mTOR in Brain Physiology and Pathologies

Reinstating Aberrant mTORC1 Activity in Huntington’s Disease Mice Improves Disease Phenotypes

(2015) John H. Lee et al.   NEURON

Glutamate Receptor Antagonists as Fast-Acting Therapeutic Alternatives for the Treatment of Depression: Ketamine and Other Compounds

(2014) Mark J. Niciu et al.   Annual Review of Pharmacology and Toxicology

Altered macroautophagy in the spinal cord of SOD1 mutant mice

(2014) Liang Li et al.   Autophagy

MTOR-independent, autophagic enhancer trehalose prolongs motor neuron survival and ameliorates the autophagic flux defect in a mouse model of amyotrophic lateral sclerosis

(2014) Xiaojie Zhang et al.   Autophagy

Neuropathological role of PI3K/Akt/mTOR axis in Down syndrome brain

(2014) Marzia Perluigi et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Pivotal Role of mTORC2 and Involvement of Ribosomal Protein S6 in Cardioprotective Signaling

(2014) Toshiyuki Yano et al.   CIRCULATION RESEARCH

Getting ready for building: signaling and autophagosome biogenesis

(2014) A. Abada et al.   EMBO REPORTS

Baicalein induces autophagic cell death through AMPK/ULK1 activation and downregulation of mTORC1 complex components in human cancer cells

(2014) Pramod Aryal et al.   FEBS Journal

Interaction of mTOR and Erk1/2 signaling to regulate oligodendrocyte differentiation

(2014) JinXiang Dai et al.   GLIA

Repeated stimulation of dopamine D1-like receptor and hyperactivation of mTOR signaling lead to generalized seizures, altered dentate gyrus plasticity, and memory deficits

(2014) Giuseppe Gangarossa et al.   HIPPOCAMPUS

Functional Effects of a Pathogenic Mutation inCereblon(CRBN) on the Regulation of Protein Synthesis via the AMPK-mTOR Cascade

(2014) Kwang Min Lee et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Role of Akt and Mammalian Target of Rapamycin in Functional Outcome after Concussive Brain Injury in Mice

(2014) Xiaoxia Zhu et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Opioid receptor–triggered spinal mTORC1 activation contributes to morphine tolerance and hyperalgesia

(2014) Ji-Tian Xu et al.   JOURNAL OF CLINICAL INVESTIGATION

mTOR Hyperactivation in Down Syndrome Hippocampus Appears Early During Development

(2014) Anand M. Iyer et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

Stimulated Emission Depletion (STED) Microscopy Reveals Nanoscale Defects in the Developmental Trajectory of Dendritic Spine Morphogenesis in a Mouse Model of Fragile X Syndrome

(2014) L. S. Wijetunge et al.   JOURNAL OF NEUROSCIENCE

Ezh2 Regulates Adult Hippocampal Neurogenesis and Memory

(2014) J. Zhang et al.   JOURNAL OF NEUROSCIENCE

Genetic Reduction of Mammalian Target of Rapamycin Ameliorates Alzheimer's Disease-Like Cognitive and Pathological Deficits by Restoring Hippocampal Gene Expression Signature

(2014) A. Caccamo et al.   JOURNAL OF NEUROSCIENCE

Conditional Ablation of Raptor or Rictor Has Differential Impact on Oligodendrocyte Differentiation and CNS Myelination

(2014) K. K. Bercury et al.   JOURNAL OF NEUROSCIENCE

Mammalian Target of Rapamycin Promotes Oligodendrocyte Differentiation, Initiation and Extent of CNS Myelination

(2014) S. E. Wahl et al.   JOURNAL OF NEUROSCIENCE

Balanced mTORC1 Activity in Oligodendrocytes Is Required for Accurate CNS Myelination

(2014) F. Lebrun-Julien et al.   JOURNAL OF NEUROSCIENCE

Quercetin attenuates renal ischemia/reperfusion injury via an activation of AMP-activated protein kinase-regulated autophagy pathway

(2014) Bo-Lin Chen et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

Influence of mTOR in energy and metabolic homeostasis

(2014) Magalie Haissaguerre et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

5-HT6 Receptor Recruitment of mTOR Modulates Seizure Activity in Epilepsy

(2014) Liang Wang et al.   MOLECULAR NEUROBIOLOGY

Coordinated regulation of protein synthesis and degradation by mTORC1

(2014) Yinan Zhang et al.   NATURE

The mTOR signaling pathway and neuronal stem/progenitor cell proliferation in the hippocampus are altered during the development of absence epilepsy in a genetic animal model

(2014) Emilio Russo et al.   NEUROLOGICAL SCIENCES

Loss of mTOR-Dependent Macroautophagy Causes Autistic-like Synaptic Pruning Deficits

(2014) Guomei Tang et al.   NEURON

mTORC1 Inhibition in the Nucleus Accumbens ‘Protects’ Against the Expression of Drug Seeking and ‘Relapse’ and Is Associated with Reductions in GluA1 AMPAR and CAMKIIα Levels

(2014) Morgan H James et al.   NEUROPSYCHOPHARMACOLOGY

Huntingtin promotes mTORC1 signaling in the pathogenesis of Huntington's disease

(2014) W. M. Pryor et al.   Science Signaling

mTORC1 signaling controls multiple steps in ribosome biogenesis

(2014) Valentina Iadevaia et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

mTOR and autophagy: A dynamic relationship governed by nutrients and energy

(2014) E.A. Dunlop et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Lost in the jungle: new hurdles for optic nerve axon regeneration

(2014) Vincent Pernet et al.   TRENDS IN NEUROSCIENCES

Betulin inhibits lung carcinoma proliferation through activation of AMPK signaling

(2014) Xian-Dong Li et al.   TUMOR BIOLOGY

Auditory Processing in Fragile X Syndrome

(2014) Sarah E. Rotschafer et al.   Frontiers in Cellular Neuroscience

Parkin loss of function contributes to RTP801 elevation and neurodegeneration in Parkinson’s disease

(2014) J Romaní-Aumedes et al.   Cell Death & Disease

Akt and mTOR mediate programmed necrosis in neurons

(2014) Q Liu et al.   Cell Death & Disease

Activation of Rheb, but not of mTORC1, impairs spine synapse morphogenesis in tuberous sclerosis complex

(2014) Shin Yasuda et al.   Scientific Reports

mTOR signaling contributes to motor skill learning in mice

(2014) Yan Bergeron et al.   Frontiers in Molecular Neuroscience

mTOR signaling and its roles in normal and abnormal brain development

(2014) Nobuyuki Takei et al.   Frontiers in Molecular Neuroscience

Deletion of PTEN produces autism-like behavioral deficits and alterations in synaptic proteins

(2014) Joaquin N. Lugo et al.   Frontiers in Molecular Neuroscience

Mechanisms regulating neuronal excitability and seizure development following mTOR pathway hyperactivation

(2014) Candi L. LaSarge et al.   Frontiers in Molecular Neuroscience

Rictor/mTORC2 facilitates central regulation of energy and glucose homeostasis

(2014) Heidi E. Kocalis et al.   Molecular Metabolism

Mutant BRAF V600E protein in ganglioglioma is predominantly expressed by neuronal tumor cells

(2013) Christian Koelsche et al.   ACTA NEUROPATHOLOGICA

AMP-Activated Protein Kinase Signaling Protects Oligodendrocytes that Restore Central Nervous System Functions in an Experimental Autoimmune Encephalomyelitis Model

(2013) Ajaib S. Paintlia et al.   AMERICAN JOURNAL OF PATHOLOGY

Everolimus treatment of refractory epilepsy in tuberous sclerosis complex

(2013) Darcy A. Krueger et al.   ANNALS OF NEUROLOGY

mTOR direct interactions with Rheb-GTPase and raptor: sub-cellular localization using fluorescence lifetime imaging

(2013) Rahul B Yadav et al.   BMC CELL BIOLOGY

mTOR/PRAS40 interaction: Hypertrophy or proliferation

(2013) Mirko Völkers et al.   CELL CYCLE

Rheb Regulates Mitophagy Induced by Mitochondrial Energetic Status

(2013) Su Melser et al.   Cell Metabolism

Axonal protein synthesis and the regulation of primary afferent function

(2013) Ilona Obara et al.   Developmental Neurobiology

A critical review of mTOR inhibitors and epilepsy: from basic science to clinical trials

(2013) Michael Wong   Expert Review of Neurotherapeutics

A functional role of NMDA receptor in regulating the differentiation of oligodendrocyte precursor cells and remyelination

(2013) Cui Li et al.   GLIA

Memory accuracy predicts hippocampal mTOR pathway activation following retrieval of contextual fear memory

(2013) Georgette M. Gafford et al.   HIPPOCAMPUS

Mammalian Target of Rapamycin (mTor) Mediates Tau Protein Dyshomeostasis

(2013) Zhi Tang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Rhes, a Striatal-selective Protein Implicated in Huntington Disease, Binds Beclin-1 and Activates Autophagy

(2013) Robert G. Mealer et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Ablation of the mTORC2 component rictor in brain or Purkinje cells affects size and neuron morphology

(2013) Venus Thomanetz et al.   JOURNAL OF CELL BIOLOGY

Chronic Rapamycin Restores Brain Vascular Integrity and Function Through NO Synthase Activation and Improves Memory in Symptomatic Mice Modeling Alzheimer’s Disease

(2013) Ai-Ling Lin et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Rapamycin extends murine lifespan but has limited effects on aging

(2013) Frauke Neff et al.   JOURNAL OF CLINICAL INVESTIGATION

Transient and rapid activation of Akt/GSK-3β and mTORC1 signaling by D3 dopamine receptor stimulation in dorsal striatum and nucleus accumbens

(2013) Marie-Josèphe Salles et al.   JOURNAL OF NEUROCHEMISTRY

Selective Regulation of GluA Subunit Synthesis and AMPA Receptor-Mediated Synaptic Function and Plasticity by the Translation Repressor 4E-BP2 in Hippocampal Pyramidal Cells

(2013) I. Ran et al.   JOURNAL OF NEUROSCIENCE

Rheb Activation in Subventricular Zone Progenitors Leads to Heterotopia, Ectopic Neuronal Differentiation, and Rapamycin-Sensitive Olfactory Micronodules and Dendrite Hypertrophy of Newborn Neurons

(2013) C. A. Lafourcade et al.   JOURNAL OF NEUROSCIENCE

Rhes Deletion Is Neuroprotective in the 3-Nitropropionic Acid Model of Huntington's Disease

(2013) R. G. Mealer et al.   JOURNAL OF NEUROSCIENCE

Dendritic Arborization and Spine Dynamics Are Abnormal in the Mouse Model of MECP2 Duplication Syndrome

(2013) M. Jiang et al.   JOURNAL OF NEUROSCIENCE

PI3K-Akt Signaling Activates mTOR-Mediated Epileptogenesis in Organotypic Hippocampal Culture Model of Post-Traumatic Epilepsy

(2013) Y. Berdichevsky et al.   JOURNAL OF NEUROSCIENCE

Minireview: Nutrient Sensing by G Protein-Coupled Receptors

(2013) Eric M. Wauson et al.   MOLECULAR ENDOCRINOLOGY

The mTOR Signaling Pathway Regulates Pain-Related Synaptic Plasticity in Rat Entorhinal-Hippocampal Pathways

(2013) Dan Lyu et al.   Molecular Pain

mTOR kinase structure, mechanism and regulation

(2013) Haijuan Yang et al.   NATURE

TSC on the peroxisome controls mTORC1

(2013) Don Benjamin et al.   NATURE CELL BIOLOGY

Mutations in DEPDC5 cause familial focal epilepsy with variable foci

(2013) Leanne M Dibbens et al.   NATURE GENETICS

Targeting the endocannabinoid system in the treatment of fragile X syndrome

(2013) Arnau Busquets-Garcia et al.   NATURE MEDICINE

The role of autophagy in neurodegenerative disease

(2013) Ralph A Nixon   NATURE MEDICINE

Disruption of alcohol-related memories by mTORC1 inhibition prevents relapse

(2013) Segev Barak et al.   NATURE NEUROSCIENCE

mTORC2 controls actin polymerization required for consolidation of long-term memory

(2013) Wei Huang et al.   NATURE NEUROSCIENCE

mTOR complexes in neurodevelopmental and neuropsychiatric disorders

(2013) Mauro Costa-Mattioli et al.   NATURE NEUROSCIENCE

Mammalian target of rapamycin hyperactivity mediates the detrimental effects of a high sucrose diet on Alzheimer's disease pathology

(2013) Miranda E. Orr et al.   NEUROBIOLOGY OF AGING

mTOR Inhibition Ameliorates Cognitive and Affective Deficits Caused by Disc1 Knockdown in Adult-Born Dentate Granule Neurons

(2013) Miou Zhou et al.   NEURON

Neuroprotection through Excitability and mTOR Required in ALS Motoneurons to Delay Disease and Extend Survival

(2013) Smita Saxena et al.   NEURON

Translational Control of Entrainment and Synchrony of the Suprachiasmatic Circadian Clock by mTOR/4E-BP1 Signaling

(2013) Ruifeng Cao et al.   NEURON

Excitatory/Inhibitory Synaptic Imbalance Leads to Hippocampal Hyperexcitability in Mouse Models of Tuberous Sclerosis

(2013) Helen S. Bateup et al.   NEURON

mTORC1-dependent protein synthesis underlying rapid antidepressant effect requires GABABR signaling

(2013) E.R. Workman et al.   NEUROPHARMACOLOGY

Focal malformations of cortical development: New vistas for molecular pathogenesis

(2013) K.-C. Lim et al.   NEUROSCIENCE

Molecular targets for cancer therapy in the PI3K/AKT/mTOR pathway

(2013) Jiri Polivka et al.   PHARMACOLOGY & THERAPEUTICS

Attenuation of Rhes Activity Significantly Delays the Appearance of Behavioral Symptoms in a Mouse Model of Huntington's Disease

(2013) Brandon A. Baiamonte et al.   PLoS One

Dysregulation of synaptic plasticity precedes appearance of morphological defects in a Pten conditional knockout mouse model of autism

(2013) K. Takeuchi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

mTOR Inhibition Alleviates Mitochondrial Disease in a Mouse Model of Leigh Syndrome

(2013) S. C. Johnson et al.   SCIENCE

A Tumor Suppressor Complex with GAP Activity for the Rag GTPases That Signal Amino Acid Sufficiency to mTORC1

(2013) L. Bar-Peled et al.   SCIENCE

Rapamycin Prevents Seizures After Depletion of STRADA in a Rare Neurodevelopmental Disorder

(2013) W. E. Parker et al.   Science Translational Medicine

Rheb and mammalian target of rapamycin in mitochondrial homoeostasis

(2013) M. J. Groenewoud et al.   Open Biology

Role of PRAS40 in Akt and mTOR signaling in health and disease

(2012) Claudia Wiza et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Rapamycin inhibits the growth of glioblastoma

(2012) Antonietta Arcella et al.   BRAIN RESEARCH

mTOR Signaling in Growth Control and Disease

(2012) Mathieu Laplante et al.   CELL

Rapamycin increases lifespan and inhibits spontaneous tumorigenesis in inbred female mice

(2012) Vladimir N. Anisimov et al.   CELL CYCLE

mTOR signaling in neural stem cells: from basic biology to disease

(2012) Laura Magri et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Targeting mTOR as a novel therapeutic strategy for traumatic CNS injuries

(2012) Aruni S. Arachchige Don et al.   DRUG DISCOVERY TODAY

5-HT6receptor recruitment of mTOR as a mechanism for perturbed cognition in schizophrenia

(2012) Julie Meffre et al.   EMBO Molecular Medicine

Regulation of TOR by small GTPases

(2012) Raúl V Durán et al.   EMBO REPORTS

Pentylenetetrazole-induced seizures cause acute, but not chronic, mTOR pathway activation in rat

(2012) Bo Zhang et al.   EPILEPSIA

mTOR Pathway Overactivation in BRAF Mutated Papillary Thyroid Carcinoma

(2012) Alexandra Faustino et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Over-expression of heat shock factor 1 phenocopies the effect of chronic inhibition of TOR by rapamycin and is sufficient to ameliorate Alzheimer's-like deficits in mice modeling the disease

(2012) Anson Pierce et al.   JOURNAL OF NEUROCHEMISTRY

Arrest of Myelination and Reduced Axon Growth When Schwann Cells Lack mTOR

(2012) D. L. Sherman et al.   JOURNAL OF NEUROSCIENCE

Evidence for a Fragile X Mental Retardation Protein-Mediated Translational Switch in Metabotropic Glutamate Receptor-Triggered Arc Translation and Long-Term Depression

(2012) F. Niere et al.   JOURNAL OF NEUROSCIENCE

Spinal Cord NMDA Receptor-Mediated Activation of Mammalian Target of Rapamycin Is Required for the Development and Maintenance of Bone Cancer-Induced Pain Hypersensitivities in Rats

(2012) Ming-Hung Shih et al.   JOURNAL OF PAIN

The G Protein-Coupled Taste Receptor T1R1/T1R3 Regulates mTORC1 and Autophagy

(2012) Eric M. Wauson et al.   MOLECULAR CELL

mTOR and tau phosphorylated proteins in the hippocampal tissue of rats with type 2 diabetes and Alzheimer’s disease

(2012) YUN-QING MA et al.   Molecular Medicine Reports

Autistic-like behaviour and cerebellar dysfunction in Purkinje cell Tsc1 mutant mice

(2012) Peter T. Tsai et al.   NATURE

A unifying model for mTORC1-mediated regulation of mRNA translation

(2012) Carson C. Thoreen et al.   NATURE

De novo somatic mutations in components of the PI3K-AKT3-mTOR pathway cause hemimegalencephaly

(2012) Jeong Ho Lee et al.   NATURE GENETICS

PTEN promoter methylation and activation of the PI3K/Akt/mTOR pathway in pediatric gliomas and influence on clinical outcome

(2012) S. Mueller et al.   NEURO-ONCOLOGY

Rapamycin Ameliorates Age-Dependent Obesity Associated with Increased mTOR Signaling in Hypothalamic POMC Neurons

(2012) Shi-Bing Yang et al.   NEURON

Enhancement of Dorsal Hippocampal Activity by Knockdown of HCN1 Channels Leads to Anxiolytic- and Antidepressant-like Behaviors

(2012) Chung Sub Kim et al.   NEURON

Excessive Activation of mTOR in Postnatally Generated Granule Cells Is Sufficient to Cause Epilepsy

(2012) Raymund Y.K. Pun et al.   NEURON

Somatic Activation of AKT3 Causes Hemispheric Developmental Brain Malformations

(2012) Annapurna Poduri et al.   NEURON

From genes to cognition in tuberous sclerosis: Implications for mTOR inhibitor-based treatment approaches

(2012) Dan Ehninger   NEUROPHARMACOLOGY

Chronic inhibition of mammalian target of rapamycin by rapamycin modulates cognitive and non-cognitive components of behavior throughout lifespan in mice

(2012) J. Halloran et al.   NEUROSCIENCE

The trouble with spines in fragile X syndrome: density, maturity and plasticity

(2012) C.X. He et al.   NEUROSCIENCE

BRAFV600E Negatively Regulates the AKT Pathway in Melanoma Cell Lines

(2012) Brenden Chen et al.   PLoS One

Hypothalamic mTOR Signaling Mediates the Orexigenic Action of Ghrelin

(2012) Luís Martins et al.   PLoS One

Synaptic plasticity in depression: Molecular, cellular and functional correlates

(2012) W.N. Marsden   PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY

Inhibition of calcineurin in the prefrontal cortex induced depressive-like behavior through mTOR signaling pathway

(2012) Jing-Jie Yu et al.   PSYCHOPHARMACOLOGY

Rapamycin-Induced Insulin Resistance Is Mediated by mTORC2 Loss and Uncoupled from Longevity

(2012) D. W. Lamming et al.   SCIENCE

Signaling pathways underlying the pathophysiology and treatment of depression: novel mechanisms for rapid-acting agents

(2012) Ronald S. Duman et al.   TRENDS IN NEUROSCIENCES

Overexpression of S6 Kinase 1 in Brain Tumours Is Associated with Induction of Hypoxia-Responsive Genes and Predicts Patients' Survival

(2012) Heba M.S. Ismail   Journal of Oncology

Analysis of BRAF V600E mutation in 1,320 nervous system tumors reveals high mutation frequencies in pleomorphic xanthoastrocytoma, ganglioglioma and extra-cerebellar pilocytic astrocytoma

(2011) Genevieve Schindler et al.   ACTA NEUROPATHOLOGICA

Rapamycin attenuates the expression of cocaine-induced place preference and behavioral sensitization

(2011) Jeffrey Bailey et al.   ADDICTION BIOLOGY

Lifelong rapamycin administration ameliorates age-dependent cognitive deficits by reducing IL-1β and enhancing NMDA signaling

