Targeting pathological leak of ryanodine receptors: preclinical progress and the potential impact on treatments for cardiac arrhythmias and heart failure
Published 2019 View Full Article
- Home
- Publications
- Publication Search
- Publication Details
Title
Targeting pathological leak of ryanodine receptors: preclinical progress and the potential impact on treatments for cardiac arrhythmias and heart failure
Authors
Keywords
-
Journal
EXPERT OPINION ON THERAPEUTIC TARGETS
Volume 24, Issue 1, Pages 25-36
Publisher
Informa UK Limited
Online
2019-12-24
DOI
10.1080/14728222.2020.1708326
References
Ask authors/readers for more resources
Related references
Note: Only part of the references are listed.- Unnatural verticilide enantiomer inhibits type 2 ryanodine receptor-mediated calcium leak and is antiarrhythmic
- (2019) Suzanne M. Batiste et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Gene Therapy for Catecholaminergic Polymorphic Ventricular Tachycardia by Inhibition of Ca 2+ /Calmodulin-Dependent Kinase II
- (2019) Vassilios J. Bezzerides et al. CIRCULATION
- Ryanodine receptor dysfunction in human disorders
- (2018) Alexander Kushnir et al. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH
- Enhanced Cardiomyocyte NLRP3 Inflammasome Signaling Promotes Atrial Fibrillation
- (2018) Chunxia Yao et al. CIRCULATION
- EL20, a potent antiarrhythmic compound, selectively inhibits calmodulin-deficient ryanodine receptor type 2
- (2018) Robert C. Klipp et al. HEART RHYTHM
- Myocardial Interstitial Fibrosis in Heart Failure
- (2018) Arantxa González et al. JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
- Activation of RyR2 by class I kinase inhibitors
- (2018) A D Chakraborty et al. BRITISH JOURNAL OF PHARMACOLOGY
- Non-β-Blocking Carvedilol Analog, VK-II-86, Prevents Ouabain-Induced Cardiotoxicity
- (2018) Luis A. Gonano et al. CIRCULATION JOURNAL
- Calcium in the Pathophysiology of Atrial Fibrillation and Heart Failure
- (2018) Nathan C. Denham et al. Frontiers in Physiology
- Treatment of catecholaminergic polymorphic ventricular tachycardia in mice using novel RyR2-modifying drugs
- (2017) Na Li et al. INTERNATIONAL JOURNAL OF CARDIOLOGY
- The structural basis of ryanodine receptor ion channel function
- (2017) Gerhard Meissner JOURNAL OF GENERAL PHYSIOLOGY
- Serine/Threonine Phosphatases in Atrial Fibrillation
- (2017) Jordi Heijman et al. JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY
- Calcium-mediated cellular triggered activity in atrial fibrillation
- (2017) Dobromir Dobrev et al. JOURNAL OF PHYSIOLOGY-LONDON
- SPEG (Striated Muscle Preferentially Expressed Protein Kinase) Is Essential for Cardiac Function by Regulating Junctional Membrane Complex ActivityNovelty and Significance
- (2016) Ann P. Quick et al. CIRCULATION RESEARCH
- The emerging role of calmodulin regulation of RyR2 in controlling heart rhythm, the progression of heart failure and the antiarrhythmic action of dantrolene
- (2016) Kafa Walweel et al. CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY
- Patient-Specific Human Induced Pluripotent Stem Cell Model Assessed with Electrical Pacing Validates S107 as a Potential Therapeutic Agent for Catecholaminergic Polymorphic Ventricular Tachycardia
- (2016) Kenichi Sasaki et al. PLoS One
- Identification of microRNA–mRNA dysregulations in paroxysmal atrial fibrillation
- (2015) David Y. Chiang et al. INTERNATIONAL JOURNAL OF CARDIOLOGY
- In silicoprediction of drug therapy in catecholaminergic polymorphic ventricular tachycardia
- (2015) Pei-Chi Yang et al. JOURNAL OF PHYSIOLOGY-LONDON
- Antiarrhythmic Effects of Dantrolene in Patients with Catecholaminergic Polymorphic Ventricular Tachycardia and Replication of the Responses Using iPSC Models
- (2015) Kirsi Penttinen et al. PLoS One
- Channel Activity of Cardiac Ryanodine Receptors (RyR2) Determines Potency and Efficacy of Flecainide and R-Propafenone against Arrhythmogenic Calcium Waves in Ventricular Cardiomyocytes
- (2015) Eleonora Savio-Galimberti et al. PLoS One
- Role of RyR2 Phosphorylation in Heart Failure and Arrhythmias
- (2014) Dobromir Dobrev et al. CIRCULATION RESEARCH
- Suppression of Spontaneous Ca Elevations Prevents Atrial Fibrillation in Calsequestrin 2-Null Hearts
- (2014) Michela Faggioni et al. Circulation-Arrhythmia and Electrophysiology
- Loss of MicroRNA-106b-25 Cluster Promotes Atrial Fibrillation by Enhancing Ryanodine Receptor Type-2 Expression and Calcium Release
- (2014) David Y. Chiang et al. Circulation-Arrhythmia and Electrophysiology
- Oxidation- and CaMKII-Mediated Sarcoplasmic Reticulum Ca2+Leak Triggers Atrial Fibrillation in Aging
- (2014) XIAOXIAO GUO et al. JOURNAL OF CARDIOVASCULAR ELECTROPHYSIOLOGY
- Structure of a mammalian ryanodine receptor
- (2014) Ran Zalk et al. NATURE
- Structure of the rabbit ryanodine receptor RyR1 at near-atomic resolution
- (2014) Zhen Yan et al. NATURE
- Calcium dysregulation in atrial fibrillation: the role of CaMKII
- (2014) Jordi Heijman et al. Frontiers in Pharmacology
- Triple mode of action of flecainide in catecholaminergic polymorphic ventricular tachycardia
- (2013) D. S. Steele et al. CARDIOVASCULAR RESEARCH
- Triple mode of action of flecainide in catecholaminergic polymorphic ventricular tachycardia: reply
- (2013) M. B. Sikkel et al. CARDIOVASCULAR RESEARCH
- Flecainide reduces Ca2+ spark and wave frequency via inhibition of the sarcolemmal sodium current
- (2013) Markus B. Sikkel et al. CARDIOVASCULAR RESEARCH
- Cellular and Molecular Mechanisms of Atrial Arrhythmogenesis in Patients With Paroxysmal Atrial Fibrillation
- (2013) Niels Voigt et al. CIRCULATION
- Mechanisms of Altered Ca 2+ Handling in Heart Failure
- (2013) Min Luo et al. CIRCULATION RESEARCH
- Calcium cycling proteins and heart failure: mechanisms and therapeutics
- (2013) Andrew R. Marks JOURNAL OF CLINICAL INVESTIGATION
- Mutation E169K in Junctophilin-2 Causes Atrial Fibrillation Due to Impaired RyR2 Stabilization
- (2013) David L. Beavers et al. JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
- Mutations in Calmodulin Cause Ventricular Tachycardia and Sudden Cardiac Death
- (2012) Mette Nyegaard et al. AMERICAN JOURNAL OF HUMAN GENETICS
- JTV519 (K201) reduces sarcoplasmic reticulum Ca2+leak and improves diastolic functionin vitroin murine and human non-failing myocardium
- (2012) M Sacherer et al. BRITISH JOURNAL OF PHARMACOLOGY
- Enhanced Sarcoplasmic Reticulum Ca 2+ Leak and Increased Na + -Ca 2+ Exchanger Function Underlie Delayed Afterdepolarizations in Patients With Chronic Atrial Fibrillation
- (2012) Niels Voigt et al. CIRCULATION
- Calcium Leak Through Ryanodine Receptors Leads to Atrial Fibrillation in 3 Mouse Models of Catecholaminergic Polymorphic Ventricular Tachycardia
- (2012) Jian Shan et al. CIRCULATION RESEARCH
- Role of RyR2 Phosphorylation at S2814 During Heart Failure Progression
- (2012) Jonathan L. Respress et al. CIRCULATION RESEARCH
- Ryanodine receptor inhibition potentiates the activity of Na channel blockers against spontaneous calcium elevations and delayed afterdepolarizations in Langendorff-perfused rabbit ventricles
- (2012) Young Soo Lee et al. HEART RHYTHM
- Dantrolene prevents arrhythmogenic Ca2+ release in heart failure
- (2011) Joshua T. Maxwell et al. AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
- Disrupted Junctional Membrane Complexes and Hyperactive Ryanodine Receptors After Acute Junctophilin Knockdown in Mice
- (2011) Ralph J. van Oort et al. CIRCULATION
- Inherited Dysfunction of Sarcoplasmic Reticulum Ca 2+ Handling and Arrhythmogenesis
- (2011) Silvia G. Priori et al. CIRCULATION RESEARCH
- Inhibition of Cardiac Ca 2+ Release Channels (RyR2) Determines Efficacy of Class I Antiarrhythmic Drugs in Catecholaminergic Polymorphic Ventricular Tachycardia
- (2011) Hyun Seok Hwang et al. Circulation-Arrhythmia and Electrophysiology
- Dantrolene rescues arrhythmogenic RYR2 defect in a patient-specific stem cell model of catecholaminergic polymorphic ventricular tachycardia
- (2011) Christian B. Jung et al. EMBO Molecular Medicine
- Efficacy and potency of class I antiarrhythmic drugs for suppression of Ca2+ waves in permeabilized myocytes lacking calsequestrin
