The effect of statins on RyR and RyR-associated disease

Identification of a Novel Homozygous Multi-Exon Duplication in RYR2 Among Children With Exertion-Related Unexplained Sudden Deaths in the Amish Community

(2020) David J. Tester et al.   JAMA Cardiology

Molecular characterization of the calcium release channel deficiency syndrome

(2020) David J. Tester et al.   JCI Insight

A compound heterozygosity of Tecrl gene confirmed in a catecholaminergic polymorphic ventricular tachycardia family

(2019) Lijian Xie et al.   European Journal of Medical Genetics

Extraocular muscle function is impaired in ryr3−/− mice

(2019) Jan Eckhardt et al.   JOURNAL OF GENERAL PHYSIOLOGY

Statin therapy is associated with improved survival in patients with ventricular tachyarrhythmias

(2019) Jonas Rusnak et al.   Lipids in Health and Disease

Insights Into the Pathogenesis of Catecholaminergic Polymorphic Ventricular Tachycardia From Engineered Human Heart Tissue

(2019) Sung-Jin Park et al.   CIRCULATION

Implantable cardioverter-defibrillators in previously undiagnosed patients with catecholaminergic polymorphic ventricular tachycardia resuscitated from sudden cardiac arrest

(2019) Christian van der Werf et al.   EUROPEAN HEART JOURNAL

Ryanodine receptor dysfunction in human disorders

(2018) Alexander Kushnir et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Simvastatin activates single skeletal RyR1 channels but exerts more complex regulation of the cardiac RyR2 isoform

(2018) Elisa Venturi et al.   BRITISH JOURNAL OF PHARMACOLOGY

In Vivo Ryr 2 Editing Corrects Catecholaminergic Polymorphic Ventricular Tachycardia

(2018) Xiaolu Pan et al.   CIRCULATION RESEARCH

RYR1 and CACNA1S genetic variants identified with statin-associated muscle symptoms

(2018) Paul J Isackson et al.   PHARMACOGENOMICS

2017 AHA/ACC/HRS Guideline for Management of Patients With Ventricular Arrhythmias and the Prevention of Sudden Cardiac Death: Executive Summary

(2017) Sana M. Al-Khatib et al.   HEART RHYTHM

Ca 2+ handling abnormalities in early-onset muscle diseases: Novel concepts and perspectives

(2017) Susan Treves et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

TECRL , a new life‐threatening inherited arrhythmia gene associated with overlapping clinical features of both LQTS and CPVT

(2016) Harsha D Devalla et al.   EMBO Molecular Medicine

Clinical Challenges in Catecholaminergic Polymorphic Ventricular Tachycardia

(2016) Jacopo F. Imberti et al.   Heart Lung and Circulation

A novel heterozygous mutation in cardiac calsequestrin causes autosomal dominant catecholaminergic polymorphic ventricular tachycardia

(2016) Belinda Gray et al.   HEART RHYTHM

Bridging the myoplasmic gap II: more recent advances in skeletal muscle excitation–contraction coupling

(2016) Roger A. Bannister   JOURNAL OF EXPERIMENTAL BIOLOGY

Statin-Associated Side Effects

(2016) Paul D. Thompson et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

2015 ESC GUIDELINES FOR THE MANAGEMENT OF PATIENTS WITH VENTRICULAR ARRHYTHMIAS AND THE PREVENTION OF SUDDEN CARDIAC DEATH

(2016) Priori G. Silvia et al.   RUSSIAN JOURNAL OF CARDIOLOGY

Arrhythmogenic Calmodulin Mutations Affect the Activation and Termination of Cardiac Ryanodine Receptor-mediated Ca2+Release

(2015) Mads T. Søndergaard et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Inhibition of the mevalonate pathway ameliorates anoxia-induced down-regulation of FKBP12.6 and intracellular calcium handling dysfunction in H9c2 cells

(2015) Ying Yang et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Role of RyR2 Phosphorylation in Heart Failure and Arrhythmias

(2014) Dobromir Dobrev et al.   CIRCULATION RESEARCH

Efficacy of Implantable Cardioverter Defibrillators in Young Patients With Catecholaminergic Polymorphic Ventricular Tachycardia

(2013) Christina Y. Miyake et al.   Circulation-Arrhythmia and Electrophysiology

Exertional Heat Illness, Exertional Rhabdomyolysis, and Malignant Hyperthermia

(2013) Sheila Muldoon et al.   Current Sports Medicine Reports

HRS/EHRA/APHRS Expert Consensus Statement on the Diagnosis and Management of Patients with Inherited Primary Arrhythmia Syndromes

