Metformin attenuates plaque-associated tau pathology and reduces amyloid-β burden in APP/PS1 mice

Microglial autophagy is impaired by prolonged exposure to β-amyloid peptides: evidence from experimental models and Alzheimer’s disease patients

(2020) Carlos Pomilio et al.   GeroScience

Metformin loaded phosphatidylserine nanoliposomes improve memory deficit and reduce neuroinflammation in streptozotocin-induced Alzheimer's disease model

(2020) Partow Mirzaee Saffari et al.   LIFE SCIENCES

Dynamic changes of autophagic flux induced by Abeta in the brain of postmortem Alzheimer’s disease patients, animal models and cell models

(2020) Zhimin Long et al.   Aging-US

Amyloid-β pathology enhances pathological fibrillary tau seeding induced by Alzheimer PHF in vivo

(2019) Cristina Vergara et al.   ACTA NEUROPATHOLOGICA

Humanization of the entire murine Mapt gene provides a murine model of pathological human tau propagation

(2019) Takashi Saito et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

TREM2 function impedes tau seeding in neuritic plaques

(2019) Cheryl E. G. Leyns et al.   NATURE NEUROSCIENCE

Metformin treatment prevents amyloid plaque deposition and memory impairment in APP/PS1 mice

(2018) Zhenri Ou et al.   BRAIN BEHAVIOR AND IMMUNITY

The Therapeutic Potential of Metformin in Neurodegenerative Diseases

(2018) Carola Rotermund et al.   Frontiers in Endocrinology

Incidence of Dementia is Increased in Type 2 Diabetes and Reduced by the Use of Sulfonylureas and Metformin

(2018) Chih-Cheng Hsu et al.   JOURNAL OF ALZHEIMERS DISEASE

The role of microglia in processing and spreading of bioactive tau seeds in Alzheimer’s disease

(2018) Sarah C. Hopp et al.   Journal of Neuroinflammation

Metformin attenuates diabetes-induced tau hyperphosphorylation in vitro and in vivo by enhancing autophagic clearance

(2018) Jin-Liang Chen et al.   EXPERIMENTAL NEUROLOGY

Autophagosome maturation: An epic journey from the ER to lysosomes

(2018) Yan G. Zhao et al.   JOURNAL OF CELL BIOLOGY

Autophagy and Microglia: Novel Partners in Neurodegeneration and Aging

(2017) Ainhoa Plaza-Zabala et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Differential effects of metformin on age related comorbidities in older men with type 2 diabetes

(2017) Chen-Pin Wang et al.   JOURNAL OF DIABETES AND ITS COMPLICATIONS

Amyloid-β plaques enhance Alzheimer's brain tau-seeded pathologies by facilitating neuritic plaque tau aggregation

(2017) Zhuohao He et al.   NATURE MEDICINE

Metformin vs sulfonylurea use and risk of dementia in US veterans aged ≥65 years with diabetes

(2017) Ariela R. Orkaby et al.   NEUROLOGY

Prion-like mechanisms and potential therapeutic targets in neurodegenerative disorders

(2017) Masato Hasegawa et al.   PHARMACOLOGY & THERAPEUTICS

Intranasal insulin alleviates cognitive deficits and amyloid pathology in young adult APPswe/PS1dE9 mice

(2016) Yan-Fang Mao et al.   AGING CELL

Effects of metformin on inflammation and short-term memory in streptozotocin-induced diabetic mice

(2016) Wilma Helena Oliveira et al.   BRAIN RESEARCH

The amyloid hypothesis of Alzheimer's disease at 25 years

(2016) Dennis J Selkoe et al.   EMBO Molecular Medicine

Metformin Facilitates Amyloid-β Generation by β- and γ-Secretases via Autophagy Activation

(2016) Sung Min Son et al.   JOURNAL OF ALZHEIMERS DISEASE

Metformin in Amnestic Mild Cognitive Impairment: Results of a Pilot Randomized Placebo Controlled Clinical Trial

(2016) José A. Luchsinger et al.   JOURNAL OF ALZHEIMERS DISEASE

Metformin promotes tau aggregation and exacerbates abnormal behavior in a mouse model of tauopathy

(2016) Erica Barini et al.   Molecular Neurodegeneration

Differential Roles of M1 and M2 Microglia in Neurodegenerative Diseases

(2015) Yu Tang et al.   MOLECULAR NEUROBIOLOGY

The case for rejecting the amyloid cascade hypothesis

(2015) Karl Herrup   NATURE NEUROSCIENCE

Microglia constitute a barrier that prevents neurotoxic protofibrillar Aβ42 hotspots around plaques

(2015) Carlo Condello et al.   Nature Communications

Amyloid accelerates tau propagation and toxicity in a model of early Alzheimer’s disease

(2015) Amy M Pooler et al.   Acta Neuropathologica Communications

A novel in vivo model of tau propagation with rapid and progressive neurofibrillary tangle pathology: the pattern of spread is determined by connectivity, not proximity

(2014) Zeshan Ahmed et al.   ACTA NEUROPATHOLOGICA

Intranasal insulin restores insulin signaling, increases synaptic proteins, and reduces Aβ level and microglia activation in the brains of 3xTg-AD mice

(2014) Yanxing Chen et al.   EXPERIMENTAL NEUROLOGY

Type 2 Diabetes and Antidiabetic Medications in Relation to Dementia Diagnosis

(2014) Chin Cheng et al.   JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES

Synergistic effects of amyloid-beta and wild-type human tau on dendritic spine loss in a floxed double transgenic model of Alzheimer's disease

(2014) Meredith A. Chabrier et al.   NEUROBIOLOGY OF DISEASE

Early detection of Alzheimer's disease using PiB and FDG PET

(2014) Ann D. Cohen et al.   NEUROBIOLOGY OF DISEASE

The Anti-Diabetic Drug Metformin Reduces BACE1 Protein Level by Interfering with the MID1 Complex

(2014) Moritz M. Hettich et al.   PLoS One

Insulin dysfunction and Tau pathology

(2014) Noura B. El Khoury et al.   Frontiers in Cellular Neuroscience

Amyloid-β and Tau

(2014) George S. Bloom   JAMA Neurology

Alzheimer disease therapy—moving from amyloid-β to tau

(2013) Ezio Giacobini et al.   Nature Reviews Neurology

Accelerated tau pathology with synaptic and neuronal loss in a novel triple transgenic mouse model of Alzheimer's disease

(2013) Anika Saul et al.   NEUROBIOLOGY OF AGING

Lack of Tau Proteins Rescues Neuronal Cell Death and Decreases Amyloidogenic Processing of APP in APP/PS1 Mice

(2012) Karelle Leroy et al.   AMERICAN JOURNAL OF PATHOLOGY

Demonstrated brain insulin resistance in Alzheimer’s disease patients is associated with IGF-1 resistance, IRS-1 dysregulation, and cognitive decline

(2012) Konrad Talbot et al.   JOURNAL OF CLINICAL INVESTIGATION

Metformin, Other Antidiabetic Drugs, and Risk of Alzheimer's Disease: A Population-Based Case-Control Study

(2012) Patrick Imfeld et al.   JOURNAL OF THE AMERICAN GERIATRICS SOCIETY

Effects of metformin on learning and memory behaviors and brain mitochondrial functions in high fat diet induced insulin resistant rats

(2012) Hiranya Pintana et al.   LIFE SCIENCES

In Vivo Spreading of Tau Pathology

(2012) Claudio Soto   NEURON

Propagation of Tau Pathology in a Model of Early Alzheimer's Disease

(2012) Alix de Calignon et al.   NEURON

The role of microglia at synapses in the healthy CNS: novel insights from recent imaging studies

(2012) Marie-Ève Tremblay   Neuron Glia Biology

Metformin attenuates Alzheimer's disease-like neuropathology in obese, leptin-resistant mice

(2012) Jiejie Li et al.   PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR

Trans-Synaptic Spread of Tau Pathology In Vivo

(2012) Li Liu et al.   PLoS One

Misfolded Truncated Protein   Induces Innate Immune Response via MAPK Pathway

(2011) A. Kovac et al.   JOURNAL OF IMMUNOLOGY

AMP-activated protein kinase: a potential player in Alzheimer’s disease

(2011) Antero Salminen et al.   JOURNAL OF NEUROCHEMISTRY

Soluble amyloid  -protein dimers isolated from Alzheimer cortex directly induce Tau hyperphosphorylation and neuritic degeneration

(2011) M. Jin et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Aβ Accelerates the Spatiotemporal Progression of Tau Pathology and Augments Tau Amyloidosis in an Alzheimer Mouse Model

(2010) David E. Hurtado et al.   AMERICAN JOURNAL OF PATHOLOGY

Molecular Interplay between Mammalian Target of Rapamycin (mTOR), Amyloid-β, and Tau

(2010) Antonella Caccamo et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Inhibition of mTOR by Rapamycin Abolishes Cognitive Deficits and Reduces Amyloid-β Levels in a Mouse Model of Alzheimer's Disease

(2010) Patricia Spilman et al.   PLoS One

Biguanide metformin acts on tau phosphorylation via mTOR/protein phosphatase 2A (PP2A) signaling

(2010) E. Kickstein et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Metformin increases phagocytosis and acidifies lysosomal/endosomal compartments in AMPK-dependent manner in rat primary microglia

(2009) Krzysztof Łabuzek et al.   NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY

Antidiabetic drug metformin (GlucophageR) increases biogenesis of Alzheimer's amyloid peptides via up-regulating BACE1 transcription

(2009) Y. Chen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA