Cardiac Pathophysiology and the Future of Cardiac Therapies in Duchenne Muscular Dystrophy

Acute AT1R blockade prevents isoproterenol-induced injury in mdx hearts

(2019) Tatyana A. Meyers et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Long-term evaluation of AAV-CRISPR genome editing for Duchenne muscular dystrophy

(2019) Christopher E. Nelson et al.   NATURE MEDICINE

The Role of Matrix Metalloproteinases and Tissue Inhibitors of Metalloproteinases in Duchenne Muscular Dystrophy Cardiomyopathy

(2019) Jonathan H et al.   JOURNAL OF CARDIAC FAILURE

Cardiomyocytes facing fibrotic conditions re-express extracellular matrix transcripts

(2019) Carlos O. Heras-Bautista et al.   Acta Biomaterialia

Life-Long AAV-Mediated CRISPR Genome Editing in Dystrophic Heart Improves Cardiomyopathy without Causing Serious Lesions in mdx Mice

(2019) Li Xu et al.   MOLECULAR THERAPY

Exon-skipping advances for Duchenne muscular dystrophy

(2018) Lucía Echevarría et al.   HUMAN MOLECULAR GENETICS

Diagnosis and management of Duchenne muscular dystrophy, part 3: primary care, emergency management, psychosocial care, and transitions of care across the lifespan

(2018) David J Birnkrant et al.   LANCET NEUROLOGY

Diagnosis and management of Duchenne muscular dystrophy, part 2: respiratory, cardiac, bone health, and orthopaedic management

(2018) David J Birnkrant et al.   LANCET NEUROLOGY

Regulation of fibrosis in muscular dystrophy

(2018) Lucas R. Smith et al.   MATRIX BIOLOGY

Defective Flux of Thrombospondin-4 through the Secretory Pathway Impairs Cardiomyocyte Membrane Stability and Causes Cardiomyopathy

(2018) Matthew J. Brody et al.   MOLECULAR AND CELLULAR BIOLOGY

Systemic AAV micro-dystrophin gene therapy for Duchenne muscular dystrophy

(2018) Dongsheng Duan   MOLECULAR THERAPY

ADVANCES IN THE DIAGNOSIS AND MANAGEMENT OF CARDIOMYOPATHY IN DUCHENNE MUSCULAR DYSTROPHY

(2018) Kan N. Hor et al.   NEUROMUSCULAR DISORDERS

Cardiac macrophage biology in the steady-state heart, the aging heart, and following myocardial infarction

(2018) Yonggang Ma et al.   Translational Research

NADPH oxidase mediates microtubule alterations and diaphragm dysfunction in dystrophic mice

(2018) James Anthony Loehr et al.   eLife

Gene editing restores dystrophin expression in a canine model of Duchenne muscular dystrophy

(2018) Leonela Amoasii et al.   SCIENCE

CRISPR Correction of Duchenne Muscular Dystrophy

(2018) Yi-Li Min et al.   Annual Review of Medicine

Loss of peroxiredoxin-2 exacerbates eccentric contraction-induced force loss in dystrophin-deficient muscle

(2018) John T. Olthoff et al.   Nature Communications

Muscle membrane integrity in Duchenne muscular dystrophy: recent advances in copolymer-based muscle membrane stabilizers

(2018) Evelyne M. Houang et al.   Skeletal Muscle

Off-Label Use of Ataluren in Four Non-ambulatory Patients With Nonsense Mutation Duchenne Muscular Dystrophy: Effects on Cardiac and Pulmonary Function and Muscle Strength

(2018) Daniel Ebrahimi-Fakhari et al.   Frontiers in Pediatrics

MG53 is dispensable for T-tubule maturation but critical for maintaining T-tubule integrity following cardiac stress

(2017) Caimei Zhang et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

All-Atom Molecular Dynamics-Based Analysis of Membrane-Stabilizing Copolymer Interactions with Lipid Bilayers Probed under Constant Surface Tensions

