuclear Phosphatidylinositol 4-Phosphate to Regulate Cardiac Hypertrophy

(2013) Lianghui Zhang et al.   CELL

The transverse-axial tubular system of cardiomyocytes

(2013) C. Ferrantini et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Imaging atrial arrhythmic intracellular calcium in intact heart

(2013) Wenjun Xie et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Tailoring mTOR-based therapy: molecular evidence and clinical challenges

(2013) Gaetano Santulli et al.   PHARMACOGENOMICS

Role of Leaky Neuronal Ryanodine Receptors in Stress- Induced Cognitive Dysfunction

(2012) Xiaoping Liu et al.   CELL

Age-Related Impairment in Insulin Release: The Essential Role of  2-Adrenergic Receptor

(2012) G. Santulli et al.   DIABETES

Leaky ryanodine receptors in β-sarcoglycan deficient mice: a potential common defect in muscular dystrophy

(2012) Daniel C Andersson et al.   Skeletal Muscle

Ryanodine Receptor Oxidation Causes Intracellular Calcium Leak and Muscle Weakness in Aging

(2011) Daniel C. Andersson et al.   Cell Metabolism

Meta-Analysis of Calcineurin-Inhibitor-Sparing Regimens in Kidney Transplantation

(2011) A. Sharif et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Role of chronic ryanodine receptor phosphorylation in heart failure and β-adrenergic receptor blockade in mice

(2010) Jian Shan et al.   JOURNAL OF CLINICAL INVESTIGATION

Phosphorylation of the ryanodine receptor mediates the cardiac fight or flight response in mice

(2010) Jian Shan et al.   JOURNAL OF CLINICAL INVESTIGATION

IP3-dependent, post-tetanic calcium transients induced by electrostimulation of adult skeletal muscle fibers

(2010) Mariana Casas et al.   JOURNAL OF GENERAL PHYSIOLOGY

Role of CaMKII  phosphorylation of the cardiac ryanodine receptor in the force frequency relationship and heart failure

(2010) A. Kushnir et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Leaky RyR2 trigger ventricular arrhythmias in Duchenne muscular dystrophy

(2010) J. Fauconnier et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Extracellular ATP-induced nuclear Ca2+ transient is mediated by inositol 1,4,5-trisphosphate receptors in mouse pancreatic β-cells

(2009) Zheng Chen et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Hypernitrosylated ryanodine receptor calcium release channels are leaky in dystrophic muscle

(2009) Andrew M Bellinger et al.   NATURE MEDICINE

FKBP12.6 disruption impairs glucose-induced insulin secretion

(2008) Naoya Noguchi et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Roles of IP3R and RyR Ca2+ Channels in Endoplasmic Reticulum Stress and  -Cell Death

(2008) D. S. Luciani et al.   DIABETES

Ryanodine receptor and calsequestrin in arrhythmogenesis: What we have learnt from genetic diseases and transgenic mice

(2008) Nian Liu et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Remodeling of ryanodine receptor complex causes "leaky" channels: A molecular mechanism for decreased exercise capacity

(2008) A. M. Bellinger et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA