Review
Oncology
Chibuzo Sampson, Qiuping Wang, Wuxiyar Otkur, Haifeng Zhao, Yun Lu, Xiaolong Liu, Hai-long Piao
Summary: Ubiquitination, an important post-translational modification, is crucial for maintaining cellular protein homeostasis. E3 ubiquitin ligases are the most influential enzymes in the ubiquitination process and play a significant role in cancer hallmarks. The specificity of E3 ligases and their involvement in cancer hallmarks have led to the development of compounds that target them for cancer therapy. This review highlights the role of E3 ligases in cancer hallmarks and summarizes the application and significance of targeting E3 ligases as potential cancer therapy.
CLINICAL AND TRANSLATIONAL MEDICINE
(2023)
Review
Biochemistry & Molecular Biology
Tingting Zou, Zhenghong Lin
Summary: The paragraph explains how the cell cycle is regulated by the division of cellular components and the activation of cyclin-dependent kinases. The ubiquitin-proteasome system plays a crucial role in regulating cell proliferation, genomic stability, and cancer occurrence through recognition and modification of key proteins in the cell cycle machinery.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biology
Kristin Klaeske, Maria Dix, Volker Adams, Khalil Jawad, Sandra Eifert, Christian Etz, Diyar Saeed, Michael A. Borger, Maja-Theresa Dieterlen
Summary: The study examined the expression of muscle-specific E3 ubiquitin ligases and deubiquitinases following myocardial infarction (MI) and chronic heart failure (CHF). The results showed differential regulation of these enzymes in disease states, with some showing decreased expression and others showing increased expression after MI and in CHF. This raises questions about whether these changes contribute to tissue protection or myocardial hypertrophy.
Review
Cell Biology
Eleonora Pauletto, Nils Eickhoff, Nuno A. Padrao, Christine Blattner, Wilbert Zwart
Summary: The TRIM protein family, based on structure rather than function, is increasingly known for its various biological activities in multiple diseases including hormone-driven cancers. They are described to have both tumor suppressive and oncogenic activities in hormone-driven cancers such as prostate, breast, ovarian and endometrial cancer, indicating the potential for improved prognostication and novel therapeutics in cancer care.
Article
Developmental Biology
Shaked Bar-Cohen, Mria Lorena Martinez Quiles, Alexey Baskin, Ruba Dawud, Barbara H. Jennings, Ze'ev Paroush
Summary: The cell cycle is regulated by the synthesis and degradation of phase-specific transcripts and proteins. Groucho, the orthologue of TLE1 in Drosophila, is shown to regulate normal cell cycle progression by selectively inactivating its activity through phosphorylation. This study suggests that Cdk1 is involved in phosphorylation of Groucho during the cell cycle, and Groucho may play a role in the development of human cancer.
Article
Multidisciplinary Sciences
Si Chen, Fangyuan Shao, Jianming Zeng, Sen Guo, Lijian Wang, Heng Sun, Josh Haipeng Lei, Xueying Lyu, Shuai Gao, Qiang Chen, Kai Miao, Xiaoling Xu, Chu-Xia Deng
Summary: This study identified Cullin-5 as a tumor suppressor that acts synergistically with Brca1 deficiency to promote tumorigenesis. Cullin-5 deficiency activated CREB1-CCL2 signaling, leading to an accumulation of suppressor cells and a reduction of T cells in the tumor microenvironment. Blocking CREB1 activity suppressed changes in the tumor microenvironment caused by Cullin-5 deficiency and blocked tumor progression.
Article
Biochemistry & Molecular Biology
Eun-Ju Lee, Minji Cho, Seung Bae Rho, Junsoo Park, Dhan-Ah Chae, Que Thanh Thanh Nguyen
Summary: A novel variant of beta-TrCP1, beta-TrCP1-variant 4, was identified with lower expression in ovarian cancer cell lines but abundant expression in normal and cancerous ovarian tissues. The heterodimer of variants 1 and 4 showed no functional role in downregulating beta-catenin activity, indicating that beta-TrCP1-variant 4 may act as a negative regulator of beta-TrCP1-variant 1 in SCF beta-TrCP E3 ligase-mediated ubiquitination.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2021)
Review
Cell & Tissue Engineering
Xiaobin Yang, Dingjun Hao, Baorong He
Summary: Cbl ubiquitin ligases play an important role in regulating cellular proliferation and migration, as well as bone homeostasis. Research focuses on exploring the specific role of Cbl in osteoclastogenesis and its crosstalk with other signaling pathways.
CURRENT STEM CELL RESEARCH & THERAPY
(2021)
Review
Cell Biology
Xiaoli Hu, Jiangtao Yu, Zixia Lin, Renqian Feng, Zhi-wei Wang, Gang Chen
Summary: This review highlights the involvement of WWP1 in carcinogenesis and tumor progression, discussing its dysregulated expression in cancer patients, dual functions in various human cancers, downstream substrates, and potential as a therapeutic target. Targeting WWP1 may offer promising avenues for treating human malignancies.
CELL DEATH DISCOVERY
(2021)
Article
Oncology
Pengyan Fa, Zhaojun Qiu, Qi-En Wang, Chunhong Yan, Junran Zhang
Summary: RNF126 interacts with 14-3-3 sigma to promote G2 arrest and cell cycle regulation in response to IR, providing a new target for cancer treatment.
INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS
(2022)
Article
Oncology
Shizhen Zhang, Yi Sun
Summary: CRL and APC/C, two RING-finger-type E3 ligases, regulate the cell cycle through negative crosstalk, ensuring the orderly progression of the cell cycle.
MOLECULAR & CELLULAR ONCOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Huifeng Li, Ying Zhong, Guangxu Cao, Hezhan Shi, Yiyao Liu, Lingfeng Li, Peidi Yin, Jialing Chen, Zhendong Xiao, Bin Du
Summary: This study identifies the crucial roles of METTL3 and CDC25B in cell cycle regulation, and reveals the significance of the METTL3/m(6)A/CDC25B pathway in the cell cycle.
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
(2022)
Article
Oncology
Jiechao Yang, Qiang Huang, Yang Guo, Zheqiang Wei, Liang Zhou, Hui Chen
Summary: DIAPH1 is a protein closely related to cell cycle and mitosis, with its expression affecting overall survival in patients with laryngeal squamous cell carcinoma. It promotes cell proliferation and colony formation, and influences LSCC progression by regulating cell cycle signaling pathways.
FRONTIERS IN ONCOLOGY
(2021)
Article
Cell Biology
Veronika Ecker, Lisa Brandmeier, Martina Stumpf, Piero Giansanti, Aida Varela Moreira, Lisa Pfeuffer, Marcel H. . A. M. Fens, Junyan Lu, Bernhard Kuster, Thomas Engleitner, Simon Heidegger, Roland Rad, Ingo Ringshausen, Thorsten Zenz, Clemens-Martin Wendtner, Markus Muschen, Julia Jellusova, Jurgen Ruland, Maike Buchner
Summary: Inhibition of the phosphatases DUSP1 and DUSP6 reduces cell survival and induces cell death in chronic lymphocytic leukemia. Transient inhibition of DUSP1/6 shows promise as a treatment concept for drug-resistant CLL.
Review
Cell Biology
Tatyana Bodrug, Kaeli A. Welsh, Megan Hinkle, Michael J. Emanuele, Nicholas G. Brown
Summary: The ubiquitin-proteasome system plays a crucial role in cell cycle regulation, neurobiology, and chromatin control. Recent studies have revealed new mechanisms of APC/C activity and its involvement in broader signaling pathways.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Multidisciplinary Sciences
Di Wu, Haomin Li, Mingwei Liu, Jun Qin, Yi Sun
Summary: This study reveals that the absence of Rbx1, a component of Cullin-RING ligases, in regulatory T cells leads to a severe inflammatory disease. The Ube2m-Rbx1 axis is specifically required for intrinsic regulatory processes in Treg cells.
NATURE COMMUNICATIONS
(2022)
Article
Oncology
Soumyajit Roy, Yilun Sun, Cristopher J. D. Wallis, Scott C. Morgan, Scott Grimes, Julia Malone, Amar U. Kishan, Dibya Mukherjee, Daniel E. Spratt, Fred Saad, Shawn Malone
Summary: This study developed and validated a multivariable prognostic model to predict overall survival (OS) in metastatic castrate sensitive prostate cancer (mCSPC). The model includes 11 prognostic variables and showed high predictive accuracy on a testing set.
PROSTATE CANCER AND PROSTATIC DISEASES
(2023)
Review
Cell Biology
Yue Wang, Xiao Shen, Longyuan Gong, Yongchao Zhao, Xiufang Xiong
Summary: This review summarizes the downstream substrates and upstream regulators of FBXL7, discusses its role in tumorigenesis and tumor progression, and describes its aberrant expression and association with patient survival in human cancers. Future perspectives on validating FBXL7 as a cancer biomarker for diagnosis and prognosis and/or as a potential therapeutic target for anticancer treatment are provided.
CELL DEATH DISCOVERY
(2022)
Article
Health Care Sciences & Services
Andre Esteva, Jean Feng, Douwe van der Wal, Shih-Cheng Huang, Jeffry P. Simko, Sandy DeVries, Emmalyn Chen, Edward M. Schaeffer, Todd M. Morgan, Yilun Sun, Amirata Ghorbani, Nikhil Naik, Dhruv Nathawani, Richard Socher, Jeff M. Michalski, Mack Roach, Thomas M. Pisansky, Jedidiah M. Monson, Farah Naz, James Wallace, Michelle J. Ferguson, Jean-Paul Bahary, James Zou, Matthew Lungren, Serena Yeung, Ashley E. Ross, Howard M. Sandler, Phuoc T. Tran, Daniel E. Spratt, Stephanie Pugh, Felix Y. Feng, Osama Mohamad
Summary: Prostate cancer therapy personalization is a challenge, and existing tools have limitations. This study demonstrates the prediction of long-term clinical outcomes using a multimodal deep learning architecture and clinical data, and surpasses standard tools in prognostication.
NPJ DIGITAL MEDICINE
(2022)
Article
Oncology
Shearwood McClelland, Eleanor E. Harris, Daniel E. Spratt, Chesley Cheatham, Yilun Sun, Alexandria L. Oliver, Jerry J. Jaboin, Reshma Jagsi, Daniel G. Petereit
Summary: This study evaluates the impact of patient navigation on radiation therapy access for African-American breast cancer patients. The findings suggest that patient navigation can reduce radiation therapy access disparities for African-American breast cancer patients.
REPORTS OF PRACTICAL ONCOLOGY AND RADIOTHERAPY
(2022)
Article
Clinical Neurology
Yoshie Umemura, Baber Khan, Benjamin J. Weill, Justin J. Buthorn, Anna Skakodub, Andrew J. Ridder, Kathryn S. Nevel, Yilun Sun, Adrienne Boire
Summary: Novel diagnostic techniques and neurologic biomarkers have expanded indications for cerebrospinal fluid (CSF) studies. Lumbar puncture (LP) is the most common method for obtaining CSF. Patients typically anticipate LP to be painful, but this study found that the majority of patients actually experience minimal pain. Anticipation of pain was correlated with feeling anxious and experiencing pain during LP.
NEUROLOGY-CLINICAL PRACTICE
(2022)
Article
Oncology
Ting Martin Ma, Yilun Sun, Shawn Malone, Mack Roach III, David Dearnaley, Thomas M. Pisansky, Felix Y. Feng, Howard M. Sandler, Jason A. Efstathiou, Isabel Syndikus, Emma C. Hall, Alison C. Tree, Matthew R. Sydes, Claire Cruickshank, Soumyajit Roy, Michel Bolla, Philippe Maingon, Theo De Reijke, Abdenour Nabid, Nathalie Carrier, Luis Souhami, Almudena Zapatero, Araceli Guerrero, Ana Alvarez, Carmen Gonzalez San-Segundo, Xavier Maldonado, Tahmineh Romero, Michael L. Steinberg, Luca F. Valle, Matthew B. Rettig, Nicholas G. Nickols, Jonathan E. Shoag, Robert E. Reiter, Nicholas G. Zaorsky, Angela Y. Jia, Jorge A. Garcia, Daniel E. Spratt, Amar U. Kishan
Summary: The sequencing of androgen-deprivation therapy (ADT) and radiotherapy (RT) may affect the outcome of prostate cancer depending on the size of the RT field. A study found that the sequencing of ADT has a significant impact on clinical outcomes for men receiving ADT with prostate-only RT (PORT) or whole-pelvis RT (WPRT).
JOURNAL OF CLINICAL ONCOLOGY
(2023)
Article
Oncology
Soumyajit Roy, Scott C. Morgan, Christopher J. D. Wallis, Yilun Sun, Daniel E. Spratt, Julia Malone, Scott Grimes, Dibya Mukherjee, Amar U. Kishan, Fred Saad, Shawn Malone
Summary: Pain is an important aspect of quality-of-life in mCSPC patients, but it is uncertain whether dynamic changes in pain over time can predict OS or rPFS. This study explores the association of dynamic changes in pain scores with OS and rPFS in mCSPC patients.
PROSTATE CANCER AND PROSTATIC DISEASES
(2023)
Article
Cell Biology
Shizhen Zhang, Xiahong You, Tiantian Xu, Qian Chen, Hua Li, Longyu Dou, Yilun Sun, Xiufang Xiong, Morgan A. Meredith, Yi Sun
Summary: In this study, it was found that MLN4924 increased the levels of PD-L1 mRNA and protein, which was largely independent of neddylation inactivation. The mechanism involved the activation of ERK and JNK signals, leading to AP-1 activation. MLN4924 attenuated T cell killing and this effect could be abrogated by MEK inhibitor or anti-PD-L1 antibody. Combination of MLN4924 with MEK inhibitor or anti-PD-L1 antibody enhanced the suppression of tumor growth in an in vivo xenograft tumor model.
CELL DEATH & DISEASE
(2022)
Editorial Material
Biochemistry & Molecular Biology
Di Wu, Yi Sun
Summary: Neddylation, a ubiquitylation-like post-translational modification, is essential for the maintenance of Treg functionality. The Ube2m-Rbx1 pair of neddylation enzymes plays a crucial role, while the Ube2f-Sag pair has minimal or no effect on Treg cells. Understanding the regulation of neddylation-CRLs axis in immune cells can provide insights into potential therapeutic targets for human cancers and autoimmune diseases.
Article
Biochemistry & Molecular Biology
Xue Liang, Jiping Yao, Danrui Cui, Weiyang Zheng, Yanning Liu, Guohua Lou, Bingjue Ye, Liyan Shui, Yi Sun, Yongchao Zhao, Min Zheng
Summary: This study investigated the dysregulation of TRAF2 in liver cancer and its biological function, aiming to validate TRAF2 as a promising therapeutic target for liver cancer.
CELL DEATH AND DIFFERENTIATION
(2023)
Letter
Oncology
Ting Martin, Yilun Sun, Daniel E. Spratt, Amar U. Kishan
JOURNAL OF CLINICAL ONCOLOGY
(2023)
Correction
Health Care Sciences & Services
Andre J. Esteva, Jean Feng, Douwe van der Wal, Shih-Cheng Huang, Jeffry Simko, Sandy E. DeVries, Emmalyn Chen, Edward Schaeffer, Todd Morgan, Yilun Sun, Amirata A. Ghorbani, Nikhil Naik, Dhruv G. Nathawani, Richard D. Socher, Jeff L. Michalski, Mack R. Roach III, Thomas G. Pisansky, Jedidiah Monson, Farah A. Naz, James Wallace, Michelle M. Ferguson, Jean-Paul T. Bahary, James E. Zou, Matthew Lungren, Serena Y. Yeung, Ashley Ross, Howard M. Sandler, Phouc T. Tran, Daniel E. Spratt, Stephanie Pugh, Felix Y. Feng, Osama Mohamad
NPJ DIGITAL MEDICINE
(2023)
Article
Medicine, Research & Experimental
Shizhen Zhang, Xiahong You, Yawen Zheng, Yanwen Shen, Xiufang Xiong, Yi Sun
Summary: Ubiquitin-conjugating enzyme E2C (UBE2C) plays an essential role in promoting growth and survival in lung cancer cells with Kras mutations. It induces the degradation of DEPTOR through APC/CCDH1 E3 ligase, leading to the activation of mTORC signaling pathway. This study highlights the significant role of UBE2C in Kras-mutated lung cancer and validates it as a potential therapeutic target.
JOURNAL OF CLINICAL INVESTIGATION
(2023)
