Impairment of the autophagy–lysosomal pathway in Alzheimer's diseases: Pathogenic mechanisms and therapeutic potential

Prevalence of mild cognitive impairment in community-dwelling Chinese populations aged over 55 years: a meta-analysis and systematic review

(2021) Yuan Lu et al.   BMC Geriatrics

Trehalose causes low-grade lysosomal stress to activate TFEB and the autophagy-lysosome biogenesis response

(2021) Se-Jin Jeong et al.   Autophagy

Gene-based therapies for neurodegenerative diseases

(2021) Jichao Sun et al.   NATURE NEUROSCIENCE

Re-emphasizing early Alzheimer’s disease pathology starting in select entorhinal neurons, with a special focus on mitophagy

(2021) Asgeir Kobro-Flatmoen et al.   AGEING RESEARCH REVIEWS

Acetylated tau inhibits chaperone-mediated autophagy and promotes tau pathology propagation in mice

(2021) Benjamin Caballero et al.   Nature Communications

Autophagy in liver diseases: A review

(2021) Hui Qian et al.   MOLECULAR ASPECTS OF MEDICINE

Lysosome dysfunction as a cause of neurodegenerative diseases: Lessons from frontotemporal dementia and amyotrophic lateral sclerosis

(2021) Jessica Root et al.   NEUROBIOLOGY OF DISEASE

SORL1 deficiency in human excitatory neurons causes APP-dependent defects in the endolysosome-autophagy network

(2021) Christy Hung et al.   Cell Reports

Picalm reduction exacerbates tau pathology in a murine tauopathy model

(2020) Kunie Ando et al.   ACTA NEUROPATHOLOGICA

A Curcumin Derivative Activates TFEB and Protects Against Parkinsonian Neurotoxicity in Vitro

(2020) Ziying Wang et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

β2-adrenergic agonists rescue lysosome acidification and function in PSEN1 deficiency by reversing defective ER to lysosome delivery of ClC-7

(2020) Ju-Hyun Lee et al.   JOURNAL OF MOLECULAR BIOLOGY

Berberine in the treatment of metabolism-related chronic diseases: A drug cloud (dCloud) effect to target multifactorial disorders

(2020) Wei-Jia Kong et al.   PHARMACOLOGY & THERAPEUTICS

A stress response p38 MAP kinase inhibitor SB202190 promoted TFEB/TFE3-dependent autophagy and lysosomal biogenesis independent of p38

(2020) Chuanbin Yang et al.   Redox Biology

Microglial autophagy is impaired by prolonged exposure to β-amyloid peptides: evidence from experimental models and Alzheimer’s disease patients

(2020) Carlos Pomilio et al.   GeroScience

Role and Mechanisms of Mitophagy in Liver Diseases

(2020) Xiaowen Ma et al.   Cells

The Long and the Short of PTEN in the Regulation of Mitophagy

(2020) Liming Wang et al.   Frontiers in Cell and Developmental Biology

NRBF2 is a RAB7 effector required for autophagosome maturation and mediates the association of APP-CTFs with active form of RAB7 for degradation

(2020) Cui-Zan Cai et al.   Autophagy

Molecular and cellular mechanisms underlying the pathogenesis of Alzheimer’s disease

(2020) Tiantian Guo et al.   Molecular Neurodegeneration

Synergy between amyloid-β and tau in Alzheimer’s disease

(2020) Marc Aurel Busche et al.   NATURE NEUROSCIENCE

Significance of cytosolic cathepsin D in Alzheimer's disease pathology: Protective cellular effects of PLGA nanoparticles against β‐amyloid‐toxicity

(2020) Y. Wang et al.   NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY

A research agenda for ageing in China in the 21st century (2nd edition): Focusing on basic and translational research, long-term care, policy and social networks

(2020) Evandro F. Fang et al.   AGEING RESEARCH REVIEWS

A natural product solution to aging and aging-associated diseases

(2020) Chuanbin Yang et al.   PHARMACOLOGY & THERAPEUTICS

Translating genetic risk of Alzheimer’s disease into mechanistic insight and drug targets

(2020) Annerieke Sierksma et al.   SCIENCE

Is There Justification to Treat Neurodegenerative Disorders by Repurposing Drugs? The Case of Alzheimer’s Disease, Lithium, and Autophagy

(2020) Odeya Damri et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

PLD3 Rare Variants Identified in Late-Onset Alzheimer’s Disease Affect Amyloid-β Levels in Cellular Model

(2019) Mengshan Tan et al.   Frontiers in Neuroscience

Clusterin in Alzheimer’s Disease: Mechanisms, Genetics, and Lessons From Other Pathologies

(2019) Evangeline M. Foster et al.   Frontiers in Neuroscience

Mitophagy inhibits amyloid-β and tau pathology and reverses cognitive deficits in models of Alzheimer’s disease

(2019) Evandro F. Fang et al.   NATURE NEUROSCIENCE

PSEN2 (presenilin 2) mutants linked to familial Alzheimer disease impair autophagy by altering Ca2+ homeostasis

(2019) Chiara Fedeli et al.   Autophagy

Activation of PPARA-mediated autophagy reduces Alzheimer disease-like pathology and cognitive decline in a murine model

(2019) Rongcan Luo et al.   Autophagy

BAG3 and SYNPO (synaptopodin) facilitate phospho-MAPT/Tau degradation via autophagy in neuronal processes

(2019) Changyi Ji et al.   Autophagy

SORL1 genetic variants and Alzheimer disease risk: a literature review and meta-analysis of sequencing data

(2019) Dominique Campion et al.   ACTA NEUROPATHOLOGICA

Clinical and biological effects of long-term lithium treatment in older adults with amnestic mild cognitive impairment: randomised clinical trial

(2019) Orestes V. Forlenza et al.   BRITISH JOURNAL OF PSYCHIATRY

Double deletion of PINK1 and Parkin impairs hepatic mitophagy and exacerbates acetaminophen-induced liver injury in mice

(2019) Hua Wang et al.   Redox Biology

MAPT/Tau accumulation represses autophagy flux by disrupting IST1-regulated ESCRT-III complex formation: a vicious cycle in Alzheimer neurodegeneration

(2019) Qiong Feng et al.   Autophagy

Metformin Improves Learning and Memory in the SAMP8 Mouse Model of Alzheimer’s Disease

(2019) Susan A. Farr et al.   JOURNAL OF ALZHEIMERS DISEASE

Lithium as a Treatment for Alzheimer’s Disease: The Systems Pharmacology Perspective

(2019) Harald Hampel et al.   JOURNAL OF ALZHEIMERS DISEASE

Current and emerging avenues for Alzheimer's disease drug targets

(2019) R. Loera‐Valencia et al.   JOURNAL OF INTERNAL MEDICINE

Diabetes drugs in the fight against Alzheimer's disease

(2019) Virginia Boccardi et al.   AGEING RESEARCH REVIEWS

Acetyltransferase GCN5 regulates autophagy and lysosome biogenesis by targeting TFEB

(2019) Yusha Wang et al.   EMBO REPORTS

Autophagosome-Lysosome Fusion

(2019) Péter Lőrincz et al.   JOURNAL OF MOLECULAR BIOLOGY

Autophagy protein NRBF2 has reduced expression in Alzheimer’s brains and modulates memory and amyloid-beta homeostasis in mice

(2019) Véronik Lachance et al.   Molecular Neurodegeneration

A small molecule transcription factor EB activator ameliorates beta‐amyloid precursor protein and Tau pathology in Alzheimer's disease models

(2019) Ju‐Xian Song et al.   AGING CELL

Autophagy modulator scoring system: a user-friendly tool for quantitative analysis of methodological integrity of chemical autophagy modulator studies

(2019) Yu Dong et al.   Autophagy

Berberine mitigates cognitive decline in an Alzheimer’s Disease Mouse Model by targeting both tau hyperphosphorylation and autophagic clearance

(2019) Ying Chen et al.   BIOMEDICINE & PHARMACOTHERAPY

Post-translational Modifications of Key Machinery in the Control of Mitophagy

(2019) Liming Wang et al.   TRENDS IN BIOCHEMICAL SCIENCES

Mechanisms, pathophysiological roles and methods for analyzing mitophagy – recent insights

(2018) Jessica A. Williams et al.   BIOLOGICAL CHEMISTRY

OUP accepted manuscript

(2018)   BRAIN

Cognitive benefits of lithium chloride in APP/PS1 mice are associated with enhanced brain clearance of β-amyloid

(2018) Yijun Pan et al.   BRAIN BEHAVIOR AND IMMUNITY

Metformin treatment prevents amyloid plaque deposition and memory impairment in APP/PS1 mice

(2018) Zhenri Ou et al.   BRAIN BEHAVIOR AND IMMUNITY

PTEN-L is a novel protein phosphatase for ubiquitin dephosphorylation to inhibit PINK1–Parkin-mediated mitophagy

(2018) Liming Wang et al.   CELL RESEARCH

Mitophagy and Quality Control Mechanisms in Mitochondrial Maintenance

(2018) Sarah Pickles et al.   CURRENT BIOLOGY

The complex relationship between TFEB transcription factor phosphorylation and subcellular localization

(2018) Rosa Puertollano et al.   EMBO JOURNAL

Dysfunction of different cellular degradation pathways contributes to specific β-amyloid42–induced pathologies

(2018) Xuan-Ru Ji et al.   FASEB JOURNAL

Dysfunction of autophagy and endosomal-lysosomal pathways: Roles in pathogenesis of Down syndrome and Alzheimer's Disease

(2018) Daniel J. Colacurcio et al.   FREE RADICAL BIOLOGY AND MEDICINE

Mutant APP and amyloid beta-induced defective autophagy, mitophagy, mitochondrial structural and functional changes and synaptic damage in hippocampal neurons from Alzheimer’s disease

(2018) P Hemachandra Reddy et al.   HUMAN MOLECULAR GENETICS

Hippocampal mutant APP and amyloid beta-induced cognitive decline, dendritic spine loss, defective autophagy, mitophagy and mitochondrial abnormalities in a mouse model of Alzheimer’s disease

(2018) Maria Manczak et al.   HUMAN MOLECULAR GENETICS

Role of Amyloid-β and Tau Proteins in Alzheimer’s Disease: Confuting the Amyloid Cascade

(2018) Walter Gulisano et al.   JOURNAL OF ALZHEIMERS DISEASE

Rare Variants in PLD3 Increase Risk for Alzheimer’s Disease in Han Chinese

(2018) Meng-Shan Tan et al.   JOURNAL OF ALZHEIMERS DISEASE

Aspirin induces Lysosomal biogenesis and attenuates Amyloid plaque pathology in a mouse model of Alzheimer's disease via PPARα

(2018) Sujyoti Chandra et al.   JOURNAL OF NEUROSCIENCE

Mechanism and medical implications of mammalian autophagy

(2018) Ivan Dikic et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Prevalence of preclinical Alzheimer disease

(2018) Silke Kern et al.   NEUROLOGY

PTEN-L puts a brake on mitophagy

(2018) Liming Wang et al.   Autophagy

Resveratrol and Alzheimer's disease. From molecular pathophysiology to clinical trials

(2018) Krzysztof Drygalski et al.   EXPERIMENTAL GERONTOLOGY

Differential Activation of mTOR Complex 1 Signaling in Human Brain with Mild to Severe Alzheimer's Disease

(2018) Yong-Xin Sun et al.   JOURNAL OF ALZHEIMERS DISEASE

TFEB enhances astroglial uptake of extracellular tau species and reduces tau spreading

(2018) Heidi Martini-Stoica et al.   JOURNAL OF EXPERIMENTAL MEDICINE

PLD3 and PLD4 are single-stranded acid exonucleases that regulate endosomal nucleic-acid sensing

(2018) Amanda L. Gavin et al.   NATURE IMMUNOLOGY

Trehalose induces autophagy via lysosomal-mediated TFEB activation in models of motoneuron degeneration

(2018) Paola Rusmini et al.   Autophagy

Early intrathecal infusion of everolimus restores cognitive function and mood in a murine model of Alzheimer's disease

(2018) Tommaso Cassano et al.   EXPERIMENTAL NEUROLOGY

Downregulation of autophagy by 12/15Lipoxygenase worsens the phenotype of an Alzheimer’s disease mouse model with plaques, tangles, and memory impairments

(2018) Jian-Guo Li et al.   MOLECULAR PSYCHIATRY

Emerging role of 12/15-Lipoxygenase (ALOX15) in human pathologies

(2018) Nikhlesh K. Singh et al.   PROGRESS IN LIPID RESEARCH

CRISPR/Cas9 editing of APP C-terminus attenuates β-cleavage and promotes α-cleavage

(2018) Jichao Sun et al.   Nature Communications

Ouabain activates transcription factor EB and exerts neuroprotection in models of Alzheimer's disease

(2018) Ha-Lim Song et al.   MOLECULAR AND CELLULAR NEUROSCIENCE

Cinnamic acid activates PPARα to stimulate Lysosomal biogenesis and lower Amyloid plaque pathology in an Alzheimer's disease mouse model

(2018) Sujyoti Chandra et al.   NEUROBIOLOGY OF DISEASE

The mammalian ULK1 complex and autophagy initiation

(2017) Maria Zachari et al.   Essays in Biochemistry

Berberine improves cognitive impairment by promoting autophagic clearance and inhibiting production of β-amyloid in APP/tau/PS1 mouse model of Alzheimer's disease

(2017) Min Huang et al.   EXPERIMENTAL GERONTOLOGY

Trehalose Improves Cognition in the Transgenic Tg2576 Mouse Model of Alzheimer’s Disease

(2017) Stuart D. Portbury et al.   JOURNAL OF ALZHEIMERS DISEASE

PPAR-α Activation Mediates Innate Host Defense through Induction of TFEB and Lipid Catabolism

(2017) Yi Sak Kim et al.   JOURNAL OF IMMUNOLOGY

Resveratrol regulates neuro-inflammation and induces adaptive immunity in Alzheimer’s disease

(2017) Charbel Moussa et al.   Journal of Neuroinflammation

Autophagy and Neurodegeneration: Pathogenic Mechanisms and Therapeutic Opportunities

(2017) Fiona M. Menzies et al.   NEURON

Activation of β2-adrenergic receptor promotes dendrite ramification and spine generation in APP/PS1 mice

(2017) Gao-shang Chai et al.   NEUROSCIENCE LETTERS

Tau directs intracellular trafficking by regulating the forces exerted by kinesin and dynein teams

(2017) Abdullah R. Chaudhary et al.   TRAFFIC

Mitophagy and Alzheimer’s Disease: Cellular and Molecular Mechanisms

(2017) Jesse S. Kerr et al.   TRENDS IN NEUROSCIENCES

Intraneuronal aggregation of the β-CTF fragment of APP (C99) induces Aβ-independent lysosomal-autophagic pathology

(2016) Inger Lauritzen et al.   ACTA NEUROPATHOLOGICA

Molecular genetics of early-onset Alzheimer's disease revisited

(2016) Rita Cacace et al.   Alzheimers & Dementia

TFEB and TFE3: Linking Lysosomes to Cellular Adaptation to Stress

(2016) Nina Raben et al.   Annual Review of Cell and Developmental Biology

A novel curcumin analog binds to and activates TFEB in vitro and in vivo independent of MTOR inhibition

(2016) Ju-Xian Song et al.   Autophagy

Nanoparticles restore lysosomal acidification defects: Implications for Parkinson and other lysosomal-related diseases

(2016) Mathieu Bourdenx et al.   Autophagy

Tau Biology and Tau-Directed Therapies for Alzheimer’s Disease

(2016) Lidia Bakota et al.   DRUGS

The amyloid hypothesis of Alzheimer's disease at 25 years

(2016) Dennis J Selkoe et al.   EMBO Molecular Medicine

Gypenoside XVII Enhances Lysosome Biogenesis and Autophagy Flux and Accelerates Autophagic Clearance of Amyloid-β through TFEB Activation

(2016) Xiangbao Meng et al.   JOURNAL OF ALZHEIMERS DISEASE

Metformin in Amnestic Mild Cognitive Impairment: Results of a Pilot Randomized Placebo Controlled Clinical Trial

(2016) José A. Luchsinger et al.   JOURNAL OF ALZHEIMERS DISEASE

Rapamycin rescues vascular, metabolic and learning deficits in apolipoprotein E4 transgenic mice with pre-symptomatic Alzheimer’s disease

(2016) Ai-Ling Lin et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Alzheimer's disease

(2016) Philip Scheltens et al.   LANCET

Metformin promotes tau aggregation and exacerbates abnormal behavior in a mouse model of tauopathy

(2016) Erica Barini et al.   Molecular Neurodegeneration

The road to restoring neural circuits for the treatment of Alzheimer's disease

(2016) Rebecca G. Canter et al.   NATURE

Protein kinase C controls lysosome biogenesis independently of mTORC1

(2016) Yang Li et al.   NATURE CELL BIOLOGY

Acetylated Tau Obstructs KIBRA-Mediated Signaling in Synaptic Plasticity and Promotes Tauopathy-Related Memory Loss

(2016) Tara E. Tracy et al.   NEURON

The Autophagy–Lysosomal Pathway in Neurodegeneration: A TFEB Perspective

(2016) Heidi Martini-Stoica et al.   TRENDS IN NEUROSCIENCES

Curcumin targets the TFEB-lysosome pathway for induction of autophagy

(2016) Jianbin Zhang et al.   Oncotarget

Fisetin stimulates autophagic degradation of phosphorylated tau via the activation of TFEB and Nrf2 transcription factors

(2016) Sunhyo Kim et al.   Scientific Reports

Dysregulation of Nutrient Sensing and CLEARance in Presenilin Deficiency

(2016) Kavya Reddy et al.   Cell Reports

Autophagic and lysosomal defects in human tauopathies: analysis of post-mortem brain from patients with familial Alzheimer disease, corticobasal degeneration and progressive supranuclear palsy

(2016) Antonio Piras et al.   Acta Neuropathologica Communications

Autophagy-Related Protein 7 Deficiency in Amyloid β (Aβ) Precursor Protein Transgenic Mice Decreases Aβ in the Multivesicular Bodies and Induces Aβ Accumulation in the Golgi

(2015) Per Nilsson et al.   AMERICAN JOURNAL OF PATHOLOGY

Transcriptional and epigenetic regulation of autophagy in aging

(2015) Louis R Lapierre et al.   Autophagy

Alzheimer’s Disease Risk Genes and Mechanisms of Disease Pathogenesis

(2015) Celeste M. Karch et al.   BIOLOGICAL PSYCHIATRY

Neuronal Aggregates: Formation, Clearance, and Spreading

(2015) Junghyun Lim et al.   DEVELOPMENTAL CELL

Structural basis for allosteric, substrate-dependent stimulation of SIRT1 activity by resveratrol

(2015) Duanfang Cao et al.   GENES & DEVELOPMENT

Neuronal-Targeted TFEB Accelerates Lysosomal Degradation of APP, Reducing A  Generation and Amyloid Plaque Pathogenesis

(2015) Q. Xiao et al.   JOURNAL OF NEUROSCIENCE

Critical role of acetylation in tau-mediated neurodegeneration and cognitive deficits

(2015) Sang-Won Min et al.   NATURE MEDICINE

Tau in physiology and pathology

(2015) Yipeng Wang et al.   NATURE REVIEWS NEUROSCIENCE

mTOR in Brain Physiology and Pathologies

(2015) Joël Bockaert et al.   PHYSIOLOGICAL REVIEWS

Pharmaceutical screen identifies novel target processes for activation of autophagy with a broad translational potential

(2015) Santosh Chauhan et al.   Nature Communications

Presenilin 1 Maintains Lysosomal Ca2+ Homeostasis via TRPML1 by Regulating vATPase-Mediated Lysosome Acidification

(2015) Ju-Hyun Lee et al.   Cell Reports

Mitochondrial dynamics and mitochondrial quality control

(2015) Hong-Min Ni et al.   Redox Biology

The mTOR Inhibitor Rapamycin Mitigates Perforant Pathway Neurodegeneration and Synapse Loss in a Mouse Model of Early-Stage Alzheimer-Type Tauopathy

(2015) Robert Siman et al.   PLoS One

Autophagy in microglia degrades extracellular β-amyloid fibrils and regulates the NLRP3 inflammasome

(2014) Mi-Hyang Cho et al.   Autophagy

Rapamycin: One Drug, Many Effects

(2014) Jing Li et al.   Cell Metabolism

Selective clearance of aberrant tau proteins and rescue of neurotoxicity by transcription factor EB

(2014) V. A. Polito et al.   EMBO Molecular Medicine

Corynoxine, a Natural Autophagy Enhancer, Promotes the Clearance of Alpha-Synuclein via Akt/mTOR Pathway

(2014) Lei-Lei Chen et al.   Journal of Neuroimmune Pharmacology

Genetic Reduction of Mammalian Target of Rapamycin Ameliorates Alzheimer's Disease-Like Cognitive and Pathological Deficits by Restoring Hippocampal Gene Expression Signature

(2014) A. Caccamo et al.   JOURNAL OF NEUROSCIENCE

Temsirolimus attenuates tauopathy in vitro and in vivo by targeting tau hyperphosphorylation and autophagic clearance

(2014) Teng Jiang et al.   NEUROPHARMACOLOGY

Temsirolimus promotes autophagic clearance of amyloid-β and provides protective effects in cellular and animal models of Alzheimer's disease

(2014) Teng Jiang et al.   PHARMACOLOGICAL RESEARCH

Clusterin: a key player in cancer chemoresistance and its inhibition

(2014) Tomas Koltai   OncoTargets and Therapy

Nrf2 reduces levels of phosphorylated tau protein by inducing autophagy adaptor protein NDP52

(2014) Chulman Jo et al.   Nature Communications

NRBF2 regulates autophagy and prevents liver injury by modulating Atg14L-linked phosphatidylinositol-3 kinase III activity

(2014) Jiahong Lu et al.   Nature Communications

PICALM modulates autophagy activity and tau accumulation

(2014) Kevin Moreau et al.   Nature Communications

Clusterin facilitates stress-induced lipidation of LC3 and autophagosome biogenesis to enhance cancer cell survival

(2014) Fan Zhang et al.   Nature Communications

PLD3 is accumulated on neuritic plaques in Alzheimer’s disease brains

(2014) Jun-ichi Satoh et al.   Alzheimers Research & Therapy

Amyloid-β and Tau

(2014) George S. Bloom   JAMA Neurology

Clathrin adaptor CALM/PICALM is associated with neurofibrillary tangles and is cleaved in Alzheimer’s brains

(2013) Kunie Ando et al.   ACTA NEUROPATHOLOGICA

The reciprocal roles of PARK2 and mitofusins in mitophagy and mitochondrial spheroid formation

(2013) Xiao-Ming Yin et al.   Autophagy

Latrepirdine (Dimebon®), a potential Alzheimer therapeutic, regulates autophagy and neuropathology in an Alzheimer mouse model

(2013) John W. Steele et al.   Autophagy

Dual suppressive effect of MTORC1 on autophagy

(2013) Jing Zhou et al.   Autophagy

Activation of lysosomal function in the course of autophagy via mTORC1 suppression and autophagosome-lysosome fusion

(2013) Jing Zhou et al.   CELL RESEARCH

Autophagy regulation by nutrient signaling

(2013) Ryan C Russell et al.   CELL RESEARCH

Chaperone-mediated autophagy: roles in disease and aging

(2013) Ana Maria Cuervo et al.   CELL RESEARCH

Autophagy Enhancer Carbamazepine Alleviates Memory Deficits and Cerebral Amyloid-β Pathology in a Mouse Model of Alzheimer's Disease

(2013) Lixi Li et al.   Current Alzheimer Research

Genetic ablation and short-duration inhibition of lipoxygenase results in increased macroautophagy

(2013) Insook Jang et al.   EXPERIMENTAL CELL RESEARCH

Autophagy and microtubules - new story, old players

(2013) R. Mackeh et al.   JOURNAL OF CELL SCIENCE

Trehalose rescues Alzheimer's disease phenotypes in APP/PS1 transgenic mice

(2013) Jing Du et al.   JOURNAL OF PHARMACY AND PHARMACOLOGY

Tracking pathophysiological processes in Alzheimer's disease: an updated hypothetical model of dynamic biomarkers

(2013) Clifford R Jack et al.   LANCET NEUROLOGY

Targeting the mTOR Signaling Network for Alzheimer’s Disease Therapy

(2013) Chong Wang et al.   MOLECULAR NEUROBIOLOGY

Rare coding variants in the phospholipase D3 gene confer risk for Alzheimer’s disease

(2013) Carlos Cruchaga et al.   NATURE

Identification of a candidate therapeutic autophagy-inducing peptide

(2013) Sanae Shoji-Kawata et al.   NATURE

Rapamycin Attenuates the Progression of Tau Pathology in P301S Tau Transgenic Mice

(2013) Sefika Ozcelik et al.   PLoS One

Ubiquilin-1 and protein quality control in Alzheimer disease

(2013) Amina El Ayadi et al.   Prion

Adaptor complex AP2/PICALM, through interaction with LC3, targets Alzheimer's APP-CTF for terminal degradation via autophagy

(2013) Y. Tian et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Impaired autophagy and APP processing in Alzheimer's disease: The potential role of Beclin 1 interactome

(2013) Antero Salminen et al.   PROGRESS IN NEUROBIOLOGY

At the end of the autophagic road: an emerging understanding of lysosomal functions in autophagy

(2013) Han-Ming Shen et al.   TRENDS IN BIOCHEMICAL SCIENCES

Aβ Secretion and Plaque Formation Depend on Autophagy

(2013) Per Nilsson et al.   Cell Reports

Proteolytic Degradation of Amyloid  -Protein

(2013) T. Saido et al.   Cold Spring Harbor Perspectives in Medicine

Progranulin Mutations as Risk Factors for Alzheimer Disease

(2013) David C. Perry et al.   JAMA Neurology

Isorhynchophylline, a natural alkaloid, promotes the degradation of alpha-synuclein in neuronal cells via inducing autophagy

(2012) Jia-Hong Lu et al.   Autophagy

Degradation of tau protein by autophagy and proteasomal pathways: Figure 1

(2012) Yipeng Wang et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

A lysosome-to-nucleus signalling mechanism senses and regulates the lysosome via mTOR and TFEB

(2012) Carmine Settembre et al.   EMBO JOURNAL

Macroautophagy deficiency mediates age-dependent neurodegeneration through a phospho-tau pathway

(2012) Keiichi Inoue et al.   Molecular Neurodegeneration

Defective lysosomal proteolysis and axonal transport are early pathogenic events that worsen with age leading to increased APP metabolism and synaptic Abeta in transgenic APP/PS1 hippocampus

(2012) Manuel Torres et al.   Molecular Neurodegeneration

Latrepirdine improves cognition and arrests progression of neuropathology in an Alzheimer's mouse model

(2012) J W Steele et al.   MOLECULAR PSYCHIATRY

The toxic Aβ oligomer and Alzheimer's disease: an emperor in need of clothes

(2012) Iryna Benilova et al.   NATURE NEUROSCIENCE

Abnormal accumulation of autophagic vesicles correlates with axonal and synaptic pathology in young Alzheimer’s mice hippocampus

(2011) Raquel Sanchez-Varo et al.   ACTA NEUROPATHOLOGICA

Autophagy and Aging

(2011) David C. Rubinsztein et al.   CELL

A small-molecule enhancer of autophagy decreases levels of Aβ and APP-CTF via Atg5-dependent autophagy pathway

(2011) Yuan Tian et al.   FASEB JOURNAL

Ubiquilin-1 Is a Molecular Chaperone for the Amyloid Precursor Protein

(2011) Emily S. Stieren et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Naturally Secreted Amyloid-β Increases Mammalian Target of Rapamycin (mTOR) Activity via a PRAS40-mediated Mechanism

(2011) Antonella Caccamo et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The amyloid cascade hypothesis for Alzheimer's disease: an appraisal for the development of therapeutics

(2011) Eric Karran et al.   NATURE REVIEWS DRUG DISCOVERY

Inducing Autophagy by Rapamycin Before, but Not After, the Formation of Plaques and Tangles Ameliorates Cognitive Deficits

(2011) Smita Majumder et al.   PLoS One

TFEB Links Autophagy to Lysosomal Biogenesis

(2011) C. Settembre et al.   SCIENCE

Brain aging and Aβ1–42 neurotoxicity converge via deterioration in autophagy–lysosomal system: a conditional Drosophila model linking Alzheimer’s neurodegeneration with aging

(2010) Daijun Ling et al.   ACTA NEUROPATHOLOGICA

Meta-analysis Confirms CR1, CLU, and PICALM as Alzheimer Disease Risk Loci and Reveals Interactions With APOE Genotypes

(2010) Gyungah Jun   ARCHIVES OF NEUROLOGY

Lysosomal Proteolysis and Autophagy Require Presenilin 1 and Are Disrupted by Alzheimer-Related PS1 Mutations

(2010) Ju-Hyun Lee et al.   CELL

The Role of Tau in Alzheimer's Disease and Related Disorders

(2010) Rodrigo Medeiros et al.   CNS Neuroscience & Therapeutics

AMP-activated Protein Kinase Signaling Activation by Resveratrol Modulates Amyloid-β Peptide Metabolism

(2010) Valérie Vingtdeux et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Molecular Interplay between Mammalian Target of Rapamycin (mTOR), Amyloid-β, and Tau

(2010) Antonella Caccamo et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Mechanisms of mitophagy

(2010) Richard J. Youle et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Inhibition of mTOR by Rapamycin Abolishes Cognitive Deficits and Reduces Amyloid-β Levels in a Mouse Model of Alzheimer's Disease

(2010) Patricia Spilman et al.   PLoS One

Lysosomal Dysfunction Promotes Cleavage and Neurotoxicity of Tau In Vivo

(2010) Vikram Khurana et al.   PLoS Genetics

Mechanisms of tau-induced neurodegeneration

(2009) Khalid Iqbal et al.   ACTA NEUROPATHOLOGICA

PLIC proteins or ubiquilins regulate autophagy-dependent cell survival during nutrient starvation

(2009) Elsa-Noah N'Diaye et al.   EMBO REPORTS

Tau fragmentation, aggregation and clearance: the dual role of lysosomal processing

(2009) Yipeng Wang et al.   HUMAN MOLECULAR GENETICS

Recent advances in the chemistry, biosynthesis and pharmacology of rapamycin analogs

(2009) Edmund I. Graziani   NATURAL PRODUCT REPORTS

Genome-wide association study identifies variants at CLU and CR1 associated with Alzheimer's disease

(2009) Jean-Charles Lambert et al.   NATURE GENETICS

Genome-wide association study identifies variants at CLU and PICALM associated with Alzheimer's disease

(2009) Denise Harold et al.   NATURE GENETICS

Cathepsin D gene and the risk of Alzheimer's disease: A population-based study and meta-analysis

(2009) M. Schuur et al.   NEUROBIOLOGY OF AGING

Abeta42-Induced Neurodegeneration via an Age-Dependent Autophagic-Lysosomal Injury in Drosophila

(2009) Daijun Ling et al.   PLoS One

Autophagic-lysosomal perturbation enhances tau aggregation in transfectants with induced wild-type tau expression

(2008) Tadanori Hamano et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

mTOR-dependent signalling in Alzheimer's disease

(2008) Jin-Jing Pei et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Loss of LR11/SORLA Enhances Early Pathology in a Mouse Model of Amyloidosis: Evidence for a Proximal Role in Alzheimer's Disease

(2008) S. E. Dodson et al.   JOURNAL OF NEUROSCIENCE

Effect of dimebon on cognition, activities of daily living, behaviour, and global function in patients with mild-to-moderate Alzheimer's disease: a randomised, double-blind, placebo-controlled study

(2008) Rachelle S Doody et al.   LANCET

Differential Regulation of Dynein and Kinesin Motor Proteins by Tau

(2008) R. Dixit et al.   SCIENCE