TREM2 Mediates Microglial Anti-Inflammatory Activations in Alzheimer’s Disease: Lessons Learned from Transcriptomics

Novel Alzheimer risk genes determine the microglia response to amyloid‐β but not to TAU pathology

(2020) Annerieke Sierksma et al.   EMBO Molecular Medicine

Trem2 Deletion Reduces Late-Stage Amyloid Plaque Accumulation, Elevates the Aβ42:Aβ40 Ratio, and Exacerbates Axonal Dystrophy and Dendritic Spine Loss in the PS2APP Alzheimer's Mouse Model

(2020) William J. Meilandt et al.   JOURNAL OF NEUROSCIENCE

The Dual Role of Microglia in the Progression of Alzheimer's Disease

(2020) Kate M. Onuska   JOURNAL OF NEUROSCIENCE

Human and mouse single-nucleus transcriptomics reveal TREM2-dependent and TREM2-independent cellular responses in Alzheimer’s disease

(2020) Yingyue Zhou et al.   NATURE MEDICINE

Microglia Heterogeneity in the Single-Cell Era

(2020) Takahiro Masuda et al.   Cell Reports

Microglial Homeostasis Requires Balanced CSF-1/CSF-2 Receptor Signaling

(2020) Violeta Chitu et al.   Cell Reports

TREM2 suppresses the proinflammatory response to facilitate PRRSV infection via PI3K/NF-κB signaling

(2020) Zhenbang Zhu et al.   PLoS Pathogens

The Physiology, Pathology, and Potential Therapeutic Applications of the TREM2 Signaling Pathway

(2020) Aleksandra Deczkowska et al.   CELL

Coupled scRNA-Seq and Intracellular Protein Activity Reveal an Immunosuppressive Role of TREM2 in Cancer

(2020) Yonatan Katzenelenbogen et al.   CELL

TREM2 Modulation Remodels the Tumor Myeloid Landscape Enhancing Anti-PD-1 Immunotherapy

(2020) Martina Molgora et al.   CELL

Trem2 deficiency differentially affects phenotype and transcriptome of human APOE3 and APOE4 mice

(2020) Nicholas F. Fitz et al.   Molecular Neurodegeneration

The Role of TGFβ Signaling in Microglia Maturation and Activation

(2020) Björn Spittau et al.   TRENDS IN IMMUNOLOGY

Alzheimer’s Patient Microglia Exhibit Enhanced Aging and Unique Transcriptional Activation

(2020) Karpagam Srinivasan et al.   Cell Reports

Fibrillar Aβ triggers microglial proteome alterations and dysfunction in Alzheimer mouse models

(2020) Laura Sebastian Monasor et al.   eLife

Microglia: Agents of the CNS Pro-Inflammatory Response

(2020) José A. Rodríguez-Gómez et al.   Cells

Genome-wide meta-analysis identifies new loci and functional pathways influencing Alzheimer’s disease risk

(2019) Iris E. Jansen et al.   NATURE GENETICS

A Microglial Signature Directing Human Aging and Neurodegeneration-Related Gene Networks

(2019) Shradha Mukherjee et al.   Frontiers in Neuroscience

Single-cell transcriptomic analysis of Alzheimer’s disease

(2019) Hansruedi Mathys et al.   NATURE

Impact of TREM2 risk variants on brain region-specific immune activation and plaque microenvironment in Alzheimer’s disease patient brain samples

(2019) Stefan Prokop et al.   ACTA NEUROPATHOLOGICA

A Breakdown in Metabolic Reprogramming Causes Microglia Dysfunction in Alzheimer's Disease

(2019) Sung Hoon Baik et al.   Cell Metabolism

TREM2 Acts Downstream of CD33 in Modulating Microglial Pathology in Alzheimer’s Disease

(2019) Ana Griciuc et al.   NEURON

Phenotypic Expansion in Nasu-Hakola Disease: Immunological Findings in Three Patients and Proposal of a Unifying Pathogenic Hypothesis

(2019) Edoardo Errichiello et al.   Frontiers in Immunology

The Transcriptional Landscape of Microglial Genes in Aging and Neurodegenerative Disease

(2019) Luke W. Bonham et al.   Frontiers in Immunology

The neuropathological diagnosis of Alzheimer’s disease

(2019) Michael A. DeTure et al.   Molecular Neurodegeneration

The role of innate immune responses and neuroinflammation in amyloid accumulation and progression of Alzheimer's disease

(2019) Alessandra Webers et al.   IMMUNOLOGY AND CELL BIOLOGY

A single-cell atlas of entorhinal cortex from individuals with Alzheimer’s disease reveals cell-type-specific gene expression regulation

(2019) Alexandra Grubman et al.   NATURE NEUROSCIENCE

Sustained microglial depletion with CSF1R inhibitor impairs parenchymal plaque development in an Alzheimer’s disease model

(2019) Elizabeth Spangenberg et al.   Nature Communications

Disease-Associated Microglia: A Universal Immune Sensor of Neurodegeneration

(2018) Aleksandra Deczkowska et al.   CELL

TREM2 inhibits inflammatory responses in mouse microglia by suppressing the PI3K/NF-κB signaling

(2018) Caixia Li et al.   CELL BIOLOGY INTERNATIONAL

Increased expression of TREM2 in peripheral cells from mild cognitive impairment patients who progress into Alzheimer's disease

(2018) M. Casati et al.   EUROPEAN JOURNAL OF NEUROLOGY

Data integration for functional annotation of regulatory single nucleotide polymorphisms associated with Alzheimer's disease susceptibility

(2018) Sanila Amber et al.   GENE

Humanized TREM2 mice reveal microglia-intrinsic and -extrinsic effects of R47H polymorphism

(2018) Wilbur M. Song et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Identification and therapeutic modulation of a pro-inflammatory subset of disease-associated-microglia in Alzheimer’s disease

(2018) Srikant Rangaraju et al.   Molecular Neurodegeneration

TREM2 Is a Receptor for β-Amyloid that Mediates Microglial Function

(2018) Yingjun Zhao et al.   NEURON

Elevated TREM2 Gene Dosage Reprograms Microglia Responsivity and Ameliorates Pathological Phenotypes in Alzheimer’s Disease Models

(2018) C.Y. Daniel Lee et al.   NEURON

Diverse Brain Myeloid Expression Profiles Reveal Distinct Microglial Activation States and Aspects of Alzheimer’s Disease Not Evident in Mouse Models

(2018) Brad A. Friedman et al.   Cell Reports

Increased Expression of TREM2 in Peripheral Blood of Alzheimer's Disease Patients

(2018) Nan Hu et al.   JOURNAL OF ALZHEIMERS DISEASE

Microglia in neurodegeneration

(2018) Suzanne Hickman et al.   NATURE NEUROSCIENCE

Microglial signatures and their role in health and disease

(2018) Oleg Butovsky et al.   NATURE REVIEWS NEUROSCIENCE

High‐affinity interactions and signal transduction between Aβ oligomers and TREM2

(2018) Christian B Lessard et al.   EMBO Molecular Medicine

New insights into the role of TREM2 in Alzheimer’s disease

(2018) Maud Gratuze et al.   Molecular Neurodegeneration

Single-cell transcriptomics of 20 mouse organs creates a Tabula Muris

(2018) et al.   NATURE

STRING v11: protein–protein association networks with increased coverage, supporting functional discovery in genome-wide experimental datasets

(2018) Damian Szklarczyk et al.   NUCLEIC ACIDS RESEARCH

TREM-2 negatively regulates LPS-mediated inflammatory response in rat bone marrow-derived MSCs

(2017) Pei Ye et al.   Molecular Medicine Reports

TREM2 in Neurodegenerative Diseases

(2017) Taylor R. Jay et al.   Molecular Neurodegeneration

Immune hyperreactivity of Aβ plaque-associated microglia in Alzheimer's disease

(2017) Zhuoran Yin et al.   NEUROBIOLOGY OF AGING

Contribution to Alzheimer's disease risk of rare variants in TREM2, SORL1, and ABCA7 in 1779 cases and 1273 controls

(2017) Céline Bellenguez et al.   NEUROBIOLOGY OF AGING

Elucidating the Role of TREM2 in Alzheimer’s Disease

(2017) Jason D. Ulrich et al.   NEURON

TREM2 deficiency attenuates neuroinflammation and protects against neurodegeneration in a mouse model of tauopathy

(2017) Cheryl E. G. Leyns et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

RIPK1 mediates a disease-associated microglial response in Alzheimer’s disease

(2017) Dimitry Ofengeim et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

TREM2, Microglia, and Neurodegenerative Diseases

(2017) Felix L. Yeh et al.   TRENDS IN MOLECULAR MEDICINE

Neuroinflammation in Alzheimer's disease: Current evidence and future directions

(2016) Valeria Calsolaro et al.   Alzheimers & Dementia

TREMs in Alzheimer's disease: Genetic and clinical investigations

(2016) Jia Cheng et al.   CLINICA CHIMICA ACTA

Microglial genes regulating neuroinflammation in the progression of Alzheimer's disease

(2016) Claudio Villegas-Llerena et al.   CURRENT OPINION IN NEUROBIOLOGY

Disease Progression-Dependent Effects of TREM2 Deficiency in a Mouse Model of Alzheimer's Disease

(2016) Taylor R. Jay et al.   JOURNAL OF NEUROSCIENCE

Genetic variations underlying Alzheimer's disease: evidence from genome-wide association studies and beyond

(2016) Elise Cuyvers et al.   LANCET NEUROLOGY

TREM2 Overexpression has No Improvement on Neuropathology and Cognitive Impairment in Aging APPswe/PS1dE9 Mice

(2016) Teng Jiang et al.   MOLECULAR NEUROBIOLOGY

Increased DNA methylation near TREM2 is consistently seen in the superior temporal gyrus in Alzheimer's disease brain

(2016) Adam R. Smith et al.   NEUROBIOLOGY OF AGING

TREM2 Haplodeficiency in Mice and Humans Impairs the Microglia Barrier Function Leading to Decreased Amyloid Compaction and Severe Axonal Dystrophy

(2016) Peng Yuan et al.   NEURON

TREM2 Binds to Apolipoproteins, Including APOE and CLU/APOJ, and Thereby Facilitates Uptake of Amyloid-Beta by Microglia

(2016) Felix L. Yeh et al.   NEURON

Untangling the brain’s neuroinflammatory and neurodegenerative transcriptional responses

(2016) Karpagam Srinivasan et al.   Nature Communications

TREM2 upregulation correlates with 5-hydroxymethycytosine enrichment in Alzheimer’s disease hippocampus

(2016) Naiara Celarain et al.   Clinical Epigenetics

TREM2 Lipid Sensing Sustains the Microglial Response in an Alzheimer’s Disease Model

(2015) Yaming Wang et al.   CELL

The Triggering Receptor Expressed on Myeloid Cells 2: A Molecular Link of Neuroinflammation and Neurodegenerative Diseases

(2015) Jochen Walter   JOURNAL OF BIOLOGICAL CHEMISTRY

TREM2 sustains microglial expansion during aging and response to demyelination

(2015) Pietro Luigi Poliani et al.   JOURNAL OF CLINICAL INVESTIGATION

Replacement of brain-resident myeloid cells does not alter cerebral amyloid-β deposition in mouse models of Alzheimer’s disease

(2015) Nicholas H. Varvel et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Changes in the expression of genes related to neuroinflammation over the course of sporadic Alzheimer’s disease progression: CX3CL1, TREM2, and PPARγ

(2015) S. Strobel et al.   JOURNAL OF NEURAL TRANSMISSION

Neuroinflammation in Alzheimer's disease

(2015) Michael T Heneka et al.   LANCET NEUROLOGY

Genetic Factors Affecting Late-Onset Alzheimer’s Disease Susceptibility

(2015) Maryam Rezazadeh et al.   NEUROMOLECULAR MEDICINE

FunRich: An open access standalone functional enrichment and interaction network analysis tool

(2015) Mohashin Pathan et al.   PROTEOMICS

TREM2 Protein Expression Changes Correlate with Alzheimer's Disease Neurodegenerative Pathologies in Post-Mortem Temporal Cortices

(2014) Lih-Fen Lue et al.   BRAIN PATHOLOGY

Altered microglial response to Aβ plaques in APPPS1-21 mice heterozygous for TREM2

(2014) Jason D Ulrich et al.   Molecular Neurodegeneration

Isolation of glia from Alzheimer's mice reveals inflammation and dysfunction

(2014) Marie Orre et al.   NEUROBIOLOGY OF AGING

Upregulation of TREM2 Ameliorates Neuropathology and Rescues Spatial Cognitive Impairment in a Transgenic Mouse Model of Alzheimer’s Disease

(2014) Teng Jiang et al.   NEUROPSYCHOPHARMACOLOGY

Gene-Wide Analysis Detects Two New Susceptibility Genes for Alzheimer's Disease

(2014) Valentina Escott-Price et al.   PLoS One

Chronic Neuroinflammation in Alzheimer’s Disease: New Perspectives on Animal Models and Promising Candidate Drugs

(2014) Christopher Millington et al.   Biomed Research International

Causal analysis approaches in Ingenuity Pathway Analysis

(2013) Andreas Krämer et al.   BIOINFORMATICS

TREM2 in neurodegeneration: evidence for association of the p.R47H variant with frontotemporal dementia and Parkinson’s disease

(2013) Sruti Rayaprolu et al.   Molecular Neurodegeneration

Meta-analysis of 74,046 individuals identifies 11 new susceptibility loci for Alzheimer's disease

(2013) Jean-Charles Lambert et al.   NATURE GENETICS

Regulation of TREM2 expression by an NF-кB-sensitive miRNA-34a

(2013) Yuhai Zhao et al.   NEUROREPORT

TREM2 Variants in Alzheimer's Disease

(2012) Rita Guerreiro et al.   NEW ENGLAND JOURNAL OF MEDICINE

Direct Inhibition of Human RANK+ Osteoclast Precursors Identifies a Homeostatic Function of IL-1 

(2010) B. Lee et al.   JOURNAL OF IMMUNOLOGY

Alzheimer's Disease

(2010) Henry W. Querfurth et al.   NEW ENGLAND JOURNAL OF MEDICINE

Genome-wide analysis reveals mechanisms modulating autophagy in normal brain aging and in Alzheimer's disease

(2010) M. M. Lipinski et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA