Cell cycle regulation by complex nanomachines

2.5Å-resolution structure of the human CDK-activating kinase bound to the clinical inhibitor ICEC0942

(2021) Basil J. Greber et al.   BIOPHYSICAL JOURNAL

Ubiquitin ligation to F-box protein targets by SCF–RBR E3–E3 super-assembly

(2021) Daniel Horn-Ghetko et al.   NATURE

Structures of monomeric and dimeric PRC2:EZH1 reveal flexible modules involved in chromatin compaction

(2021) Daniel Grau et al.   Nature Communications

Mechanisms of signalling-memory governing progression through the eukaryotic cell cycle

(2021) Béla Novák et al.   CURRENT OPINION IN CELL BIOLOGY

NEDD8 nucleates a multivalent cullin–RING–UBE2D ubiquitin ligation assembly

(2020) Kheewoong Baek et al.   NATURE

A living biobank of ovarian cancer ex vivo models reveals profound mitotic heterogeneity

(2020) Louisa Nelson et al.   Nature Communications

Cyclin A triggers Mitosis either via the Greatwall kinase pathway or Cyclin B

(2020) Nadia Hégarat et al.   EMBO JOURNAL

A unique binding mode of Nek2A to the APC /C allows its ubiquitination during prometaphase

(2020) Claudio Alfieri et al.   EMBO REPORTS

The Palette of Techniques for Cell Cycle Analysis

(2020) Anna E. Eastman et al.   FEBS LETTERS

The Roles of Cyclin-Dependent Kinases in Cell-Cycle Progression and Therapeutic Strategies in Human Breast Cancer

(2020) Lei Ding et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Three‐dimensional organization of the cytoskeleton: A cryo‐electron tomography perspective

(2020) Saikat Chakraborty et al.   PROTEIN SCIENCE

Mechanisms generating cancer genome complexity from a single cell division error

(2020) Neil T. Umbreit et al.   SCIENCE

Roles of CDK/Cyclin complexes in transcription and pre-mRNA splicing: Cyclins L and CDK11 at the cross-roads of cell cycle and regulation of gene expression

(2020) Pascal Loyer et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

A processive phosphorylation circuit with multiple kinase inputs and mutually diversional routes controls G1/S decision

(2020) Rainis Venta et al.   Nature Communications

Quantifying CDK inhibitor selectivity in live cells

(2020) Carrow I. Wells et al.   Nature Communications

F-Box Proteins and Cancer

(2020) Kanae Yumimoto et al.   Cancers

Restriction point regulation at the crossroads between quiescence and cell proliferation

(2020) Betheney R. Pennycook et al.   FEBS LETTERS

Time-resolved cryo-EM using Spotiton

(2020) Venkata P. Dandey et al.   NATURE METHODS

Complex Cartography: Regulation of E2F Transcription Factors by Cyclin F and Ubiquitin

(2020) Michael J. Emanuele et al.   TRENDS IN CELL BIOLOGY

Modular microfluidics enables kinetic insight from time-resolved cryo-EM

(2020) Märt-Erik Mäeots et al.   Nature Communications

Regulation of cell cycle drivers by Cullin-RING ubiquitin ligases

(2020) Sang-Min Jang et al.   EXPERIMENTAL AND MOLECULAR MEDICINE

Integrating Old and New Paradigms of G1/S Control

(2020) Seth M. Rubin et al.   MOLECULAR CELL

Closed mitosis requires local disassembly of the nuclear envelope

(2020) Gautam Dey et al.   NATURE

Single-particle cryo-EM at atomic resolution

(2020) Takanori Nakane et al.   NATURE

The cryoelectron microscopy structure of the human CDK-activating kinase

(2020) Basil J. Greber et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A time‐resolved cryo‐EM Study of S. cerevisiae 80S Ribosome Protein Composition in Response to a Change in Carbon Source

(2020) Ming Sun et al.   PROTEOMICS

The Negative Cross-Talk between SAG/RBX2/ROC2 and APC/C E3 Ligases in Regulation of Cell Cycle Progression and Drug Resistance

(2020) Shizhen Zhang et al.   Cell Reports

Structural basis for PRC2 decoding of active histone methylation marks H3K36me2/3

(2020) Ksenia Finogenova et al.   eLife

NEDD8 and ubiquitin ligation by cullin-RING E3 ligases

(2020) Kheewoong Baek et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

Role of Integrative Structural Biology in Understanding Transcriptional Initiation

(2019) Mike Trnka et al.   METHODS

Cyclin-Specific Docking Mechanisms Reveal the Complexity of M-CDK Function in the Cell Cycle

(2019) Mihkel Örd et al.   MOLECULAR CELL

Cyclin D-Cdk4,6 Drives Cell-Cycle Progression via the Retinoblastoma Protein’s C-Terminal Helix

(2019) Benjamin R. Topacio et al.   MOLECULAR CELL

Cyclin F Controls Cell-Cycle Transcriptional Outputs by Directing the Degradation of the Three Activator E2Fs

(2019) Linda Clijsters et al.   MOLECULAR CELL

Two Distinct E2F Transcriptional Modules Drive Cell Cycles and Differentiation

(2019) Maria C. Cuitiño et al.   Cell Reports

An order-to-disorder structural switch activates the FoxM1 transcription factor

(2019) Aimee H Marceau et al.   eLife

Multisite phosphorylation code of CDK

(2019) Mihkel Örd et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Integrated NMR and cryo-EM atomic-resolution structure determination of a half-megadalton enzyme complex

(2019) Diego F. Gauto et al.   Nature Communications

Cyclin F‐dependent degradation of E2F7 is critical for DNA repair and G2‐phase progression

(2019) Ruixue Yuan et al.   EMBO JOURNAL

DNA damage kinase signaling: checkpoint and repair at 30 years

(2019) Michael Charles Lanz et al.   EMBO JOURNAL

E2F1 proteolysis via SCF ‐cyclin F underlies synthetic lethality between cyclin F loss and Chk1 inhibition

(2019) Kamila Burdova et al.   EMBO JOURNAL

Preparation for DNA Replication: The Key to a Successful S phase

(2019) Juanita C. Limas et al.   FEBS LETTERS

Bistable switches as integrators and actuators during cell cycle progression

(2019) Wayne Stallaert et al.   FEBS LETTERS

Structural basis of nucleosome recognition and modification by MLL methyltransferases

(2019) Han Xue et al.   NATURE

The big picture of chromatin biology by cryo-EM

(2019) Seongmin Jang et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

Structural basis of Cullin 2 RING E3 ligase regulation by the COP9 signalosome

(2019) Sarah V. Faull et al.   Nature Communications

p27 allosterically activates cyclin-dependent kinase 4 and antagonizes palbociclib inhibition

(2019) Keelan Z. Guiley et al.   SCIENCE

Cryo-EM structure of the human MLL1 core complex bound to the nucleosome

(2019) Sang Ho Park et al.   Nature Communications

Structural interconversions of the anaphase-promoting complex/cyclosome (APC/C) regulate cell cycle transitions

(2019) David Barford   CURRENT OPINION IN STRUCTURAL BIOLOGY

Role of ubiquitylation of components of mitotic checkpoint complex in their dissociation from anaphase-promoting complex/cyclosome

(2018) Danielle Sitry-Shevah et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structures of human PRC2 with its cofactors AEBP2 and JARID2

(2018) Vignesh Kasinath et al.   SCIENCE

Structure and Conformational Dynamics of a COMPASS Histone H3K4 Methyltransferase Complex

(2018) Qianhui Qu et al.   CELL

From the resolution revolution to evolution: structural insights into the evolutionary relationships between vesicle coats and the nuclear pore

(2018) Martin Beck et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

EMI1 switches from being a substrate to an inhibitor of APC/CCDH1 to start the cell cycle

(2018) Steven D. Cappell et al.   NATURE

Structural mechanism of Myb–MuvB assembly

(2018) Keelan Z. Guiley et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Single-particle cryo-EM—How did it get here and where will it go

(2018) Yifan Cheng   SCIENCE

Structural insights into the functional diversity of the CDK–cyclin family

(2018) Daniel J. Wood et al.   Open Biology

Ectopic Activation of the Spindle Assembly Checkpoint Signaling Cascade Reveals Its Biochemical Design

(2018) Chu Chen et al.   CURRENT BIOLOGY

The HDAC-Associated Sin3B Protein Represses DREAM Complex Targets and Cooperates with APC/C to Promote Quiescence

(2018) Anthony J. Bainor et al.   Cell Reports

Posing the APC/C E3 Ubiquitin Ligase to Orchestrate Cell Division

(2018) Edmond R. Watson et al.   TRENDS IN CELL BIOLOGY

Structural basis of the phosphorylation-independent recognition of cyclin D1 by the SCFFBXO31ubiquitin ligase

(2017) Yunfeng Li et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Conservation and divergence of C-terminal domain structure in the retinoblastoma protein family

(2017) Tyler J. Liban et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Architecture of eukaryotic mRNA 3′-end processing machinery

(2017) Ana Casañal et al.   SCIENCE

DNA damage during S-phase mediates the proliferation-quiescence decision in the subsequent G1 via p21 expression

(2017) Alexis R. Barr et al.   Nature Communications

Visualizing the complex functions and mechanisms of the anaphase promoting complex/cyclosome (APC/C)

(2017) Claudio Alfieri et al.   Open Biology

The DREAM complex through its subunit Lin37 cooperates with Rb to initiate quiescence

(2017) Christina FS Mages et al.   eLife

Two Distinct Types of E3 Ligases Work in Unison to Regulate Substrate Ubiquitylation

(2016) Daniel C. Scott et al.   CELL

Feedback regulation between atypical E2Fs and APC/CCdh1coordinates cell cycle progression

(2016) Michiel Boekhout et al.   EMBO REPORTS

Structural Conservation and E2F Binding Specificity within the Retinoblastoma Pocket Protein Family

(2016) Tyler J. Liban et al.   JOURNAL OF MOLECULAR BIOLOGY

Building a Regulatory Network with Short Linear Sequence Motifs: Lessons from the Degrons of the Anaphase-Promoting Complex

(2016) Norman E. Davey et al.   MOLECULAR CELL

3D-CLEM Reveals that a Major Portion of Mitotic Chromosomes Is Not Chromatin

(2016) Daniel G. Booth et al.   MOLECULAR CELL

Cryo-EM of Mitotic Checkpoint Complex-Bound APC/C Reveals Reciprocal and Conformational Regulation of Ubiquitin Ligation

(2016) Masaya Yamaguchi et al.   MOLECULAR CELL

Unravelling biological macromolecules with cryo-electron microscopy

(2016) Rafael Fernandez-Leiro et al.   NATURE

Molecular mechanism of APC/C activation by mitotic phosphorylation

(2016) Suyang Zhang et al.   NATURE

Molecular basis of APC/C regulation by the spindle assembly checkpoint

(2016) Claudio Alfieri et al.   NATURE

How cryo-electron microscopy and X-ray crystallography complement each other

(2016) Hong-Wei Wang et al.   PROTEIN SCIENCE

Atomic structure of Hsp90-Cdc37-Cdk4 reveals that Hsp90 traps and stabilizes an unfolded kinase

(2016) K. A. Verba et al.   SCIENCE

Cryo-Electron Tomography: Can it Reveal the Molecular Sociology of Cells in Atomic Detail?

(2016) Martin Beck et al.   TRENDS IN CELL BIOLOGY

Structural basis for LIN54 recognition of CHR elements in cell cycle-regulated promoters

(2016) Aimee H. Marceau et al.   Nature Communications

APC/C and SCF cyclin F Constitute a Reciprocal Feedback Circuit Controlling S-Phase Entry

(2016) Rajarshi Choudhury et al.   Cell Reports

Roles of pRB in the Regulation of Nucleosome and Chromatin Structures

(2016) Chiharu Uchida   Biomed Research International

Structural and kinetic analysis of the COP9-Signalosome activation and the cullin-RING ubiquitin ligase deneddylation cycle

(2016) Ruzbeh Mosadeghi et al.   eLife

The structure of the core NuRD repression complex provides insights into its interaction with chromatin

(2016) Christopher J Millard et al.   eLife

Targeting Cullin–RING E3 ubiquitin ligases for drug discovery: structure, assembly and small-molecule modulation

(2015) Emil Bulatov et al.   BIOCHEMICAL JOURNAL

Models in biology: lessons from modeling regulation of the eukaryotic cell cycle

(2015) John J. Tyson et al.   BMC BIOLOGY

A Primer to Single-Particle Cryo-Electron Microscopy

(2015) Yifan Cheng et al.   CELL

The Molecular Biology of Spindle Assembly Checkpoint Signaling Dynamics

(2015) Andrea Musacchio   CURRENT BIOLOGY

The ABBA Motif Binds APC/C Activators and Is Shared by APC/C Substrates and Regulators

(2015) Barbara Di Fiore et al.   DEVELOPMENTAL CELL

Structural mechanisms of DREAM complex assembly and regulation

(2015) Keelan Z. Guiley et al.   GENES & DEVELOPMENT

The DREAM complex promotes gene body H2A.Z for target repression

(2015) Isabel Latorre et al.   GENES & DEVELOPMENT

Nek2A destruction marks APC/C activation at the prophase-to-prometaphase transition by spindle-checkpoint-restricted Cdc20

(2015) M. Boekhout et al.   JOURNAL OF CELL SCIENCE

Atomic structure of the APC/C and its mechanism of protein ubiquitination

(2015) Leifu Chang et al.   NATURE

The history and future of targeting cyclin-dependent kinases in cancer therapy

(2015) Uzma Asghar et al.   NATURE REVIEWS DRUG DISCOVERY

Spatiotemporal regulation of the anaphase-promoting complex in mitosis

(2015) Sushama Sivakumar et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Short- and long-term effects of chromosome mis-segregation and aneuploidy

(2015) Stefano Santaguida et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

RING E3 mechanism for ubiquitin ligation to a disordered substrate visualized for human anaphase-promoting complex

(2015) Nicholas G. Brown et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structural insights into the DNA-binding specificity of E2F family transcription factors

(2015) Ekaterina Morgunova et al.   Nature Communications

CDK1 structures reveal conserved and unique features of the essential cell cycle CDK

(2015) Nicholas R. Brown et al.   Nature Communications

A Glimpse of Structural Biology through X-Ray Crystallography

(2014) Yigong Shi   CELL

Molecular architecture and mechanism of the anaphase-promoting complex

(2014) Leifu Chang et al.   NATURE

A novel cell-cycle-indicator, mVenus-p27K−, identifies quiescent cells and visualizes G0–G1 transition

(2014) Toshihiko Oki et al.   Scientific Reports

Ubiquitin Ligases and Cell Cycle Control

(2013) Leonardo K. Teixeira et al.   Annual Review of Biochemistry

Mechanisms controlling the temporal degradation of Nek2A and Kif18A by the APC/C–Cdc20 complex

(2013) Garry G Sedgwick et al.   EMBO JOURNAL

Panta rhei: The APC/C at steady state

(2013) Ivana Primorac et al.   JOURNAL OF CELL BIOLOGY

Insights into Degron Recognition by APC/C Coactivators from the Structure of an Acm1-Cdh1 Complex

(2013) Jun He et al.   MOLECULAR CELL

The spindle assembly checkpoint works like a rheostat rather than a toggle switch

(2013) Philippe Collin et al.   NATURE CELL BIOLOGY

Mechanisms and function of substrate recruitment by F-box proteins

(2013) Jeffrey R. Skaar et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Control of cell cycle transcription during G1 and S phases

(2013) Cosetta Bertoli et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Cks confers specificity to phosphorylation-dependent CDK signaling pathways

(2013) Denise A McGrath et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Multisite phosphorylation networks as signal processors for Cdk1

(2013) Mardo Kõivomägi et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

The MuvB complex sequentially recruits B-Myb and FoxM1 to promote mitotic gene expression

(2012) S. Sadasivam et al.   GENES & DEVELOPMENT

Structures of inactive retinoblastoma protein reveal multiple mechanisms for cell cycle control

(2012) J. R. Burke et al.   GENES & DEVELOPMENT

The APC/C Subunit Mnd2/Apc15 Promotes Cdc20 Autoubiquitination and Spindle Assembly Checkpoint Inactivation

(2012) Scott A. Foster et al.   MOLECULAR CELL

Structure of the mitotic checkpoint complex

(2012) William C. H. Chao et al.   NATURE

APC15 mediates CDC20 autoubiquitylation by APC/CMCC and disassembly of the mitotic checkpoint complex

(2012) Kristina Uzunova et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Structural plasticity of histones H3–H4 facilitates their allosteric exchange between RbAp48 and ASF1

(2012) Wei Zhang et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Deciphering the retinoblastoma protein phosphorylation code

(2012) Seth M. Rubin   TRENDS IN BIOCHEMICAL SCIENCES

A cyclin without cyclin-dependent kinases: cyclin F controls genome stability through ubiquitin-mediated proteolysis

(2012) Vincenzo D’Angiolella et al.   TRENDS IN CELL BIOLOGY

The retinoblastoma family of proteins and their regulatory functions in the mammalian cell division cycle

(2012) Shauna A Henley et al.   Cell Division

DYRK1A protein kinase promotes quiescence and senescence through DREAM complex assembly

(2011) L. Litovchick et al.   GENES & DEVELOPMENT

APC15 drives the turnover of MCC-CDC20 to make the spindle assembly checkpoint responsive to kinetochore attachment

(2011) Jörg Mansfeld et al.   NATURE CELL BIOLOGY

The CHR promoter element controls cell cycle-dependent gene transcription and binds the DREAM and MMB complexes

(2011) Gerd A. Müller et al.   NUCLEIC ACIDS RESEARCH

Structural insights into anaphase-promoting complex function and mechanism

(2011) D. Barford   PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

Structural Basis of Dimerization-dependent Ubiquitination by the SCFFbx4Ubiquitin Ligase

(2010) Yunfeng Li et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

From Rabbit Reticulocytes to Clam Oocytes: In Search of the System That Targets Mitotic Cyclins for Degradation

(2010) Avram Hershko   MOLECULAR BIOLOGY OF THE CELL

Structures of APC/CCdh1 with substrates identify Cdh1 and Apc10 as the D-box co-receptor

(2010) Paula C. A. da Fonseca et al.   NATURE

Serine/Threonine Phosphatases: Mechanism through Structure

(2009) Yigong Shi   CELL

An inhibitor of NEDD8-activating enzyme as a new approach to treat cancer

(2009) Teresa A. Soucy et al.   NATURE

The structure of CDK4/cyclin D3 has implications for models of CDK activation

(2009) T. Takaki et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Crystal structure of human CDK4 in complex with a D-type cyclin

(2009) P. J. Day et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structural Insights into NEDD8 Activation of Cullin-RING Ligases: Conformational Control of Conjugation

(2008) David M. Duda et al.   CELL

Multimodal Activation of the Ubiquitin Ligase SCF by Nedd8 Conjugation

(2008) Anjanabha Saha et al.   MOLECULAR CELL

A bistable Rb–E2F switch underlies the restriction point

(2008) Guang Yao et al.   NATURE CELL BIOLOGY

Structural Basis for the Recognition of Histone H4 by the Histone-Chaperone RbAp46

(2008) Natalia V. Murzina et al.   STRUCTURE