(2017) Evelyne M. Houang et al.   JOURNAL OF PHYSICAL CHEMISTRY B

Roles of Angiotensin Peptides and Recombinant Human ACE2 in Heart Failure

(2017) Ratnadeep Basu et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Progress toward Gene Therapy for Duchenne Muscular Dystrophy

(2017) Joel R. Chamberlain et al.   MOLECULAR THERAPY

Eplerenone for early cardiomyopathy in Duchenne muscular dystrophy: results of a two-year open-label extension trial

(2017) Subha V. Raman et al.   Orphanet Journal of Rare Diseases

AT1 receptor signaling pathways in the cardiovascular system

(2017) Tatsuo Kawai et al.   PHARMACOLOGICAL RESEARCH

Transient receptor potential channel 6 regulates abnormal cardiac S-nitrosylation in Duchenne muscular dystrophy

(2017) Heaseung Sophia Chung et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Effects of systemic multiexon skipping with peptide-conjugated morpholinos in the heart of a dog model of Duchenne muscular dystrophy

(2017) Yusuke Echigoya et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Single-cut genome editing restores dystrophin expression in a new mouse model of muscular dystrophy

(2017) Leonela Amoasii et al.   Science Translational Medicine

ACE inhibition to slow progression of myocardial fibrosis in muscular dystrophies

(2017) Vincenzo Russo et al.   TRENDS IN CARDIOVASCULAR MEDICINE

Reducing sarcolipin expression mitigates Duchenne muscular dystrophy and associated cardiomyopathy in mice

(2017) Antanina Voit et al.   Nature Communications

Predictors of Death in Adults With Duchenne Muscular Dystrophy–Associated Cardiomyopathy

(2017) Daniel Cheeran et al.   Journal of the American Heart Association

Dystrophic Cardiomyopathy—Potential Role of Calcium in Pathogenesis, Treatment and Novel Therapies

(2017) Victoria P. A. Johnstone et al.   Genes

A Five-Repeat Micro-Dystrophin Gene Ameliorated Dystrophic Phenotype in the Severe DBA/2J-mdx Model of Duchenne Muscular Dystrophy

(2017) Chady H. Hakim et al.   Molecular Therapy-Methods & Clinical Development

Hypoxia-induced cardiac injury in dystrophic mice

(2016) Zachary Stelter et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Longitudinal effect of eteplirsen versus historical control on ambulation in Duchenne muscular dystrophy

(2016) Jerry R. Mendell et al.   ANNALS OF NEUROLOGY

Duchenne Muscular Dystrophy Mice and Men

(2016) Jill A. Rafael-Fortney et al.   CIRCULATION RESEARCH

Angiotensin II type 2 receptor (AT2R) in renal and cardiovascular disease

(2016) B. S. M. Chow et al.   CLINICAL SCIENCE

Independent variability of microtubule perturbations associated with dystrophinopathy

(2016) Joseph J. Belanto et al.   HUMAN MOLECULAR GENETICS

Myeloid cells are capable of synthesizing aldosterone to exacerbate damage in muscular dystrophy

(2016) Jessica A. Chadwick et al.   HUMAN MOLECULAR GENETICS

Dystrophin-Deficient Cardiomyopathy

(2016) Forum Kamdar et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Angiotensin-Converting Enzyme Inhibitors or Angiotensin Receptor Blockers in Patients Without Heart Failure? Insights From 254,301 Patients From Randomized Trials

(2016) Sripal Bangalore et al.   MAYO CLINIC PROCEEDINGS

High-fidelity CRISPR–Cas9 nucleases with no detectable genome-wide off-target effects

(2016) Benjamin P. Kleinstiver et al.   NATURE

Absence of Dystrophin Disrupts Skeletal Muscle Signaling: Roles of Ca2+, Reactive Oxygen Species, and Nitric Oxide in the Development of Muscular Dystrophy

