Is There Justification to Treat Neurodegenerative Disorders by Repurposing Drugs? The Case of Alzheimer’s Disease, Lithium, and Autophagy

Implications of Selective Autophagy Dysfunction for ALS Pathology

(2020) Emiliano Vicencio et al.   Cells

Beneficial effects of low-dose lithium on cognitive ability and pathological alteration of Alzheimer’s disease transgenic mice model

(2020) Meng Liu et al.   NEUROREPORT

Mitophagy inhibits amyloid-β and tau pathology and reverses cognitive deficits in models of Alzheimer’s disease

(2019) Evandro F. Fang et al.   NATURE NEUROSCIENCE

NP03, a Microdose Lithium Formulation, Blunts Early Amyloid Post-Plaque Neuropathology in McGill-R-Thy1-APP Alzheimer-Like Transgenic Rats

(2019) Edward N. Wilson et al.   JOURNAL OF ALZHEIMERS DISEASE

The Synaptic Autophagy Cycle

(2019) Ori J. Lieberman et al.   JOURNAL OF MOLECULAR BIOLOGY

Cognitive benefits of lithium chloride in APP/PS1 mice are associated with enhanced brain clearance of β-amyloid

(2018) Yijun Pan et al.   BRAIN BEHAVIOR AND IMMUNITY

Long-Term Treatment with Lithium Alleviates Memory Deficits and Reduces Amyloid-β Production in an Aged Alzheimer's Disease Transgenic Mouse Model

(2018) Xin Zhang et al.   JOURNAL OF ALZHEIMERS DISEASE

Autophagy in Aging and Alzheimer's Disease: Pathologic or Protective?

(2018) Aaron Barnett et al.   JOURNAL OF ALZHEIMERS DISEASE

The effect of lithium on thyroid function in patients with bipolar disorder.

(2018) Agnieszka Kraszewska et al.   Psychiatria Polska

Molecular Mechanisms of Lithium Action: Switching the Light on Multiple Targets for Dementia Using Animal Models

(2018) Fiona Kerr et al.   Frontiers in Molecular Neuroscience

Parkinson’s Disease: Biomarkers, Treatment, and Risk Factors

(2018) Fatemeh N. Emamzadeh et al.   Frontiers in Neuroscience

Challenging the Negative Perception of Lithium and Optimizing Its Long-Term Administration

(2018) Janusz K. Rybakowski   Frontiers in Molecular Neuroscience

From direct to indirect lithium targets: a comprehensive review of omics data

(2017) Magali Roux et al.   Metallomics

The New News about Lithium: An Underutilized Treatment in the United States

(2017) Robert M Post   NEUROPSYCHOPHARMACOLOGY

TBK1: a new player in ALS linking autophagy and neuroinflammation

(2017) James A. Oakes et al.   Molecular Brain

BACE1 inhibition by microdose lithium formulation NP03 rescues memory loss and early stage amyloid neuropathology

(2017) E N Wilson et al.   Translational Psychiatry

Increase of BDNF Serum Concentration in Lithium Treated Patients with Early Alzheimer's Disease

(2017) Thomas Leyhe et al.   JOURNAL OF ALZHEIMERS DISEASE

Lithium Treatment Arrests the Development of Neurofibrillary Tangles in Mutant Tau Transgenic Mice with Advanced Neurofibrillary Pathology

(2017) Karelle Leroy et al.   JOURNAL OF ALZHEIMERS DISEASE

A Novel Transgenic Rat Model with a Full Alzheimer's-Like Amyloid Pathology Displays Pre-Plaque Intracellular Amyloid-β-Associated Cognitive Impairment

(2017) Wanda Carolina Leon et al.   JOURNAL OF ALZHEIMERS DISEASE

Drug Repositioning for Alzheimer’s Disease Based on Systematic ‘omics’ Data Mining

(2017) Ming Zhang et al.   PLoS One

Role of neuroinflammation in neurodegenerative diseases (Review)

(2016) WEI-WEI CHEN et al.   Molecular Medicine Reports

IP3 accumulation and/or inositol depletion: two downstream lithium’s effects that may mediate its behavioral and cellular changes

(2016) Y Sade et al.   Translational Psychiatry

Lithium Poisoning

(2016) Jonathan Baird-Gunning et al.   JOURNAL OF INTENSIVE CARE MEDICINE

Pathological mechanisms in progressive multiple sclerosis

(2015) Don H Mahad et al.   LANCET NEUROLOGY

Chronic Microdose Lithium Treatment Prevented Memory Loss and Neurohistopathological Changes in a Transgenic Mouse Model of Alzheimer's Disease

(2015) Marielza Andrade Nunes et al.   PLoS One

Effects of Lithium on Inflammation

(2014) Ahmad Nassar et al.   ACS Chemical Neuroscience

Neuroprotective Effects of Lithium: Implications for the Treatment of Alzheimer’s Disease and Related Neurodegenerative Disorders

(2014) O. V. Forlenza et al.   ACS Chemical Neuroscience

Frontotemporal dementia: a bridge between dementia and neuromuscular disease

(2014) Adeline S.L. Ng et al.   Annals of the New York Academy of Sciences

Dissection of genetic factors associated with amyotrophic lateral sclerosis

(2014) Claire S. Leblond et al.   EXPERIMENTAL NEUROLOGY

Long-Term, Low-Dose Lithium Treatment Does Not Impair Renal Function in the Elderly

(2014) Ivan Aprahamian et al.   JOURNAL OF CLINICAL PSYCHIATRY

The phenotypic variability of amyotrophic lateral sclerosis

(2014) Bart Swinnen et al.   Nature Reviews Neurology

Beneficial synergistic effects of microdose lithium with pyrroloquinoline quinone in an Alzheimer's disease mouse model

(2014) Lei Zhao et al.   NEUROBIOLOGY OF AGING

Brain Intraventricular Injection of Amyloid-β in Zebrafish Embryo Impairs Cognition and Increases Tau Phosphorylation, Effects Reversed by Lithium

(2014) Laura Roesler Nery et al.   PLoS One

Dysfunctional autophagy in Alzheimer’s disease: pathogenic roles and therapeutic implications

(2014) Jun-Hua Liang et al.   Neuroscience Bulletin

Repackaging FDA-approved drugs for degenerative diseases: promises and challenges

(2014) Jeffrey L Cummings et al.   Expert Review of Clinical Pharmacology

Models of α-synuclein aggregation in Parkinson’s disease

(2014) Rosa María Giráldez-Pérez et al.   Acta Neuropathologica Communications

Amyotrophic lateral sclerosis: Problems and prospects

(2013) Jemeen Sreedharan et al.   ANNALS OF NEUROLOGY

Discovering New Treatments for Alzheimer's Disease by Repurposing Approved Medications

(2013) Brian Appleby et al.   CURRENT TOPICS IN MEDICINAL CHEMISTRY

A Review: Treatment of Alzheimer’s Disease Discovered in Repurposed Agents

(2013) Brian S. Appleby et al.   DEMENTIA AND GERIATRIC COGNITIVE DISORDERS

Tau pathology and neurodegeneration

(2013) Maria Grazia Spillantini et al.   LANCET NEUROLOGY

Inositol-Related Gene Knockouts Mimic Lithium’s Effect on Mitochondrial Function

(2013) Lilach Toker et al.   NEUROPSYCHOPHARMACOLOGY

Drugs in Search of Diseases

(2013) S. M. Paul et al.   Science Translational Medicine

In vivo modification of Abeta plaque toxicity as a novel neuroprotective lithium-mediated therapy for Alzheimer’s disease pathology

(2013) Laura Trujillo-Estrada et al.   Acta Neuropathologica Communications

Lithium treatment induces proteasomal degradation of over-expressed acetylcholinesterase (AChE-S) and inhibit GSK3β

(2012) Peng Jing et al.   CHEMICO-BIOLOGICAL INTERACTIONS

The genetics of multiple sclerosis: an up-to-date review

(2012) Pierre-Antoine Gourraud et al.   IMMUNOLOGICAL REVIEWS

GSK-3α and GSK-3β Proteins Are Involved in Early Stages of Chondrocyte Differentiation with Functional Redundancy through RelA Protein Phosphorylation

(2012) Shozo Itoh et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Lithium Reduces BACE1 Overexpression, Beta Amyloid Accumulation, and Spatial Learning Deficits in Mice with Traumatic Brain Injury

(2012) Fengshan Yu et al.   JOURNAL OF NEUROTRAUMA

Drug repositioning for Alzheimer's disease

(2012) Anne Corbett et al.   NATURE REVIEWS DRUG DISCOVERY

NP03, a novel low-dose lithium formulation, is neuroprotective in the YAC128 mouse model of Huntington disease

(2012) Mahmoud A. Pouladi et al.   NEUROBIOLOGY OF DISEASE

Regulation of Presynaptic Neurotransmission by Macroautophagy

(2012) Daniela Hernandez et al.   NEURON

Alemtuzumab Therapy for Multiple Sclerosis

(2012) Alasdair J. Coles   Neurotherapeutics

Lithium Treatment of APPSwDI/NOS2−/− Mice Leads to Reduced Hyperphosphorylated Tau, Increased Amyloid Deposition and Altered Inflammatory Phenotype

(2012) Tiffany L. Sudduth et al.   PLoS One

Acetylcholinesterase Involvement in Apoptosis

(2012) Xue-Jun Zhang et al.   Frontiers in Molecular Neuroscience

Chronic Divalproex Sodium to Attenuate Agitation and Clinical Progression of Alzheimer Disease

(2011) Pierre N. Tariot   ARCHIVES OF GENERAL PSYCHIATRY

Disease-modifying properties of long-term lithium treatment for amnestic mild cognitive impairment: randomised controlled trial

(2011) Orestes V. Forlenza et al.   BRITISH JOURNAL OF PSYCHIATRY

Influence of Lithium Treatment on GDNF Serum and CSF Concentrations in Patients with Early Alzheimers Disease

(2011) Guido Straten et al.   Current Alzheimer Research

Glycogen synthase kinase-3 is essential for β-arrestin-2 complex formation and lithium-sensitive behaviors in mice

(2011) W. Timothy O’Brien et al.   JOURNAL OF CLINICAL INVESTIGATION

Lithium Fails to Protect Dopaminergic Neurons in the 6-OHDA Model of Parkinson’s Disease

(2011) Yue Yong et al.   NEUROCHEMICAL RESEARCH

Deconstruction for Reconstruction: The Role of Proteolysis in Neural Plasticity and Disease

(2011) Baris Bingol et al.   NEURON

AKT Kinase Activity Is Required for Lithium to Modulate Mood-Related Behaviors in Mice

(2011) Jen Q Pan et al.   NEUROPSYCHOPHARMACOLOGY

Genetic inactivation of GSK3α rescues spine deficits in Disc1-L100P mutant mice

(2011) Frankie H.F. Lee et al.   SCHIZOPHRENIA RESEARCH

Autophagy, a guardian against neurodegeneration

(2010) Moisés García-Arencibia et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Lithium reduces apoptosis and autophagy after neonatal hypoxia–ischemia

(2010) Q Li et al.   Cell Death & Disease

Inhibition of GSK-3 Ameliorates Aβ Pathology in an Adult-Onset Drosophila Model of Alzheimer's Disease

(2010) Oyinkan Sofola et al.   PLoS Genetics

Lithium-induced enhancement of mitochondrial oxidative phosphorylation in human brain tissue

(2009) Iris C Maurer et al.   BIPOLAR DISORDERS

Autophagy in disease: a double-edged sword with therapeutic potential

(2009) Wim Martinet et al.   CLINICAL SCIENCE

Lithium Pharmacodynamics and Pharmacogenetics: Focus on Inositol Mono Phosphatase (IMPase), Inositol Poliphosphatase (IPPase) and Glycogen Sinthase Kinase 3 Beta (GSK-3 Beta)

(2009) Alessandro Serretti et al.   CURRENT MEDICINAL CHEMISTRY

Lithium Trial in Alzheimer's Disease

(2009) Harald Hampel et al.   JOURNAL OF CLINICAL PSYCHIATRY

Lithium prevents excitotoxic cell death of motoneurons in organotypic slice cultures of spinal cord

(2009) J. Calderó et al.   NEUROSCIENCE

Amyotrophic lateral sclerosis

(2009) Lokesh C Wijesekera et al.   Orphanet Journal of Rare Diseases

Multiple Sclerosis: An Immune or Neurodegenerative Disorder?

(2008) Bruce D. Trapp et al.   Annual Review of Neuroscience

Lithium Treatment and Risk of Dementia

(2008) Lars Vedel Kessing et al.   ARCHIVES OF GENERAL PSYCHIATRY

Brain lithium,N-acetyl aspartate andmyo-inositol levels in older adults with bipolar disorder treated with lithium: a lithium-7 and proton magnetic resonance spectroscopy study

(2008) Brent P Forester et al.   BIPOLAR DISORDERS

Lithium reduces Gsk3b mRNA levels: implications for Alzheimer Disease

(2008) Camila Teixeira Mendes et al.   EUROPEAN ARCHIVES OF PSYCHIATRY AND CLINICAL NEUROSCIENCE

Mechanisms of neurodegeneration in Huntington’s disease

(2008) Joana M. Gil et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

A feasibility and tolerability study of lithium in Alzheimer's disease

(2008) Alastair Macdonald et al.   INTERNATIONAL JOURNAL OF GERIATRIC PSYCHIATRY

Wild Type α-Synuclein Is Degraded by Chaperone-mediated Autophagy and Macroautophagy in Neuronal Cells

(2008) Tereza Vogiatzi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Parkin is recruited selectively to impaired mitochondria and promotes their autophagy

(2008) Derek Narendra et al.   JOURNAL OF CELL BIOLOGY

Autophagy Induction and Autophagosome Clearance in Neurons: Relationship to Autophagic Pathology in Alzheimer's Disease

(2008) B. Boland et al.   JOURNAL OF NEUROSCIENCE

Lithium down-regulates tau in cultured cortical neurons: A possible mechanism of neuroprotection

(2008) A. Rametti et al.   NEUROSCIENCE LETTERS

N-Acetylcholinesterase-Induced Apoptosis in Alzheimer's Disease

(2008) Debra Toiber et al.   PLoS One

Epidemiology and clinical features of amyotrophic lateral sclerosis in Ireland between 1995 and 2004

(2007) O O'Toole et al.   JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY