Toxoplasma gondii Parasitophorous Vacuole Membrane-Associated Dense Granule Proteins Orchestrate Chronic Infection and GRA12 Underpins Resistance to Host Gamma Interferon

Gene target discovery with network analysis in Toxoplasma gondii

(2019) Andres M. Alonso et al.   Scientific Reports

The dense granule protein 8 (GRA8) is a component of the sub-pellicular cytoskeleton in Toxoplasma gondii

(2019) Rubén Darío Díaz-Martín et al.   PARASITOLOGY RESEARCH

Enrichment and Proteomic Characterization of the Cyst Wall from In Vitro Toxoplasma gondii Cysts

(2019) Vincent Tu et al.   mBio

Partners in anti- crime: how interferon-inducible GTPases and autophagy proteins team up in cell-intrinsic host defense

(2018) Jörn Coers et al.   CURRENT OPINION IN IMMUNOLOGY

MYR1-Dependent Effectors Are the Major Drivers of a Host Cell’s Early Response to Toxoplasma , Including Counteracting MYR1-Independent Effects

(2018) Adit Naor et al.   mBio

Identification of a novel protein complex essential for effector translocation across the parasitophorous vacuole membrane of Toxoplasma gondii

(2018) Nicole D. Marino et al.   PLoS Pathogens

The parasiteToxoplasmasequesters diverse Rab host vesicles within an intravacuolar network

(2017) Julia D. Romano et al.   JOURNAL OF CELL BIOLOGY

Observations on bradyzoite biology

(2017) Vincent Tu et al.   MICROBES AND INFECTION

Making Home Sweet and Sturdy: Toxoplasma gondii ppGalNAc-Ts Glycosylate in Hierarchical Order and Confer Cyst Wall Rigidity

(2017) Tadakimi Tomita et al.   mBio

Host lipid droplets: An important source of lipids salvaged by the intracellular parasite Toxoplasma gondii

(2017) Sabrina J. Nolan et al.   PLoS Pathogens

Toxoplasma gondii F-actin forms an extensive filamentous network required for material exchange and parasite maturation

(2017) Javier Periz et al.   eLife

Toxoplasma depends on lysosomal consumption of autophagosomes for persistent infection

(2017) Manlio Di Cristina et al.   Nature Microbiology

TRIM21 is critical for survival of Toxoplasma gondii infection and localises to GBP-positive parasite vacuoles

(2017) Clémence Foltz et al.   Scientific Reports

Genetic Mapping of Pathogenesis Determinants inToxoplasma gondii

(2016) Michael S. Behnke et al.   Annual Review of Microbiology

Loss of the interferon-γ-inducible regulatory immunity-related GTPase (IRG), Irgm1, causes activation of effector IRG proteins on lysosomes, damaging lysosomal function and predicting the dramatic susceptibility of Irgm1-deficient mice to infection

(2016) Jelena Maric-Biresev et al.   BMC BIOLOGY

The ROP18 and ROP5 gene allele types are highly predictive of virulence in mice across globally distributed strains of Toxoplasma gondii

(2016) Elliot Keats Shwab et al.   INTERNATIONAL JOURNAL FOR PARASITOLOGY

The Toxoplasma gondii Rhoptry Kinome Is Essential for Chronic Infection

(2016) Barbara A. Fox et al.   mBio

A Novel Secreted Protein, MYR1, Is Central to Toxoplasma ’s Manipulation of Host Cells

(2016) Magdalena Franco et al.   mBio

In Vivo Biotinylation of the Toxoplasma Parasitophorous Vacuole Reveals Novel Dense Granule Proteins Important for Parasite Growth and Pathogenesis

(2016) Santhosh M. Nadipuram et al.   mBio

Secretion of Rhoptry and Dense Granule Effector Proteins by Nonreplicating Toxoplasma gondii Uracil Auxotrophs Controls the Development of Antitumor Immunity

(2016) Barbara A. Fox et al.   PLoS Genetics

Neurons are the Primary Target Cell for the Brain-Tropic Intracellular Parasite Toxoplasma gondii

(2016) Carla M. Cabral et al.   PLoS Pathogens

Endothelial cells are a replicative niche for entry of Toxoplasma gondii to the central nervous system

(2016) Christoph Konradt et al.   Nature Microbiology

The Rhoptry Pseudokinase ROP54 Modulates Toxoplasma gondii Virulence and Host GBP2 Loading

(2016) Elliot W. Kim et al.   mSphere

Phenotypes Associated with Knockouts of Eight Dense Granule Gene Loci (GRA2-9) in Virulent Toxoplasma gondii

(2016) Leah M. Rommereim et al.   PLoS One

The Toxoplasma Dense Granule Proteins GRA17 and GRA23 Mediate the Movement of Small Molecules between the Host and the Parasitophorous Vacuole

(2015) Daniel A. Gold et al.   Cell Host & Microbe

TheToxoplasma gondiirhoptry protein ROP18 is an Irga6-specific kinase and regulated by the dense granule protein GRA7

(2015) Thomas Hermanns et al.   CELLULAR MICROBIOLOGY

Toxoplasma gondii GRA7-Induced TRAF6 Activation Contributes to Host Protective Immunity

(2015) Chul-Su Yang et al.   INFECTION AND IMMUNITY

New views of the Toxoplasma gondii parasitophorous vacuole as revealed by Helium Ion Microscopy (HIM)

(2015) Wanderley de Souza et al.   JOURNAL OF STRUCTURAL BIOLOGY

Ubiquitin systems mark pathogen-containing vacuoles as targets for host defense by guanylate binding proteins

(2015) Arun K. Haldar et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Toxoplasma secretory granules: one population or more?

(2015) Corinne Mercier et al.   TRENDS IN PARASITOLOGY

Intravacuolar Membranes Regulate CD8 T Cell Recognition of Membrane-Bound Toxoplasma gondii Protective Antigen

(2015) Jodie Lopez et al.   Cell Reports

Rhoptry Proteins ROP5 and ROP18 Are Major Murine Virulence Factors in Genetically Divergent South American Strains of Toxoplasma gondii

(2015) Michael S. Behnke et al.   PLoS Genetics

Fundamental Roles of the Golgi-Associated Toxoplasma Aspartyl Protease, ASP5, at the Host-Parasite Interface

(2015) Pierre-Mehdi Hammoudi et al.   PLoS Pathogens

An aspartyl protease defines a novel pathway for export of Toxoplasma proteins into the host cell

(2015) Michael J Coffey et al.   eLife

The Toxoplasma Pseudokinase ROP5 Forms Complexes with ROP18 and ROP17 Kinases that Synergize to Control Acute Virulence in Mice

(2014) Ronald D. Etheridge et al.   Cell Host & Microbe

TheToxoplasmaPseudokinase ROP5 Is an Allosteric Inhibitor of the Immunity-related GTPases

(2014) Michael L. Reese et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Selective and strain-specific NFAT4 activation by theToxoplasma gondiipolymorphic dense granule protein GRA6

(2014) Ji Su Ma et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Cell-Mediated Immunity to Toxoplasma gondii Develops Primarily by Local Th1 Host Immune Responses in the Absence of Parasite Replication

(2014) J. P. Gigley et al.   JOURNAL OF IMMUNOLOGY

Toxoplasma GRA7 effector increases turnover of immunity-related GTPases and contributes to acute virulence in the mouse

(2014) A. Alaganan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Toxoplasma gondii Ingests and Digests Host Cytosolic Proteins

(2014) Z. Dou et al.   mBio

Avirulent Toxoplasma gondii Generates Therapeutic Antitumor Immunity by Reversing Immunosuppression in the Ovarian Cancer Microenvironment

(2013) Jason R. Baird et al.   CANCER RESEARCH

Toxoplasma gondii Rhoptry 16 Kinase Promotes Host Resistance to Oral Infection and Intestinal Inflammation Only in the Context of the Dense Granule Protein GRA15

(2013) Kirk D. C. Jensen et al.   INFECTION AND IMMUNITY

Toxoplasma gondii salvages sphingolipids from the host Golgi through the rerouting of selected Rab vesicles to the parasitophorous vacuole

(2013) Julia D. Romano et al.   MOLECULAR BIOLOGY OF THE CELL

Toxoplasma gondii Triggers Phosphorylation and Nuclear Translocation of Dendritic Cell STAT1 while Simultaneously Blocking IFNγ-Induced STAT1 Transcriptional Activity

(2013) Anne G. Schneider et al.   PLoS One

IRG and GBP Host Resistance Factors Target Aberrant, “Non-self” Vacuoles Characterized by the Missing of “Self” IRGM Proteins

(2013) Arun K. Haldar et al.   PLoS Pathogens

A Nucleotide Sugar Transporter Involved in Glycosylation of the Toxoplasma Tissue Cyst Wall Is Required for Efficient Persistence of Bradyzoites

(2013) Carolina E. Caffaro et al.   PLoS Pathogens

The Toxoplasma gondii Cyst Wall Protein CST1 Is Critical for Cyst Wall Integrity and Promotes Bradyzoite Persistence

(2013) Tadakimi Tomita et al.   PLoS Pathogens

Fiji: an open-source platform for biological-image analysis

(2012) Johannes Schindelin et al.   NATURE METHODS

A Toxoplasma gondii Pseudokinase Inhibits Host IRG Resistance Proteins

(2012) Martin C. Fleckenstein et al.   PLOS BIOLOGY

The Rhoptry Proteins ROP18 and ROP5 Mediate Toxoplasma gondii Evasion of the Murine, But Not the Human, Interferon-Gamma Response

(2012) Wendy Niedelman et al.   PLoS Pathogens

The Polymorphic Pseudokinase ROP5 Controls Virulence in Toxoplasma gondii by Regulating the Active Kinase ROP18

(2012) Michael S. Behnke et al.   PLoS Pathogens

Toxoplasma Polymorphic Effectors Determine Macrophage Polarization and Intestinal Inflammation

(2011) Kirk D.C. Jensen et al.   Cell Host & Microbe

The organization of the wall filaments and characterization of the matrix structures of Toxoplasma gondii cyst form

(2011) Leandro Lemgruber et al.   CELLULAR MICROBIOLOGY

Development of high-throughput methods to quantify cysts of Toxoplasma gondii

(2011) D. Aldebert et al.   CYTOMETRY PART A

Evidence for Host Cells as the Major Contributor of Lipids in the Intravacuolar Network of Toxoplasma-Infected Cells

(2011) Carolina E. Caffaro et al.   EUKARYOTIC CELL

Type II Toxoplasma gondii KU80 Knockout Strains Enable Functional Analysis of Genes Required for Cyst Development and Latent Infection

(2011) Barbara A. Fox et al.   EUKARYOTIC CELL

Immunity-related GTPase M (IRGM) Proteins Influence the Localization of Guanylate-binding Protein 2 (GBP2) by Modulating Macroautophagy

(2011) Maria K. Traver et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Strain-specific activation of the NF-κB pathway by GRA15, a novelToxoplasma gondiidense granule protein

(2011) Emily E. Rosowski et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Polymorphic family of injected pseudokinases is paramount in Toxoplasma virulence

(2011) M. L. Reese et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Virulence differences in Toxoplasma mediated by amplification of a family of polymorphic pseudokinases

(2011) M. S. Behnke et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Phosphorylation of Immunity-Related GTPases by a Toxoplasma gondii-Secreted Kinase Promotes Macrophage Survival and Virulence

(2010) Sarah J. Fentress et al.   Cell Host & Microbe

Coordinated loading of IRG resistance GTPases on to the Toxoplasma gondii parasitophorous vacuole

(2010) Aliaksandr Khaminets et al.   CELLULAR MICROBIOLOGY

Avirulent Uracil Auxotrophs Based on Disruption of Orotidine-5'-Monophosphate Decarboxylase Elicit Protective Immunity to Toxoplasma gondii

(2010) B. A. Fox et al.   INFECTION AND IMMUNITY

Toxoplasma gondii Cyst Wall Formation in Activated Bone Marrow-derived Macrophages and Bradyzoite Conditions

(2010) Crystal Tobin et al.   Jove-Journal of Visualized Experiments

Efficient Gene Replacements inToxoplasma gondiiStrains Deficient for Nonhomologous End Joining

(2009) Barbara A. Fox et al.   EUKARYOTIC CELL

Toxoplasmosis: A history of clinical observations

(2009) Louis M. Weiss et al.   INTERNATIONAL JOURNAL FOR PARASITOLOGY

Balance of Irgm protein activities determines IFN-γ-induced host defense

(2009) Stanley C. Henry et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Population Structure ofToxoplasma gondii: Clonal Expansion Driven by Infrequent Recombination and Selective Sweeps

(2008) L. David Sibley et al.   Annual Review of Microbiology

Clinical Practice: Management ofToxoplasma gondiiInfection during Pregnancy

(2008) Jose G. Montoya et al.   CLINICAL INFECTIOUS DISEASES

Intervacuolar Transport and Unique Topology of GRA14, a Novel Dense Granule Protein in Toxoplasma gondii

(2008) M. E. Rome et al.   INFECTION AND IMMUNITY

The Toxoplasma gondii Dense Granule Protein GRA7 Is Phosphorylated upon Invasion and Forms an Unexpected Association with the Rhoptry Proteins ROP2 and ROP4

(2008) J. D. Dunn et al.   INFECTION AND IMMUNITY

GRA12, a Toxoplasma dense granule protein associated with the intravacuolar membranous nanotubular network

(2008) Adeline Michelin et al.   INTERNATIONAL JOURNAL FOR PARASITOLOGY

Functional domains of the Toxoplasma GRA2 protein in the formation of the membranous nanotubular network of the parasitophorous vacuole

(2007) Laetitia Travier et al.   INTERNATIONAL JOURNAL FOR PARASITOLOGY