Toxoplasma gondii dense granule protein GRA24 drives MyD88-independent p38 MAPK activation, IL-12 production and induction of protective immunity

In Vivo CRISPR Screen Identifies TgWIP as a Toxoplasma Modulator of Dendritic Cell Migration

(2019) Lamba Omar Sangaré et al.   Cell Host & Microbe

Structural Basis for the Subversion of MAP Kinase Signaling by an Intrinsically Disordered Parasite Secreted Agonist

(2017) Erika Pellegrini et al.   STRUCTURE

Adhesion of Toxoplasma gondii tachyzoite-infected vehicle leukocytes to capillary endothelial cells triggers timely parasite egression

(2017) Minami Baba et al.   Scientific Reports

Toxoplasma Effector Recruits the Mi-2/NuRD Complex to Repress STAT1 Transcription and Block IFN-γ-Dependent Gene Expression

(2016) Philipp Olias et al.   Cell Host & Microbe

A Novel Secreted Protein, MYR1, Is Central to Toxoplasma ’s Manipulation of Host Cells

(2016) Magdalena Franco et al.   mBio

Secretion of Rhoptry and Dense Granule Effector Proteins by Nonreplicating Toxoplasma gondii Uracil Auxotrophs Controls the Development of Antitumor Immunity

(2016) Barbara A. Fox et al.   PLoS Genetics

Neospora caninum Activates p38 MAPK as an Evasion Mechanism against Innate Immunity

(2016) Caroline M. Mota et al.   Frontiers in Microbiology

The aspartyl protease TgASP5 mediates the export of theToxoplasmaGRA16 and GRA24 effectors into host cells

(2015) Aurélie Curt-Varesano et al.   CELLULAR MICROBIOLOGY

Toxoplasma 's ways of manipulating the host transcriptome via secreted effectors

(2015) Mohamed-Ali Hakimi et al.   CURRENT OPINION IN MICROBIOLOGY

Impact ofToxoplasma gondiion Dendritic Cell Subset Function in the Intestinal Mucosa

(2015) Sara B. Cohen et al.   JOURNAL OF IMMUNOLOGY

The IL-12 Response of Primary Human Dendritic Cells and Monocytes toToxoplasma gondiiIs Stimulated by Phagocytosis of Live Parasites Rather Than Host Cell Invasion

(2015) Kevin W. Tosh et al.   JOURNAL OF IMMUNOLOGY

An aspartyl protease defines a novel pathway for export of Toxoplasma proteins into the host cell

(2015) Michael J Coffey et al.   eLife

Innate Resistance against Toxoplasma gondii: An Evolutionary Tale of Mice, Cats, and Men

(2014) Ricardo T. Gazzinelli et al.   Cell Host & Microbe

Selective and strain-specific NFAT4 activation by theToxoplasma gondiipolymorphic dense granule protein GRA6

(2014) Ji Su Ma et al.   JOURNAL OF EXPERIMENTAL MEDICINE

TLR Adaptor MyD88 Is Essential for Pathogen Control during Oral Toxoplasma gondii Infection but Not Adaptive Immunity Induced by a Vaccine Strain of the Parasite

(2014) W. Sukhumavasi et al.   JOURNAL OF IMMUNOLOGY

Combined Action of Nucleic Acid-Sensing Toll-like Receptors and TLR11/TLR12 Heterodimers Imparts Resistance to Toxoplasma gondii in Mice

(2013) Warrison A. Andrade et al.   Cell Host & Microbe

Host Cell Subversion by Toxoplasma GRA16, an Exported Dense Granule Protein that Targets the Host Cell Nucleus and Alters Gene Expression

(2013) Alexandre Bougdour et al.   Cell Host & Microbe

Toxoplasmaexports dense granule proteins beyond the vacuole to the host cell nucleus and rewires the host genome expression

(2013) Alexandre Bougdour et al.   CELLULAR MICROBIOLOGY

AToxoplasmadense granule protein, GRA24, modulates the early immune response to infection by promoting a direct and sustained host p38 MAPK activation

(2013) Laurence Braun et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Cooperation of TLR12 and TLR11 in the IRF8-Dependent IL-12 Response to Toxoplasma gondii Profilin

(2013) M. Raetz et al.   JOURNAL OF IMMUNOLOGY

TLR-independent neutrophil-derived IFN-  is important for host resistance to intracellular pathogens

(2013) C. R. Sturge et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

IRG and GBP Host Resistance Factors Target Aberrant, “Non-self” Vacuoles Characterized by the Missing of “Self” IRGM Proteins

(2013) Arun K. Haldar et al.   PLoS Pathogens

CXCR3-Dependent CD4+ T Cells Are Required to Activate Inflammatory Monocytes for Defense against Intestinal Infection

(2013) Sara B. Cohen et al.   PLoS Pathogens

Epidemiology of and Diagnostic Strategies for Toxoplasmosis

(2012) F. Robert-Gangneux et al.   CLINICAL MICROBIOLOGY REVIEWS

Experimental and natural infections in MyD88- and IRAK-4-deficient mice and humans

(2012) Horst von Bernuth et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Murine Guanylate Binding Protein 2 (mGBP2) controls Toxoplasma gondii replication

(2012) D. Degrandi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Immune response and immunopathology during toxoplasmosis

(2012) Christopher D. Dupont et al.   Seminars in Immunopathology

Toxoplasma Polymorphic Effectors Determine Macrophage Polarization and Intestinal Inflammation

(2011) Kirk D.C. Jensen et al.   Cell Host & Microbe

CD8α+ Dendritic Cells Are the Critical Source of Interleukin-12 that Controls Acute Infection by Toxoplasma gondii Tachyzoites

(2011) Mona Mashayekhi et al.   IMMUNITY

Strain-specific activation of the NF-κB pathway by GRA15, a novelToxoplasma gondiidense granule protein

(2011) Emily E. Rosowski et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Toxoplasma gondii Rhoptry Kinase ROP16 Activates STAT3 and STAT6 Resulting in Cytokine Inhibition and Arginase-1-Dependent Growth Control

(2011) Barbara A. Butcher et al.   PLoS Pathogens

Avirulent Uracil Auxotrophs Based on Disruption of Orotidine-5'-Monophosphate Decarboxylase Elicit Protective Immunity to Toxoplasma gondii

(2010) B. A. Fox et al.   INFECTION AND IMMUNITY

UNC93B1 Is Essential for TLR11 Activation and IL-12-dependent Host Resistance toToxoplasma gondii

(2010) Reed Pifer et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Critical coordination of innate immune defense against Toxoplasma gondii by dendritic cells responding via their Toll-like receptors

(2010) B. Hou et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Disruption of the Toxoplasma gondii Parasitophorous Vacuole by IFNγ-Inducible Immunity-Related GTPases (IRG Proteins) Triggers Necrotic Cell Death

(2009) Yang O. Zhao et al.   PLoS Pathogens

Toxoplasma Profilin Is Essential for Host Cell Invasion and TLR11-Dependent Induction of an Interleukin-12 Response

(2008) Fabienne Plattner et al.   Cell Host & Microbe

Pyogenic Bacterial Infections in Humans with MyD88 Deficiency

(2008) H. von Bernuth et al.   SCIENCE