Dysfunction of different cellular degradation pathways contributes to specific β-amyloid42–induced pathologies

The ubiquitin proteasomal system: a potential target for the management of Alzheimer's disease

(2016) Kundlik Gadhave et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Compartment-Specific Regulation of Autophagy in Primary Neurons

(2016) Sandra Maday et al.   JOURNAL OF NEUROSCIENCE

The Ubiquitin-Proteasome System: Potential Therapeutic Targets for Alzheimer’s Disease and Spinal Cord Injury

(2016) Bing Gong et al.   Frontiers in Molecular Neuroscience

Targeting molecules to medicine with mTOR, autophagy and neurodegenerative disorders

(2015) Kenneth Maiese   BRITISH JOURNAL OF CLINICAL PHARMACOLOGY

An Aβ42 uptake and degradation via Rg3 requires an activation of caveolin, clathrin and Aβ-degrading enzymes in microglia

(2015) Su Kil Jang et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Dynamin-2 mutations associated with centronuclear myopathy are hypermorphic and lead to T-tubule fragmentation

(2015) Yu-Han Chin et al.   HUMAN MOLECULAR GENETICS

Clearance of amyloid β-protein and its role in the spreading of Alzheimer's disease pathology

(2015) Dietmar R. Thal   Frontiers in Aging Neuroscience

A dPIP5K Dependent Pool of Phosphatidylinositol 4,5 Bisphosphate (PIP2) Is Required for G-Protein Coupled Signal Transduction in Drosophila Photoreceptors

(2015) Purbani Chakrabarti et al.   PLoS Genetics

Genetic interactions betweenDrosophila melanogasterAtg1 and paxillin reveal a role for paxillin in autophagosome formation

(2014) Guang-Chao Chen et al.   Autophagy

Aβ1-42 monomers or oligomers have different effects on autophagy and apoptosis

(2014) Michela Guglielmotto et al.   Autophagy

Lys203 and Lys382 are Essential for the Proteasomal Degradation of BACE1

(2014) Rong Wang et al.   Current Alzheimer Research

Genetic Reduction of Mammalian Target of Rapamycin Ameliorates Alzheimer's Disease-Like Cognitive and Pathological Deficits by Restoring Hippocampal Gene Expression Signature

(2014) A. Caccamo et al.   JOURNAL OF NEUROSCIENCE

Perilous journey: a tour of the ubiquitin–proteasome system

(2014) Gary Kleiger et al.   TRENDS IN CELL BIOLOGY

The 37kDa/67kDa Laminin Receptor acts as a receptor for Aβ42 internalization

(2014) Bianca Da Costa Dias et al.   Scientific Reports

Soluble forms of polyQ-expanded huntingtin rather than large aggregates cause endoplasmic reticulum stress

(2013) Julia Leitman et al.   Nature Communications

Proteolytic Degradation of Amyloid  -Protein

(2013) T. Saido et al.   Cold Spring Harbor Perspectives in Medicine

Autophagy: A double-edged sword in Alzheimer’s disease

(2012) Ying-Tsen Tung et al.   JOURNAL OF BIOSCIENCES

Epidermal growth factor receptor is a preferred target for treating Amyloid- -induced memory loss

(2012) L. Wang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Intraneuronal amyloid β oligomers cause cell death via endoplasmic reticulum stress, endosomal/lysosomal leakage, and mitochondrial dysfunction in vivo

(2011) Tomohiro Umeda et al.   JOURNAL OF NEUROSCIENCE RESEARCH

Inhibition of β-amyloid1-42 internalization attenuates neuronal death by stabilizing the endosomal-lysosomal system in rat cortical cultured neurons

(2011) M.S. Song et al.   NEUROSCIENCE

Functional Links Between A  Toxicity, Endocytic Trafficking, and Alzheimer's Disease Risk Factors in Yeast

(2011) S. Treusch et al.   SCIENCE

APP and APLP1 are degraded through autophagy in response to proteasome inhibition in neuronal cells

(2011) Fangfang Zhou et al.   Protein & Cell

Alzheimer's Disease-Associated Ubiquilin-1 Regulates Presenilin-1 Accumulation and Aggresome Formation

(2010) Jayashree Viswanathan et al.   TRAFFIC

Rab7 Regulates Late Endocytic Trafficking Downstream of Multivesicular Body Biogenesis and Cargo Sequestration

(2009) Phillip A. Vanlandingham et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Abeta42-Induced Neurodegeneration via an Age-Dependent Autophagic-Lysosomal Injury in Drosophila

(2009) Daijun Ling et al.   PLoS One

The endoplasmic reticulum-Golgi pathway is a target for translocation and aggregation of mutant superoxide dismutase linked to ALS

(2008) Makoto Urushitani et al.   FASEB JOURNAL

Dissecting the role of PtdIns(4,5)P2 in endocytosis and recycling of the transferrin receptor

(2008) N. Abe et al.   JOURNAL OF CELL SCIENCE

Autophagy Induction and Autophagosome Clearance in Neurons: Relationship to Autophagic Pathology in Alzheimer's Disease

(2008) B. Boland et al.   JOURNAL OF NEUROSCIENCE

Aβ42 Mutants with Different Aggregation Profiles Induce Distinct Pathologies in Drosophila

(2008) Koichi Iijima et al.   PLoS One