Journal
INFECTION AND IMMUNITY
Volume 88, Issue 5, Pages -Publisher
AMER SOC MICROBIOLOGY
DOI: 10.1128/IAI.00054-20
Keywords
Toxoplasma gondii; GABARAPL2; IFN-gamma; autophagy adaptors
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Funding
- National Key Research and Development Program of China [2017YFD0501304]
- National Natural Science Foundation of China [31702231]
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Gamma interferon (IFN-gamma)-induced innate immune responses play important roles in the inhibition of Toxoplasma gondii infection. It has been reported that IFN-gamma stimulates non-acidification-dependent growth restriction of T. gondii in HeLa cells, but the mechanism remains unclear. Here, we found that gamma-aminobutyric acid (GABA) receptor-associated protein-like 2 (GABARAPL2) plays a critical role in parasite restriction in IFN-gamma-treated HeLa cells. GABARAPL2 is recruited to membrane structures surrounding parasitophorous vacuoles (PV). Autophagy adaptors are required for the proper localization and function of GABARAPL2 in the IFN-gamma-induced immune response. These findings provide further understanding of a noncanonical autophagy pathway responsible for IFN-gamma-dependent inhibition of T. gondii growth in human HeLa cells and demonstrate the critical role of GABARAPL2 in this response.
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