Metformin Improves Learning and Memory in the SAMP8 Mouse Model of Alzheimer’s Disease

Metformin treatment prevents amyloid plaque deposition and memory impairment in APP/PS1 mice

(2018) Zhenri Ou et al.   BRAIN BEHAVIOR AND IMMUNITY

Tau Proteins and Tauopathies in Alzheimer’s Disease

(2018) Fong Ping Chong et al.   CELLULAR AND MOLECULAR NEUROBIOLOGY

Tau-targeting therapies for Alzheimer disease

(2018) Erin E. Congdon et al.   Nature Reviews Neurology

Intraneuronal accumulation of C99 contributes to synaptic alterations, apathy-like behavior, and spatial learning deficits in 3xTgAD and 2xTgAD mice

(2018) Alexandre Bourgeois et al.   NEUROBIOLOGY OF AGING

Alzheimer’s disease master regulators analysis: search for potential molecular targets and drug repositioning candidates

(2018) D. M. Vargas et al.   Alzheimers Research & Therapy

Metformin treatment ameliorates diabetes-associated decline in hippocampal neurogenesis and memory via phosphorylation of insulin receptor substrate 1

(2018) Daisuke Tanokashira et al.   FEBS Open Bio

The effects of safranal, a constitute of saffron, and metformin on spatial learning and memory impairments in type-1 diabetic rats: behavioral and hippocampal histopathological and biochemical evaluations

(2018) Fatemeh Delkhosh-Kasmaie et al.   BIOMEDICINE & PHARMACOTHERAPY

Incidence of Dementia is Increased in Type 2 Diabetes and Reduced by the Use of Sulfonylureas and Metformin

(2018) Chih-Cheng Hsu et al.   JOURNAL OF ALZHEIMERS DISEASE

Effect of Alpha-Lipoic Acid on Memory, Oxidation, and Lifespan in SAMP8 Mice

(2018) Susan A. Farr et al.   JOURNAL OF ALZHEIMERS DISEASE

Peripheral Administration of Antisense Oligonucleotides Targeting the Amyloid-β Protein Precursor Reverses AβPP and LRP-1 Overexpression in the Aged SAMP8 Mouse Brain

(2018) Michelle A. Erickson et al.   JOURNAL OF ALZHEIMERS DISEASE

Central and Peripheral Administration of Antisense Oligonucleotide Targeting Amyloid-β Protein Precursor Improves Learning and Memory and Reduces Neuroinflammatory Cytokines in Tg2576 (AβPPswe) Mice

(2018) Susan A. Farr et al.   JOURNAL OF ALZHEIMERS DISEASE

PE859, A Novel Curcumin Derivative, Inhibits Amyloid-β and Tau Aggregation, and Ameliorates Cognitive Dysfunction in Senescence-Accelerated Mouse Prone 8

(2017) Michiaki Okuda et al.   JOURNAL OF ALZHEIMERS DISEASE

Alzheimer’s Disease: Past, Present, and Future

(2017) Mark W. Bondi et al.   JOURNAL OF THE INTERNATIONAL NEUROPSYCHOLOGICAL SOCIETY

Metformin vs sulfonylurea use and risk of dementia in US veterans aged ≥65 years with diabetes

(2017) Ariela R. Orkaby et al.   NEUROLOGY

Involvement of insulin resistance in D-galactose-induced age-related dementia in rats: Protective role of metformin and saxagliptin

(2017) Sara Kenawy et al.   PLoS One

Effects of metformin exposure on neurodegenerative diseases in elderly patients with type 2 diabetes mellitus

(2017) Yi-Chun Kuan et al.   PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY

From Aging to Alzheimer's Disease: Unveiling “The Switch” with the Senescence-Accelerated Mouse Model (SAMP8)

(2017) Merce Pallas et al.   JOURNAL OF ALZHEIMERS DISEASE

A Physiological Role for Amyloid-β Protein: Enhancement of Learning and Memory

(2017) John E. Morley et al.   JOURNAL OF ALZHEIMERS DISEASE

Intraneuronal aggregation of the β-CTF fragment of APP (C99) induces Aβ-independent lysosomal-autophagic pathology

(2016) Inger Lauritzen et al.   ACTA NEUROPATHOLOGICA

Protein Kinase C Activation as a Potential Therapeutic Strategy in Alzheimer's Disease: Is there a Role for Embryonic Lethal Abnormal Vision-like Proteins?

(2016) Virpi Talman et al.   BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY

Peripheral Administration of GSK-3β Antisense Oligonucleotide Improves Learning and Memory in SAMP8 and Tg2576 Mouse Models of Alzheimer’s Disease

(2016) Susan A. Farr et al.   JOURNAL OF ALZHEIMERS DISEASE

Metformin promotes tau aggregation and exacerbates abnormal behavior in a mouse model of tauopathy

(2016) Erica Barini et al.   Molecular Neurodegeneration

Alteration of mTOR signaling occurs early in the progression of Alzheimer disease (AD): analysis of brain from subjects with pre-clinical AD, amnestic mild cognitive impairment and late-stage AD

(2015) Antonella Tramutola et al.   JOURNAL OF NEUROCHEMISTRY

Towards universal therapeutics for memory disorders

(2015) Miao-Kun Sun et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Early alterations in energy metabolism in the hippocampus of APPswe/PS1dE9 mouse model of Alzheimer's disease

(2014) Ignacio Pedrós et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Repurposing Diabetes Drugs for Brain Insulin Resistance in Alzheimer Disease

(2014) M. Yarchoan et al.   DIABETES

The Anti-Diabetic Drug Metformin Reduces BACE1 Protein Level by Interfering with the MID1 Complex

(2014) Moritz M. Hettich et al.   PLoS One

Translocation of PKC by Yessotoxin in an in Vitro Model of Alzheimer’s Disease with Improvement of Tau and β-Amyloid Pathology

(2013) Eva Alonso et al.   ACS Chemical Neuroscience

Relationship between metformin use, vitamin B12 deficiency, hyperhomocysteinemia and vascular complications in patients with type 2 diabetes

(2013) Yuka Sato et al.   ENDOCRINE JOURNAL

Antisense oligonucleotide against GSK-3β in brain of SAMP8 mice improves learning and memory and decreases oxidative stress: Involvement of transcription factor Nrf2 and implications for Alzheimer disease

(2013) Susan A. Farr et al.   FREE RADICAL BIOLOGY AND MEDICINE

SAMP8 mice have altered hippocampal gene expression in long term potentiation, phosphatidylinositol signaling, and endocytosis pathways

(2013) Harvey J. Armbrecht et al.   NEUROBIOLOGY OF AGING

Diabetes drugs and neurological disorders: new views and therapeutic possibilities

(2013) Cesare Patrone et al.   Lancet Diabetes & Endocrinology

Metformin Activates an Atypical PKC-CBP Pathway to Promote Neurogenesis and Enhance Spatial Memory Formation

(2012) Jing Wang et al.   Cell Stem Cell

The SAMP8 Mouse: A Model to Develop Therapeutic Interventions for Alzheimers Disease

(2012) John E. Morley et al.   CURRENT PHARMACEUTICAL DESIGN

Citrulline and arginine utility in treating nitric oxide deficiency in mitochondrial disorders

(2012) Ayman W. El-Hattab et al.   MOLECULAR GENETICS AND METABOLISM

The senescence accelerated mouse (SAMP8) as a model for oxidative stress and Alzheimer's disease

(2011) John E. Morley et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Abnormal tau, mitochondrial dysfunction, impaired axonal transport of mitochondria, and synaptic deprivation in Alzheimer's disease

(2011) P. Hemachandra Reddy   BRAIN RESEARCH

Biguanide metformin acts on tau phosphorylation via mTOR/protein phosphatase 2A (PP2A) signaling

(2010) E. Kickstein et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Insulin, PKC signaling pathways and synaptic remodeling during memory storage and neuronal repair

(2008) Thomas. J. Nelson et al.   EUROPEAN JOURNAL OF PHARMACOLOGY