Journal
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
Volume 115, Issue 40, Pages 10016-10021Publisher
NATL ACAD SCIENCES
DOI: 10.1073/pnas.1808136115
Keywords
cell cycle; transcription factor; Myb; MuvB; DREAM
Categories
Funding
- NIH [F31CA206244, R01CA128836, R01CA188571, R01CA132685, R01GM124148]
- UC Office of the President, Multicampus Research Programs and Initiatives [MR-15-328599]
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The MuvB transcriptional regulatory complex, which controls cell-cycle-dependent gene expression, cooperates with B-Myb to activate genes required for the G2 and M phases of the cell cycle. We have identified the domain in B-Myb that is essential for the assembly of the Myb-MuvB (MMB) complex. We determined a crystal structure that reveals how this B-Myb domain binds MuvB through the adaptor protein LIN52 and the scaffold protein LIN9. The structure and biochemical analysis provide an understanding of how oncogenic B-Myb is recruited to regulate genes required for cell-cycle progression, and the MMB interface presents a potential therapeutic target to inhibit cancer cell proliferation.
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