NEDD8 and ubiquitin ligation by cullin-RING E3 ligases

Proteolysis-Targeting Chimeras as Therapeutics and Tools for Biological Discovery

(2020) George M. Burslem et al.   CELL

Harnessing the Power of Proteolysis for Targeted Protein Inactivation

(2020) Rati Verma et al.   MOLECULAR CELL

NEDD8 nucleates a multivalent cullin–RING–UBE2D ubiquitin ligation assembly

(2020) Kheewoong Baek et al.   NATURE

Ubiquitin chain-elongating enzyme UBE2S activates the RING E3 ligase APC/C for substrate priming

(2020) Raquel C. Martinez-Chacin et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Structural basis for DNA damage-induced phosphoregulation of MDM2 RING domain

(2020) Helge M. Magnussen et al.   Nature Communications

Ubiquitin transfer by a RING E3 ligase occurs from a closed E2~ubiquitin conformation

(2020) Emma Branigan et al.   Nature Communications

Structural insights into substrate recognition by the SOCS2 E3 ubiquitin ligase

(2019) Wei-Wei Kung et al.   Nature Communications

Structural insights into E1 recognition and the ubiquitin-conjugating activity of the E2 enzyme Cdc34

(2019) Katelyn M. Williams et al.   Nature Communications

Robust cullin-RING ligase function is established by a multiplicity of poly-ubiquitylation pathways

(2019) Spencer Hill et al.   eLife

Recognition of the Diglycine C-End Degron by CRL2KLHDC2 Ubiquitin Ligase

(2018) Domniţa-Valeria Rusnac et al.   MOLECULAR CELL

Posing the APC/C E3 Ubiquitin Ligase to Orchestrate Cell Division

(2018) Edmond R. Watson et al.   TRENDS IN CELL BIOLOGY

Two Distinct Types of E3 Ligases Work in Unison to Regulate Substrate Ubiquitylation

(2016) Daniel C. Scott et al.   CELL

Functional role of TRIM E3 ligase oligomerization and regulation of catalytic activity

(2016) Marios G Koliopoulos et al.   EMBO JOURNAL

Structure of the E6/E6AP/p53 complex required for HPV-mediated degradation of p53

(2016) Denise Martinez-Zapien et al.   NATURE

Capturing a substrate in an activated RING E3/E2–SUMO complex

(2016) Frederick C. Streich Jr et al.   NATURE

Structural basis of lenalidomide-induced CK1α degradation by the CRL4CRBN ubiquitin ligase

(2016) Georg Petzold et al.   NATURE

Targeting Cullin–RING E3 ubiquitin ligases for drug discovery: structure, assembly and small-molecule modulation

(2015) Emil Bulatov et al.   BIOCHEMICAL JOURNAL

Insights into Ubiquitination from the Unique Clamp-like Binding of the RING E3 AO7 to the E2 UbcH5B

(2015) Shengjian Li et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Activation of a Primed RING E3-E2–Ubiquitin Complex by Non-Covalent Ubiquitin

(2015) Lori Buetow et al.   MOLECULAR CELL

RING E3 mechanism for ubiquitin ligation to a disordered substrate visualized for human anaphase-promoting complex

(2015) Nicholas G. Brown et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Gln40 deamidation blocks structural reconfiguration and activation of SCF ubiquitin ligase complex by Nedd8

(2015) Clinton Yu et al.   Nature Communications

Structure of a RING E3 Trapped in Action Reveals Ligation Mechanism for the Ubiquitin-like Protein NEDD8

(2014) Daniel C. Scott et al.   CELL

Allosteric activation of the RNF146 ubiquitin ligase by a poly(ADP-ribosyl)ation signal

(2014) Paul A. DaRosa et al.   NATURE

Crystal structure of the PRC1 ubiquitylation module bound to the nucleosome

(2014) Robert K. McGinty et al.   NATURE

The nucleosome acidic patch plays a critical role in RNF168-dependent ubiquitination of histone H2A

(2014) Francesca Mattiroli et al.   Nature Communications

Cand1 Promotes Assembly of New SCF Complexes through Dynamic Exchange of F Box Proteins

(2013) Nathan W. Pierce et al.   CELL

A Structurally Unique E2-Binding Domain Activates Ubiquitination by the ERAD E2, Ubc7p, through Multiple Mechanisms

(2013) Meredith B. Metzger et al.   MOLECULAR CELL

Essentiality of a non-RING element in priming donor ubiquitin for catalysis by a monomeric E3

(2013) Hao Dou et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

The Ubiquitin Code

(2012) David Komander et al.   Annual Review of Biochemistry

Structure of an E3:E2∼Ub Complex Reveals an Allosteric Mechanism Shared among RING/U-box Ligases

(2012) Jonathan N. Pruneda et al.   MOLECULAR CELL

Structure of a RING E3 ligase and ubiquitin-loaded E2 primed for catalysis

(2012) Anna Plechanovová et al.   NATURE

BIRC7–E2 ubiquitin conjugate structure reveals the mechanism of ubiquitin transfer by a RING dimer

(2012) Hao Dou et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

The Mechanism of Linkage-Specific Ubiquitin Chain Elongation by a Single-Subunit E2

(2011) Katherine E. Wickliffe et al.   CELL

Essential Role for Ubiquitin-Ubiquitin-Conjugating Enzyme Interaction in Ubiquitin Discharge from Cdc34 to Substrate

(2011) Anjanabha Saha et al.   MOLECULAR CELL

E3 ligase Rad18 promotes monoubiquitination rather than ubiquitin chain formation by E2 enzyme Rad6

(2011) R. G. Hibbert et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

N-Terminal Acetylation Acts as an Avidity Enhancer Within an Interconnected Multiprotein Complex

(2011) D. C. Scott et al.   SCIENCE

A Dual E3 Mechanism for Rub1 Ligation to Cdc53

(2010) Daniel C. Scott et al.   MOLECULAR CELL

E2-RING Expansion of the NEDD8 Cascade Confers Specificity to Cullin Modification

(2009) Danny T. Huang et al.   MOLECULAR CELL

Structures of SPOP-Substrate Complexes: Insights into Molecular Architectures of BTB-Cul3 Ubiquitin Ligases

(2009) Min Zhuang et al.   MOLECULAR CELL

Structural Insights into NEDD8 Activation of Cullin-RING Ligases: Conformational Control of Conjugation

(2008) David M. Duda et al.   CELL

Structure of the MDM2/MDMX RING domain heterodimer reveals dimerization is required for their ubiquitylation in trans

(2008) K Linke et al.   CELL DEATH AND DIFFERENTIATION