Dendritic Spines: Mediators of Cognitive Resilience in Aging and Alzheimer’s Disease

Association of Klotho-VS Heterozygosity With Risk of Alzheimer Disease in Individuals Who Carry APOE4

(2020) Michael E. Belloy et al.   JAMA Neurology

KLOTHO heterozygosity attenuates APOE4-related amyloid burden in preclinical AD

(2019) Claire M. Erickson et al.   NEUROLOGY

The selective RhoA inhibitor Rhosin promotes stress resiliency through enhancing D1-MSN plasticity and reducing hyperexcitability

(2019) T. Chase Francis et al.   BIOLOGICAL PSYCHIATRY

Klotho deficiency affects the spine morphology and network synchronization of neurons

(2019) Hai T. Vo et al.   MOLECULAR AND CELLULAR NEUROSCIENCE

Hippocampal gene expression patterns linked to late-life physical activity oppose age and AD-related transcriptional decline

(2019) Nicole C. Berchtold et al.   NEUROBIOLOGY OF AGING

Pharmacologic inhibition of LIMK1 provides dendritic spine resilience against β-amyloid

(2019) Benjamin W. Henderson et al.   Science Signaling

Inhibition of Rac1-dependent forgetting alleviates memory deficits in animal models of Alzheimer’s disease

(2019) Wenjuan Wu et al.   Protein & Cell

Complement C3 Is Activated in Human AD Brain and Is Required for Neurodegeneration in Mouse Models of Amyloidosis and Tauopathy

(2019) Tiffany Wu et al.   Cell Reports

Amyloid β synaptotoxicity is Wnt-PCP dependent and blocked by fasudil

(2018) Katherine J. Sellers et al.   Alzheimers & Dementia

Voluntary wheel running promotes resilience to chronic social defeat stress in mice: a role for nucleus accumbens ΔFosB

(2018) Joram D. Mul et al.   NEUROPSYCHOPHARMACOLOGY

Chronic 2P-STED imaging reveals high turnover of dendritic spines in the hippocampus in vivo

(2018) Thomas Pfeiffer et al.   eLife

Assessing Synaptic Density in Alzheimer Disease With Synaptic Vesicle Glycoprotein 2A Positron Emission Tomographic Imaging

(2018) Ming-Kai Chen et al.   JAMA Neurology

Three-dimensional analysis of synapses in the transentorhinal cortex of Alzheimer’s disease patients

(2018) M. Domínguez-Álvaro et al.   Acta Neuropathologica Communications

Rac1 activation links tau hyperphosphorylation and Aβ dysmetabolism in Alzheimer’s disease

(2018) Mirta Borin et al.   Acta Neuropathologica Communications

Dynamic Microtubules in Alzheimer’s Disease: Association with Dendritic Spine Pathology

(2018) E. I. Pchitskaya et al.   BIOCHEMISTRY-MOSCOW

Absolute 10-year risk of dementia by age, sex andAPOEgenotype: a population-based cohort study

(2018) Katrine L. Rasmussen et al.   CANADIAN MEDICAL ASSOCIATION JOURNAL

Association of the Alzheimer's Disease Clusterin Risk Allele with Plasma Clusterin Concentration

(2018) Britta Schürmann et al.   JOURNAL OF ALZHEIMERS DISEASE

Synaptic Loss in the Inferior Temporal Gyrus in Mild Cognitive Impairment and Alzheimer's Disease

(2018) Stephen W. Scheff et al.   JOURNAL OF ALZHEIMERS DISEASE

Deconstructing and targeting the genomic architecture of human neurodegeneration

(2018) Philip L. De Jager et al.   NATURE NEUROSCIENCE

Dendritic spine remodeling accompanies Alzheimer’s disease pathology and genetic susceptibility in cognitively normal aging

(2018) Benjamin D. Boros et al.   NEUROBIOLOGY OF AGING

Physical activity for brain health in older adults

(2018) Teresa Liu-Ambrose et al.   Applied Physiology Nutrition and Metabolism

Synaptotoxicity in Alzheimer's Disease Involved a Dysregulation of Actin Cytoskeleton Dynamics through Cofilin 1 Phosphorylation

(2018) Travis Rush et al.   JOURNAL OF NEUROSCIENCE

Tau impairs neural circuits, dominating amyloid-β effects, in Alzheimer models in vivo

(2018) Marc Aurel Busche et al.   NATURE NEUROSCIENCE

Changes in the Synaptic Proteome in Tauopathy and Rescue of Tau-Induced Synapse Loss by C1q Antibodies

(2018) Borislav Dejanovic et al.   NEURON

Resilience to cognitive impairment in the oldest-old: design of the EMIF-AD 90+ study

(2018) Nienke Legdeur et al.   BMC Geriatrics

Ketamine and selective activation of parvalbumin interneurons inhibit stress-induced dendritic spine elimination

(2018) Lhotse Hei Lui Ng et al.   Translational Psychiatry

Hippocampal phosphorylated tau induced cognitive decline, dendritic spine loss and mitochondrial abnormalities in a mouse model of Alzheimer’s disease

(2017) Ramesh Kandimalla et al.   HUMAN MOLECULAR GENETICS

New waves in dendritic spine actin cytoskeleton: From branches and bundles to rings, from actin binding proteins to post-translational modifications

(2017) Enni Bertling et al.   MOLECULAR AND CELLULAR NEUROSCIENCE

Of microtubules and memory: implications for microtubule dynamics in dendrites and spines

(2017) Erik W. Dent   MOLECULAR BIOLOGY OF THE CELL

Reduced cortical excitatory synapse number in APOE4 mice is associated with increased calcineurin activity

(2017) Aidan L. Neustadtl et al.   NEUROREPORT

Spread of tau down neural circuits precedes synapse and neuronal loss in the rTgTauEC mouse model of early Alzheimer's disease

(2017) Eleanor K. Pickett et al.   SYNAPSE

Linkage, whole genome sequence, and biological data implicate variants in RAB10 in Alzheimer’s disease resilience

(2017) Perry G. Ridge et al.   Genome Medicine

Identification of genes associated with dissociation of cognitive performance and neuropathological burden: Multistep analysis of genetic, epigenetic, and transcriptional data

(2017) Charles C. White et al.   PLOS MEDICINE

Regional differences in dendritic spine density confer resilience to chronic social defeat stress

(2017) Youge Qu et al.   ACTA NEUROPSYCHIATRICA

Treadmill exercise suppressed stress-induced dendritic spine elimination in mouse barrel cortex and improved working memory via BDNF/TrkB pathway

(2017) K Chen et al.   Translational Psychiatry

Neuropathologic Studies of the Baltimore Longitudinal Study of Aging (BLSA)

(2017) Richard J. O'Brien et al.   JOURNAL OF ALZHEIMERS DISEASE

Brain Lesions at Autopsy in Older Japanese-American Men as Related to Cognitive Impairment and Dementia in the Final Years of Life: A Summary Report from the Honolulu-Asia Aging Study

(2017) Lon White   JOURNAL OF ALZHEIMERS DISEASE

Decreasing prevalence of dementia in 85-year olds examined 22 years apart: the influence of education and stroke

(2017) Ingmar Skoog et al.   Scientific Reports

Lifestyle Factors and Dementia in the Oldest-old

(2016) Annlia Paganini-Hill et al.   ALZHEIMER DISEASE & ASSOCIATED DISORDERS

Human tau increases amyloid β plaque size but not amyloid β-mediated synapse loss in a novel mouse model of Alzheimer's disease

(2016) Rosemary J. Jackson et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

Oxidative stress and hippocampal synaptic protein levels in elderly cognitively intact individuals with Alzheimer's disease pathology

(2016) Stephen W. Scheff et al.   NEUROBIOLOGY OF AGING

Novel allele-dependent role for APOE in controlling the rate of synapse pruning by astrocytes

(2016) Won-Suk Chung et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Complement and microglia mediate early synapse loss in Alzheimer mouse models

(2016) S. Hong et al.   SCIENCE

Relative Contributions of Specific Activity Histories and Spontaneous Processes to Size Remodeling of Glutamatergic Synapses

(2016) Roman Dvorkin et al.   PLOS BIOLOGY

Synaptic Proteins in the Hippocampus Indicative of Increased Neuronal Activity in CA3 in Schizophrenia

(2015) Wei Li et al.   AMERICAN JOURNAL OF PSYCHIATRY

Alzheimer’s Disease Risk Genes and Mechanisms of Disease Pathogenesis

(2015) Celeste M. Karch et al.   BIOLOGICAL PSYCHIATRY

Regional Differences in Brain-Derived Neurotrophic Factor Levels and Dendritic Spine Density Confer Resilience to Inescapable Stress

(2015) C. Yang et al.   INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY

Life Extension Factor Klotho Prevents Mortality and Enhances Cognition in hAPP Transgenic Mice

(2015) D. B. Dubal et al.   JOURNAL OF NEUROSCIENCE

Intensity and Types of Physical Exercise in Relation to Dementia Risk Reduction in Community-Living Older Adults

(2015) Allen T.C. Lee et al.   Journal of the American Medical Directors Association

Amyloid accelerates tau propagation and toxicity in a model of early Alzheimer’s disease

(2015) Amy M Pooler et al.   Acta Neuropathologica Communications

Tau phosphorylation and tau mislocalization mediate soluble Aβ oligomer-induced AMPA glutamate receptor signaling deficits

(2014) Eric C. Miller et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

Synergistic effects of amyloid-beta and wild-type human tau on dendritic spine loss in a floxed double transgenic model of Alzheimer's disease

(2014) Meredith A. Chabrier et al.   NEUROBIOLOGY OF DISEASE

Structural and Molecular Remodeling of Dendritic Spine Substructures during Long-Term Potentiation

(2014) Miquel Bosch et al.   NEURON

Dendritic Structural Degeneration Is Functionally Linked to Cellular Hyperexcitability in a Mouse Model of Alzheimer’s Disease

(2014) Zuzana Šišková et al.   NEURON

Memory deficits correlate with tau and spine pathology in P301SMAPTtransgenic mice

(2014) Hong Xu et al.   NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY

Differential effects of aging on dendritic spines in visual cortex and prefrontal cortex of the rhesus monkey

(2014) M.E. Young et al.   NEUROSCIENCE

Life Extension Factor Klotho Enhances Cognition

(2014) Dena B. Dubal et al.   Cell Reports

Cognitive and social lifestyle: links with neuropathology and cognition in late life

(2013) David A. Bennett et al.   ACTA NEUROPATHOLOGICA

Synaptic Regulation of Microtubule Dynamics in Dendritic Spines by Calcium, F-Actin, and Drebrin

(2013) E. B. Merriam et al.   JOURNAL OF NEUROSCIENCE

Studying synapses in human brain with array tomography and electron microscopy

(2013) Kevin R Kay et al.   Nature Protocols

Apolipoprotein E and Alzheimer disease: risk, mechanisms and therapy

(2013) Chia-Chen Liu et al.   Nature Reviews Neurology

Neuronal Morphology Goes Digital: A Research Hub for Cellular and System Neuroscience

(2013) Ruchi Parekh et al.   NEURON

Tau Causes Synapse Loss without Disrupting Calcium Homeostasis in the rTg4510 Model of Tauopathy

(2013) Katherine J. Kopeikina et al.   PLoS One

Impaired plasticity of cortical dendritic spines in P301S tau transgenic mice

(2013) Nadine A Hoffmann et al.   Acta Neuropathologica Communications

The Ca2+ and Rho GTPase signaling pathways underlying activity-dependent actin remodeling at dendritic spines

(2012) Takeo Saneyoshi et al.   Cytoskeleton

Dendritic spines: from structure to in vivo function

(2012) Nathalie L Rochefort et al.   EMBO REPORTS

Cognitive reserve in ageing and Alzheimer's disease

(2012) Yaakov Stern   LANCET NEUROLOGY

The ageing cortical synapse: hallmarks and implications for cognitive decline

(2012) John H. Morrison et al.   NATURE REVIEWS NEUROSCIENCE

Cellular, synaptic, and biochemical features of resilient cognition in Alzheimer's disease

(2012) Steven E. Arnold et al.   NEUROBIOLOGY OF AGING

Association between apolipoprotein E gene polymorphism and the risk of vascular dementia: A meta-analysis

(2012) Yan-Wei Yin et al.   NEUROSCIENCE LETTERS

Asymptomatic Alzheimers Disease: A Prodrome or a State of Resilience?

(2011) I. Driscoll et al.   Current Alzheimer Research

A half century of experimental neuroanatomical tracing

(2011) José L. Lanciego et al.   JOURNAL OF CHEMICAL NEUROANATOMY

Early Improved and Late Defective Cognition Is Reflected by Dendritic Spines in Tau.P301L Mice

(2011) A. Kremer et al.   JOURNAL OF NEUROSCIENCE

Evidence for Reduced Experience-Dependent Dendritic Spine Plasticity in the Aging Prefrontal Cortex

(2011) E. B. Bloss et al.   JOURNAL OF NEUROSCIENCE

Amyloid- /Fyn-Induced Synaptic, Network, and Cognitive Impairments Depend on Tau Levels in Multiple Mouse Models of Alzheimer's Disease

(2011) E. D. Roberson et al.   JOURNAL OF NEUROSCIENCE

In vivotwo-photon uncaging of glutamate revealing the structure-function relationships of dendritic spines in the neocortex of adult mice

(2011) Jun Noguchi et al.   JOURNAL OF PHYSIOLOGY-LONDON

High-throughput, detailed, cell-specific neuroanatomy of dendritic spines using microinjection and confocal microscopy

(2011) Dani Dumitriu et al.   Nature Protocols

The Postsynaptic Organization of Synapses

(2011) M. Sheng et al.   Cold Spring Harbor Perspectives in Biology

Changes in dendritic complexity and spine morphology in transgenic mice expressing human wild-type tau

(2010) Dara L. Dickstein et al.   Brain Structure & Function

Stable Mossy Fiber Long-Term Potentiation Requires Calcium Influx at the Granule Cell Soma, Protein Synthesis, and Microtubule-Dependent Axonal Transport

(2010) S. J. Barnes et al.   JOURNAL OF NEUROSCIENCE

Loss of GluN2B-Containing NMDA Receptors in CA1 Hippocampus and Cortex Impairs Long-Term Depression, Reduces Dendritic Spine Density, and Disrupts Learning

(2010) J. L. Brigman et al.   JOURNAL OF NEUROSCIENCE

Selective Changes in Thin Spine Density and Morphology in Monkey Prefrontal Cortex Correlate with Aging-Related Cognitive Impairment

(2010) D. Dumitriu et al.   JOURNAL OF NEUROSCIENCE

Genetic variations in the CLU and PICALM genes are associated with cognitive function in the oldest old

(2010) Jonas Mengel-From et al.   NEUROBIOLOGY OF AGING

Physical activity predicts gray matter volume in late adulthood: The Cardiovascular Health Study

(2010) K. I. Erickson et al.   NEUROLOGY

Tau Mislocalization to Dendritic Spines Mediates Synaptic Dysfunction Independently of Neurodegeneration

(2010) Brian R. Hoover et al.   NEURON

Different Rho GTPase–dependent signaling pathways initiate sequential steps in the consolidation of long-term potentiation

(2009) Christopher S. Rex et al.   JOURNAL OF CELL BIOLOGY

Interfering with the Actin Network and Its Effect on Long-Term Potentiation and Synaptic Tagging in Hippocampal CA1 Neurons in Slices In Vitro

(2009) B. Ramachandran et al.   JOURNAL OF NEUROSCIENCE

ApoE4 Decreases Spine Density and Dendritic Complexity in Cortical Neurons In Vivo

(2009) S. B. Dumanis et al.   JOURNAL OF NEUROSCIENCE

The Mn-superoxide dismutase single nucleotide polymorphism rs4880 and the glutathione peroxidase 1 single nucleotide polymorphism rs1050450 are associated with aging and longevity in the oldest old

(2009) Mette Soerensen et al.   MECHANISMS OF AGEING AND DEVELOPMENT

Experience-dependent structural synaptic plasticity in the mammalian brain

(2009) Anthony Holtmaat et al.   NATURE REVIEWS NEUROSCIENCE

The Nun Study: Clinically silent AD, neuronal hypertrophy, and linguistic skills in early life

(2009) D. Iacono et al.   NEUROLOGY

Dynamic Microtubules Regulate Dendritic Spine Morphology and Synaptic Plasticity

(2009) Jacek Jaworski et al.   NEURON

Structural and functional alterations to rat medial prefrontal cortex following chronic restraint stress and recovery

(2009) D.S. Goldwater et al.   NEUROSCIENCE

Age, Neuropathology, and Dementia

(2009) George M. Savva et al.   NEW ENGLAND JOURNAL OF MEDICINE

N-WASP and the Arp2/3 Complex Are Critical Regulators of Actin in the Development of Dendritic Spines and Synapses

(2008) Adam M. Wegner et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Activity-Dependent Dynamic Microtubule Invasion of Dendritic Spines

(2008) X. Hu et al.   JOURNAL OF NEUROSCIENCE

Principles of Long-Term Dynamics of Dendritic Spines

(2008) N. Yasumatsu et al.   JOURNAL OF NEUROSCIENCE

Vascular risk factors and dementia in the general population aged >85 years

(2008) Sari Rastas et al.   NEUROBIOLOGY OF AGING

Physical activity and risk of neurodegenerative disease: a systematic review of prospective evidence

(2008) M. Hamer et al.   PSYCHOLOGICAL MEDICINE

Synaptic proteins, neuropathology and cognitive status in the oldest-old

(2007) Elizabeth Head et al.   NEUROBIOLOGY OF AGING