Effector-triggered immunity and pathogen sensing in metazoans

Characterization of pyrin dephosphorylation and inflammasome activation in macrophages as triggered by the Yersinia effectors YopE and YopT

(2019) Natasha P. Medici et al.   INFECTION AND IMMUNITY

Functional degradation: A mechanism of NLRP1 inflammasome activation by diverse pathogen enzymes

(2019) Andrew Sandstrom et al.   SCIENCE

Serine 25 phosphorylation inhibits RIPK1 kinase-dependent cell death in models of infection and inflammation

(2019) Yves Dondelinger et al.   Nature Communications

Inflammasomes: Threat-Assessment Organelles of the Innate Immune System

(2019) Charles L. Evavold et al.   IMMUNITY

Protein-Injection Machines in Bacteria

(2018) Jorge E. Galán et al.   CELL

The pyrin inflammasome: from sensing RhoA GTPases-inhibiting toxins to triggering autoinflammatory syndromes

(2018) Yvan Jamilloux et al.   Pathogens and Disease

Identification of a novel anoikis signalling pathway using the fungal virulence factor gliotoxin

(2018) Florian Haun et al.   Nature Communications

Salmonella stimulates pro-inflammatory signalling through p21-activated kinases bypassing innate immune receptors

(2018) Hui Sun et al.   Nature Microbiology

PtdIns4P on dispersed trans-Golgi network mediates NLRP3 inflammasome activation

(2018) Jueqi Chen et al.   NATURE

Caspase-8 induces cleavage of gasdermin D to elicit pyroptosis during Yersinia infection

(2018) Joseph Sarhan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Pathogen blockade of TAK1 triggers caspase-8–dependent cleavage of gasdermin D and cell death

(2018) Pontus Orning et al.   SCIENCE

RIPK1-dependent apoptosis bypasses pathogen blockade of innate signaling to promote immune defense

(2017) Lance W. Peterson et al.   JOURNAL OF EXPERIMENTAL MEDICINE

MK2 Phosphorylates RIPK1 to Prevent TNF-Induced Cell Death

(2017) Isabel Jaco et al.   MOLECULAR CELL

p38MAPK/MK2-dependent phosphorylation controls cytotoxic RIPK1 signalling in inflammation and infection

(2017) Manoj B. Menon et al.   NATURE CELL BIOLOGY

Galectin-3 directs antimicrobial guanylate binding proteins to vacuoles furnished with bacterial secretion systems

(2017) Eric M. Feeley et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Positive and Negative Regulation of the Master Metabolic Regulator mTORC1 by Two Families of Legionella pneumophila Effectors

(2017) Justin A. De Leon et al.   Cell Reports

Global analysis of gene expression reveals mRNA superinduction is required for the inducible immune response to a bacterial pathogen

(2017) Kevin C Barry et al.   eLife

EspL is a bacterial cysteine protease effector that cleaves RHIM proteins to block necroptosis and inflammation

(2017) Jaclyn S. Pearson et al.   Nature Microbiology

Germline NLRP1 Mutations Cause Skin Inflammatory and Cancer Susceptibility Syndromes via Inflammasome Activation

(2016) Franklin L. Zhong et al.   CELL

Roles of Caspases in Necrotic Cell Death

(2016) Junying Yuan et al.   CELL

IRGB10 Liberates Bacterial Ligands for Sensing by the AIM2 and Caspase-11-NLRP3 Inflammasomes

(2016) Si Ming Man et al.   CELL

A Burkholderia Type VI Effector Deamidates Rho GTPases to Activate the Pyrin Inflammasome and Trigger Inflammation

(2016) Daniel F. Aubert et al.   Cell Host & Microbe

The Yersinia Virulence Factor YopM Hijacks Host Kinases to Inhibit Type III Effector-Triggered Activation of the Pyrin Inflammasome

(2016) Lawton K. Chung et al.   Cell Host & Microbe

The integrated stress response

(2016) Karolina Pakos‐Zebrucka et al.   EMBO REPORTS

Cell-Extrinsic TNF Collaborates with TRIF Signaling To PromoteYersinia-Induced Apoptosis

(2016) Lance W. Peterson et al.   JOURNAL OF IMMUNOLOGY

Interferon-inducible guanylate-binding proteins at the interface of cell-autonomous immunity and inflammasome activation

(2016) Si Ming Man et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Interferon-Inducible GTPases in Host Resistance, Inflammation and Disease

(2016) Danielle Pilla-Moffett et al.   JOURNAL OF MOLECULAR BIOLOGY

NOD1 and NOD2 signalling links ER stress with inflammation

(2016) A. Marijke Keestra-Gounder et al.   NATURE

Interferon-induced guanylate-binding proteins in inflammasome activation and host defense

(2016) Bae-Hoon Kim et al.   NATURE IMMUNOLOGY

Pyrin inflammasome activation and RhoA signaling in the autoinflammatory diseases FMF and HIDS

(2016) Yong Hwan Park et al.   NATURE IMMUNOLOGY

Site-specific phosphorylation and microtubule dynamics control Pyrin inflammasome activation

(2016) Wenqing Gao et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Intracellular innate immune surveillance devices in plants and animals

(2016) J. D. G. Jones et al.   SCIENCE

The C. elegans CCAAT-Enhancer-Binding Protein Gamma Is Required for Surveillance Immunity

(2016) Kirthi C. Reddy et al.   Cell Reports

Functional and Evolutionary Analyses Identify Proteolysis as a General Mechanism for NLRP1 Inflammasome Activation

(2016) Joseph Chavarría-Smith et al.   PLoS Pathogens

The Yersinia pestis Effector YopM Inhibits Pyrin Inflammasome Activation

(2016) Dmitry Ratner et al.   PLoS Pathogens

Surveillance Immunity: An Emerging Paradigm of Innate Defense Activation in Caenorhabditis elegans

(2016) Read Pukkila-Worley   PLoS Pathogens

The Ins and Outs of Anthrax Toxin

(2016) Sarah Friebe et al.   Toxins

Effector-Triggered Immunity: From Pathogen Perception to Robust Defense

(2015) Haitao Cui et al.   Annual Review of Plant Biology

A Single Bacterial Immune Evasion Strategy Dismantles Both MyD88 and TRIF Signaling Pathways Downstream of TLR4

(2015) Charles V. Rosadini et al.   Cell Host & Microbe

Interferon-inducible GTPases in cell autonomous and innate immunity

(2015) Etienne Meunier et al.   CELLULAR MICROBIOLOGY

Caspase-11 activates a canonical NLRP3 inflammasome by promoting K+efflux

(2015) Sebastian Rühl et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Guanylate Binding Proteins Enable Rapid Activation of Canonical and Noncanonical Inflammasomes in Chlamydia-Infected Macrophages

(2015) Ryan Finethy et al.   INFECTION AND IMMUNITY

Suppression of RIP3-dependent Necroptosis by Human Cytomegalovirus

(2015) Shinya Omoto et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

NF-κB-Independent Role of IKKα/IKKβ in Preventing RIPK1 Kinase-Dependent Apoptotic and Necroptotic Cell Death during TNF Signaling

(2015) Yves Dondelinger et al.   MOLECULAR CELL

Control of adaptive immunity by the innate immune system

(2015) Akiko Iwasaki et al.   NATURE IMMUNOLOGY

Inhibition of host cell translation elongation byLegionella pneumophilablocks the host cell unfolded protein response

(2015) Andrew D. Hempstead et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

IL-1R signaling enables bystander cells to overcome bacterial blockade of host protein synthesis

(2015) Alan M. Copenhaver et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Inflammasome Activation in Response to the Yersinia Type III Secretion System Requires Hyperinjection of Translocon Proteins YopB and YopD

(2015) Erin E. Zwack et al.   mBio

Legionella suppresses the host unfolded protein response via multiple mechanisms

(2015) Sean Treacy-Abarca et al.   Nature Communications

DAMPs from Cell Death to New Life

(2015) Emilie Vénéreau et al.   Frontiers in Immunology

Influenza A Virus NS1 Protein Inhibits the NLRP3 Inflammasome

(2015) Woo-Chang Cheong et al.   PLoS One

Mechanisms and Functions of Inflammasomes

(2014) Mohamed Lamkanfi et al.   CELL

 -PIX and Rac1 GTPase Mediate Trafficking and Negative Regulation of NOD2

(2014) J. Eitel et al.   JOURNAL OF IMMUNOLOGY

Caspase-11 activation requires lysis of pathogen-containing vacuoles by IFN-induced GTPases

(2014) Etienne Meunier et al.   NATURE

Innate immune sensing of bacterial modifications of Rho GTPases by the Pyrin inflammasome

(2014) Hao Xu et al.   NATURE

Bacteria, the endoplasmic reticulum and the unfolded protein response: friends or foes?

(2014) Jean Celli et al.   NATURE REVIEWS MICROBIOLOGY

Guanylate binding proteins promote caspase-11-dependent pyroptosis in response to cytoplasmic LPS

(2014) D. M. Pilla et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Caspase-8 mediates caspase-1 processing and innate immune defense in response to bacterial blockade of NF- B and MAPK signaling

(2014) N. H. Philip et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Caspase-8 and RIP kinases regulate bacteria-induced innate immune responses and cell death

(2014) D. Weng et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Dual Role for Inflammasome Sensors NLRP1 and NLRP3 in Murine Resistance to Toxoplasma gondii

(2014) G. Gorfu et al.   mBio

Effector triggered immunity

(2014) Rajmohan Rajamuthiah et al.   Virulence

The Cofilin Phosphatase Slingshot Homolog 1 (SSH1) Links NOD1 Signaling to Actin Remodeling

(2014) Harald Bielig et al.   PLoS Pathogens

The Frustrated Host Response to Legionella pneumophila Is Bypassed by MyD88-Dependent Translation of Pro-inflammatory Cytokines

(2014) Seblewongel Asrat et al.   PLoS Pathogens

AvrBsT Acetylates Arabidopsis ACIP1, a Protein that Associates with Microtubules and Is Required for Immunity

(2014) Mi Sun Cheong et al.   PLoS Pathogens

Inflammasome Sensor NLRP1 Controls Rat Macrophage Susceptibility to Toxoplasma gondii

(2014) Kimberly M. Cirelli et al.   PLoS Pathogens

Listeriaphospholipases subvert host autophagic defenses by stalling pre-autophagosomal structures

(2013) Ivan Tattoli et al.   EMBO JOURNAL

Hijacking of Rho GTPases during bacterial infection

(2013) Emmanuel Lemichez et al.   EXPERIMENTAL CELL RESEARCH

RIP3: a molecular switch for necrosis and inflammation

(2013) K. Moriwaki et al.   GENES & DEVELOPMENT

Mitochondrial Cardiolipin Is Required for Nlrp3 Inflammasome Activation

(2013) Shankar S. Iyer et al.   IMMUNITY

K+ Efflux Is the Common Trigger of NLRP3 Inflammasome Activation by Bacterial Toxins and Particulate Matter

(2013) Raúl Muñoz-Planillo et al.   IMMUNITY

NLRP1 Is an Inflammasome Sensor for Toxoplasma gondii

(2013) Sarah E. Ewald et al.   INFECTION AND IMMUNITY

IL-1  Signaling Initiates the Inflammatory Response to Virulent Legionella pneumophila In Vivo

(2013) K. C. Barry et al.   JOURNAL OF IMMUNOLOGY

Manipulation of small Rho GTPases is a pathogen-induced process detected by NOD1

(2013) A. Marijke Keestra et al.   NATURE

Pathogen signatures activate a ubiquitination pathway that modulates the function of the metabolic checkpoint kinase mTOR

(2013) Stanimir S Ivanov et al.   NATURE IMMUNOLOGY

Regulation of RIP1 kinase signalling at the crossroads of inflammation and cell death

(2013) Dimitry Ofengeim et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Gene Expression Regulation by Upstream Open Reading Frames and Human Disease

(2013) Cristina Barbosa et al.   PLoS Genetics

Direct Proteolytic Cleavage of NLRP1B Is Necessary and Sufficient for Inflammasome Activation by Anthrax Lethal Factor

(2013) Joseph Chavarría-Smith et al.   PLoS Pathogens

Inactivation of Conserved C. elegans Genes Engages Pathogen- and Xenobiotic-Associated Defenses

(2012) Justine A. Melo et al.   CELL

DAI/ZBP1/DLM-1 Complexes with RIP3 to Mediate Virus-Induced Programmed Necrosis that Is Targeted by Murine Cytomegalovirus vIRA

(2012) Jason W. Upton et al.   Cell Host & Microbe

Host Translational Inhibition by Pseudomonas aeruginosa Exotoxin A Triggers an Immune Response in Caenorhabditis elegans

(2012) Deborah L. McEwan et al.   Cell Host & Microbe

C. elegans Detects Pathogen-Induced Translational Inhibition to Activate Immune Signaling

(2012) Tiffany L. Dunbar et al.   Cell Host & Microbe

Amino Acid Starvation Induced by Invasive Bacterial Pathogens Triggers an Innate Host Defense Program

(2012) Ivan Tattoli et al.   Cell Host & Microbe

Activation of Host Mitogen-Activated Protein Kinases by Secreted Legionella pneumophila Effectors That Inhibit Host Protein Translation

(2012) Mary F. Fontana et al.   INFECTION AND IMMUNITY

Cellular Entry of Human Papillomavirus Type 16 Involves Activation of the Phosphatidylinositol 3-Kinase/Akt/mTOR Pathway and Inhibition of Autophagy

(2012) Z. Surviladze et al.   JOURNAL OF VIROLOGY

YopK controls both rate and fidelity of Yop translocation

(2012) Rebecca Dewoody et al.   MOLECULAR MICROBIOLOGY

Proteolytic Processing of Nlrp1b Is Required for Inflammasome Activity

(2012) Bradley C. Frew et al.   PLoS Pathogens

Anthrax Lethal Factor Cleavage of Nlrp1 Is Required for Activation of the Inflammasome

(2012) Jonathan L. Levinsohn et al.   PLoS Pathogens

The bacterial and cellular determinants controlling the recruitment of mTOR to the Salmonella-containing vacuole

(2012) I. Tattoli et al.   Biology Open

Leishmania Repression of Host Translation through mTOR Cleavage Is Required for Parasite Survival and Infection

(2011) Maritza Jaramillo et al.   Cell Host & Microbe

Pathogen-Derived Effectors Trigger Protective Immunity via Activation of the Rac2 Enzyme and the IMD or Rip Kinase Signaling Pathway

(2011) Laurent Boyer et al.   IMMUNITY

Sensing damage by the NLRP3 inflammasome

(2011) Jaklien C. Leemans et al.   IMMUNOLOGICAL REVIEWS

Measles Virus V Protein Inhibits NLRP3 Inflammasome-Mediated Interleukin-1  Secretion

(2011) N. Komune et al.   JOURNAL OF VIROLOGY

Human Cytomegalovirus Infection Maintains mTOR Activity and Its Perinuclear Localization during Amino Acid Deprivation

(2011) A. J. Clippinger et al.   JOURNAL OF VIROLOGY

Anthrax and the inflammasome

(2011) Mahtab Moayeri et al.   MICROBES AND INFECTION

cIAPs Block Ripoptosome Formation, a RIP1/Caspase-8 Containing Intracellular Cell Death Complex Differentially Regulated by cFLIP Isoforms

(2011) Maria Feoktistova et al.   MOLECULAR CELL

The Ripoptosome, a Signaling Platform that Assembles in Response to Genotoxic Stress and Loss of IAPs

