The Polymorphic Pseudokinase ROP5 Controls Virulence in Toxoplasma gondii by Regulating the Active Kinase ROP18

A Cluster of Interferon-γ-Inducible p65 GTPases Plays a Critical Role in Host Defense against Toxoplasma gondii

(2012) Masahiro Yamamoto et al.   IMMUNITY

A Toxoplasma gondii Pseudokinase Inhibits Host IRG Resistance Proteins

(2012) Martin C. Fleckenstein et al.   PLOS BIOLOGY

The Rhoptry Proteins ROP18 and ROP5 Mediate Toxoplasma gondii Evasion of the Murine, But Not the Human, Interferon-Gamma Response

(2012) Wendy Niedelman et al.   PLoS Pathogens

The secreted kinase ROP18 defends Toxoplasma's border

(2011) Sarah J. Fentress et al.   BIOESSAYS

CD8α+ Dendritic Cells Are the Critical Source of Interleukin-12 that Controls Acute Infection by Toxoplasma gondii Tachyzoites

(2011) Mona Mashayekhi et al.   IMMUNITY

Genetic analyses of atypical Toxoplasma gondii strains reveal a fourth clonal lineage in North America

(2011) Asis Khan et al.   INTERNATIONAL JOURNAL FOR PARASITOLOGY

Immunity-related GTPase M (IRGM) Proteins Influence the Localization of Guanylate-binding Protein 2 (GBP2) by Modulating Macroautophagy

(2011) Maria K. Traver et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A Conserved Non-canonical Motif in the Pseudoactive Site of the ROP5 Pseudokinase Domain Mediates Its Effect on Toxoplasma Virulence

(2011) Michael L. Reese et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

ATF6β is a host cellular target of theToxoplasma gondiivirulence factor ROP18

(2011) Masahiro Yamamoto et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Improved techniques for endogenous epitope tagging and gene deletion in Toxoplasma gondii

(2011) Rajendra Upadhya et al.   JOURNAL OF MICROBIOLOGICAL METHODS

The IFN-γ-Inducible GTPase, Irga6, Protects Mice against Toxoplasma gondii but Not against Plasmodium berghei and Some Other Intracellular Pathogens

(2011) Oliver Liesenfeld et al.   PLoS One

Determinants of GBP Recruitment to Toxoplasma gondii Vacuoles and the Parasitic Factors That Control It

(2011) Sebastian Virreira Winter et al.   PLoS One

Polymorphic family of injected pseudokinases is paramount in Toxoplasma virulence

(2011) M. L. Reese et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Virulence differences in Toxoplasma mediated by amplification of a family of polymorphic pseudokinases

(2011) M. S. Behnke et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A Family of IFN- -Inducible 65-kD GTPases Protects Against Bacterial Infection

(2011) B.-H. Kim et al.   SCIENCE

Integrative Genomic Approaches Highlight a Family of Parasite-Specific Kinases that Regulate Host Responses

(2010) Lucia Peixoto et al.   Cell Host & Microbe

Phosphorylation of Immunity-Related GTPases by a Toxoplasma gondii-Secreted Kinase Promotes Macrophage Survival and Virulence

(2010) Sarah J. Fentress et al.   Cell Host & Microbe

Coordinated loading of IRG resistance GTPases on to the Toxoplasma gondii parasitophorous vacuole

(2010) Aliaksandr Khaminets et al.   CELLULAR MICROBIOLOGY

Pseudokinases-remnants of evolution or key allosteric regulators?

(2010) Elton Zeqiraj et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

Phosphorylation of Mouse Immunity-Related GTPase (IRG) Resistance Proteins Is an Evasion Strategy for Virulent Toxoplasma gondii

(2010) Tobias Steinfeldt et al.   PLOS BIOLOGY

Novel structural and regulatory features of rhoptry secretory kinases in Toxoplasma gondii

(2009) Wei Qiu et al.   EMBO JOURNAL

Virulent Toxoplasma gondii Evade Immunity-Related GTPase-Mediated Parasite Vacuole Disruption within Primed Macrophages

(2009) Y. Zhao et al.   JOURNAL OF IMMUNOLOGY

Regulation of macrophage motility by Irgm1

(2009) Stanley C. Henry et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Balance of Irgm protein activities determines IFN-γ-induced host defense

(2009) Stanley C. Henry et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Structure of the LKB1-STRAD-MO25 Complex Reveals an Allosteric Mechanism of Kinase Activation

(2009) E. Zeqiraj et al.   SCIENCE

ROP2 from Toxoplasma gondii: A Virulence Factor with a Protein-Kinase Fold and No Enzymatic Activity

(2009) Gilles Labesse et al.   STRUCTURE

ATP and MO25α Regulate the Conformational State of the STRADα Pseudokinase and Activation of the LKB1 Tumour Suppressor

(2009) Elton Zeqiraj et al.   PLOS BIOLOGY

Autophagosome-Independent Essential Function for the Autophagy Protein Atg5 in Cellular Immunity to Intracellular Pathogens

(2008) Zijiang Zhao et al.   Cell Host & Microbe

The p47 GTPase Lrg-47 (Irgm1) Links Host Defense and Hematopoietic Stem Cell Proliferation

(2008) Carl G. Feng et al.   Cell Stem Cell

Regulatory interactions between IRG resistance GTPases in the cellular response to Toxoplasma gondii

(2008) Julia P Hunn et al.   EMBO JOURNAL

Gr1+ Inflammatory Monocytes Are Required for Mucosal Resistance to the Pathogen Toxoplasma gondii

(2008) Ildiko R. Dunay et al.   IMMUNITY

The Gamma Interferon (IFN- )-Inducible GTP-Binding Protein IGTP Is Necessary for Toxoplasma Vacuolar Disruption and Induces Parasite Egression in IFN- -Stimulated Astrocytes

(2008) T. Melzer et al.   INFECTION AND IMMUNITY

The Toxoplasma gondii Dense Granule Protein GRA7 Is Phosphorylated upon Invasion and Forms an Unexpected Association with the Rhoptry Proteins ROP2 and ROP4

(2008) J. D. Dunn et al.   INFECTION AND IMMUNITY

The transcription of bradyzoite genes inToxoplasma gondiiis controlled by autonomous promoter elements

(2008) Michael S. Behnke et al.   MOLECULAR MICROBIOLOGY

Deletion polymorphism upstream of IRGM associated with altered IRGM expression and Crohn's disease

(2008) Steven A McCarroll et al.   NATURE GENETICS

Emerging themes in IFN-γ-induced macrophage immunity by the p47 and p65 GTPase families

(2007) Avinash R. Shenoy et al.   IMMUNOBIOLOGY