AMPK: A bridge between diabetes mellitus and Alzheimer's disease

Central and Peripheral Metabolic Defects Contribute to the Pathogenesis of Alzheimer’s Disease: Targeting Mitochondria for Diagnosis and Prevention

(2020) Yunhua Peng et al.   ANTIOXIDANTS & REDOX SIGNALING

Caveolin: A New Link Between Diabetes and AD

(2020) Andrei Surguchov   CELLULAR AND MOLECULAR NEUROBIOLOGY

AMP‐activated protein kinase (AMPK) regulates autophagy, inflammation, and immunity and contributes to osteoclastdifferentiation and function

(2020) Xishuai Tong et al.   BIOLOGY OF THE CELL

Panax quinquefolium saponin Optimizes Energy Homeostasis by Modulating AMPK-Activated Metabolic Pathways in Hypoxia-Reperfusion Induced Cardiomyocytes

(2020) Yong-hui Yu et al.   Chinese Journal of Integrative Medicine

Adiponectin and Cognitive Decline

(2020) Maria Rosaria Rizzo et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Cardiac metabolism as a driver and therapeutic target of myocardial infarction

(2020) Coert J. Zuurbier et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Amelioration of High-Insulin-Induced Skeletal Muscle Cell Insulin Resistance by Resveratrol Is Linked to Activation of AMPK and Restoration of GLUT4 Translocation

(2020) Filip Vlavcheski et al.   Nutrients

Bisdemethoxycurcumin inhibits oxidative stress and antagonizes Alzheimer's disease by up‐regulating SIRT1

(2020) Yan Xu et al.   Brain and Behavior

Peripheral clearance of brain-derived Aβ in Alzheimer's disease: pathophysiology and therapeutic perspectives

(2020) Yuan Cheng et al.   Translational Neurodegeneration

The effect of Berberine on weight loss in order to prevent obesity: A systematic review

(2020) Zahra Ilyas et al.   BIOMEDICINE & PHARMACOTHERAPY

Brain insulin resistance in Alzheimer's disease and related disorders: mechanisms and therapeutic approaches

(2020) Derek Kellar et al.   LANCET NEUROLOGY

(−)-Hydroxycitric acid regulates energy metabolism by activation of AMPK - PGC1α - NRF1 signal pathway in primary chicken hepatocytes

(2020) Longlong Li et al.   LIFE SCIENCES

Insulin and leptin as potential cognitive enhancers in metabolic disorders and Alzheimer's disease

(2020) Diana C.P. Mejido et al.   NEUROPHARMACOLOGY

Neuro-Protective Role of Metformin in Patients with Acute Stroke and Type 2 Diabetes Mellitus via AMPK/Mammalian Target of Rapamycin (mTOR) Signaling Pathway and Oxidative Stress

(2019) Min Zhao et al.   MEDICAL SCIENCE MONITOR

Sodium oligomannate therapeutically remodels gut microbiota and suppresses gut bacterial amino acids-shaped neuroinflammation to inhibit Alzheimer’s disease progression

(2019) Xinyi Wang et al.   CELL RESEARCH

Insulin resistance and hippocampal dysfunction: Disentangling peripheral and brain causes from consequences

(2019) Claudia A. Grillo et al.   EXPERIMENTAL NEUROLOGY

GluT4: A central player in hippocampal memory and brain insulin resistance

(2019) Ewan C. McNay et al.   EXPERIMENTAL NEUROLOGY

mTOR in Down syndrome: Role in Aß and tau neuropathology and transition to Alzheimer disease-like dementia

(2018) Fabio Di Domenico et al.   FREE RADICAL BIOLOGY AND MEDICINE

Mitochondria and Mitochondrial Cascades in Alzheimer’s Disease

(2018) Russell H. Swerdlow   JOURNAL OF ALZHEIMERS DISEASE

Insulin as a hormone regulator of the synthesis and release of leptin by white adipose tissue

(2018) Gleuber Henrique Marques-Oliveira et al.   PEPTIDES

SIRT3 activator Honokiol attenuates β-Amyloid by modulating amyloidogenic pathway

(2018) Sindhu Ramesh et al.   PLoS One

Insulin Resistance as a Therapeutic Target in the Treatment of Alzheimer's Disease: A State-of-the-Art Review

(2018) Christian Benedict et al.   Frontiers in Neuroscience

Is TAK1 a Direct Upstream Kinase of AMPK?

(2018) Dietbert Neumann   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Comparing Brain Amyloid Deposition, Glucose Metabolism, and Atrophy in Mild Cognitive Impairment with and without a Family History of Dementia

(2018) Lisa Mosconi et al.   JOURNAL OF ALZHEIMERS DISEASE

AMPK Activation Ameliorates Alzheimer's Disease-Like Pathology and Spatial Memory Impairment in a Streptozotocin-Induced Alzheimer's Disease Model in Rats

(2018) Lai-Ling Du et al.   JOURNAL OF ALZHEIMERS DISEASE

Upregulation of miR-181 Decreases c-Fos and SIRT-1 in the Hippocampus of 3xTg-AD Mice

(2018) Carlos J. Rodriguez-Ortiz et al.   JOURNAL OF ALZHEIMERS DISEASE

Protective role of Dihydromyricetin in Alzheimer’s disease rat model associated with activating AMPK/SIRT1 signaling pathway

(2018) Ping Sun et al.   BIOSCIENCE REPORTS

Insulin Resistance in Alzheimer's Disease

(2018) Laís S. S. Ferreira et al.   Frontiers in Neuroscience

In Vivo Decoding Mechanisms of the Temporal Patterns of Blood Insulin by the Insulin-AKT Pathway in the Liver

(2018) Hiroyuki Kubota et al.   Cell Systems

Hippocampal phosphorylated tau induced cognitive decline, dendritic spine loss and mitochondrial abnormalities in a mouse model of Alzheimer’s disease

(2017) Ramesh Kandimalla et al.   HUMAN MOLECULAR GENETICS

Amyloid-β oligomers transiently inhibit AMP-activated kinase and cause metabolic defects in hippocampal neurons

(2017) Gisele S. Seixas da Silva et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

AMPK: guardian of metabolism and mitochondrial homeostasis

(2017) Sébastien Herzig et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Glucocorticoid-mediated activation of GSK3β promotes tau phosphorylation and impairs memory in type 2 diabetes

(2017) Aditi Dey et al.   NEUROBIOLOGY OF AGING

Hypothalamic AMPK-induced autophagy increases food intake by regulating NPY and POMC expression

(2016) Tae Seok Oh et al.   Autophagy

Myeloid-Cell-Derived VEGF Maintains Brain Glucose Uptake and Limits Cognitive Impairment in Obesity

(2016) Alexander Jais et al.   CELL

Metformin in Amnestic Mild Cognitive Impairment: Results of a Pilot Randomized Placebo Controlled Clinical Trial

(2016) José A. Luchsinger et al.   JOURNAL OF ALZHEIMERS DISEASE

AMPK Activation Prevents and Reverses Drug-Induced Mitochondrial and Hepatocyte Injury by Promoting Mitochondrial Fusion and Function

(2016) Sun Woo Sophie Kang et al.   PLoS One

AMP-activated protein kinase attenuates oxLDL uptake in macrophages through PP2A/NF-κB/LOX-1 pathway

(2016) Bo Chen et al.   VASCULAR PHARMACOLOGY

Adiponectin signaling and function in insulin target tissues

(2016) Hong Ruan et al.   Journal of Molecular Cell Biology

Open-gate mutants of the mammalian proteasome show enhanced ubiquitin-conjugate degradation

(2016) Won Hoon Choi et al.   Nature Communications

The role of alterations in mitochondrial dynamics and PGC-1α over-expression in fast muscle atrophy following hindlimb unloading

(2015) Jessica Cannavino et al.   JOURNAL OF PHYSIOLOGY-LONDON

Macrophage recruitment in obese adipose tissue

(2015) Y. Bai et al.   Obesity Reviews

Berberine inhibits hepatic gluconeogenesisviathe LKB1-AMPK-TORC2 signaling pathway in streptozotocin-induced diabetic rats

(2015) Shu-Jun Jiang   WORLD JOURNAL OF GASTROENTEROLOGY

AMPK—Sensing Energy while Talking to Other Signaling Pathways

(2014) D. Grahame Hardie   Cell Metabolism

Structural basis of AMPK regulation by adenine nucleotides and glycogen

(2014) Xiaodan Li et al.   CELL RESEARCH

Role of insulin signaling impairment, adiponectin and dyslipidemia in peripheral and central neuropathy in mice

(2014) N. J. Anderson et al.   Disease Models & Mechanisms

The Central Role of AMP-Kinase and Energy Homeostasis Impairment in Alzheimer’s Disease: A Multifactor Network Analysis

(2013) Laura Caberlotto et al.   PLoS One

AMP-activated protein kinase: new regulation, new roles?

(2012) David Carling et al.   BIOCHEMICAL JOURNAL

An anti-diabetes agent protects the mouse brain from defective insulin signaling caused by Alzheimer’s disease–associated Aβ oligomers

(2012) Theresa R. Bomfim et al.   JOURNAL OF CLINICAL INVESTIGATION

Demonstrated brain insulin resistance in Alzheimer’s disease patients is associated with IGF-1 resistance, IRS-1 dysregulation, and cognitive decline

(2012) Konrad Talbot et al.   JOURNAL OF CLINICAL INVESTIGATION

Leptin boosts cellular metabolism by activating AMPK and the sirtuins to reduce tau phosphorylation and β-amyloid in neurons

(2011) Steven J. Greco et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

A partially folded structure of amyloid-beta(1–40) in an aqueous environment

(2011) Subramanian Vivekanandan et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

AMP-activated protein kinase (AMPK) is a tau kinase, activated in response to amyloid β-peptide exposure

(2011) Claire Thornton et al.   BIOCHEMICAL JOURNAL

The AMPK signalling pathway coordinates cell growth, autophagy and metabolism

(2011) Maria M. Mihaylova et al.   NATURE CELL BIOLOGY

Peripheral insulin-sensitizer drug metformin ameliorates neuronal insulin resistance and Alzheimer’s-like changes

(2011) Amit Gupta et al.   NEUROPHARMACOLOGY

AMPK is abnormally activated in tangle- and pre-tangle-bearing neurons in Alzheimer’s disease and other tauopathies

(2010) Valérie Vingtdeux et al.   ACTA NEUROPATHOLOGICA

Metabolic-cognitive syndrome: A cross-talk between metabolic syndrome and Alzheimer's disease

(2010) Vincenza Frisardi et al.   AGEING RESEARCH REVIEWS

Brain Glucose Hypometabolism and Oxidative Stress in Preclinical Alzheimer's Disease

(2010) Lisa Mosconi et al.   Annals of the New York Academy of Sciences

Interdependence of AMPK and SIRT1 for Metabolic Adaptation to Fasting and Exercise in Skeletal Muscle

(2010) Carles Cantó et al.   Cell Metabolism

AMPK-dependent Repression of Hepatic Gluconeogenesis via Disruption of CREB·CRTC2 Complex by Orphan Nuclear Receptor Small Heterodimer Partner

(2010) Ji-Min Lee et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Effects of AMP-Activated Protein Kinase in Cerebral Ischemia

(2010) Jun Li et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Quercetin activates AMP-activated protein kinase by reducing PP2C expression protecting old mouse brain against high cholesterol-induced neurotoxicity

(2010) Jun Lu et al.   JOURNAL OF PATHOLOGY

Gamma-secretase activating protein is a therapeutic target for Alzheimer’s disease

(2010) Gen He et al.   NATURE

Acetylation of Tau Inhibits Its Degradation and Contributes to Tauopathy

(2010) Sang-Won Min et al.   NEURON

Berberine improves lipid dysregulation in obesity by controlling central and peripheral AMPK activity

(2009) Woo Sik Kim et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Leptin regulates tau phosphorylation and amyloid through AMPK in neuronal cells

(2009) Steven J. Greco et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Adiponectin-Activated AMPK Stimulates Dephosphorylation of AKT through Protein Phosphatase 2A Activation

(2009) K.-y. Kim et al.   CANCER RESEARCH

CRTC2 (TORC2) Contributes to the Transcriptional Response to Fasting in the Liver but Is Not Required for the Maintenance of Glucose Homeostasis

(2009) John Le Lay et al.   Cell Metabolism

AMPK regulates energy expenditure by modulating NAD+ metabolism and SIRT1 activity

(2009) Carles Cantó et al.   NATURE

Leptin inhibits glycogen synthase kinase-3β to prevent tau phosphorylation in neuronal cells

(2009) Steven J. Greco et al.   NEUROSCIENCE LETTERS

Antidiabetic drug metformin (GlucophageR) increases biogenesis of Alzheimer's amyloid peptides via up-regulating BACE1 transcription

(2009) Y. Chen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Increased glycogen stores due to γ-AMPK overexpression protects against ischemia and reperfusion damage

(2008) Michal Ofir et al.   BIOCHEMICAL PHARMACOLOGY

I PP2A 1 Affects Tau Phosphorylation via Association with the Catalytic Subunit of Protein Phosphatase 2A

(2008) She Chen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Sirtuin 1 Reduction Parallels the Accumulation of Tau in Alzheimer Disease

(2008) Carl Julien et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

Impaired insulin secretion increases the risk of Alzheimer disease

(2008) E. Ronnemaa et al.   NEUROLOGY