The Toxoplasma effector TEEGR promotes parasite persistence by modulating NF-κB signalling via EZH2

A latent ability to persist: differentiation in Toxoplasma gondii

(2018) Victoria Jeffers et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Evasion of Human Neutrophil-Mediated Host Defense during Toxoplasma gondii Infection

(2018) Tatiane S. Lima et al.   mBio

Epithelial EZH2 serves as an epigenetic determinant in experimental colitis by inhibiting TNFα-mediated inflammation and apoptosis

(2017) Yongfeng Liu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Toxoplasma Effector Recruits the Mi-2/NuRD Complex to Repress STAT1 Transcription and Block IFN-γ-Dependent Gene Expression

(2016) Philipp Olias et al.   Cell Host & Microbe

Toxoplasma gondiiTgIST co-opts host chromatin repressors dampening STAT1-dependent gene regulation and IFN-γ–mediated host defenses

(2016) Gabrielle Gay et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Integration of TP53, DREAM, MMB-FOXM1 and RB-E2F target gene analyses identifies cell cycle gene regulatory networks

(2016) Martin Fischer et al.   NUCLEIC ACIDS RESEARCH

Tissue-specific targeting of cell fate regulatory genes by E2f factors

(2015) L M Julian et al.   CELL DEATH AND DIFFERENTIATION

Dynamic reorganization of the AC16 cardiomyocyte transcriptome in response to TNFα signaling revealed by integrated genomic analyses

(2014) Xin Luo et al.   BMC GENOMICS

Dual Role for Inflammasome Sensors NLRP1 and NLRP3 in Murine Resistance to Toxoplasma gondii

(2014) G. Gorfu et al.   mBio

Regulation of the NF-κB-Mediated Transcription of Inflammatory Genes

(2014) Dev Bhatt et al.   Frontiers in Immunology

Host Cell Subversion by Toxoplasma GRA16, an Exported Dense Granule Protein that Targets the Host Cell Nucleus and Alters Gene Expression

(2013) Alexandre Bougdour et al.   Cell Host & Microbe

AToxoplasmadense granule protein, GRA24, modulates the early immune response to infection by promoting a direct and sustained host p38 MAPK activation

(2013) Laurence Braun et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Subset of genes targeted by transcription factor NF-κB in TNFα-stimulated human HeLa cells

(2012) Yujun Xing et al.   FUNCTIONAL & INTEGRATIVE GENOMICS

A High-Throughput Chromatin Immunoprecipitation Approach Reveals Principles of Dynamic Gene Regulation in Mammals

(2012) Manuel Garber et al.   MOLECULAR CELL

EZH2 inhibition as a therapeutic strategy for lymphoma with EZH2-activating mutations

(2012) Michael T. McCabe et al.   NATURE

Modulation of innate immunity by Toxoplasma gondii virulence effectors

(2012) Christopher A. Hunter et al.   NATURE REVIEWS MICROBIOLOGY

The IRG protein-based resistance mechanism in mice and its relation to virulence in Toxoplasma gondii

(2011) Jonathan C Howard et al.   CURRENT OPINION IN MICROBIOLOGY

Strain-specific activation of the NF-κB pathway by GRA15, a novelToxoplasma gondiidense granule protein

(2011) Emily E. Rosowski et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Context-Specific Regulation of NF-κB Target Gene Expression by EZH2 in Breast Cancers

(2011) Shuet Theng Lee et al.   MOLECULAR CELL

The Polycomb complex PRC2 and its mark in life

(2011) Raphaël Margueron et al.   NATURE

Wide-ranging functions of E2F4 in transcriptional activation and repression revealed by genome-wide analysis

(2011) Bum-Kyu Lee et al.   NUCLEIC ACIDS RESEARCH

Determinants of GBP Recruitment to Toxoplasma gondii Vacuoles and the Parasitic Factors That Control It

(2011) Sebastian Virreira Winter et al.   PLoS One

Toxoplasma gondii effectors are master regulators of the inflammatory response

(2011) Mariane B. Melo et al.   TRENDS IN PARASITOLOGY

An operational definition of epigenetics

(2009) S. L. Berger et al.   GENES & DEVELOPMENT

Combinatorial pharmacologic approaches target EZH2-mediated gene repression in breast cancer cells

(2009) F. Sun et al.   MOLECULAR CANCER THERAPEUTICS

Gr1+ Inflammatory Monocytes Are Required for Mucosal Resistance to the Pathogen Toxoplasma gondii

(2008) Ildiko R. Dunay et al.   IMMUNITY