(2013) Silvia G. Priori et al.   HEART RHYTHM

Mutations in RYR1 are a common cause of exertional myalgia and rhabdomyolysis

(2013) N. Dlamini et al.   NEUROMUSCULAR DISORDERS

CaMKII inhibition rectifies arrhythmic phenotype in a patient-specific model of catecholaminergic polymorphic ventricular tachycardia

(2013) E Di Pasquale et al.   Cell Death & Disease

Stac3 is a component of the excitation–contraction coupling machinery and mutated in Native American myopathy

(2013) Eric J. Horstick et al.   Nature Communications

Mice with RyR1 mutation (Y524S) undergo hypermetabolic response to simvastatin

(2013) Mark Knoblauch et al.   Skeletal Muscle

Mutations in Calmodulin Cause Ventricular Tachycardia and Sudden Cardiac Death

(2012) Mette Nyegaard et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Functional interaction between calsequestrin and ryanodine receptor in the heart

(2012) Marta Gaburjakova et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Effect of Statins on Skeletal Muscle Function

(2012) Beth A. Parker et al.   CIRCULATION

Absence of triadin, a protein of the calcium release complex, is responsible for cardiac arrhythmia with sudden death in human

(2012) Nathalie Roux-Buisson et al.   HUMAN MOLECULAR GENETICS

Rosuvastatin-attenuated heart failure in aged spontaneously hypertensive ratsviaPKCα/β2 signal pathway

(2012) Zhaohui Qiu et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Malignant hyperthermia

(2012) O Bandschapp et al.   SWISS MEDICAL WEEKLY

Ryanodine Receptor Phosphorylation, Calcium/Calmodulin-Dependent Protein Kinase II, and Life-Threatening Ventricular Arrhythmias

(2012) Mark D. McCauley et al.   TRENDS IN CARDIOVASCULAR MEDICINE

Intravenous Epinephrine Infusion Test in Diagnosis of Catecholaminergic Polymorphic Ventricular Tachycardia

(2011) ANNUKKA MARJAMAA et al.   JOURNAL OF CARDIOVASCULAR ELECTROPHYSIOLOGY

Genetic risk for malignant hyperthermia in non-anesthesia-induced myopathies

(2011) Georgirene D. Vladutiu et al.   MOLECULAR GENETICS AND METABOLISM

The Effect of Statin Therapy on Ventricular Tachyarrhythmias: A Meta-Analysis

(2010) Nikolas Wanahita et al.   AMERICAN JOURNAL OF THERAPEUTICS

Statins Alter Intracellular Calcium Homeostasis in Malignant Hyperthermia Susceptible Individuals

(2010) T. Metterlein et al.   Cardiovascular Therapeutics

Ryanodine Receptor Phosphorylation by Calcium/Calmodulin-Dependent Protein Kinase II Promotes Life-Threatening Ventricular Arrhythmias in Mice With Heart Failure

(2010) Ralph J. van Oort et al.   CIRCULATION

Calmodulin kinase II inhibition prevents arrhythmias in RyR2R4496C+/− mice with catecholaminergic polymorphic ventricular tachycardia

(2010) Nian Liu et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Ryanodine Receptors: Structure, Expression, Molecular Details, and Function in Calcium Release

(2010) J. T. Lanner et al.   Cold Spring Harbor Perspectives in Biology

The Relationship Between Exertional Heat Illness, Exertional Rhabdomyolysis, and Malignant Hyperthermia

(2009) John F. Capacchione et al.   ANESTHESIA AND ANALGESIA

Exertional Rhabdomyolysis and Malignant Hyperthermia in a Patient with Ryanodine Receptor Type 1 Gene, L-type Calcium Channel α-1 Subunit Gene, and Calsequestrin-1 Gene Polymorphisms

(2009) John F. Capacchione et al.   ANESTHESIOLOGY

The role of CACNA1Sin predisposition to malignant hyperthermia

(2009) Danielle Carpenter et al.   BMC Medical Genetics

Association between statin-associated myopathy and skeletal muscle damage

(2009) M. G. Mohaupt et al.   CANADIAN MEDICAL ASSOCIATION JOURNAL

Incidence and Risk Factors of Arrhythmic Events in Catecholaminergic Polymorphic Ventricular Tachycardia

(2009) Meiso Hayashi et al.   CIRCULATION

The RYR2-Encoded Ryanodine Receptor/Calcium Release Channel in Patients Diagnosed Previously With Either Catecholaminergic Polymorphic Ventricular Tachycardia or Genotype Negative, Exercise-Induced Long QT Syndrome

(2009) Argelia Medeiros-Domingo et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Calcium-Induced Calcium Release in Skeletal Muscle

(2009) Makoto Endo   PHYSIOLOGICAL REVIEWS

RyR1 S-Nitrosylation Underlies Environmental Heat Stroke and Sudden Death in Y522S RyR1 Knockin Mice

(2008) William J. Durham et al.   CELL