Re-emphasizing early Alzheimer’s disease pathology starting in select entorhinal neurons, with a special focus on mitophagy

Molecular characterization of selectively vulnerable neurons in Alzheimer’s disease

(2021) Kun Leng et al.   NATURE NEUROSCIENCE

LRP1 is a master regulator of tau uptake and spread

(2020) Jennifer N. Rauch et al.   NATURE

Construction of a human cell landscape at single-cell level

(2020) Xiaoping Han et al.   NATURE

Mitophagy regulates integrity of mitochondria at synapses and is critical for synaptic maintenance

(2020) Sinsuk Han et al.   EMBO REPORTS

The entorhinal cortex of the monkey: VI. Organization of projections from the hippocampus, subiculum, presubiculum, and parasubiculum

(2020) Menno P. Witter et al.   JOURNAL OF COMPARATIVE NEUROLOGY

Disrupted Place Cell Remapping and Impaired Grid Cells in a Knockin Model of Alzheimer's Disease

(2020) Heechul Jun et al.   NEURON

Mitophagy alterations in Alzheimer's disease are associated with granulovacuolar degeneration and early tau pathology

(2020) Xu Hou et al.   Alzheimers & Dementia

Mitophagy inhibits amyloid-β and tau pathology and reverses cognitive deficits in models of Alzheimer’s disease

(2019) Evandro F. Fang et al.   NATURE NEUROSCIENCE

Neuronal chemo‐architecture of the entorhinal cortex: A comparative review

(2019) Asgeir Kobro‐Flatmoen et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

Experimental evidence for the age dependence of tau protein spread in the brain

(2019) Susanne Wegmann et al.   Science Advances

Neurons and networks in the entorhinal cortex: A reappraisal of the lateral and medial entorhinal subdivisions mediating parallel cortical pathways

(2019) Eirik S. Nilssen et al.   HIPPOCAMPUS

Microtubules gate tau condensation to spatially regulate microtubule functions

(2019) Ruensern Tan et al.   NATURE CELL BIOLOGY

Kinetically distinct phases of tau on microtubules regulate kinesin motors and severing enzymes

(2019) Valerie Siahaan et al.   NATURE CELL BIOLOGY

Ageing as a risk factor for neurodegenerative disease

(2019) Yujun Hou et al.   Nature Reviews Neurology

Amyloid-β PET—Correlation with cerebrospinal fluid biomarkers and prediction of Alzheimer´s disease diagnosis in a memory clinic

(2019) Ebba Gløersen Müller et al.   PLoS One

Cortical tau deposition follows patterns of entorhinal functional connectivity in aging

(2019) Jenna N Adams et al.   eLife

Tau Misfolding Efficiently Propagates between Individual Intact Hippocampal Neurons

(2019) Grace I. Hallinan et al.   JOURNAL OF NEUROSCIENCE

NLRP3 inflammasome activation drives tau pathology

(2019) Christina Ising et al.   NATURE

A single-cell atlas of entorhinal cortex from individuals with Alzheimer’s disease reveals cell-type-specific gene expression regulation

(2019) Alexandra Grubman et al.   NATURE NEUROSCIENCE

Microglial mitophagy mitigates neuroinflammation in Alzheimer's disease

(2019) Sofie Lautrup et al.   NEUROCHEMISTRY INTERNATIONAL

NAD+ augmentation restores mitophagy and limits accelerated aging in Werner syndrome

(2019) Evandro F. Fang et al.   Nature Communications

Impaired mitochondrial calcium efflux contributes to disease progression in models of Alzheimer’s disease

(2019) Pooja Jadiya et al.   Nature Communications

Regional mitochondrial DNA and cell-type changes in post-mortem brains of non-diabetic Alzheimer’s disease are not present in diabetic Alzheimer’s disease

(2019) Elisabeth B. Thubron et al.   Scientific Reports

Convergent Projections from Perirhinal and Postrhinal Cortices Suggest a Multisensory Nature of Lateral, but Not Medial, Entorhinal Cortex

(2019) Thanh P. Doan et al.   Cell Reports

Integrated proteogenetic analysis reveals the landscape of a mitochondrial-autophagosome synapse during PARK2-dependent mitophagy

(2019) Jin-Mi Heo et al.   Science Advances

Reelin in the Years: decline in the number of reelin immunoreactive neurons in layer II of the entorhinal cortex in aged monkeys with memory impairment

(2019) Jeffrey M. Long et al.   NEUROBIOLOGY OF AGING

Tau seeding activity begins in the transentorhinal/entorhinal regions and anticipates phospho-tau pathology in Alzheimer’s disease and PART

(2018) Sarah K. Kaufman et al.   ACTA NEUROPATHOLOGICA

Tau Does Not Stabilize Axonal Microtubules but Rather Enables Them to Have Long Labile Domains

(2018) Liang Qiang et al.   CURRENT BIOLOGY

Competition between microtubule-associated proteins directs motor transport

(2018) Brigette Y. Monroy et al.   Nature Communications

Unconventional Secretion Mediates the Trans-cellular Spreading of Tau

(2018) Taxiarchis Katsinelos et al.   Cell Reports

Extracellular Monomeric and Aggregated Tau Efficiently Enter Human Neurons through Overlapping but Distinct Pathways

(2018) Lewis D. Evans et al.   Cell Reports

Absolute 10-year risk of dementia by age, sex andAPOEgenotype: a population-based cohort study

(2018) Katrine L. Rasmussen et al.   CANADIAN MEDICAL ASSOCIATION JOURNAL

Entorhinal Cortex Thickness Predicts Cognitive Decline in Alzheimer's Disease

(2018) Latha Velayudhan et al.   JOURNAL OF ALZHEIMERS DISEASE

TFEB enhances astroglial uptake of extracellular tau species and reduces tau spreading

(2018) Heidi Martini-Stoica et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Inhibitory connectivity dominates the fan cell network in layer II of lateral entorhinal cortex

(2018) Eirik S. Nilssen et al.   JOURNAL OF NEUROSCIENCE

Integrating time from experience in the lateral entorhinal cortex

(2018) Albert Tsao et al.   NATURE

Tau/MAPT disease-associated variant A152T alters tau function and toxicity via impaired retrograde axonal transport

(2018) Victoria J Butler et al.   HUMAN MOLECULAR GENETICS

A histone acetylome-wide association study of Alzheimer’s disease identifies disease-associated H3K27ac differences in the entorhinal cortex

(2018) Sarah J. Marzi et al.   NATURE NEUROSCIENCE

A tau homeostasis signature is linked with the cellular and regional vulnerability of excitatory neurons to tau pathology

(2018) Hongjun Fu et al.   NATURE NEUROSCIENCE

Reversal of ApoE4-induced recycling block as a novel prevention approach for Alzheimer’s disease

(2018) Xunde Xian et al.   eLife

Cortical thickness atrophy in the transentorhinal cortex in mild cognitive impairment

(2018) Sue Kulason et al.   NeuroImage-Clinical

ApoE4 markedly exacerbates tau-mediated neurodegeneration in a mouse model of tauopathy

(2017) Yang Shi et al.   NATURE

Enhancing mitochondrial proteostasis reduces amyloid-β proteotoxicity

(2017) Vincenzo Sorrentino et al.   NATURE

Spatial representation in the hippocampal formation: a history

(2017) Edvard I Moser et al.   NATURE NEUROSCIENCE

Human anterolateral entorhinal cortex volumes are associated with cognitive decline in aging prior to clinical diagnosis

(2017) Rosanna K. Olsen et al.   NEUROBIOLOGY OF AGING

Releasing Syntaphilin Removes Stressed Mitochondria from Axons Independent of Mitophagy under Pathophysiological Conditions

(2017) Mei-Yao Lin et al.   NEURON

Prion protein inhibits fast axonal transport through a mechanism involving casein kinase 2

(2017) Emiliano Zamponi et al.   PLoS One

Mitophagy and Alzheimer’s Disease: Cellular and Molecular Mechanisms

(2017) Jesse S. Kerr et al.   TRENDS IN NEUROSCIENCES

Earliest accumulation of β-amyloid occurs within the default-mode network and concurrently affects brain connectivity

(2017) Sebastian Palmqvist et al.   Nature Communications

Soluble pre-fibrillar tau and β-amyloid species emerge in early human Alzheimer’s disease and track disease progression and cognitive decline

(2016) David J. Koss et al.   ACTA NEUROPATHOLOGICA

Autophagy flux in CA1 neurons of Alzheimer hippocampus: Increased induction overburdens failing lysosomes to propel neuritic dystrophy

(2016) Matteo Bordi et al.   Autophagy

Restricted Location of PSEN2/γ-Secretase Determines Substrate Specificity and Generates an Intracellular Aβ Pool

(2016) Ragna Sannerud et al.   CELL

Parkinson’s Disease-Related Proteins PINK1 and Parkin Repress Mitochondrial Antigen Presentation

(2016) Diana Matheoud et al.   CELL

The amyloid hypothesis of Alzheimer's disease at 25 years

(2016) Dennis J Selkoe et al.   EMBO Molecular Medicine

Facilitation of axon regeneration by enhancing mitochondrial transport and rescuing energy deficits

(2016) Bing Zhou et al.   JOURNAL OF CELL BIOLOGY

Age-Related Phasic Patterns of Mitochondrial Maintenance in Adult Caenorhabditis elegans Neurons

(2016) N. S. Morsci et al.   JOURNAL OF NEUROSCIENCE

The road to restoring neural circuits for the treatment of Alzheimer's disease

(2016) Rebecca G. Canter et al.   NATURE

Transfer of mitochondria from astrocytes to neurons after stroke

(2016) Kazuhide Hayakawa et al.   NATURE

Reelin-immunoreactive neurons in entorhinal cortex layer II selectively express intracellular amyloid in early Alzheimer's disease

(2016) Asgeir Kobro-Flatmoen et al.   NEUROBIOLOGY OF DISEASE

Loss of Bin1 Promotes the Propagation of Tau Pathology

(2016) Sara Calafate et al.   Cell Reports

The β-amyloid peptide compromises Reelin signaling in Alzheimer’s disease

(2016) Inmaculada Cuchillo-Ibañez et al.   Scientific Reports

Insular projections to the parahippocampal region in the rat

(2015) Mathias L. Mathiasen et al.   JOURNAL OF COMPARATIVE NEUROLOGY

Coordination of mitophagy and mitochondrial biogenesis during ageing in C. elegans

(2015) Konstantinos Palikaras et al.   NATURE

The ubiquitin kinase PINK1 recruits autophagy receptors to induce mitophagy

(2015) Michael Lazarou et al.   NATURE

Alzheimer's and Parkinson's diseases: The prion concept in relation to assembled A , tau, and  -synuclein

(2015) M. Goedert   SCIENCE

Functional subregions of the human entorhinal cortex

(2015) Anne Maass et al.   eLife

Functional topography of the human entorhinal cortex

(2015) Tobias Navarro Schröder et al.   eLife

Early neurone loss in Alzheimer’s disease: cortical or subcortical?

(2015) Thomas Arendt et al.   Acta Neuropathologica Communications

Oxidative stress-mediated activation of extracellular signal-regulated kinase contributes to mild cognitive impairment-related mitochondrial dysfunction

(2014) Xueqi Gan et al.   FREE RADICAL BIOLOGY AND MEDICINE

From details to large scale: The representation of environmental positions follows a granularity gradient along the human hippocampal and entorhinal anterior-posterior axis

(2014) Hallvard Røe Evensmoen et al.   HIPPOCAMPUS

Advancing research diagnostic criteria for Alzheimer's disease: the IWG-2 criteria

(2014) Bruno Dubois et al.   LANCET NEUROLOGY

Intracellular amyloid and the neuronal origin of Alzheimer neuritic plaques

(2014) Anna Pensalfini et al.   NEUROBIOLOGY OF DISEASE

Can We Reconcile the Declarative Memory and Spatial Navigation Views on Hippocampal Function?

(2014) Howard Eichenbaum et al.   NEURON

Distinct Tau Prion Strains Propagate in Cells and Mice and Define Different Tauopathies

(2014) David W. Sanders et al.   NEURON

Transcellular degradation of axonal mitochondria

(2014) Chung-ha O. Davis et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Island Cells Control Temporal Association Memory

(2014) T. Kitamura et al.   SCIENCE

Traces of Experience in the Lateral Entorhinal Cortex

(2013) Albert Tsao et al.   CURRENT BIOLOGY

The Anterior Hippocampus Supports a Coarse, Global Environmental Representation and the Posterior Hippocampus Supports Fine-grained, Local Environmental Representations

(2013) Hallvard Røe Evensmoen et al.   JOURNAL OF COGNITIVE NEUROSCIENCE

Topographic organization of orbitofrontal projections to the parahippocampal region in rats

(2013) Hideki Kondo et al.   JOURNAL OF COMPARATIVE NEUROLOGY

Amyloid-  Peptide Oligomers Disrupt Axonal Transport through an NMDA Receptor-Dependent Mechanism That Is Mediated by Glycogen Synthase Kinase 3  in Primary Cultured Hippocampal Neurons

(2013) H. Decker et al.   JOURNAL OF NEUROSCIENCE

Recurrent inhibitory circuitry as a mechanism for grid formation

(2013) Jonathan J Couey et al.   NATURE NEUROSCIENCE

The CAMKK2-AMPK Kinase Pathway Mediates the Synaptotoxic Effects of Aβ Oligomers through Tau Phosphorylation

(2013) Georges Mairet-Coello et al.   NEURON

Beta-Amyloid Impairs Reelin Signaling

(2013) Inmaculada Cuchillo-Ibáñez et al.   PLoS One

Motile Axonal Mitochondria Contribute to the Variability of Presynaptic Strength

(2013) Tao Sun et al.   Cell Reports

Identification of the human medial temporal lobe regions on magnetic resonance images

(2012) Edit Frankó et al.   HUMAN BRAIN MAPPING

Correlation of Alzheimer Disease Neuropathologic Changes With Cognitive Status: A Review of the Literature

(2012) Peter T. Nelson et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

Apolipoprotein E, Especially Apolipoprotein E4, Increases the Oligomerization of Amyloid   Peptide

(2012) T. Hashimoto et al.   JOURNAL OF NEUROSCIENCE

NLRP3 is activated in Alzheimer’s disease and contributes to pathology in APP/PS1 mice

(2012) Michael T. Heneka et al.   NATURE

The toxic Aβ oligomer and Alzheimer's disease: an emperor in need of clothes

(2012) Iryna Benilova et al.   NATURE NEUROSCIENCE

Mitochondrial transport in neurons: impact on synaptic homeostasis and neurodegeneration

(2012) Zu-Hang Sheng et al.   NATURE REVIEWS NEUROSCIENCE

Involvement of PGC-1α in the formation and maintenance of neuronal dendritic spines

(2012) Aiwu Cheng et al.   Nature Communications

The diagnosis of dementia due to Alzheimer’s disease: Recommendations from the National Institute on Aging-Alzheimer’s Association workgroups on diagnostic guidelines for Alzheimer's disease

(2011) Guy M. McKhann et al.   Alzheimers & Dementia

PINK1 and Parkin Target Miro for Phosphorylation and Degradation to Arrest Mitochondrial Motility

