Lessons from Toxoplasma: Host responses that mediate parasite control and the microbial effectors that subvert them

The Antisocial Network: Cross Talk Between Cell Death Programs in Host Defense

(2021) Annelise G. Snyder et al.   Annual Review of Immunology

Seizing control: how dense granule effector proteins enable Toxoplasma to take charge

(2021) Michael W. Panas et al.   MOLECULAR MICROBIOLOGY

Toxoplasma gondii Extends the Life Span of Infected Human Neutrophils by Inducing Cytosolic PCNA and Blocking Activation of Apoptotic Caspases

(2021) Tatiane S. Lima et al.   mBio

Acquisition of Host Cytosolic Protein by Toxoplasma gondii Bradyzoites

(2021) Geetha Kannan et al.   mSphere

IL-33 promotes innate lymphoid cell-dependent IFN-γ production required for innate immunity to Toxoplasma gondii

(2021) Joseph T Clark et al.   eLife

Toxoplasma gondii secreted effectors co-opt host repressor complexes to inhibit necroptosis

(2021) Alex Rosenberg et al.   Cell Host & Microbe

Toxoplasma gondii Matrix Antigen 1 Is a Secreted Immunomodulatory Effector

(2021) Tadakimi Tomita et al.   mBio

Cell-autonomous Toxoplasma killing program requires Irgm2 but not its microbe vacuolar localization

(2021) Ariel Pradipta et al.   Life Science Alliance

Identification of a Master Regulator of Differentiation in Toxoplasma

(2020) Benjamin S. Waldman et al.   CELL

GABARAPL2 is critical for growth restriction of Toxoplasma gondii in HeLa cells treated with IFN-γ

(2020) Zhaoxia Zhang et al.   INFECTION AND IMMUNITY

The Toxoplasma gondii virulence factor ROP16 acts in cis and trans, and suppresses T cell responses

(2020) Longfei Chen et al.   JOURNAL OF EXPERIMENTAL MEDICINE

The Molecular Mechanism of Polymer Formation of Farnesylated Human Guanylate-binding Protein 1

(2020) Linda Sistemich et al.   JOURNAL OF MOLECULAR BIOLOGY

Essential Role of mGBP7 for Survival of Toxoplasma gondii Infection

(2020) Nora Steffens et al.   mBio

The Toxoplasma gondii Cyst Wall Interactome

(2020) Vincent Tu et al.   mBio

Toxoplasma gondii Parasitophorous Vacuole Membrane-Associated Dense Granule Proteins Regulate Maturation of the Cyst Wall

(2020) Rebekah B. Guevara et al.   mSphere

The zebrafish as a novel model for the in vivo study of Toxoplasma gondii replication and interaction with macrophages

(2020) Nagisa Yoshida et al.   Disease Models & Mechanisms

Convergent Met and voltage-gated Ca2+ channel signaling drives hypermigration of Toxoplasma-infected dendritic cells

(2020) Einar B. Ólafsson et al.   JOURNAL OF CELL SCIENCE

The role of macrophages in protective and pathological responses to Toxoplasma gondii

(2020) Jeongho Park et al.   PARASITE IMMUNOLOGY

In Vitro Characterization of Protein Effector Export in the Bradyzoite Stage of Toxoplasma gondii

(2020) Joshua Mayoral et al.   mBio

Toxoplasma  GRA15 and GRA24 are important activators of the host innate immune response in the absence of TLR11

(2020) Debanjan Mukhopadhyay et al.   PLoS Pathogens

Toxoplasma gondii dense granule protein GRA24 drives MyD88-independent p38 MAPK activation, IL-12 production and induction of protective immunity

(2020) Heather L. Mercer et al.   PLoS Pathogens

Bacterial Factors Targeting the Nucleus: The Growing Family of Nucleomodulins

(2020) Hélène Bierne et al.   Toxins

Differential Impacts on Host Transcription by ROP and GRA Effectors from the Intracellular Parasite Toxoplasma gondii

(2020) Suchita Rastogi et al.   mBio

Toxoplasma gondii Co-opts the Unfolded Protein Response To Enhance Migration and Dissemination of Infected Host Cells

(2020) Leonardo Augusto et al.   mBio

Gasdermin-D-dependent IL-1α release from microglia promotes protective immunity during chronic Toxoplasma gondii infection

(2020) Samantha J. Batista et al.   Nature Communications

Human GBP1 Differentially Targets Salmonella and Toxoplasma to License Recognition of Microbial Ligands and Caspase-Mediated Death

(2020) Daniel Fisch et al.   Cell Reports

Toxoplasma gondii   GRA60 is an effector protein that modulates host cell autonomous immunity and contributes to virulence

(2020) Mary Akinyi Nyonda et al.   CELLULAR MICROBIOLOGY

ISG15 Connects Autophagy and IFN-γ-Dependent Control of Toxoplasma gondii Infection in Human Cells

(2020) Jaya Bhushan et al.   mBio

Genome-wide screens identify Toxoplasma gondii determinants of parasite fitness in IFNγ-activated murine macrophages

(2020) Yifan Wang et al.   Nature Communications

Phosphorylation of Toxoplasma gondii Secreted Proteins during Acute and Chronic Stages of Infection

(2020) Joanna C. Young et al.   mSphere

Human guanylate binding proteins: nanomachines orchestrating host defense

(2020) Miriam Kutsch et al.   FEBS Journal

Toxoplasma gondii PPM3C, a secreted protein phosphatase, affects parasitophorous vacuole effector export

(2020) Joshua Mayoral et al.   PLoS Pathogens

Three Toxoplasma gondii Dense Granule Proteins Are Required for Induction of Lewis Rat Macrophage Pyroptosis

(2019) Yifan Wang et al.   mBio

Molecular mechanism for the control of virulent Toxoplasma gondii infections in wild-derived mice

(2019) Mateo Murillo-León et al.   Nature Communications

Interferon-induced guanylate-binding proteins: Guardians of host defense in health and disease

(2019) Kyle Tretina et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Infection-Induced Intestinal Dysbiosis Is Mediated by Macrophage Activation and Nitrate Production

(2019) Shuai Wang et al.   mBio

Toxoplasma Controls Host Cyclin E Expression through the Use of a Novel MYR1-Dependent Effector Protein, HCE1

(2019) Michael W. Panas et al.   mBio

Defining host–pathogen interactions employing an artificial intelligence workflow

(2019) Daniel Fisch et al.   eLife

Toxoplasma Effector GRA15-Dependent Suppression of IFN-γ-Induced Antiparasitic Response in Human Neurons

(2019) Hironori Bando et al.   Frontiers in Cellular and Infection Microbiology

Interplay Between Toxoplasma gondii, Autophagy, and Autophagy Proteins

(2019) Carlos S. Subauste   Frontiers in Cellular and Infection Microbiology

The Toxoplasma effector TEEGR promotes parasite persistence by modulating NF-κB signalling via EZH2

(2019) Laurence Braun et al.   Nature Microbiology

Toxoplasma gondii induces prolonged host epidermal growth factor receptor signalling to prevent parasite elimination by autophagy: Perspectives for in vivo control of the parasite

(2019) Yalitza Lopez Corcino et al.   CELLULAR MICROBIOLOGY

Human GBP1 is a microbe‐specific gatekeeper of macrophage apoptosis and pyroptosis

(2019) Daniel Fisch et al.   EMBO JOURNAL

Caspase-8 promotes c-Rel–dependent inflammatory cytokine expression and resistance against Toxoplasma gondii

(2019) Alexandra A. DeLaney et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Toxoplasma gondii Parasitophorous Vacuole Membrane-Associated Dense Granule Proteins Orchestrate Chronic Infection and GRA12 Underpins Resistance to Host Gamma Interferon

(2019) Barbara A. Fox et al.   mBio

Robust Control of a Brain-Persisting Parasite through MHC I Presentation by Infected Neurons

(2019) Anna Salvioni et al.   Cell Reports

TLR11-independent inflammasome activation is critical for CD4+ T cell-derived IFN-γ production and host resistance to Toxoplasma gondii

(2019) Américo H. López-Yglesias et al.   PLoS Pathogens

The secreted kinase ROP17 promotes Toxoplasma gondii dissemination by hijacking monocyte tissue migration

(2019) Lisa L. Drewry et al.   Nature Microbiology

Translocation of Dense Granule Effectors across the Parasitophorous Vacuole Membrane in Toxoplasma-Infected Cells Requires the Activity of ROP17, a Rhoptry Protein Kinase

(2019) Michael W. Panas et al.   mSphere

Toxoplasma gondii effector TgIST blocks type I interferon signaling to promote infection

(2019) Sumit K. Matta et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

DPP8/9 inhibitors are universal activators of functional NLRP1 alleles

(2019) Kuo Gai et al.   Cell Death & Disease

Toxoplasma gondii activates a Syk-CARD9-NF-κB signaling axis and gasdermin D-independent release of IL-1β during infection of primary human monocytes

(2019) William J. Pandori et al.   PLoS Pathogens

The GRA17 Parasitophorous Vacuole Membrane Permeability Pore Contributes to Bradyzoite Viability

(2019) Tatiana Paredes-Santos et al.   Frontiers in Cellular and Infection Microbiology

In Vivo CRISPR Screen Identifies TgWIP as a Toxoplasma Modulator of Dendritic Cell Migration

(2019) Lamba Omar Sangaré et al.   Cell Host & Microbe

A CRISPR platform for targeted in vivo screens identifies Toxoplasma gondii virulence factors in mice

(2019) Joanna Young et al.   Nature Communications

Effector-triggered immunity and pathogen sensing in metazoans

(2019) Natasha Lopes Fischer et al.   Nature Microbiology

Toxoplasma gondiidisrupts β1 integrin signaling and focal adhesion formation during monocyte hypermotility

(2018) Joshua H. Cook et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Cysteine-Reactive Free ISG15 Generates IL-1β–Producing CD8α+Dendritic Cells at the Site of Infection

(2018) Anna Napolitano et al.   JOURNAL OF IMMUNOLOGY

Semi-automated quantification and neuroanatomical mapping of heterogeneous cell populations

(2018) Oscar A. Mendez et al.   JOURNAL OF NEUROSCIENCE METHODS

ISG15 in antiviral immunity and beyond

(2018) Yi-Chieh Perng et al.   NATURE REVIEWS MICROBIOLOGY

P2X7 receptor mediates NLRP3-dependent IL-1β secretion and parasite proliferation in Toxoplasma gondii-infected human small intestinal epithelial cells

(2018) Juan-Hua Quan et al.   Parasites & Vectors

Evasion of Human Neutrophil-Mediated Host Defense during Toxoplasma gondii Infection

(2018) Tatiane S. Lima et al.   mBio

MYR1-Dependent Effectors Are the Major Drivers of a Host Cell’s Early Response to Toxoplasma , Including Counteracting MYR1-Independent Effects

(2018) Adit Naor et al.   mBio

Identification of a novel protein complex essential for effector translocation across the parasitophorous vacuole membrane of Toxoplasma gondii

(2018) Nicole D. Marino et al.   PLoS Pathogens

The role of host autophagy machinery in controlling Toxoplasma infection

(2018) Sébastien Besteiro   Virulence

Toxoplasma Effector TgIST Targets Host IDO1 to Antagonize the IFN-γ-Induced Anti-parasitic Response in Human Cells

(2018) Hironori Bando et al.   Frontiers in Immunology

Alarmin S100A11 initiates a chemokine response to the human pathogen Toxoplasma gondii

(2018) Alexandra Safronova et al.   NATURE IMMUNOLOGY

Characterization of a Toxoplasma effector uncovers an alternative GSK3/β-catenin-regulatory pathway of inflammation

(2018) Huan He et al.   eLife

Toxoplasma Does Not Secrete the GRA16 and GRA24 Effectors Beyond the Parasitophorous Vacuole Membrane of Tissue Cysts

(2018) Shruthi Krishnamurthy et al.   Frontiers in Cellular and Infection Microbiology

Protective and Pathological Immunity during Central Nervous System Infections

(2017) Robyn S. Klein et al.   IMMUNITY

Metabolic regulation of macrophage phenotype and function

(2017) Shilpi Saha et al.   IMMUNOLOGICAL REVIEWS

NLRP3 and Potassium Efflux Drive Rapid IL-1β Release from Primary Human Monocytes duringToxoplasma gondiiInfection

(2017) Lanny Gov et al.   JOURNAL OF IMMUNOLOGY

Guanylate-binding protein 1 (GBP1) contributes to the immunity of human mesenchymal stromal cells againstToxoplasma gondii

(2017) Aiping Qin et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Galectin-3 directs antimicrobial guanylate binding proteins to vacuoles furnished with bacterial secretion systems

(2017) Eric M. Feeley et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Detection of Cytosolic Shigella flexneri via a C-Terminal Triple-Arginine Motif of GBP1 Inhibits Actin-Based Motility

(2017) Anthony S. Piro et al.   mBio

Toxoplasma gondii induces FAK-Src-STAT3 signaling during infection of host cells that prevents parasite targeting by autophagy

(2017) Jose-Andres C. Portillo et al.   PLoS Pathogens

The P2X7 Receptor Mediates Toxoplasma gondii Control in Macrophages through Canonical NLRP3 Inflammasome Activation and Reactive Oxygen Species Production

(2017) Aline Cristina Abreu Moreira-Souza et al.   Frontiers in Immunology

TRIM21 is critical for survival of Toxoplasma gondii infection and localises to GBP-positive parasite vacuoles

(2017) Clémence Foltz et al.   Scientific Reports

Targeting by AutophaGy proteins (TAG): Targeting of IFNG-inducible GTPases to membranes by the LC3 conjugation system of autophagy

(2016) Sungwoo Park et al.   Autophagy

Loss of the interferon-γ-inducible regulatory immunity-related GTPase (IRG), Irgm1, causes activation of effector IRG proteins on lysosomes, damaging lysosomal function and predicting the dramatic susceptibility of Irgm1-deficient mice to infection

(2016) Jelena Maric-Biresev et al.   BMC BIOLOGY

Toxoplasma Effector Recruits the Mi-2/NuRD Complex to Repress STAT1 Transcription and Block IFN-γ-Dependent Gene Expression

(2016) Philipp Olias et al.   Cell Host & Microbe

Secreted protein kinases regulate cyst burden during chronic toxoplasmosis

(2016) Nathaniel G. Jones et al.   CELLULAR MICROBIOLOGY

Human GBP1 does not localize to pathogen vacuoles but restrictsToxoplasma gondii

(2016) Ashleigh C. Johnston et al.   CELLULAR MICROBIOLOGY

P2X7 receptor-dependent tuning of gut epithelial responses to infection

(2016) Szu-Wei Huang et al.   IMMUNOLOGY AND CELL BIOLOGY

Toxoplasma gondiiTgIST co-opts host chromatin repressors dampening STAT1-dependent gene regulation and IFN-γ–mediated host defenses

(2016) Gabrielle Gay et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Interferon-Inducible GTPases in Host Resistance, Inflammation and Disease

(2016) Danielle Pilla-Moffett et al.   JOURNAL OF MOLECULAR BIOLOGY

The Toxoplasma gondii Rhoptry Kinome Is Essential for Chronic Infection

(2016) Barbara A. Fox et al.   mBio

STAT1 Signaling in Astrocytes Is Essential for Control of Infection in the Central Nervous System

(2016) Shinya Hidano et al.   mBio

K63-Linked Ubiquitination Targets Toxoplasma gondii for Endo-lysosomal Destruction in IFNγ-Stimulated Human Cells

(2016) Barbara Clough et al.   PLoS Pathogens

Neurons are the Primary Target Cell for the Brain-Tropic Intracellular Parasite Toxoplasma gondii

(2016) Carla M. Cabral et al.   PLoS Pathogens

Guanylate binding proteins directly attack Toxoplasma gondii via supramolecular complexes

(2016) Elisabeth Kravets et al.   eLife

Endothelial cells are a replicative niche for entry of Toxoplasma gondii to the central nervous system

(2016) Christoph Konradt et al.   Nature Microbiology

TheToxoplasma gondiirhoptry protein ROP18 is an Irga6-specific kinase and regulated by the dense granule protein GRA7

(2015) Thomas Hermanns et al.   CELLULAR MICROBIOLOGY

The IL-12 Response of Primary Human Dendritic Cells and Monocytes toToxoplasma gondiiIs Stimulated by Phagocytosis of Live Parasites Rather Than Host Cell Invasion

(2015) Kevin W. Tosh et al.   JOURNAL OF IMMUNOLOGY

Ubiquitin systems mark pathogen-containing vacuoles as targets for host defense by guanylate binding proteins

(2015) Arun K. Haldar et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Novel Approaches Reveal that Toxoplasma gondii Bradyzoites within Tissue Cysts Are Dynamic and Replicating Entities In Vivo

(2015) Elizabeth Watts et al.   mBio

A Noncanonical Autophagy Pathway Restricts Toxoplasma gondii Growth in a Strain-Specific Manner in IFN-γ-Activated Human Cells

(2015) Elizabeth M. Selleck et al.   mBio

Intravacuolar Membranes Regulate CD8 T Cell Recognition of Membrane-Bound Toxoplasma gondii Protective Antigen

(2015) Jodie Lopez et al.   Cell Reports

p62 Plays a Specific Role in Interferon-γ-Induced Presentation of a Toxoplasma Vacuolar Antigen

(2015) Youngae Lee et al.   Cell Reports

Fundamental Roles of the Golgi-Associated Toxoplasma Aspartyl Protease, ASP5, at the Host-Parasite Interface

(2015) Pierre-Mehdi Hammoudi et al.   PLoS Pathogens

Phenotypic complementation of genetic immunodeficiency by chronic herpesvirus infection

(2015) Donna A MacDuff et al.   eLife

An aspartyl protease defines a novel pathway for export of Toxoplasma proteins into the host cell

(2015) Michael J Coffey et al.   eLife

The Toxoplasma Pseudokinase ROP5 Forms Complexes with ROP18 and ROP17 Kinases that Synergize to Control Acute Virulence in Mice

(2014) Ronald D. Etheridge et al.   Cell Host & Microbe

The Parasitophorous Vacuole Membrane of Toxoplasma gondii Is Targeted for Disruption by Ubiquitin-like Conjugation Systems of Autophagy

(2014) Jayoung Choi et al.   IMMUNITY

Internalization and TLR-dependent type I interferon production by monocytes in response to Toxoplasma gondii

(2014) Seong-Ji Han et al.   IMMUNOLOGY AND CELL BIOLOGY

Use of Transgenic Parasites and Host Reporters To Dissect Events That Promote Interleukin-12 Production during Toxoplasmosis

(2014) David A. Christian et al.   INFECTION AND IMMUNITY

Natural killer cell intrinsic toll-like receptor MyD88 signaling contributes to IL-12-dependent IFN-γ production by mice during infection with Toxoplasma gondii

(2014) Yiyue Ge et al.   INTERNATIONAL JOURNAL FOR PARASITOLOGY

Toxoplasma gondiiVirulence Factor ROP18 Inhibits the Host NF-κB Pathway by Promoting p65 Degradation

(2014) Jian Du et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Toxoplasma gondii Prevents Chromatin Remodeling Initiated by TLR-Triggered Macrophage Activation

(2014) J. Leng et al.   JOURNAL OF IMMUNOLOGY

TLR Adaptor MyD88 Is Essential for Pathogen Control during Oral Toxoplasma gondii Infection but Not Adaptive Immunity Induced by a Vaccine Strain of the Parasite

(2014) W. Sukhumavasi et al.   JOURNAL OF IMMUNOLOGY

Role of Mouse and Human Autophagy Proteins in IFN- -Induced Cell-Autonomous Responses against Toxoplasma gondii

(2014) J. Ohshima et al.   JOURNAL OF IMMUNOLOGY

The E2-Like Conjugation Enzyme Atg3 Promotes Binding of IRG and Gbp Proteins to Chlamydia- and Toxoplasma-Containing Vacuoles and Host Resistance

(2014) Arun K. Haldar et al.   PLoS One

Toxoplasma GRA7 effector increases turnover of immunity-related GTPases and contributes to acute virulence in the mouse

(2014) A. Alaganan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Dual Role for Inflammasome Sensors NLRP1 and NLRP3 in Murine Resistance to Toxoplasma gondii

(2014) G. Gorfu et al.   mBio

miR-146a and miR-155 Delineate a MicroRNA Fingerprint Associated with Toxoplasma Persistence in the Host Brain

(2014) Dominique Cannella et al.   Cell Reports

Inflammasome Sensor NLRP1 Controls Rat Macrophage Susceptibility to Toxoplasma gondii

(2014) Kimberly M. Cirelli et al.   PLoS Pathogens

Combined Action of Nucleic Acid-Sensing Toll-like Receptors and TLR11/TLR12 Heterodimers Imparts Resistance to Toxoplasma gondii in Mice

(2013) Warrison A. Andrade et al.   Cell Host & Microbe

Host Cell Subversion by Toxoplasma GRA16, an Exported Dense Granule Protein that Targets the Host Cell Nucleus and Alters Gene Expression

(2013) Alexandre Bougdour et al.   Cell Host & Microbe

Toxoplasma gondii Inhibits Gamma Interferon (IFN-γ)- and IFN-β-Induced Host Cell STAT1 Transcriptional Activity by Increasing the Association of STAT1 with DNA

(2013) Emily E. Rosowski et al.   INFECTION AND IMMUNITY

NLRP1 Is an Inflammasome Sensor for Toxoplasma gondii

(2013) Sarah E. Ewald et al.   INFECTION AND IMMUNITY

AToxoplasmadense granule protein, GRA24, modulates the early immune response to infection by promoting a direct and sustained host p38 MAPK activation

(2013) Laurence Braun et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Toxoplasma gondii modulates the dynamics of human monocyte adhesion to vascular endothelium under fluidic shear stress

(2013) Katherine S. Harker et al.   JOURNAL OF LEUKOCYTE BIOLOGY

The Protein Kinase Double-Stranded RNA-Dependent (PKR) Enhances Protection against Disease Cause by a Non-Viral Pathogen

(2013) Pauline Sebby Ogolla et al.   PLoS Pathogens

IRG and GBP Host Resistance Factors Target Aberrant, “Non-self” Vacuoles Characterized by the Missing of “Self” IRGM Proteins

(2013) Arun K. Haldar et al.   PLoS Pathogens

Transcriptional Analysis of Murine Macrophages Infected with Different Toxoplasma Strains Identifies Novel Regulation of Host Signaling Pathways

(2013) Mariane B. Melo et al.   PLoS Pathogens

Guanylate-binding Protein 1 (Gbp1) Contributes to Cell-autonomous Immunity against Toxoplasma gondii

(2013) Elizabeth M. Selleck et al.   PLoS Pathogens

Toxoplasma gondii-Induced Activation of EGFR Prevents Autophagy Protein-Mediated Killing of the Parasite

(2013) Luis Muniz-Feliciano et al.   PLoS Pathogens

Reciprocal virulence and resistance polymorphism in the relationship between Toxoplasma gondii and the house mouse

(2013) Jingtao Lilue et al.   eLife

A Cluster of Interferon-γ-Inducible p65 GTPases Plays a Critical Role in Host Defense against Toxoplasma gondii

(2012) Masahiro Yamamoto et al.   IMMUNITY

Recognition of Profilin by Toll-like Receptor 12 Is Critical for Host Resistance to Toxoplasma gondii

(2012) A. Alicia Koblansky et al.   IMMUNITY

Murine Guanylate Binding Protein 2 (mGBP2) controls Toxoplasma gondii replication

(2012) D. Degrandi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Toxoplasma Co-opts Host Cells It Does Not Invade

(2012) Anita A. Koshy et al.   PLoS Pathogens

The Rhoptry Proteins ROP18 and ROP5 Mediate Toxoplasma gondii Evasion of the Murine, But Not the Human, Interferon-Gamma Response

(2012) Wendy Niedelman et al.   PLoS Pathogens

The Polymorphic Pseudokinase ROP5 Controls Virulence in Toxoplasma gondii by Regulating the Active Kinase ROP18

(2012) Michael S. Behnke et al.   PLoS Pathogens

Toxoplasma Polymorphic Effectors Determine Macrophage Polarization and Intestinal Inflammation

(2011) Kirk D.C. Jensen et al.   Cell Host & Microbe

A Conserved Non-canonical Motif in the Pseudoactive Site of the ROP5 Pseudokinase Domain Mediates Its Effect on Toxoplasma Virulence

(2011) Michael L. Reese et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

ATF6β is a host cellular target of theToxoplasma gondiivirulence factor ROP18

(2011) Masahiro Yamamoto et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Strain-specific activation of the NF-κB pathway by GRA15, a novelToxoplasma gondiidense granule protein

(2011) Emily E. Rosowski et al.   JOURNAL OF EXPERIMENTAL MEDICINE

The IFN-γ-Inducible GTPase, Irga6, Protects Mice against Toxoplasma gondii but Not against Plasmodium berghei and Some Other Intracellular Pathogens

(2011) Oliver Liesenfeld et al.   PLoS One

Determinants of GBP Recruitment to Toxoplasma gondii Vacuoles and the Parasitic Factors That Control It

(2011) Sebastian Virreira Winter et al.   PLoS One

A Family of IFN- -Inducible 65-kD GTPases Protects Against Bacterial Infection

(2011) B.-H. Kim et al.   SCIENCE

Toxoplasma gondii Rhoptry Kinase ROP16 Activates STAT3 and STAT6 Resulting in Cytokine Inhibition and Arginase-1-Dependent Growth Control

(2011) Barbara A. Butcher et al.   PLoS Pathogens

Integrative Genomic Approaches Highlight a Family of Parasite-Specific Kinases that Regulate Host Responses

(2010) Lucia Peixoto et al.   Cell Host & Microbe

Phosphorylation of Immunity-Related GTPases by a Toxoplasma gondii-Secreted Kinase Promotes Macrophage Survival and Virulence

(2010) Sarah J. Fentress et al.   Cell Host & Microbe

Coordinated loading of IRG resistance GTPases on to the Toxoplasma gondii parasitophorous vacuole

(2010) Aliaksandr Khaminets et al.   CELLULAR MICROBIOLOGY

NALP1 Influences Susceptibility to Human Congenital Toxoplasmosis, Proinflammatory Cytokine Response, and Fate ofToxoplasma gondii-Infected Monocytic Cells

(2010) William H. Witola et al.   INFECTION AND IMMUNITY

UNC93B1 Is Essential for TLR11 Activation and IL-12-dependent Host Resistance toToxoplasma gondii

(2010) Reed Pifer et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

P2X7 Receptor-Mediated Killing of an Intracellular Parasite, Toxoplasma gondii, by Human and Murine Macrophages

(2010) M. P. Lees et al.   JOURNAL OF IMMUNOLOGY

UNC93B1 Mediates Host Resistance to Infection with Toxoplasma gondii

(2010) Mariane B. Melo et al.   PLoS Pathogens

Balance of Irgm protein activities determines IFN-γ-induced host defense

(2009) Stanley C. Henry et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Targeting of the GTPase Irgm1 to the phagosomal membrane via PtdIns(3,4)P2 and PtdIns(3,4,5)P3 promotes immunity to mycobacteria

(2009) Sangeeta Tiwari et al.   NATURE IMMUNOLOGY

IFN-γ-Inducible Irga6 Mediates Host Resistance against Chlamydia trachomatis via Autophagy

(2009) Munir A. Al-Zeer et al.   PLoS One

Analyses of murine GBP homology clusters based on in silico, in vitro and in vivo studies

(2008) Alexandra Kresse et al.   BMC GENOMICS

Autophagosome-Independent Essential Function for the Autophagy Protein Atg5 in Cellular Immunity to Intracellular Pathogens

(2008) Zijiang Zhao et al.   Cell Host & Microbe

The p47 GTPase Lrg-47 (Irgm1) Links Host Defense and Hematopoietic Stem Cell Proliferation

(2008) Carl G. Feng et al.   Cell Stem Cell

Regulatory interactions between IRG resistance GTPases in the cellular response to Toxoplasma gondii

(2008) Julia P Hunn et al.   EMBO JOURNAL

The Gamma Interferon (IFN- )-Inducible GTP-Binding Protein IGTP Is Necessary for Toxoplasma Vacuolar Disruption and Induces Parasite Egression in IFN- -Stimulated Astrocytes

(2008) T. Melzer et al.   INFECTION AND IMMUNITY