(2016) David G. Allen et al.   PHYSIOLOGICAL REVIEWS

Thrombospondin expression in myofibers stabilizes muscle membranes

(2016) Davy Vanhoutte et al.   eLife

Activation of Both the Calpain and Ubiquitin-Proteasome Systems Contributes to Septic Cardiomyopathy through Dystrophin Loss/Disruption and mTOR Inhibition

(2016) Ana Caroline Silva Freitas et al.   PLoS One

The Pathogenesis and Therapy of Muscular Dystrophies

(2015) Simon Guiraud et al.   Annual Review of Genomics and Human Genetics

Dystrophic cardiomyopathy: role of TRPV2 channels in stretch-induced cell damage

(2015) Charlotte Lorin et al.   CARDIOVASCULAR RESEARCH

Mitochondrial dysfunctions during progression of dystrophic cardiomyopathy

(2015) Victoria Kyrychenko et al.   CELL CALCIUM

Contemporary Cardiac Issues in Duchenne Muscular Dystrophy: Table.

(2015) Elizabeth M. McNally et al.   CIRCULATION

Role of Sodium and Calcium Dysregulation in Tachyarrhythmias in Sudden Cardiac Death

(2015) S. Wagner et al.   CIRCULATION RESEARCH

Pathophysiological role of oxidative stress in systolic and diastolic heart failure and its therapeutic implications

(2015) Thomas Münzel et al.   EUROPEAN HEART JOURNAL

The TREAT-NMD DMD Global Database: Analysis of More than 7,000 Duchenne Muscular Dystrophy Mutations

(2015) Catherine L. Bladen et al.   HUMAN MUTATION

Cognitive and Neurobehavioral Profile in Boys With Duchenne Muscular Dystrophy

(2015) Rudaina Banihani et al.   JOURNAL OF CHILD NEUROLOGY

Crosstalk between RyR2 oxidation and phosphorylation contributes to cardiac dysfunction in mice with Duchenne muscular dystrophy

(2015) Qiongling Wang et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Eplerenone for early cardiomyopathy in Duchenne muscular dystrophy: a randomised, double-blind, placebo-controlled trial

(2015) Subha V Raman et al.   LANCET NEUROLOGY

Chronic effects of losartan on the muscles and the serologic profiles of mdx mice

(2015) Eun-Mi Lee et al.   LIFE SCIENCES

Dystrophin–glycoprotein complex regulates muscle nitric oxide production through mechanoregulation of AMPK signaling

(2015) Joanne F. Garbincius et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Postnatal genome editing partially restores dystrophin expression in a mouse model of muscular dystrophy

(2015) C. Long et al.   SCIENCE

In vivo genome editing improves muscle function in a mouse model of Duchenne muscular dystrophy

(2015) C. E. Nelson et al.   SCIENCE

Glucocorticoid Therapy for Duchenne Cardiomyopathy: A Hobson's Choice?

(2015) Subha V. Raman et al.   Journal of the American Heart Association

Myocardial Fibrosis Burden Predicts Left Ventricular Ejection Fraction and Is Associated With Age and Steroid Treatment Duration in Duchenne Muscular Dystrophy

(2015) A. Tandon et al.   Journal of the American Heart Association

Membrane-stabilizing copolymers confer marked protection to dystrophic skeletal muscle in vivo

(2015) Evelyne M Houang et al.   Molecular Therapy-Methods & Clinical Development

Early Detection of Myocardial Bioenergetic Deficits: A 9.4 Tesla Complete Non Invasive 31P MR Spectroscopy Study in Mice with Muscular Dystrophy

(2015) Weina Cui et al.   PLoS One

NADPH oxidase-2 inhibition restores contractility and intracellular calcium handling and reduces arrhythmogenicity in dystrophic cardiomyopathy

(2014) Daniel R. Gonzalez et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Sildenafil does not improve cardiomyopathy in Duchenne/Becker muscular dystrophy

(2014) Doris G. Leung et al.   ANNALS OF NEUROLOGY

Dysregulation of calcium homeostasis in muscular dystrophies

(2014) Ainara Vallejo-Illarramendi et al.   EXPERT REVIEWS IN MOLECULAR MEDICINE

Becker muscular dystrophy severity is linked to the structure of dystrophin

(2014) Aurélie Nicolas et al.   HUMAN MOLECULAR GENETICS

Partial restoration of cardiac function with  PDZ nNOS in aged mdx model of Duchenne cardiomyopathy

(2014) Y. Lai et al.   HUMAN MOLECULAR GENETICS

Dystrobrevin increases dystrophin's binding to the dystrophin–glycoprotein complex and provides protection during cardiac stress

(2014) Jana Strakova et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Cooperative international neuromuscular research group duchenne natural history study demonstrates insufficient diagnosis and treatment of cardiomyopathy in duchenne muscular dystrophy

(2014) Christopher Spurney et al.   MUSCLE & NERVE

A systematic review and meta-analysis on the epidemiology of Duchenne and Becker muscular dystrophy

(2014) Jean K. Mah et al.   NEUROMUSCULAR DISORDERS

Prednisolone Attenuates Improvement of Cardiac and Skeletal Contractile Function and Histopathology by Lisinopril and Spironolactone in the mdx Mouse Model of Duchenne Muscular Dystrophy

(2014) Paul M. L. Janssen et al.   PLoS One

L-type Ca2+ channel contributes to alterations in mitochondrial calcium handling in the mdx ventricular myocyte

(2013) Helena M. Viola et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Enhanced currents through L-type calcium channels in cardiomyocytes disturb the electrophysiology of the dystrophic heart

(2013) Xaver Koenig et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

The pathogenesis of cardiac fibrosis

(2013) Ping Kong et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Non-ACE Pathway-induced Angiotensin II Production

(2013) Yoshinari Uehara et al.   CURRENT PHARMACEUTICAL DESIGN

VBP15, a novel anti-inflammatory and membrane-stabilizer, improves muscular dystrophy without side effects

(2013) Christopher R. Heier et al.   EMBO Molecular Medicine

Wasting mechanisms in muscular dystrophy

(2013) Jonghyun Shin et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Alterations of dystrophin-associated glycoproteins in the heart lacking dystrophin or dystrophin and utrophin

(2013) Katharine M. Sharpe et al.   JOURNAL OF MUSCLE RESEARCH AND CELL MOTILITY

Oral Corticosteroids and Onset of Cardiomyopathy in Duchenne Muscular Dystrophy

(2013) Brent J. Barber et al.   JOURNAL OF PEDIATRICS

All-Cause Mortality and Cardiovascular Outcomes With Prophylactic Steroid Therapy in Duchenne Muscular Dystrophy

(2013) Gernot Schram et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Plasmapheresis Eliminates the Negative Impact of AAV Antibodies on Microdystrophin Gene Expression Following Vascular Delivery

(2013) LG Chicoine et al.   MOLECULAR THERAPY

Corticosteroids in Duchenne muscular dystrophy: Major variations in practice

(2013) Robert C. Griggs et al.   MUSCLE & NERVE

High-frequency off-target mutagenesis induced by CRISPR-Cas nucleases in human cells

(2013) Yanfang Fu et al.   NATURE BIOTECHNOLOGY

Pre-existing Anti–Adeno-Associated Virus Antibodies as a Challenge in AAV Gene Therapy

(2013) Vedell Louis Jeune et al.   Human Gene Therapy Methods

Effects of Angiotensin-Converting Enzyme Inhibitors and/or Beta Blockers on the Cardiomyopathy in Duchenne Muscular Dystrophy

(2012) Laurence Viollet et al.   AMERICAN JOURNAL OF CARDIOLOGY

Evidence-based path to newborn screening for duchenne muscular dystrophy

(2012) Jerry R. Mendell et al.   ANNALS OF NEUROLOGY

Angiotensin II-Induced Production of Mitochondrial Reactive Oxygen Species: Potential Mechanisms and Relevance for Cardiovascular Disease

(2012) Sergey I. Dikalov et al.   ANTIOXIDANTS & REDOX SIGNALING

Nitric oxide signalling pathway in Duchenne muscular dystrophy mice: up-regulation of L-arginine transporters

(2012) Jayalakshmi Ramachandran et al.   BIOCHEMICAL JOURNAL

Role of Mitochondrial Ca2+ in the Regulation of Cellular Energetics

(2012) Brian Glancy et al.   BIOCHEMISTRY

The role of calpains in myocardial remodelling and heart failure

(2012) E. Letavernier et al.   CARDIOVASCULAR RESEARCH

Increased Resting Intracellular Calcium Modulates NF-κB-dependent Inducible Nitric-oxide Synthase Gene Expression in DystrophicmdxSkeletal Myotubes

(2012) Francisco Altamirano et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

X-ROS signaling in the heart and skeletal muscle: Stretch-dependent local ROS regulates [Ca2+]i

(2012) Benjamin L. Prosser et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Evaluation of the North Star Ambulatory Assessment scale and cardiac abnormalities in ambulant boys with Duchenne muscular dystrophy

(2012) Yakup Ergul et al.   JOURNAL OF PAEDIATRICS AND CHILD HEALTH

Enhancing Muscle Membrane Repair by Gene Delivery of MG53 Ameliorates Muscular Dystrophy and Heart Failure in δ-Sarcoglycan-deficient Hamsters

(2012) Bo He et al.   MOLECULAR THERAPY

Novel Approaches to Corticosteroid Treatment in Duchenne Muscular Dystrophy

(2012) Eric P. Hoffman et al.   Physical Medicine and Rehabilitation Clinics of North America

Proteomic Analysis Reveals New Cardiac-Specific Dystrophin-Associated Proteins

(2012) Eric K. Johnson et al.   PLoS One

Tadalafil Alleviates Muscle Ischemia in Patients with Becker Muscular Dystrophy

(2012) E. A. Martin et al.   Science Translational Medicine

Recombinant MG53 Protein Modulates Therapeutic Cell Membrane Repair in Treatment of Muscular Dystrophy

(2012) N. Weisleder et al.   Science Translational Medicine

Pip6-PMO, A New Generation of Peptide-oligonucleotide Conjugates With Improved Cardiac Exon Skipping Activity for DMD Treatment

(2012) Corinne Betts et al.   Molecular Therapy-Nucleic Acids

Early Treatment With Lisinopril and Spironolactone Preserves Cardiac and Skeletal Muscle in Duchenne Muscular Dystrophy Mice

(2011) Jill A. Rafael-Fortney et al.   CIRCULATION

Improvement of cardiac fibrosis in dystrophic mice by rAAV9-mediated microdystrophin transduction

(2011) J-H Shin et al.   GENE THERAPY

Losartan Decreases Cardiac Muscle Fibrosis and Improves Cardiac Function in Dystrophin-Deficient Mdx Mice

(2011) Christopher F. Spurney et al.   JOURNAL OF CARDIOVASCULAR PHARMACOLOGY AND THERAPEUTICS

Cardiomyopathy of duchenne muscular dystrophy: Current understanding and future directions

(2011) Christopher F. Spurney   MUSCLE & NERVE

Neuronal Nitric Oxide Synthase-Rescue of Dystrophin/Utrophin Double Knockout Mice does not Require nNOS Localization to the Cell Membrane

(2011) Michelle Wehling-Henricks et al.   PLoS One

X-ROS Signaling: Rapid Mechano-Chemo Transduction in Heart

(2011) B. L. Prosser et al.   SCIENCE

Lower leg muscle involvement in Duchenne muscular dystrophy: an MR imaging and spectroscopy study

(2011) Martin Torriani et al.   SKELETAL RADIOLOGY

Stress-induced opening of the permeability transition pore in the dystrophin-deficient heart is attenuated by acute treatment with sildenafil

(2010) Alexis Ascah et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Angiotensin II receptors and drug discovery in cardiovascular disease

(2010) Chiranjib Dasgupta et al.   DRUG DISCOVERY TODAY

Carvedilol can Prevent Cardiac Events in Duchenne Muscular Dystrophy

(2010) Tsuyoshi Matsumura et al.   INTERNAL MEDICINE

Duchenne muscular dystrophy – What causes the increased membrane permeability in skeletal muscle?

(2010) David G. Allen et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Chronic administration of membrane sealant prevents severe cardiac injury and ventricular dilatation in dystrophic dogs

(2010) DeWayne Townsend et al.   JOURNAL OF CLINICAL INVESTIGATION

Leaky RyR2 trigger ventricular arrhythmias in Duchenne muscular dystrophy

(2010) J. Fauconnier et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Genetic inhibition of PKA phosphorylation of RyR2 prevents dystrophic cardiomyopathy

(2010) S. Sarma et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Sildenafil reverses cardiac dysfunction in the mdx mouse model of Duchenne muscular dystrophy

(2010) C. M. Adamo et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Transient opening of mitochondrial permeability transition pore by reactive oxygen species protects myocardium from ischemia-reperfusion injury

(2009) Masao Saotome et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Efficacy of systemic morpholino exon-skipping in duchenne dystrophy dogs

(2009) Toshifumi Yokota et al.   ANNALS OF NEUROLOGY

Mitochondrial calcium and the permeability transition in cell death

(2009) John J. Lemasters et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

Analysis of Dystrophin Deletion Mutations Predicts Age of Cardiomyopathy Onset in Becker Muscular Dystrophy

(2009) Rita Wen Kaspar et al.   Circulation-Cardiovascular Genetics

Contrasting effects of steroids and angiotensin-converting-enzyme inhibitors in a mouse model of dystrophin-deficient cardiomyopathy

(2009) Ralf Bauer et al.   EUROPEAN JOURNAL OF HEART FAILURE

Dose-dependent restoration of dystrophin expression in cardiac muscle of dystrophic mice by systemically delivered morpholino

(2009) B Wu et al.   GENE THERAPY

Inhibition of the renin–angiotensin system and target organ protection

(2009) Jun Iwanami et al.   HYPERTENSION RESEARCH

Circumferential Strain Analysis Identifies Strata of Cardiomyopathy in Duchenne Muscular Dystrophy

(2009) Kan N. Hor et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

The Sympathetic Nervous System in Heart Failure

(2009) Filippos Triposkiadis et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Hypernitrosylated ryanodine receptor calcium release channels are leaky in dystrophic muscle

(2009) Andrew M Bellinger et al.   NATURE MEDICINE

Cardiac fibroblasts: At the heart of myocardial remodeling

(2009) Karen E. Porter et al.   PHARMACOLOGY & THERAPEUTICS

Construction and analysis of compact muscle-specific promoters for AAV vectors

(2008) B Wang et al.   GENE THERAPY

Cell-penetrating peptide-conjugated antisense oligonucleotides restore systemic muscle and cardiac dystrophin expression and function

(2008) HaiFang Yin et al.   HUMAN MOLECULAR GENETICS

Abnormal cardiac morphology, function and energy metabolism in the dystrophic mdx mouse: An MRI and MRS study

(2008) Wen Zhang et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

MG53 nucleates assembly of cell membrane repair machinery

(2008) Chuanxi Cai et al.   NATURE CELL BIOLOGY

Genetic and pharmacologic inhibition of mitochondrial-dependent necrosis attenuates muscular dystrophy

(2008) Douglas P Millay et al.   NATURE MEDICINE

Sildenafil and cardiomyocyte-specific cGMP signaling prevent cardiomyopathic changes associated with dystrophin deficiency

(2008) M. Khairallah et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA