Lithium as a Treatment for Alzheimer’s Disease: The Systems Pharmacology Perspective

Treatment Combinations for Alzheimer’s Disease: Current And Future Pharmacotherapy Options

(2019) Jeffrey L. Cummings et al.   JOURNAL OF ALZHEIMERS DISEASE

Human cognition involves the dynamic integration of neural activity and neuromodulatory systems

(2019) James M. Shine et al.   NATURE NEUROSCIENCE

A critical appraisal of amyloid-β-targeting therapies for Alzheimer disease

(2019) Francesco Panza et al.   Nature Reviews Neurology

Beyond the neuron–cellular interactions early in Alzheimer disease pathogenesis

(2019) Christopher M. Henstridge et al.   NATURE REVIEWS NEUROSCIENCE

Ultra-large library docking for discovering new chemotypes

(2019) Jiankun Lyu et al.   NATURE

The role of astroglia in Alzheimer's disease: pathophysiology and clinical implications

(2019) Amaia M Arranz et al.   LANCET NEUROLOGY

GSK3β overexpression driven by GFAP promoter improves rotarod performance

(2019) Jerónimo Jurado-Arjona et al.   BRAIN RESEARCH

The cholinergic system in the pathophysiology and treatment of Alzheimer’s disease

(2018) Harald Hampel et al.   BRAIN

Lithium, Stress, and Resilience in Bipolar Disorder: Deciphering this key homeostatic synaptic plasticity regulator

(2018) Rodrigo Machado-Vieira   JOURNAL OF AFFECTIVE DISORDERS

Revolution of Alzheimer Precision Neurology. Passageway of Systems Biology and Neurophysiology

(2018) Harald Hampel et al.   JOURNAL OF ALZHEIMERS DISEASE

Chronic Lithium Treatment Increases Telomere Length in Parietal Cortex and Hippocampus of Triple-Transgenic Alzheimer’s Disease Mice

(2018) Giancarlo de Mattos Cardillo et al.   JOURNAL OF ALZHEIMERS DISEASE

Tau-targeting therapies for Alzheimer disease

(2018) Erin E. Congdon et al.   Nature Reviews Neurology

Efficacy of Larotrectinib in TRK Fusion–Positive Cancers in Adults and Children

(2018) Alexander Drilon et al.   NEW ENGLAND JOURNAL OF MEDICINE

Precision pharmacology for Alzheimer’s disease

(2018) Harald Hampel et al.   PHARMACOLOGICAL RESEARCH

A mathematical model of multisite phosphorylation of tau protein

(2018) Alexander Stepanov et al.   PLoS One

Impact of amyloid-beta changes on cognitive outcomes in Alzheimer’s disease: analysis of clinical trials using a quantitative systems pharmacology model

(2018) Hugo Geerts et al.   Alzheimers Research & Therapy

Brain Aging and APOE ε4 Interact to Reveal Potential Neuronal Compensation in Healthy Older Adults

(2018) Elisa Scheller et al.   Frontiers in Aging Neuroscience

Relevance of Phosphorylation and Truncation of Tau to the Etiopathogenesis of Alzheimer’s Disease

(2018) Yan Zhou et al.   Frontiers in Aging Neuroscience

Long-Term Treatment with Lithium Alleviates Memory Deficits and Reduces Amyloid-β Production in an Aged Alzheimer's Disease Transgenic Mouse Model

(2018) Xin Zhang et al.   JOURNAL OF ALZHEIMERS DISEASE

Molecular Mechanisms of Lithium Action: Switching the Light on Multiple Targets for Dementia Using Animal Models

(2018) Fiona Kerr et al.   Frontiers in Molecular Neuroscience

Blood-based biomarkers for Alzheimer disease: mapping the road to the clinic

(2018) Harald Hampel et al.   Nature Reviews Neurology

Amyloid in Alzheimer’s Disease: Guilty Beyond Reasonable Doubt?

(2017) Christian Behl   TRENDS IN PHARMACOLOGICAL SCIENCES

Cancer Precision Medicine: From Cancer Screening to Drug Selection and Personalized Immunotherapy

(2017) Xiaolan Deng et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

LISPRO mitigates β-amyloid and associated pathologies in Alzheimer’s mice

(2017) Ahsan Habib et al.   Cell Death & Disease

BACE1 inhibition by microdose lithium formulation NP03 rescues memory loss and early stage amyloid neuropathology

(2017) E N Wilson et al.   Translational Psychiatry

FLEXITau: Quantifying Post-translational Modifications of Tau Protein in Vitro and in Human Disease

(2016) Waltraud Mair et al.   ANALYTICAL CHEMISTRY

Glycogen synthase kinase-3β regulates fractalkine production by altering its trafficking from Golgi to plasma membrane: implications for Alzheimer’s disease

(2016) Almudena Fuster-Matanzo et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Lithium, a Therapy for AD: Current Evidence from Clinical Trials of Neurodegenerative Disorders

(2016) Orestes V. Forlenza et al.   Current Alzheimer Research

GSK3β Overexpression in Dentate Gyrus Neural Precursor Cells Expands the Progenitor Pool and Enhances Memory Skills

(2016) Jerónimo Jurado-Arjona et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Lithium suppression of tau induces brain iron accumulation and neurodegeneration

(2016) P Lei et al.   MOLECULAR PSYCHIATRY

Network abnormalities and interneuron dysfunction in Alzheimer disease

(2016) Jorge J. Palop et al.   NATURE REVIEWS NEUROSCIENCE

Pseudophosphorylation of Tau at distinct epitopes or the presence of the P301L mutation targets the microtubule-associated protein Tau to dendritic spines

(2015) Di Xia et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

A Novel, Ultrasensitive Assay for Tau: Potential for Assessing Traumatic Brain Injury in Tissues and Biofluids

(2015) Richard Rubenstein et al.   JOURNAL OF NEUROTRAUMA

Lithium in the treatment of bipolar disorder: pharmacology and pharmacogenetics

(2015) M Alda   MOLECULAR PSYCHIATRY

Cellular senescence in aging and age-related disease: from mechanisms to therapy

(2015) Bennett G Childs et al.   NATURE MEDICINE

Tau post-translational modifications in wild-type and human amyloid precursor protein transgenic mice

(2015) Meaghan Morris et al.   NATURE NEUROSCIENCE

Correlated gene expression supports synchronous activity in brain networks

(2015) J. Richiardi et al.   SCIENCE

Chronic Microdose Lithium Treatment Prevented Memory Loss and Neurohistopathological Changes in a Transgenic Mouse Model of Alzheimer's Disease

(2015) Marielza Andrade Nunes et al.   PLoS One

GSK-3β dysregulation contributes to parkinson’s-like pathophysiology with associated region-specific phosphorylation and accumulation of tau and α-synuclein

(2014) J J Credle et al.   CELL DEATH AND DIFFERENTIATION

Genomics-Enabled Drug Repositioning and Repurposing

(2014) Aidan Power et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Beneficial synergistic effects of microdose lithium with pyrroloquinoline quinone in an Alzheimer's disease mouse model

(2014) Lei Zhao et al.   NEUROBIOLOGY OF AGING

Extracellular α-Synuclein Leads to Microtubule Destabilization via GSK-3β-Dependent Tau Phosphorylation in PC12 Cells

(2014) Magdalena Gąssowska et al.   PLoS One

Intraneuronal tau aggregation precedes diffuse plaque deposition, but amyloid-β changes occur before increases of tau in cerebrospinal fluid

(2013) Heiko Braak et al.   ACTA NEUROPATHOLOGICA

Dissecting phenotypic traits linked to human resilience to Alzheimer’s pathology

(2013) Beatriz G. Perez-Nievas et al.   BRAIN

Network-Based Approaches in Drug Discovery and Early Development

(2013) J M Harrold et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

Quantitative systems pharmacology as an extension of PK/PD modeling in CNS research and development

(2013) Hugo Geerts et al.   JOURNAL OF PHARMACOKINETICS AND PHARMACODYNAMICS

Glycogen synthase kinase-3 inhibitors: Rescuers of cognitive impairments

(2013) Margaret K. King et al.   PHARMACOLOGY & THERAPEUTICS

Inflammation in Alzheimer Disease--A Brief Review of the Basic Science and Clinical Literature

(2013) T. Wyss-Coray et al.   Cold Spring Harbor Perspectives in Medicine

Development of biomarkers to chart all Alzheimer’s disease stages: The royal road to cutting the therapeutic Gordian Knot

(2012) Harald Hampel et al.   Alzheimers & Dementia

Lithium treatment induces proteasomal degradation of over-expressed acetylcholinesterase (AChE-S) and inhibit GSK3β

(2012) Peng Jing et al.   CHEMICO-BIOLOGICAL INTERACTIONS

Targeting Synaptic Dysfunction in Alzheimer’s Disease Therapy

(2012) Robert Nisticò et al.   MOLECULAR NEUROBIOLOGY

Synergistic influence of phosphorylation and metal ions on tau oligomer formation and coaggregation with α-synuclein at the single molecule level

(2012) Georg Nübling et al.   Molecular Neurodegeneration

FLEXIQinase, a mass spectrometry–based assay, to unveil multikinase mechanisms

(2012) Sasha A Singh et al.   NATURE METHODS

Lithium Treatment of APPSwDI/NOS2−/− Mice Leads to Reduced Hyperphosphorylated Tau, Increased Amyloid Deposition and Altered Inflammatory Phenotype

(2012) Tiffany L. Sudduth et al.   PLoS One

Simulations of symptomatic treatments for Alzheimer's disease: computational analysis of pathology and mechanisms of drug action

(2012) Patrick D Roberts et al.   Alzheimers Research & Therapy

Inhibition of GSK3 by lithium, from single molecules to signaling networks

(2012) Laure Freland et al.   Frontiers in Molecular Neuroscience

Systems Pharmacology: Network Analysis to Identify Multiscale Mechanisms of Drug Action

(2011) Shan Zhao et al.   Annual Review of Pharmacology and Toxicology

Divergent Network Connectivity Changes in Healthy APOE ε4 Carriers

(2011) William W. Seeley   ARCHIVES OF NEUROLOGY

Tau Protein Is Required for Amyloid  -Induced Impairment of Hippocampal Long-Term Potentiation

(2011) O. A. Shipton et al.   JOURNAL OF NEUROSCIENCE

Aβ1–42 inhibition of LTP is mediated by a signaling pathway involving caspase-3, Akt1 and GSK-3β

(2011) Jihoon Jo et al.   NATURE NEUROSCIENCE

Biomarkers for Alzheimer's disease: academic, industry and regulatory perspectives

(2010) Harald Hampel et al.   NATURE REVIEWS DRUG DISCOVERY

Dysregulation of the mTOR Pathway Mediates Impairment of Synaptic Plasticity in a Mouse Model of Alzheimer's Disease

(2010) Tao Ma et al.   PLoS One

Extending Healthy Life Span--From Yeast to Humans

(2010) L. Fontana et al.   SCIENCE

Can Lithium or Valproate Untie Tangles in Alzheimer's Disease?

(2009) Pierre N. Tariot et al.   JOURNAL OF CLINICAL PSYCHIATRY

Lithium Trial in Alzheimer's Disease

(2009) Harald Hampel et al.   JOURNAL OF CLINICAL PSYCHIATRY

Lithium nephrotoxicity revisited

(2009) Jean-Pierre Grünfeld et al.   Nature Reviews Nephrology

Tau-knockout mice show reduced GSK3-induced hippocampal degeneration and learning deficits

(2009) Elena Gómez de Barreda et al.   NEUROBIOLOGY OF DISEASE

DNA Damage, Aging, and Cancer

(2009) Jan H.J. Hoeijmakers   NEW ENGLAND JOURNAL OF MEDICINE

Amyloid-β Binds to the Extracellular Cysteine-rich Domain of Frizzled and Inhibits Wnt/β-Catenin Signaling

(2008) Margaret H. Magdesian et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

GSK-3β Is Required for Memory Reconsolidation in Adult Brain

(2008) Tetsuya Kimura et al.   PLoS One