(2011) Tencho Tenev et al.   MOLECULAR CELL

The RACK1 Signaling Scaffold Protein Selectively Interacts with Yersinia pseudotuberculosis Virulence Function

(2011) Sara E. Thorslund et al.   PLoS One

The Unfolded Protein Response: From Stress Pathway to Homeostatic Regulation

(2011) P. Walter et al.   SCIENCE

Secreted Bacterial Effectors That Inhibit Host Protein Synthesis Are Critical for Induction of the Innate Immune Response to Virulent Legionella pneumophila

(2011) Mary F. Fontana et al.   PLoS Pathogens

A Yersinia Effector Protein Promotes Virulence by Preventing Inflammasome Recognition of the Type III Secretion System

(2010) Igor E. Brodsky et al.   Cell Host & Microbe

Dominant Inhibition of Akt/Protein Kinase B Signaling by the Matrix Protein of a Negative-Strand RNA Virus

(2010) E. F. Dunn et al.   JOURNAL OF VIROLOGY

Influenza virus activates inflammasomes via its intracellular M2 ion channel

(2010) Takeshi Ichinohe et al.   NATURE IMMUNOLOGY

bZIP transcription factor zip-2 mediates an early response to Pseudomonas aeruginosa infection in Caenorhabditis elegans

(2010) K. A. Estes et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Type III Effectors NleE and NleB from Enteropathogenic E. coli and OspZ from Shigella Block Nuclear Translocation of NF-κB p65

(2010) Hayley J. Newton et al.   PLoS Pathogens

Patterns of Pathogenesis: Discrimination of Pathogenic and Nonpathogenic Microbes by the Innate Immune System

(2009) Russell E. Vance et al.   Cell Host & Microbe

Targeting eEF1A by aLegionella pneumophilaeffector leads to inhibition of protein synthesis and induction of host stress response

(2009) Xihui Shen et al.   CELLULAR MICROBIOLOGY

Intracellular parasitism withToxoplasma gondiistimulates mammalian-target-of-rapamycin-dependent host cell growth despite impaired signalling to S6K1 and 4E-BP1

(2009) Yubao Wang et al.   CELLULAR MICROBIOLOGY

Approaching the Asymptote: 20 Years Later

(2009) Ruslan Medzhitov   IMMUNITY

Activation of the PI3K/Akt Pathway Early during Vaccinia and Cowpox Virus Infections Is Required for both Host Survival and Viral Replication

(2009) J. A. P. Soares et al.   JOURNAL OF VIROLOGY

A bacterial E3 ubiquitin ligase IpaH9.8 targets NEMO/IKKγ to dampen the host NF-κB-mediated inflammatory response

(2009) Hiroshi Ashida et al.   NATURE CELL BIOLOGY

Staphylococcus aureus α-Hemolysin Activates the NLRP3-Inflammasome in Human and Mouse Monocytic Cells

(2009) Robin R. Craven et al.   PLoS One

Salmonella Typhimurium Type III Secretion Effectors Stimulate Innate Immune Responses in Cultured Epithelial Cells

(2009) Vincent M. Bruno et al.   PLoS Pathogens

Inflammasomes: guardians of cytosolic sanctity

(2008) Mohamed Lamkanfi et al.   IMMUNOLOGICAL REVIEWS

Lgt: a Family of Cytotoxic Glucosyltransferases Produced by Legionella pneumophila

(2008) Y. Belyi et al.   JOURNAL OF BACTERIOLOGY

The Legionella pneumophila replication vacuole: making a cosy niche inside host cells

(2008) Ralph R. Isberg et al.   NATURE REVIEWS MICROBIOLOGY

GEF-H1 Mediated Control of NOD1 Dependent NF-κB Activation by Shigella Effectors

(2008) Atsuko Fukazawa et al.   PLoS Pathogens

Type IV Secretion-Dependent Activation of Host MAP Kinases Induces an Increased Proinflammatory Cytokine Response to Legionella pneumophila

(2008) Sunny Shin et al.   PLoS Pathogens