Journal
BMC BIOLOGY
Volume 13, Issue -, Pages -Publisher
BIOMED CENTRAL LTD
DOI: 10.1186/s12915-015-0158-9
Keywords
Mathematical models; Mitosis-promoting factor; Cell cycle checkpoints; Regulated kinases; Regulated phosphatases; Regulated proteolysis
Categories
Funding
- National Science Foundation [DMS-1225160]
- National Institutes of Health of the USA [R01-GM078989, Ro1-GM095955]
- EC [MitoSys/241548]
- BBSRC [BB/MM00354X/1]
- Biotechnology and Biological Sciences Research Council [BB/M00354X/1] Funding Source: researchfish
- BBSRC [BB/M00354X/1] Funding Source: UKRI
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In this essay we illustrate some general principles of mathematical modeling in biology by our experiences in studying the molecular regulatory network underlying eukaryotic cell division. We discuss how and why the models moved from simple, parsimonious cartoons to more complex, detailed mechanisms with many kinetic parameters. We describe how the mature models made surprising and informative predictions about the control system that were later confirmed experimentally. Along the way, we comment on the 'parameter estimation problem' and conclude with an appeal for a greater role for mathematical models in molecular cell biology.
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