- (2011) Eleonora Savio Galimberti et al. JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY
- Flecainide Therapy Reduces Exercise-Induced Ventricular Arrhythmias in Patients With Catecholaminergic Polymorphic Ventricular Tachycardia
- (2011) Christian van der Werf et al. JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
- Carvedilol and its new analogs suppress arrhythmogenic store overload–induced Ca2+ release
- (2011) Qiang Zhou et al. NATURE MEDICINE
- Defective calmodulin binding to the cardiac ryanodine receptor plays a key role in CPVT-associated channel dysfunction
- (2010) Xiaojuan Xu et al. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
- Ryanodine Receptor Phosphorylation by Calcium/Calmodulin-Dependent Protein Kinase II Promotes Life-Threatening Ventricular Arrhythmias in Mice With Heart Failure
- (2010) Ralph J. van Oort et al. CIRCULATION
- Dantrolene, a Therapeutic Agent for Malignant Hyperthermia, Inhibits Catecholaminergic Polymorphic Ventricular Tachycardia in a RyR2R2474S/+ Knock-In Mouse Model
- (2010) Shigeki Kobayashi et al. CIRCULATION JOURNAL
- Ryanodine receptor mutations in arrhythmia: The continuing mystery of channel dysfunction
- (2010) N. Lowri Thomas et al. FEBS LETTERS
- Purkinje cell calcium dysregulation is the cellular mechanism that underlies catecholaminergic polymorphic ventricular tachycardia
- (2010) Todd J. Herron et al. HEART RHYTHM
- ImpairedS-Nitrosylation of the Ryanodine Receptor Caused by Xanthine Oxidase Activity Contributes to Calcium Leak in Heart Failure
- (2010) Daniel R. Gonzalez et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Role of chronic ryanodine receptor phosphorylation in heart failure and β-adrenergic receptor blockade in mice
- (2010) Jian Shan et al. JOURNAL OF CLINICAL INVESTIGATION
- Phosphorylation of the ryanodine receptor mediates the cardiac fight or flight response in mice
- (2010) Jian Shan et al. JOURNAL OF CLINICAL INVESTIGATION
- K201 improves aspects of the contractile performance of human failing myocardium via reduction in Ca2+ leak from the sarcoplasmic reticulum
- (2009) Karl Toischer et al. BASIC RESEARCH IN CARDIOLOGY
- Flecainide inhibits arrhythmogenic Ca2+ waves by open state block of ryanodine receptor Ca2+ release channels and reduction of Ca2+ spark mass
- (2009) Fredrick A. Hilliard et al. JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY
- Dantrolene, a Therapeutic Agent for Malignant Hyperthermia, Markedly Improves the Function of Failing Cardiomyocytes by Stabilizing Interdomain Interactions Within the Ryanodine Receptor
- (2009) Shigeki Kobayashi et al. JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
- Flecainide prevents catecholaminergic polymorphic ventricular tachycardia in mice and humans
- (2009) Hiroshi Watanabe et al. NATURE MEDICINE
- Defective domain-domain interactions within the ryanodine receptor as a critical cause of diastolic Ca2+ leak in failing hearts
- (2008) H. Tateishi et al. CARDIOVASCULAR RESEARCH
- Identification of Target Domains of the Cardiac Ryanodine Receptor to Correct Channel Disorder in Failing Hearts
- (2008) Takeshi Yamamoto et al. CIRCULATION
- Adrenergic Regulation of Cardiac Contractility Does Not Involve Phosphorylation of the Cardiac Ryanodine Receptor at Serine 2808
- (2008) Scott M. MacDonnell et al. CIRCULATION RESEARCH
- Redox Modification of Ryanodine Receptors Contributes to Sarcoplasmic Reticulum Ca 2+ Leak in Chronic Heart Failure
- (2008) Dmitry Terentyev et al. CIRCULATION RESEARCH
- Remodeling of ryanodine receptor complex causes "leaky" channels: A molecular mechanism for decreased exercise capacity
- (2008) A. M. Bellinger et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
Create your own webinar
Interested in hosting your own webinar? Check the schedule and propose your idea to the Peeref Content Team.
Create NowBecome a Peeref-certified reviewer
The Peeref Institute provides free reviewer training that teaches the core competencies of the academic peer review process.
Get Started