What have we learned from the streptozotocin-induced animal model of sporadic Alzheimer’s disease, about the therapeutic strategies in Alzheimer’s research

Modeling Sporadic Alzheimer's Disease: The Insulin Resistant Brain State Generates Multiple Long-Term Morphobiological Abnormalities Including Hyperphosphorylated Tau Protein and Amyloid-β

(2017) Melita Salkovic-Petrisic et al.   JOURNAL OF ALZHEIMERS DISEASE

Hippocampal Alterations in Rats Submitted to Streptozotocin-Induced Dementia Model are Prevented by Aminoguanidine

(2017) Letícia Rodrigues et al.   JOURNAL OF ALZHEIMERS DISEASE

Carvedilol Reestablishes Long-Term Potentiation in a Mouse Model of Alzheimer's Disease

(2017) Isabel Arrieta-Cruz et al.   JOURNAL OF ALZHEIMERS DISEASE

A Multi-Center Randomized Proof-of-Concept Clinical Trial Applying [18F]FDG-PET for Evaluation of Metabolic Therapy with Rosiglitazone XR in Mild to Moderate Alzheimer's Disease

(2017) Sofia Tzimopoulou et al.   JOURNAL OF ALZHEIMERS DISEASE

Treating transgenic Alzheimer mice with a β-secretase inhibitor, what have we learned?

(2016) Jordan Tang et al.   Aging-US

Memory restorative role of statins in experimental dementia: an evidence of their cholesterol dependent and independent actions

(2014) Yogita Dalla et al.   Pharmacological Reports

The Novel Multi-Target Iron Chelating-Radical Scavenging Compound M30 Possesses Beneficial Effects on Major Hallmarks of Alzheimer's Disease

(2012) Lana Kupershmidt et al.   ANTIOXIDANTS & REDOX SIGNALING

Antioxidants for Alzheimer Disease

(2012) Douglas R. Galasko et al.   ARCHIVES OF NEUROLOGY

Cognitive decline in STZ-3V rats is largely due to dysfunctional insulin signalling through the dentate gyrus

(2012) Akiko Sheala Shingo et al.   BEHAVIOURAL BRAIN RESEARCH

The role of iron as a mediator of oxidative stress in Alzheimer disease

(2012) Rudy J. Castellani et al.   BIOFACTORS

Glycogen Synthase Kinase-3 (GSK-3) Inhibitors for the Treatment of Alzheimers Disease

(2012) Miguel Medina et al.   CURRENT PHARMACEUTICAL DESIGN

Neuroprotection by the multitarget iron chelator M30 on age-related alterations in mice

(2012) Lana Kupershmidt et al.   MECHANISMS OF AGEING AND DEVELOPMENT

Rutin prevents cognitive impairments by ameliorating oxidative stress and neuroinflammation in rat model of sporadic dementia of Alzheimer type

(2012) H. Javed et al.   NEUROSCIENCE

Neuroprotective effect of RO-20-1724-a phosphodiesterase4 inhibitor against intracerebroventricular streptozotocin induced cognitive deficit and oxidative stress in rats

(2012) Vivek Sharma et al.   PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR

Amelioration of neurodegenerative changes in cellular and rat models of diabetes-related Alzheimer’s disease by exendin-4

(2011) Song Chen et al.   AGE

Insulin-resistant brain state: The culprit in sporadic Alzheimer's disease?

(2011) Sónia C. Correia et al.   AGEING RESEARCH REVIEWS

Extended results of the Alzheimer’s disease anti-inflammatory prevention trial

(2011) John C. Breitner et al.   Alzheimers & Dementia

Cholesterol Level and Statin Use in Alzheimer Disease

(2011) Nina E. Shepardson   ARCHIVES OF NEUROLOGY

Cholesterol Level and Statin Use in Alzheimer Disease

(2011) Nina E. Shepardson   ARCHIVES OF NEUROLOGY

Improvement of brain energy metabolism and cholinergic functions contributes to the beneficial effects of silibinin against streptozotocin induced memory impairment

(2011) Santoshkumar Tota et al.   BEHAVIOURAL BRAIN RESEARCH

ICV STZ induced impairment in memory and neuronal mitochondrial function: A protective role of nicotinic receptor

(2011) Gunjan Saxena et al.   BEHAVIOURAL BRAIN RESEARCH

Lithium, phenserine, memantine and pioglitazone reverse memory deficit and restore phospho-GSK3β decreased in hippocampus in intracerebroventricular streptozotocin induced memory deficit model

(2011) Teresa Ponce-Lopez et al.   BRAIN RESEARCH

Disease-modifying properties of long-term lithium treatment for amnestic mild cognitive impairment: randomised controlled trial

(2011) Orestes V. Forlenza et al.   BRITISH JOURNAL OF PSYCHIATRY

Neuroprotector effect of p,p'-methoxyl-diphenyl diselenide in a model of sporadic dementia of Alzheimer's type in mice: contribution of antioxidant mechanism

(2011) Simone Pinton et al.   CELL BIOCHEMISTRY AND FUNCTION

Rosiglitazone Does Not Improve Cognition or Global Function when Used as Adjunctive Therapy to AChE Inhibitors in Mild-to-Moderate Alzheimers Disease: Two Phase 3 Studies

(2011) C. Harrington et al.   Current Alzheimer Research

Modulation of nitrergic pathway by sesamol prevents cognitive deficits and associated biochemical alterations in intracerebroventricular streptozotocin administered rats

(2011) Shubham Misra et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

(Val8) glucagon-like peptide-1 prevents tau hyperphosphorylation, impairment of spatial learning and ultra-structural cellular damage induced by streptozotocin in rat brains

(2011) Lin Li et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Insulin receptor signaling in rat hippocampus: A study in STZ (ICV) induced memory deficit model

(2011) Rahul Agrawal et al.   EUROPEAN NEUROPSYCHOPHARMACOLOGY

Perindopril, a centrally active angiotensin-converting enzyme inhibitor, prevents cognitive impairment in mouse models of Alzheimer's disease

(2011) Yi-Fei Dong et al.   FASEB JOURNAL

Possible implications of insulin resistance and glucose metabolism in Alzheimer’s disease pathogenesis

(2011) Domenico Bosco et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Differential role of cyclooxygenase isozymes on neuronal density in hippocampus CA1 region of intracerebroventricular streptozotocin treated rat brain

(2011) Dinesh K. Dhull et al.   JOURNAL OF CHEMICAL NEUROANATOMY

Neuroprotective Effect of Cyclooxygenase Inhibitors in ICV-STZ Induced Sporadic Alzheimer’s Disease in Rats

(2011) Dinesh Kumar Dhull et al.   JOURNAL OF MOLECULAR NEUROSCIENCE

The neuroprotective effect of two statins: simvastatin and pravastatin on a streptozotocin-induced model of Alzheimer’s disease in rats

(2011) Ana Carolina Tramontina et al.   JOURNAL OF NEURAL TRANSMISSION

Cerebral amyloid angiopathy in streptozotocin rat model of sporadic Alzheimer’s disease: a long-term follow up study

(2011) Melita Salkovic-Petrisic et al.   JOURNAL OF NEURAL TRANSMISSION

Developing β-secretase inhibitors for treatment of Alzheimer’s disease

(2011) Arun K. Ghosh et al.   JOURNAL OF NEUROCHEMISTRY

Melatonin treatment restores mitochondrial function in Alzheimer’s mice: a mitochondrial protective role of melatonin membrane receptor signaling

(2011) Natasa Dragicevic et al.   JOURNAL OF PINEAL RESEARCH

Molecular mechanisms linking diabetes mellitus and Alzheimer disease: beta-amyloid peptide, insulin signaling, and neuronal function

(2011) Shuko Takeda et al.   Molecular BioSystems

Novel molecular targets of the neuroprotective/neurorescue multimodal iron chelating drug M30 in the mouse brain

(2011) L. Kupershmidt et al.   NEUROSCIENCE

Changes in hippocampal synapses and learning-memory abilities in a streptozotocin-treated rat model and intervention by using fasudil hydrochloride

(2011) Y. Hou et al.   NEUROSCIENCE

2.14.3 NEURORESTORATIVE, NEUROPROTECTIVE AND CELL CYCLE ARREST ACTIVITY OF NOVEL MULTI TARGET DRUGS IN ANIMAL MODELS OF PARKINSON'S DISEASE

(2011) M.B.H. Youdim   PARKINSONISM & RELATED DISORDERS

A Randomized Pilot Clinical Trial of the Safety of Pioglitazone in Treatment of Patients With Alzheimer Disease

(2010) David S. Geldmacher et al.   ARCHIVES OF NEUROLOGY

Protective effect of quercetin against intracerebral streptozotocin induced reduction in cerebral blood flow and impairment of memory in mice

(2010) Santoshkumar Tota et al.   BEHAVIOURAL BRAIN RESEARCH

Potential of ezetimibe in memory deficits associated with dementia of alzheimer′s type in mice

(2010) Nirmal Singh et al.   INDIAN JOURNAL OF PHARMACOLOGY

Treadmill training restores spatial cognitive deficits and neurochemical alterations in the hippocampus of rats submitted to an intracerebroventricular administration of streptozotocin

(2010) Letícia Rodrigues et al.   JOURNAL OF NEURAL TRANSMISSION

Effects of Erythropoietin on Memory Deficits and Brain Oxidative Stress in the Mouse Models of Dementia

(2010) Rohit Kumar et al.   KOREAN JOURNAL OF PHYSIOLOGY & PHARMACOLOGY

Involvement of PPAR-gamma in curcumin-mediated beneficial effects in experimental dementia

(2010) Puneet Rinwa et al.   NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY

Oxidative stress in Alzheimer disease: A possibility for prevention

(2010) David J. Bonda et al.   NEUROPHARMACOLOGY

Rosiglitazone Rescues Memory Impairment in Alzheimer's Transgenic Mice: Mechanisms Involving a Reduced Amyloid and Tau Pathology

(2010) Luis Escribano et al.   NEUROPSYCHOPHARMACOLOGY

Organoselenium improves memory decline in mice: Involvement of acetylcholinesterase activity

(2010) Simone Pinton et al.   NEUROSCIENCE LETTERS

Protective Effects of Intranasal Losartan in the APP/PS1 Transgenic Mouse Model of Alzheimer Disease

(2010) Lusine Danielyan et al.   REJUVENATION RESEARCH

‘Too much good news’ – are Alzheimer mouse models trying to tell us how to prevent, not cure, Alzheimer's disease?

(2010) Kathleen R. Zahs et al.   TRENDS IN NEUROSCIENCES

Effects of Pycnogenol and vitamin E on cognitive deficits and oxidative damage induced by intracerebroventricular streptozotocin in rats

(2009) Tauheed Ishrat et al.   BEHAVIOURAL PHARMACOLOGY

Selenium prevents cognitive decline and oxidative damage in rat model of streptozotocin-induced experimental dementia of Alzheimer's type

(2009) Tauheed Ishrat et al.   BRAIN RESEARCH

Amelioration of intracerebroventricular streptozotocin induced cognitive dysfunction and oxidative stress by vinpocetine — a PDE1 inhibitor

(2009) Rahul Deshmukh et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Amelioration of cognitive deficits and neurodegeneration by curcumin in rat model of sporadic dementia of Alzheimer's type (SDAT)☆

(2009) Tauheed Ishrat et al.   EUROPEAN NEUROPSYCHOPHARMACOLOGY

Exploring mechanism of pioglitazone-induced memory restorative effect in experimental dementia

(2009) Baljinder Kaur et al.   FUNDAMENTAL & CLINICAL PHARMACOLOGY

Lithium Trial in Alzheimer's Disease

(2009) Harald Hampel et al.   JOURNAL OF CLINICAL PSYCHIATRY

Statins Reduce the Neurofibrillary Tangle Burden in a Mouse Model of Tauopathy

(2009) Moran Boimel et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

 -Amyloid Oligomers Induce Phosphorylation of Tau and Inactivation of Insulin Receptor Substrate via c-Jun N-Terminal Kinase Signaling: Suppression by Omega-3 Fatty Acids and Curcumin

(2009) Q.-L. Ma et al.   JOURNAL OF NEUROSCIENCE

Effect of chronic treatment of carvedilol on oxidative stress in an intracerebroventricular streptozotocin induced model of dementia in rats

(2009) Atish Kumar Prakash et al.   JOURNAL OF PHARMACY AND PHARMACOLOGY

Protective effect of curcumin against intracerebral streptozotocin induced impairment in memory and cerebral blood flow

(2009) Himani Awasthi et al.   LIFE SCIENCES

Activation of Wnt signaling by lithium and rosiglitazone reduced spatial memory impairment and neurodegeneration in brains of an APPswe/PSEN1ΔE9 mouse model of Alzheimer's disease

(2009) E M Toledo et al.   MOLECULAR PSYCHIATRY

Efficacy of PPAR-γ agonist pioglitazone in mild Alzheimer disease

(2009) Tomohiko Sato et al.   NEUROBIOLOGY OF AGING

Consumption of Grape Seed Extract Prevents Amyloid-β Deposition and Attenuates Inflammation in Brain of an Alzheimer’s Disease Mouse

(2009) Yan-Jiang Wang et al.   NEUROTOXICITY RESEARCH

Effect of curcumin on brain insulin receptors and memory functions in STZ (ICV) induced dementia model of rat

(2009) Rahul Agrawal et al.   PHARMACOLOGICAL RESEARCH

Chronic treatment with tocotrienol, an isoform of vitamin E, prevents intracerebroventricular streptozotocin-induced cognitive impairment and oxidative–nitrosative stress in rats

(2009) Vinod Tiwari et al.   PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR

Melatonin alleviates memory deficits and neuronal degeneration induced by intracerebroventricular administration of streptozotocin in rats

(2009) Gunjan Saxena et al.   PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR

Curcumin ameliorates impaired insulin/IGF signalling and memory deficit in a streptozotocin-treated rat model

(2008) Ahmet Turan Isik et al.   AGE

Angiotensin Converting Enzyme Inhibitors and Cognitive and Functional Decline in Patients with Alzheimer's Disease: An Observational Study

(2008) Ihab M. Hajjar et al.   American Journal of Alzheimers Disease and Other Dementias

Wheel-running in a transgenic mouse model of Alzheimer's disease: Protection or symptom?

(2008) Helene Richter et al.   BEHAVIOURAL BRAIN RESEARCH

Candesartan improves memory decline in mice: Involvement of AT1 receptors in memory deficit induced by intracerebral streptozotocin

(2008) Santoshkumar Tota et al.   BEHAVIOURAL BRAIN RESEARCH

Therapeutic potential of resveratrol in Alzheimer's disease

(2008) Valérie Vingtdeux et al.   BMC NEUROSCIENCE

Study of neuroprotection of donepezil, a therapy for Alzheimer's disease

(2008) S. Akasofu et al.   CHEMICO-BIOLOGICAL INTERACTIONS

Complete Rescue of Cerebrovascular Function in Aged Alzheimer's Disease Transgenic Mice by Antioxidants and Pioglitazone, a Peroxisome Proliferator-Activated Receptor   Agonist

(2008) N. Nicolakakis et al.   JOURNAL OF NEUROSCIENCE

Modulation of celecoxib- and streptozotocin-induced experimental dementia of Alzheimer's disease by pitavastatin and donepezil

(2008) Bhupesh Sharma et al.   JOURNAL OF PSYCHOPHARMACOLOGY

Long-term effects of Aβ42 immunisation in Alzheimer's disease: follow-up of a randomised, placebo-controlled phase I trial

(2008) Clive Holmes et al.   LANCET

Effects of treadmill exercise on memory and c-Fos expression in the hippocampus of the rats with intracerebroventricular injection of streptozotocin

(2008) Yong-Seok Jee et al.   NEUROSCIENCE LETTERS

Exploitation of HIV protease inhibitor Indinavir as a memory restorative agent in experimental dementia

(2008) Bhupesh Sharma et al.   PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR

New polyphenols active on β-amyloid aggregation

(2007) Céline Rivière et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Effect of donepezil and tacrine on oxidative stress in intracerebral streptozotocin-induced model of dementia in mice

(2007) Gunjan Saxena et al.   EUROPEAN JOURNAL OF PHARMACOLOGY