(2011) Xinnan Wang et al.   CELL

Cellular properties of principal neurons in the rat entorhinal cortex. I. The lateral entorhinal cortex

(2011) Cathrin B. Canto et al.   HIPPOCAMPUS

Cellular properties of principal neurons in the rat entorhinal cortex. II. The medial entorhinal cortex

(2011) Cathrin B. Canto et al.   HIPPOCAMPUS

Impaired mitochondrial dynamics and abnormal interaction of amyloid beta with mitochondrial protein Drp1 in neurons from patients with Alzheimer's disease: implications for neuronal damage

(2011) Maria Manczak et al.   HUMAN MOLECULAR GENETICS

Impaired mitochondrial biogenesis, defective axonal transport of mitochondria, abnormal mitochondrial dynamics and synaptic degeneration in a mouse model of Alzheimer's disease

(2011) M. J. Calkins et al.   HUMAN MOLECULAR GENETICS

Stages of the Pathologic Process in Alzheimer Disease: Age Categories From 1 to 100 Years

(2011) Heiko Braak et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

The organization of the human cerebral cortex estimated by intrinsic functional connectivity

(2011) B. T. Thomas Yeo et al.   JOURNAL OF NEUROPHYSIOLOGY

APOE E4 status predicts age-related cognitive decline in the ninth decade: longitudinal follow-up of the Lothian Birth Cohort 1921

(2011) O J G Schiepers et al.   MOLECULAR PSYCHIATRY

Intraneuronal β-amyloid accumulation and synapse pathology in Alzheimer’s disease

(2010) Gunnar K. Gouras et al.   ACTA NEUROPATHOLOGICA

Size-dependent neurotoxicity of β-amyloid oligomers

(2010) Paulius Cizas et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

Lysosomal Proteolysis and Autophagy Require Presenilin 1 and Are Disrupted by Alzheimer-Related PS1 Mutations

(2010) Ju-Hyun Lee et al.   CELL

Target-selective GABAergic control of entorhinal cortex output

(2010) Csaba Varga et al.   NATURE NEUROSCIENCE

ApoE4 reduces glutamate receptor function and synaptic plasticity by selectively impairing ApoE receptor recycling

(2010) Y. Chen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Tau Reduction Prevents Aβ-Induced Defects in Axonal Transport: Fig. 1

(2010) Keith A. Vossel et al.   SCIENCE

Classification and basic pathology of Alzheimer disease

(2009) Charles Duyckaerts et al.   ACTA NEUROPATHOLOGICA

Reelin Stabilizes the Actin Cytoskeleton of Neuronal Processes by Inducing n-Cofilin Phosphorylation at Serine3

(2009) X. Chai et al.   JOURNAL OF NEUROSCIENCE

The anatomy of memory: an interactive overview of the parahippocampal–hippocampal network

(2009) N. M. van Strien et al.   NATURE REVIEWS NEUROSCIENCE

Neuropathology of nondemented aging: Presumptive evidence for preclinical Alzheimer disease

(2009) Joseph L. Price et al.   NEUROBIOLOGY OF AGING

Distinct Pools of β-Amyloid in Alzheimer Disease–Affected Brain

(2008) Joshua R. Steinerman et al.   ARCHIVES OF NEUROLOGY

Cargo-Selected Transport from the Mitochondria to Peroxisomes Is Mediated by Vesicular Carriers

(2008) Margaret Neuspiel et al.   CURRENT BIOLOGY

Entorhinal cortex of the monkey: IV. Topographical and laminar organization of cortical afferents

(2008) Ricardo Insausti et al.   JOURNAL OF COMPARATIVE NEUROLOGY

Mitochondria in Neuroplasticity and Neurological Disorders

(2008) Mark P. Mattson et al.   NEURON

Differential Regulation of Dynein and Kinesin Motor Proteins by Tau

(2008) R. Dixit et al.   SCIENCE