The arrhythmogenic N53I variant subtly changes the structure and dynamics in the calmodulin N-terminal domain, altering its interaction with the cardiac ryanodine receptor

Arrhythmia mutations in calmodulin can disrupt cooperativity of Ca 2+ binding and cause misfolding

(2020) Kaiqian Wang et al.   JOURNAL OF PHYSIOLOGY-LONDON

Calmodulin mutations and life-threatening cardiac arrhythmias: insights from the International Calmodulinopathy Registry

(2019) Lia Crotti et al.   EUROPEAN HEART JOURNAL

Modulation of cardiac ryanodine receptor 2 by calmodulin

(2019) Deshun Gong et al.   NATURE

Role of cardiac ryanodine receptor calmodulin‐binding domains in mediating the action of arrhythmogenic calmodulin N‐domain mutation N54I

(2019) Mads T. Søndergaard et al.   FEBS Journal

Gene Transfer of Engineered Calmodulin Alleviates Ventricular Arrhythmias in a Calsequestrin‐Associated Mouse Model of Catecholaminergic Polymorphic Ventricular Tachycardia

(2018) Bin Liu et al.   Journal of the American Heart Association

Ca2+-dependent calmodulin binding to cardiac ryanodine receptor (RyR2) calmodulin-binding domains

(2018) Malene Brohus et al.   BIOCHEMICAL JOURNAL

Arrhythmia mutations in calmodulin cause conformational changes that affect interactions with the cardiac voltage-gated calcium channel

(2018) Kaiqian Wang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Novel CPVT-Associated Calmodulin Mutation inCALM3(CALM3-A103V) Activates Arrhythmogenic Ca Waves and Sparks

(2016) Nieves Gomez-Hurtado et al.   Circulation-Arrhythmia and Electrophysiology

Spectrum and Prevalence ofCALM1-,CALM2-, andCALM3-Encoded Calmodulin Variants in Long QT Syndrome and Functional Characterization of a Novel Long QT Syndrome–Associated Calmodulin Missense Variant, E141GCLINICAL PERSPECTIVE

(2016) Nicole J. Boczek et al.   Circulation-Cardiovascular Genetics

The Arrhythmogenic Calmodulin p.Phe142Leu Mutation Impairs C-domain Ca2+Binding but Not Calmodulin-dependent Inhibition of the Cardiac Ryanodine Receptor

(2016) Mads Toft Søndergaard et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Spectrum and Prevalence ofCALM1-,CALM2-, andCALM3-Encoded Calmodulin Variants in Long QT Syndrome and Functional Characterization of a Novel Long QT Syndrome–Associated Calmodulin Missense Variant, E141GCLINICAL PERSPECTIVE

(2016) Nicole J. Boczek et al.   Circulation-Cardiovascular Genetics

Distinctive malfunctions of calmodulin mutations associated with heart RyR2-mediated arrhythmic disease

(2015) Vyronia Vassilakopoulou et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Calmodulin mutations causing catecholaminergic polymorphic ventricular tachycardia confer opposing functional and biophysical molecular changes

(2015) Mads T. Søndergaard et al.   FEBS Journal

Arrhythmogenic Calmodulin Mutations Affect the Activation and Termination of Cardiac Ryanodine Receptor-mediated Ca2+Release

(2015) Mads T. Søndergaard et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Combined automated NOE assignment and structure calculation with CYANA

(2015) Peter Güntert et al.   JOURNAL OF BIOMOLECULAR NMR

Lobe-Specific Calmodulin Binding to Different Ryanodine Receptor Isoforms

(2014) Kelvin Lau et al.   BIOCHEMISTRY

Conservation of Ca2+/Calmodulin Regulation across Na and Ca2+ Channels

(2014) Manu Ben-Johny et al.   CELL

Divergent Regulation of Ryanodine Receptor 2 Calcium Release Channels by Arrhythmogenic Human Calmodulin Missense Mutants

(2014) Hyun Seok Hwang et al.   CIRCULATION RESEARCH

Novel Calmodulin Mutations Associated With Congenital Arrhythmia Susceptibility

(2014) N. Makita et al.   Circulation-Cardiovascular Genetics

Calmodulin regulation (calmodulation) of voltage-gated calcium channels

(2014) Manu Ben-Johny et al.   JOURNAL OF GENERAL PHYSIOLOGY

Calmodulin mutations associated with long QT syndrome prevent inactivation of cardiac L-type Ca2+ currents and promote proarrhythmic behavior in ventricular myocytes

(2014) Worawan B. Limpitikul et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Crystal structures of wild type and disease mutant forms of the ryanodine receptor SPRY2 domain

(2014) Kelvin Lau et al.   Nature Communications

Arrhythmogenic Calmodulin Mutations Disrupt Intracellular Cardiomyocyte Ca 2+ Regulation by Distinct Mechanisms

(2014) Guo Yin et al.   Journal of the American Heart Association

Calmodulin modulates the termination threshold for cardiac ryanodine receptor-mediated Ca2+release

(2013) Xixi Tian et al.   BIOCHEMICAL JOURNAL

Calmodulin Mutations Associated With Recurrent Cardiac Arrest in Infants

(2013) Lia Crotti et al.   CIRCULATION

Calmodulin in a Heartbeat

(2013) Anders B. Sorensen et al.   FEBS Journal

Structural diversity of calmodulin binding to its target sites

(2013) Henning Tidow et al.   FEBS Journal

A Mutation in CALM1 Encoding Calmodulin in Familial Idiopathic Ventricular Fibrillation in Childhood and Adolescence

(2013) Roos F. Marsman et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Mutations in Calmodulin Cause Ventricular Tachycardia and Sudden Cardiac Death

(2012) Mette Nyegaard et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Crystallographic basis for calcium regulation of sodium channels

(2012) M. F. Sarhan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Disease Mutations in the Ryanodine Receptor Central Region: Crystal Structures of a Phosphorylation Hot Spot Domain

(2012) Zhiguang Yuchi et al.   STRUCTURE

Modelling dynamics in protein crystal structures by ensemble refinement

(2012) B Tom Burnley et al.   eLife

Inherited Dysfunction of Sarcoplasmic Reticulum Ca 2+ Handling and Arrhythmogenesis

(2011) Silvia G. Priori et al.   CIRCULATION RESEARCH

XDS

(2010) Wolfgang Kabsch   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Features and development ofCoot

(2010) P. Emsley et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

PHENIX: a comprehensive Python-based system for macromolecular structure solution

(2010) Paul D. Adams et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

TALOS+: a hybrid method for predicting protein backbone torsion angles from NMR chemical shifts

(2009) Yang Shen et al.   JOURNAL OF BIOMOLECULAR NMR

Improving physical realism, stereochemistry, and side-chain accuracy in homology modeling: Four approaches that performed well in CASP8

(2009) Elmar Krieger et al.   PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS