ISG15 Connects Autophagy and IFN-γ-Dependent Control of Toxoplasma gondii Infection in Human Cells

The Cargo Receptor NDP52 Initiates Selective Autophagy by Recruiting the ULK Complex to Cytosol-Invading Bacteria

(2019) Benjamin J. Ravenhill et al.   MOLECULAR CELL

ISG15: It's Complicated

(2019) John V. Dzimianski et al.   JOURNAL OF MOLECULAR BIOLOGY

Toxoplasma gondii effector TgIST blocks type I interferon signaling to promote infection

(2019) Sumit K. Matta et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The in vivo ISGylome links ISG15 to metabolic pathways and autophagy upon Listeria monocytogenes infection

(2019) Yifeng Zhang et al.   Nature Communications

Human immunity to Toxoplasma gondii

(2019) Daniel Fisch et al.   PLoS Pathogens

RIG-I and Other RNA Sensors in Antiviral Immunity

(2018) Kwan T. Chow et al.   Annual Review of Immunology

Cysteine-Reactive Free ISG15 Generates IL-1β–Producing CD8α+Dendritic Cells at the Site of Infection

(2018) Anna Napolitano et al.   JOURNAL OF IMMUNOLOGY

ISG15 in antiviral immunity and beyond

(2018) Yi-Chieh Perng et al.   NATURE REVIEWS MICROBIOLOGY

Interferon Gamma Induces Reversible Metabolic Reprogramming of M1 Macrophages to Sustain Cell Viability and Pro-Inflammatory Activity

(2018) Feilong Wang et al.   EBioMedicine

Treatment of Toxoplasmosis: Historical Perspective, Animal Models, and Current Clinical Practice

(2018) Ildiko Rita Dunay et al.   CLINICAL MICROBIOLOGY REVIEWS

IFN-r-induced IFIT5 promotes epithelial-to-mesenchymal transition in prostate cancer via microRNA processing

(2018) U-Ging Lo et al.   CANCER RESEARCH

ISGylation – a key to lock the cell gates for preventing the spread of threats

(2017) Carolina Villarroya-Beltri et al.   JOURNAL OF CELL SCIENCE

The impact of ISGylation during Mycobacterium tuberculosis infection in mice

(2017) Jacqueline M. Kimmey et al.   MICROBES AND INFECTION

Guanylate-binding protein 1 (GBP1) contributes to the immunity of human mesenchymal stromal cells againstToxoplasma gondii

(2017) Aiping Qin et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Toxoplasma Parasitophorous Vacuole: An Evolving Host–Parasite Frontier

(2017) Barbara Clough et al.   TRENDS IN PARASITOLOGY

A conserved ankyrin repeat-containing protein regulates conoid stability, motility and cell invasion in Toxoplasma gondii

(2017) Shaojun Long et al.   Nature Communications

ISG15 governs mitochondrial function in macrophages following vaccinia virus infection

(2017) Sara Baldanta et al.   PLoS Pathogens

Loss of VPS13C Function in Autosomal-Recessive Parkinsonism Causes Mitochondrial Dysfunction and Increases PINK1/Parkin-Dependent Mitophagy

(2016) Suzanne Lesage et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Interferons Induce Expression of SAMHD1 in Monocytes through Down-regulation of miR-181a and miR-30a

(2016) Maximilian Riess et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The ATG conjugation systems are important for degradation of the inner autophagosomal membrane

(2016) Kotaro Tsuboyama et al.   SCIENCE

ISG15 deficiency and increased viral resistance in humans but not mice

(2016) Scott D. Speer et al.   Nature Communications

K63-Linked Ubiquitination Targets Toxoplasma gondii for Endo-lysosomal Destruction in IFNγ-Stimulated Human Cells

(2016) Barbara Clough et al.   PLoS Pathogens

Molecular basis of ubiquitin recognition by the autophagy receptor CALCOCO2

(2015) Xingqiao Xie et al.   Autophagy

The BioPlex Network: A Systematic Exploration of the Human Interactome

(2015) Edward L. Huttlin et al.   CELL

Autophagy and autophagy-related proteins in the immune system

(2015) Shusaku T Shibutani et al.   NATURE IMMUNOLOGY

A Noncanonical Autophagy Pathway Restricts Toxoplasma gondii Growth in a Strain-Specific Manner in IFN-γ-Activated Human Cells

(2015) Elizabeth M. Selleck et al.   mBio

ISG15 counteracts Listeria monocytogenes infection

(2015) Lilliana Radoshevich et al.   eLife

Interferon-Stimulated Genes: A Complex Web of Host Defenses

(2014) William M. Schneider et al.   Annual Review of Immunology

Innate Resistance against Toxoplasma gondii: An Evolutionary Tale of Mice, Cats, and Men

(2014) Ricardo T. Gazzinelli et al.   Cell Host & Microbe

Contribution of increased ISG15, ISGylation and deregulated type I IFN signaling in Usp18 mutant mice during the course of bacterial infections

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The Parasitophorous Vacuole Membrane of Toxoplasma gondii Is Targeted for Disruption by Ubiquitin-like Conjugation Systems of Autophagy

(2014) Jayoung Choi et al.   IMMUNITY

Interferon-stimulated Gene 15 (ISG15) and ISG15-linked Proteins Can Associate with Members of the Selective Autophagic Process, Histone Deacetylase 6 (HDAC6) and SQSTM1/p62

(2014) Hiroshi Nakashima et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Bacteria–autophagy interplay: a battle for survival

(2014) Ju Huang et al.   NATURE REVIEWS MICROBIOLOGY

IFN-γ Stimulates Autophagy-Mediated Clearance of Burkholderia cenocepacia in Human Cystic Fibrosis Macrophages

(2014) Kaivon Assani et al.   PLoS One

IFIT5 potentiates anti-viral response through enhancing innate immune signaling pathways

(2013) B. Zhang et al.   ACTA BIOCHIMICA ET BIOPHYSICA SINICA

Genome engineering using the CRISPR-Cas9 system

(2013) F Ann Ran et al.   Nature Protocols

Interferon-induced ISG15 pathway: an ongoing virus–host battle

(2013) Chen Zhao et al.   TRENDS IN MICROBIOLOGY

Guanylate-binding Protein 1 (Gbp1) Contributes to Cell-autonomous Immunity against Toxoplasma gondii

(2013) Elizabeth M. Selleck et al.   PLoS Pathogens

Toxoplasma gondii-Induced Activation of EGFR Prevents Autophagy Protein-Mediated Killing of the Parasite

(2013) Luis Muniz-Feliciano et al.   PLoS Pathogens

IFN-Inducible GTPases in Host Cell Defense

(2012) Bae-Hoon Kim et al.   Cell Host & Microbe

A Cluster of Interferon-γ-Inducible p65 GTPases Plays a Critical Role in Host Defense against Toxoplasma gondii

(2012) Masahiro Yamamoto et al.   IMMUNITY

A promiscuous biotin ligase fusion protein identifies proximal and interacting proteins in mammalian cells

(2012) Kyle J. Roux et al.   JOURNAL OF CELL BIOLOGY

Modulation of innate immunity by Toxoplasma gondii virulence effectors

(2012) Christopher A. Hunter et al.   NATURE REVIEWS MICROBIOLOGY

Murine Guanylate Binding Protein 2 (mGBP2) controls Toxoplasma gondii replication

(2012) D. Degrandi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mycobacterial Disease and Impaired IFN-  Immunity in Humans with Inherited ISG15 Deficiency

(2012) D. Bogunovic et al.   SCIENCE

The IRG protein-based resistance mechanism in mice and its relation to virulence in Toxoplasma gondii

(2011) Jonathan C Howard et al.   CURRENT OPINION IN MICROBIOLOGY

Invasion and intracellular survival by protozoan parasites

(2011) L. David Sibley   IMMUNOLOGICAL REVIEWS

Autophagy in immunity and inflammation

(2011) Beth Levine et al.   NATURE

Atg8: an autophagy-related ubiquitin-like protein family

(2011) Tomer Shpilka et al.   GENOME BIOLOGY

ISG15 and immune diseases

(2010) Young Joo Jeon et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Methods in Mammalian Autophagy Research

(2010) Noboru Mizushima et al.   CELL

Coordinated loading of IRG resistance GTPases on to the Toxoplasma gondii parasitophorous vacuole

(2010) Aliaksandr Khaminets et al.   CELLULAR MICROBIOLOGY

A Novel Role for IFN-Stimulated Gene Factor 3II in IFN-  Signaling and Induction of Antiviral Activity in Human Cells

(2010) A. N. Morrow et al.   JOURNAL OF IMMUNOLOGY

Interferon-Stimulated Gene 15 and the Protein ISGylation System

(2010) Dongxian Zhang et al.   JOURNAL OF INTERFERON AND CYTOKINE RESEARCH

The ISG15 Conjugation System Broadly Targets Newly Synthesized Proteins: Implications for the Antiviral Function of ISG15

(2010) Larissa A. Durfee et al.   MOLECULAR CELL

Network organization of the human autophagy system

(2010) Christian Behrends et al.   NATURE

Scaffold: A bioinformatic tool for validating MS/MS-based proteomic studies

(2010) Brian C. Searle   PROTEOMICS

Virulent Toxoplasma gondii Evade Immunity-Related GTPase-Mediated Parasite Vacuole Disruption within Primed Macrophages

(2009) Y. Zhao et al.   JOURNAL OF IMMUNOLOGY

The endogenous Toll-like receptor 4 agonist S100A8/S100A9 (calprotectin) as innate amplifier of infection, autoimmunity, and cancer

(2009) Jan M. Ehrchen et al.   JOURNAL OF LEUKOCYTE BIOLOGY

IFN-γ-Inducible Irga6 Mediates Host Resistance against Chlamydia trachomatis via Autophagy

(2009) Munir A. Al-Zeer et al.   PLoS One

Autophagosome-Independent Essential Function for the Autophagy Protein Atg5 in Cellular Immunity to Intracellular Pathogens

(2008) Zijiang Zhao et al.   Cell Host & Microbe