(2011) Smita Majumder et al.   AGING CELL

Dopaminergic pathway reconstruction by Akt/Rheb-induced axon regeneration

(2011) Sang Ryong Kim et al.   ANNALS OF NEUROLOGY

Altered inhibition in tuberous sclerosis and type IIb cortical dysplasia

(2011) Delia M. Talos et al.   ANNALS OF NEUROLOGY

SQSTM1 Mutations in Familial and Sporadic Amyotrophic Lateral Sclerosis

(2011) Faisal Fecto   ARCHIVES OF NEUROLOGY

Rapamycin treatment augments motor neuron degeneration in SOD1G93Amouse model of amyotrophic lateral sclerosis

(2011) Xiaojie Zhang et al.   Autophagy

The serine/threonine kinase ULK1 is a target of multiple phosphorylation events

(2011) Markus Bach et al.   BIOCHEMICAL JOURNAL

Glutamate N-methyl-D-aspartate Receptor Antagonists Rapidly Reverse Behavioral and Synaptic Deficits Caused by Chronic Stress Exposure

(2011) Nanxin Li et al.   BIOLOGICAL PSYCHIATRY

Decreased benzodiazepine receptor and increased GABA level in cortical tubers in tuberous sclerosis complex

(2011) Kenji Mori et al.   BRAIN & DEVELOPMENT

Metformin, Independent of AMPK, Induces mTOR Inhibition and Cell-Cycle Arrest through REDD1

(2011) I. Ben Sahra et al.   CANCER RESEARCH

Activation of mTORC2 by Association with the Ribosome

(2011) Vittoria Zinzalla et al.   CELL

mTOR Complex 1 Regulates Lipin 1 Localization to Control the SREBP Pathway

(2011) Timothy R. Peterson et al.   CELL

An emerging role for TOR signaling in mammalian tissue and stem cell physiology

(2011) Ryan C. Russell et al.   DEVELOPMENT

Rheb1 Is Required for mTORC1 and Myelination in Postnatal Brain Development

(2011) Jia Zou et al.   DEVELOPMENTAL CELL

Regulation of TFEB and V-ATPases by mTORC1

(2011) Samuel Peña-Llopis et al.   EMBO JOURNAL

GADD34 mediates cytoprotective autophagy in mutant huntingtin expressing cells via the mTOR pathway

(2011) Alise Hyrskyluoto et al.   EXPERIMENTAL CELL RESEARCH

Pten ablation in adult dopaminergic neurons is neuroprotective in Parkinson's disease models

(2011) Andrii Domanskyi et al.   FASEB JOURNAL

Reduced AKT/mTOR signaling and protein synthesis dysregulation in a Rett syndrome animal model

(2011) Sara Ricciardi et al.   HUMAN MOLECULAR GENETICS

TOR kinase complexes and cell migration

(2011) Lunhua Liu et al.   JOURNAL OF CELL BIOLOGY

Combination Therapy Targeting Akt and Mammalian Target of Rapamycin Improves Functional Outcome after Controlled Cortical Impact in Mice

(2011) Juyeon Park et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Induction of autophagy with catalytic mTOR inhibitors reduces huntingtin aggregates in a neuronal cell model

(2011) Ana Roscic et al.   JOURNAL OF NEUROCHEMISTRY

Autophagy in Spinal Cord Motor Neurons in Sporadic Amyotrophic Lateral Sclerosis

(2011) Shoichi Sasaki   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

Loss of Tsc1 In Vivo Impairs Hippocampal mGluR-LTD and Increases Excitatory Synaptic Function

(2011) H. S. Bateup et al.   JOURNAL OF NEUROSCIENCE

RTP801/REDD1 Regulates the Timing of Cortical Neurogenesis and Neuron Migration

(2011) C. Malagelada et al.   JOURNAL OF NEUROSCIENCE

An Increase in Basal BDNF Provokes Hyperactivation of the Akt-Mammalian Target of Rapamycin Pathway and Deregulation of Local Dendritic Translation in a Mouse Model of Down's Syndrome

(2011) J. A. Troca-Marin et al.   JOURNAL OF NEUROSCIENCE

Nucleolar Disruption in Dopaminergic Neurons Leads to Oxidative Damage and Parkinsonism through Repression of Mammalian Target of Rapamycin Signaling

(2011) C. Rieker et al.   JOURNAL OF NEUROSCIENCE

Disrupting Function of FK506-Binding Protein 1b/12.6 Induces the Ca2+-Dysregulation Aging Phenotype in Hippocampal Neurons

(2011) J. C. Gant et al.   JOURNAL OF NEUROSCIENCE

Rac1 Regulates the Activity of mTORC1 and mTORC2 and Controls Cellular Size

(2011) Abdelhafid Saci et al.   MOLECULAR CELL

AAV Transduction of Dopamine Neurons With Constitutively Active Rheb Protects From Neurodegeneration and Mediates Axon Regrowth

(2011) Sang Ryong Kim et al.   MOLECULAR THERAPY

Mutations causing syndromic autism define an axis of synaptic pathophysiology

(2011) Benjamin D. Auerbach et al.   NATURE

NMDA receptor blockade at rest triggers rapid behavioural antidepressant responses

(2011) Anita E. Autry et al.   NATURE

Inactivation of Rheb by PRAK-mediated phosphorylation is essential for energy-depletion-induced suppression of mTORC1

(2011) Min Zheng et al.   NATURE CELL BIOLOGY

Rhes, a striatal-enriched small G protein, mediates mTOR signaling and L-DOPA–induced dyskinesia

(2011) Srinivasa Subramaniam et al.   NATURE NEUROSCIENCE

Loss of the tuberous sclerosis complex protein tuberin causes Purkinje cell degeneration

(2011) R. Michelle Reith et al.   NEUROBIOLOGY OF DISEASE

Neuronal and glia abnormalities in Tsc1-deficient forebrain and partial rescue by rapamycin

(2011) Robert P. Carson et al.   NEUROBIOLOGY OF DISEASE

Role for mTOR Signaling and Neuronal Activity in Morphine-Induced Adaptations in Ventral Tegmental Area Dopamine Neurons

(2011) Michelle S. Mazei-Robison et al.   NEURON

Insulin promotes dendritic spine and synapse formation by the PI3K/Akt/mTOR and Rac1 signaling pathways

(2011) Cheng-Che Lee et al.   NEUROPHARMACOLOGY

Signaling pathways underlying the rapid antidepressant actions of ketamine

(2011) Ronald S. Duman et al.   NEUROPHARMACOLOGY

Networking in Autism: Leveraging Genetic, Biomarker and Model System Findings in the Search for New Treatments

(2011) Jeremy Veenstra-VanderWeele et al.   NEUROPSYCHOPHARMACOLOGY

Association of the Small GTPase Rheb with the NMDA Receptor Subunit NR3A

(2011) Nikolaus J. Sucher et al.   NEUROSIGNALS

Long-Term Continuous Corticosterone Treatment Decreases VEGF Receptor-2 Expression in Frontal Cortex

(2011) Kristy R. Howell et al.   PLoS One

Selective pharmacogenetic inhibition of mammalian target of Rapamycin complex I (mTORC1) blocks long-term synaptic plasticity and memory storage

(2011) Loredana Stoica et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The mTOR signaling pathway in the prefrontal cortex is compromised in major depressive disorder

(2011) Courtney S. Jernigan et al.   PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY

mTORC1 Senses Lysosomal Amino Acids Through an Inside-Out Mechanism That Requires the Vacuolar H+-ATPase

(2011) R. Zoncu et al.   SCIENCE

Hemimegalencephaly: a fetal case with neuropathological confirmation and review of the literature

(2010) Branavan Manoranjan et al.   ACTA NEUROPATHOLOGICA

Bicyclic triterpenoid Iripallidal induces apoptosis and inhibits Akt/mTOR pathway in glioma cells

(2010) Nitin Koul et al.   BMC CANCER

Lysosomal Proteolysis and Autophagy Require Presenilin 1 and Are Disrupted by Alzheimer-Related PS1 Mutations

(2010) Ju-Hyun Lee et al.   CELL

Ragulator-Rag Complex Targets mTORC1 to the Lysosomal Surface and Is Necessary for Its Activation by Amino Acids

(2010) Yasemin Sancak et al.   CELL

mTORC1 signaling in Parkinson disease and L-DOPA-induced dyskinesia: A sensitized matter

(2010) Emanuela Santini et al.   CELL CYCLE

Phosphorylation of PRAS40 on Thr246 by PKB/AKT facilitates efficient phosphorylation of Ser183 by mTORC1

(2010) Emmani B.M. Nascimento et al.   CELLULAR SIGNALLING

Multi-mechanisms are involved in reactive oxygen species regulation of mTORC1 signaling

(2010) Ming Li et al.   CELLULAR SIGNALLING

Laforin, the most common protein mutated in Lafora disease, regulates autophagy

(2010) Carmen Aguado et al.   HUMAN MOLECULAR GENETICS

Molecular Interplay between Mammalian Target of Rapamycin (mTOR), Amyloid-β, and Tau

(2010) Antonella Caccamo et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Mammalian Target of Rapamycin (mTOR) Activation Increases Axonal Growth Capacity of Injured Peripheral Nerves

(2010) Namiko Abe et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Caveat mTOR: aberrant signaling disrupts corticogenesis

(2010) Lucy R. Osborne   JOURNAL OF CLINICAL INVESTIGATION

STRADα deficiency results in aberrant mTORC1 signaling during corticogenesis in humans and mice

(2010) Ksenia A. Orlova et al.   JOURNAL OF CLINICAL INVESTIGATION

mTOR-mediated dedifferentiation of the retinal pigment epithelium initiates photoreceptor degeneration in mice

(2010) Chen Zhao et al.   JOURNAL OF CLINICAL INVESTIGATION

Early Progenitor Cell Marker Expression Distinguishes Type II From Type I Focal Cortical Dysplasias

(2010) Ksenia A. Orlova et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

Rapamycin Protects against Neuron Death in In Vitro andIn Vivo Models of Parkinson's Disease

(2010) C. Malagelada et al.   JOURNAL OF NEUROSCIENCE

Nucleus Accumbens Core Mammalian Target of Rapamycin Signaling Pathway Is Critical for Cue-Induced Reinstatement of Cocaine Seeking in Rats

(2010) X. Wang et al.   JOURNAL OF NEUROSCIENCE

Dysregulation of mTOR Signaling in Fragile X Syndrome

(2010) A. Sharma et al.   JOURNAL OF NEUROSCIENCE

Rapamycin, But Not Resveratrol or Simvastatin, Extends Life Span of Genetically Heterogeneous Mice

(2010) Richard A. Miller et al.   JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES

Cyclic AMP Controls mTOR through Regulation of the Dynamic Interaction between Rheb and Phosphodiesterase 4D

(2010) H. W. Kim et al.   MOLECULAR AND CELLULAR BIOLOGY

The Late Endosome is Essential for mTORC1 Signaling

(2010) Rory J. Flinn et al.   MOLECULAR BIOLOGY OF THE CELL

Activation of a Metabolic Gene Regulatory Network Downstream of mTOR Complex 1

(2010) Katrin Düvel et al.   MOLECULAR CELL

Regulation of the mTOR Complex 1 Pathway by Nutrients, Growth Factors, and Stress

(2010) Shomit Sengupta et al.   MOLECULAR CELL

cAMP-Dependent Activation of Mammalian Target of Rapamycin (mTOR) in Thyroid Cells. Implication in Mitogenesis and Activation of CDK4

(2010) Sara Blancquaert et al.   MOLECULAR ENDOCRINOLOGY

PTEN deletion enhances the regenerative ability of adult corticospinal neurons

(2010) Kai Liu et al.   NATURE NEUROSCIENCE

Tsc2-Rheb signaling regulates EphA-mediated axon guidance

(2010) Duyu Nie et al.   NATURE NEUROSCIENCE

mTOR: from growth signal integration to cancer, diabetes and ageing

(2010) Roberto Zoncu et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Pharmacological inhibition of the mammalian target of rapamycin pathway suppresses acquired epilepsy

(2010) Xiaoxing Huang et al.   NEUROBIOLOGY OF DISEASE

Group 1 mGluR-Dependent Synaptic Long-Term Depression: Mechanisms and Implications for Circuitry and Disease

(2010) Christian Lüscher et al.   NEURON

Selective Molecular Alterations in the Autophagy Pathway in Patients with Lewy Body Disease and in Models of α-Synucleinopathy

(2010) Leslie Crews et al.   PLoS One

Inhibition of mTOR by Rapamycin Abolishes Cognitive Deficits and Reduces Amyloid-β Levels in a Mouse Model of Alzheimer's Disease

(2010) Patricia Spilman et al.   PLoS One

Dysregulation of the mTOR Pathway Mediates Impairment of Synaptic Plasticity in a Mouse Model of Alzheimer's Disease

(2010) Tao Ma et al.   PLoS One

Biguanide metformin acts on tau phosphorylation via mTOR/protein phosphatase 2A (PP2A) signaling

(2010) E. Kickstein et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

mTOR-Dependent Synapse Formation Underlies the Rapid Antidepressant Effects of NMDA Antagonists

(2010) N. Li et al.   SCIENCE

Rapamycin for treating Tuberous sclerosis and Autism spectrum disorders

(2010) Dan Ehninger et al.   TRENDS IN MOLECULAR MEDICINE

Dysregulation of the Norepinephrine Transporter Sustains Cortical Hypodopaminergia and Schizophrenia-Like Behaviors in Neuronal Rictor Null Mice

(2010) Michael A. Siuta et al.   PLOS BIOLOGY

Critical Role for Hypothalamic mTOR Activity in Energy Balance

(2009) Hiroyuki Mori et al.   Cell Metabolism

Initiation of neuronal differentiation requires PI3-kinase/TOR signalling in the vertebrate neural tube

(2009) Katherine J. Fishwick et al.   DEVELOPMENTAL BIOLOGY

Rapamycin suppresses seizures and neuronal hypertrophy in a mouse model of cortical dysplasia

(2009) M. C. Ljungberg et al.   Disease Models & Mechanisms

The Mammalian Target of Rapamycin as Novel Central Regulator of Puberty Onset via Modulation of Hypothalamic Kiss1 System

(2009) J. Roa et al.   ENDOCRINOLOGY

Novel Translational Control in Arc-dependent Long Term Potentiation Consolidationin Vivo

(2009) Debabrata Panja et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

An ATP-competitive Mammalian Target of Rapamycin Inhibitor Reveals Rapamycin-resistant Functions of mTORC1

(2009) Carson C. Thoreen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

RTP801 Is Induced in Parkinson's Disease and Mediates Neuron Death by Inhibiting Akt Phosphorylation/Activation

(2009) C. Malagelada et al.   JOURNAL OF NEUROSCIENCE

Inhibition of the Mammalian Target of Rapamycin Signaling Pathway Suppresses Dentate Granule Cell Axon Sprouting in a Rodent Model of Temporal Lobe Epilepsy

(2009) P. S. Buckmaster et al.   JOURNAL OF NEUROSCIENCE

The Mammalian Target of Rapamycin Signaling Pathway Mediates Epileptogenesis in a Model of Temporal Lobe Epilepsy

(2009) L.-H. Zeng et al.   JOURNAL OF NEUROSCIENCE

The Rheb-mTOR Pathway Is Upregulated in Reactive Astrocytes of the Injured Spinal Cord

(2009) S. Codeluppi et al.   JOURNAL OF NEUROSCIENCE

Akt Signals through the Mammalian Target of Rapamycin Pathway to Regulate CNS Myelination

(2009) S. P. Narayanan et al.   JOURNAL OF NEUROSCIENCE

Pharmacological Inhibition of mTORC1 Suppresses Anatomical, Cellular, and Behavioral Abnormalities in Neural-Specific Pten Knock-Out Mice

(2009) J. Zhou et al.   JOURNAL OF NEUROSCIENCE

Pten Deletion in Adult Neural Stem/Progenitor Cells Enhances Constitutive Neurogenesis

(2009) C. Gregorian et al.   JOURNAL OF NEUROSCIENCE

Beclin 1 Gene Transfer Activates Autophagy and Ameliorates the Neurodegenerative Pathology in  -Synuclein Models of Parkinson's and Lewy Body Diseases

(2009) B. Spencer et al.   JOURNAL OF NEUROSCIENCE

mTORC1-Activated S6K1 Phosphorylates Rictor on Threonine 1135 and Regulates mTORC2 Signaling

(2009) L.-A. Julien et al.   MOLECULAR AND CELLULAR BIOLOGY

Metabolic control of puberty onset: New players, new mechanisms

(2009) Juan Roa et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Cannabinoid modulation of hippocampal long-term memory is mediated by mTOR signaling

(2009) Emma Puighermanal et al.   NATURE NEUROSCIENCE

Rapamycin activation of 4E-BP prevents parkinsonian dopaminergic neuron loss

(2009) Luke S Tain et al.   NATURE NEUROSCIENCE

DISC1 Regulates New Neuron Development in the Adult Brain via Modulation of AKT-mTOR Signaling through KIAA1212

(2009) Ju Young Kim et al.   NEURON

Rhes, a Striatal Specific Protein, Mediates Mutant-Huntingtin Cytotoxicity

(2009) S. Subramaniam et al.   SCIENCE

Structure of the LKB1-STRAD-MO25 Complex Reveals an Allosteric Mechanism of Kinase Activation

(2009) E. Zeqiraj et al.   SCIENCE

mTOR Regulation and Therapeutic Rejuvenation of Aging Hematopoietic Stem Cells

(2009) C. Chen et al.   Science Signaling

Inhibition of mTOR Signaling in Parkinson's Disease Prevents L-DOPA-Induced Dyskinesia

(2009) E. Santini et al.   Science Signaling

Immunosuppression Using the Mammalian Target of Rapamycin (mTOR) Inhibitor Everolimus: Pilot Study Shows Significant Cognitive and Affective Improvement

(2009) U.E. Lang et al.   TRANSPLANTATION PROCEEDINGS

mTOR signaling: At the crossroads of plasticity, memory and disease

(2009) Charles A. Hoeffer et al.   TRENDS IN NEUROSCIENCES

Active-Site Inhibitors of mTOR Target Rapamycin-Resistant Outputs of mTORC1 and mTORC2

(2009) Morris E Feldman et al.   PLOS BIOLOGY

The TSC1–TSC2 complex: a molecular switchboard controlling cell growth

(2008) Jingxiang Huang et al.   BIOCHEMICAL JOURNAL

Antidepressive-like effects of rapamycin in animal models: Implications for mTOR inhibition as a new target for treatment of affective disorders

(2008) C. Cleary et al.   BRAIN RESEARCH BULLETIN

Dopaminergic Modulation of Auditory Cortex-Dependent Memory Consolidation through mTOR

(2008) Horst Schicknick et al.   CEREBRAL CORTEX

Phosphorylation of 4E-BP by LRRK2 affects the maintenance of dopaminergic neurons in Drosophila

(2008) Yuzuru Imai et al.   EMBO JOURNAL

Forskolin induction of late-LTP and up-regulation of 5 TOP mRNAs translation via mTOR, ERK, and PI3K in hippocampal pyramidal cells

(2008) Delphine Gobert et al.   JOURNAL OF NEUROCHEMISTRY

The Role of Hypothalamic Mammalian Target of Rapamycin Complex 1 Signaling in Diet-Induced Obesity

(2008) D. Cota et al.   JOURNAL OF NEUROSCIENCE

Autophagy Induction and Autophagosome Clearance in Neurons: Relationship to Autophagic Pathology in Alzheimer's Disease

(2008) B. Boland et al.   JOURNAL OF NEUROSCIENCE

Response of a Neuronal Model of Tuberous Sclerosis to Mammalian Target of Rapamycin (mTOR) Inhibitors: Effects on mTORC1 and Akt Signaling Lead to Improved Survival and Function

(2008) L. Meikle et al.   JOURNAL OF NEUROSCIENCE

Homer Interactions Are Necessary for Metabotropic Glutamate Receptor-Induced Long-Term Depression and Translational Activation

(2008) J. A. Ronesi et al.   JOURNAL OF NEUROSCIENCE

Sirolimus Is Associated with New-Onset Diabetes in Kidney Transplant Recipients

(2008) O. Johnston et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Removal of S6K1 and S6K2 leads to divergent alterations in learning, memory, and synaptic plasticity

(2008) M. D. Antion et al.   LEARNING & MEMORY

Mammalian target of rapamycin (mTOR) is involved in the neuronal differentiation of neural progenitors induced by insulin

(2008) Jin Han et al.   MOLECULAR AND CELLULAR NEUROSCIENCE

AMPK Phosphorylation of Raptor Mediates a Metabolic Checkpoint

(2008) Dana M. Gwinn et al.   MOLECULAR CELL

Reversal of learning deficits in a Tsc2 +/− mouse model of tuberous sclerosis

(2008) Dan Ehninger et al.   NATURE MEDICINE

PTEN signaling in brain: neuropathology and tumorigenesis

(2008) R Endersby et al.   ONCOGENE

Promoting Axon Regeneration in the Adult CNS by Modulation of the PTEN/mTOR Pathway

(2008) K. K. Park et al.   SCIENCE

Vascular endothelial growth factor (VEGF) signaling regulates hippocampal neurons by elevation of intracellular calcium and activation of calcium/calmodulin protein kinase II and mammalian target of rapamycin

(2007) Byung Woo Kim et al.   CELLULAR SIGNALLING