Rapamycin rescues vascular, metabolic and learning deficits in apolipoprotein E4 transgenic mice with pre-symptomatic Alzheimer’s disease

Rapamycin-induced metabolic defects are reversible in both lean and obese mice

(2016) Yuhong Liu et al.   Aging-US

How longevity research can lead to therapies for Alzheimer's disease: The rapamycin story

(2015) Arlan Richardson et al.   EXPERIMENTAL GERONTOLOGY

Caloric restriction increases ketone bodies metabolism and preserves blood flow in aging brain

(2015) Ai-Ling Lin et al.   NEUROBIOLOGY OF AGING

Complex IV-deficientSurf1−/−mice initiate mitochondrial stress responses

(2014) Daniel A. Pulliam et al.   BIOCHEMICAL JOURNAL

Advances in MRI biomarkers for the diagnosis of Alzheimer's disease

(2014) Elizabeth G Kehoe et al.   Biomarkers in Medicine

Caloric Restriction Impedes Age-Related Decline of Mitochondrial Function and Neuronal Activity

(2014) Ai-Ling Lin et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Human Apolipoprotein E ε4 Expression Impairs Cerebral Vascularization and Blood—Brain Barrier Function in Mice

(2014) Wael Alata et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

mTOR inhibition improves immune function in the elderly

(2014) J. B. Mannick et al.   Science Translational Medicine

Clinical epidemiology of Alzheimer’s disease: assessing sex and gender differences

(2014) Michelle Mielke et al.   Clinical Epidemiology

Decreased in vitro Mitochondrial Function is Associated with Enhanced Brain Metabolism, Blood Flow, and Memory in Surfl-Deficient Mice

(2013) Ai-Ling Lin et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Chronic Rapamycin Restores Brain Vascular Integrity and Function Through NO Synthase Activation and Improves Memory in Symptomatic Mice Modeling Alzheimer’s Disease

(2013) Ai-Ling Lin et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Apolipoprotein E and Alzheimer disease: risk, mechanisms and therapy

(2013) Chia-Chen Liu et al.   Nature Reviews Neurology

Hippocampus-Related Cognitive Impairments in Young apoE4 Targeted Replacement Mice

(2013) Shiran Salomon-Zimri et al.   Neurodegenerative Diseases

Cerebrovascular Effects of Apolipoprotein E

(2013) Berislav V. Zlokovic   JAMA Neurology

APOE4-specific Changes in Aβ Accumulation in a New Transgenic Mouse Model of Alzheimer Disease

(2012) Katherine L. Youmans et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Apolipoprotein E ε4 and age effects on florbetapir positron emission tomography in healthy aging and Alzheimer disease

(2012) Adam S. Fleisher et al.   NEUROBIOLOGY OF AGING

Animal Research: Reporting in vivo Experiments—The ARRIVE Guidelines

(2011) Carol Kilkenny et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Common toxicities of mammalian target of rapamycin inhibitors

(2011) Scott A. Soefje et al.   Targeted Oncology

Clinical activity of mammalian target of rapamycin inhibitors in solid tumors

(2011) Yesid Alvarado et al.   Targeted Oncology

APOE ε4 Genotype and Longitudinal Changes in Cerebral Blood Flow in Normal Aging

(2010) Madhav Thambisetty et al.   ARCHIVES OF NEUROLOGY

Validation of VASO cerebral blood volume measurement with positron emission tomography

(2010) Jinsoo Uh et al.   MAGNETIC RESONANCE IN MEDICINE

Brain fuel metabolism, aging, and Alzheimer’s disease

(2010) Stephen Cunnane et al.   NUTRITION

Inhibition of mTOR by Rapamycin Abolishes Cognitive Deficits and Reduces Amyloid-β Levels in a Mouse Model of Alzheimer's Disease

(2010) Patricia Spilman et al.   PLoS One

Nonlinear coupling between cerebral blood flow, oxygen consumption, and ATP production in human visual cortex

(2010) A.-L. Lin et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Total Cerebral Blood Flow in Relation to Cognitive Function: The Rotterdam Scan Study

(2008) Mariëlle MF Poels et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM