Article
Multidisciplinary Sciences
Jenny F. Nathans, James A. Cornwell, Marwa M. Afifi, Debasish Paul, Steven D. Cappell
Summary: The study reveals that the G(1)-S checkpoint does not effectively prevent cells with damaged DNA from entering S phase and replicating their DNA, leading to different cell fate outcomes. Cells triggering the DNA damage checkpoint in G(1) phase route back to quiescence, and most damaged cells actually fail to arrest and proceed through the G(1)-S transition.
Article
Biochemistry & Molecular Biology
Wayne Stallaert, Katarzyna M. Kedziora, Colin D. Taylor, Tarek M. Zikry, Jolene S. Ranek, Holly K. Sobon, Sovanny R. Taylor, Catherine L. Young, Jeanette G. Cook, Jeremy E. Purvis
Summary: Using a combination of time-lapse microscopy, highly multiplexed single-cell imaging, and manifold learning, researchers visualized the human cell cycle and discovered the continuous variation of cell states, as well as the molecular features of cell cycle arrest and senescence.
Review
Biochemistry & Molecular Biology
Jorrit M. Enserink, Pierre Chymkowitch
Summary: Cdk1 is a master regulator of the cell cycle, controlling progression through different phases. It also directly regulates RNA polymerase activity, which is important for protein synthesis and meeting cellular demands. This regulation promotes cell cycle entry.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Wayne Stallaert, Sovanny R. Taylor, Katarzyna M. Kedziora, Colin D. Taylor, Holly K. Sobon, Catherine L. Young, Juanita C. Limas, Jonah Varblow Holloway, Martha S. Johnson, Jeanette Gowen Cook, Jeremy E. Purvis
Summary: The decision of cells to transition between proliferative and arrested states is critical for tissue development and function. By imaging and validating, researchers have revealed molecular mechanisms governing cell cycle exit and arrest, identifying multiple points of divergence and stress-specific states.
MOLECULAR SYSTEMS BIOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Pawel Lukasik, Michal Zaluski, Izabela Gutowska
Summary: Cyclin-dependent kinases are crucial in various cellular processes and their dysregulation can lead to diseases, making them potential drug targets.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Cell Biology
Yilin Fan, Tobias Meyer
Summary: Cell density and mitogen signals compete to regulate the levels of cyclin D1 and p27, determining whether cells proliferate or enter quiescence. The history of competing signals experienced by mother cells is funneled into a precise activator-inhibitor balance that controls the fate of daughter cells.
Article
Microbiology
Juri Kim, Eun-Ah Park, Mee Young Shin, Soon-Jung Park
Summary: This study investigated the functional roles of Giardia lamblia CDKs (GlCDKs) and their cognate cyclins. Using morpholino-mediated knockdown and coimmunoprecipitation, the functions of GlCDK1 and GlCDK2 were distinguished. GlCDK1 with Glcyclin 3977 plays a crucial role in flagellum formation and cell cycle control of G. lamblia, while GlCDK2 with Glcyclin 22394/6584 is involved in cell cycle control.
MICROBIOLOGY SPECTRUM
(2023)
Review
Cell Biology
Robert F. Brooks
Summary: Cell exit from quiescence following mitogenic stimulation is highly asynchronous and heterogeneous, with the RB-E2F and APC/C-CDH1 switches playing important roles in this dynamic process.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Review
Cell Biology
David A. Lewis, Tony Ly
Summary: CD8(+) T cells are crucial in immunity and immuno-oncology, as they undergo complex cellular growth, cell cycle entry, and differentiation to produce antigen-specific cytotoxic T lymphocytes. Some activated T cells will differentiate into memory T cells which are essential in adaptive immunity. This review explores the control of cell cycle entry in CD8(+) T cells and the interaction between these mechanisms and pathways regulating immunological phenotypes.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Review
Cell Biology
Aleksandra J. Pluta, Cecilia Studniarek, Shona Murphy, Chris J. Norbury
Summary: This article discusses the important roles of structurally related cyclin-dependent protein kinases (CDKs) in eukaryotic cell function, highlighting their roles in cell cycle regulation and transcriptional regulation, and the overlap between these processes.
WILEY INTERDISCIPLINARY REVIEWS-RNA
(2023)
Article
Cell Biology
Zongren Wan, Lixin Wang, Dan Yang, Pengling Li, Qing Liu, Baolan Wang
Summary: The study revealed that CKS2 is upregulated in NSCLC tissues and cells, promoting cell growth and cell cycle progression, while its knockdown suppresses tumorigenesis. CKS2 could potentially serve as a biomarker in NSCLC progression and prognosis.
Article
Biochemistry & Molecular Biology
Diego Lastra, Maribel Escoll, Antonio Cuadrado
Summary: This study explores the involvement of transcription factor NRF2 in the cell division cycle and finds that NRF2 levels are highest during S phase entry and lowest during mitosis. NRF2 depletion leads to G1 and M arrest and affects key cell cycle regulators.
Article
Multidisciplinary Sciences
Sungsoo Kim, Alessandra Leong, Minah Kim, Hee Won Yang
Summary: The study investigates how CDK4/6 initiates Rb inactivation and CDK2 activation to coordinate cell-cycle commitment and sequential G1/S transition.
SCIENTIFIC REPORTS
(2022)
Article
Endocrinology & Metabolism
David Wu, Devin L. Harrison, Teodora Szasz, Chih-Fan Yeh, Tzu-Pin Shentu, Angelo Meliton, Ru-Ting Huang, Zhengjie Zhou, Gokhan M. Mutlu, Jun Huang, Yun Fang
Summary: Research has shown that cellular metabolism is closely linked to cell movement in migrating endothelial cells, with RhoA and the glucose transporter SLC2A3 playing key roles in regulating cellular energy metabolism and cytoskeleton remodelling.
Article
Microbiology
Yanfei Zhang, Matteo Barberis
Summary: Coordination between cell cycle and metabolism is important for cell division and new cell construction. Cyclin-dependent kinases (Cdks) play a crucial role in this coordination, regulating cell division. This study reveals the possible impact of cell cycle mechanisms on cellular metabolism, finding that certain metabolic enzymes may be phosphorylated by Cdks, affecting their activities and metabolic regulation.
FRONTIERS IN MICROBIOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Lovorka Stojic, Aaron T. L. Lun, Jasmin Mangeri, Patrice Mascalchi, Valentina Quarantotti, Alexis R. Barr, Chris Bakal, John C. Marioni, Fanni Gergely, Duncan T. Odom
NUCLEIC ACIDS RESEARCH
(2018)
Article
Multidisciplinary Sciences
Frank S. Heldt, Alexis R. Barr, Sam Cooper, Chris Bakal, Bela Novak
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2018)
Editorial Material
Biochemistry & Molecular Biology
Alexis R. Barr, Joerg Mansfeld
Article
Biochemistry & Molecular Biology
Nadia Hegarat, Adrijana Crncec, Maria F. Suarez Peredo Rodriguez, Fabio Echegaray Iturra, Yan Gu, Oliver Busby, Paul F. Lang, Alexis R. Barr, Chris Bakal, Masato T. Kanemaki, Angus Lamond, Bela Novak, Tony Ly, Helfrid Hochegger
Article
Multidisciplinary Sciences
Lovorka Stojic, Aaron T. L. Lun, Patrice Mascalchi, Christina Ernst, Aisling M. Redmond, Jasmin Mangei, Alexis R. Barr, Vicky Bousgouni, Chris Bakal, John C. Marioni, Duncan T. Odom, Fanni Gergely
NATURE COMMUNICATIONS
(2020)
Article
Multidisciplinary Sciences
Betheney R. Pennycook, Eva Vesela, Silvia Peripolli, Tanya Singh, Alexis R. Barr, Cosetta Bertoli, Robertus A. M. de Bruin
NATURE COMMUNICATIONS
(2020)
Article
Microbiology
Georgia R. Squyres, Matthew J. Holmes, Sarah R. Barger, Betheney R. Pennycook, Joel Ryan, Victoria T. Yan, Ethan C. Garner
Summary: This study used live-cell single-molecule imaging to reveal that the divisome consists of two subcomplexes, showing that different components move differently. FtsZ-binding proteins were found to play a crucial role in bundling FtsZ filaments together to form Z rings, which are essential for cytokinesis.
NATURE MICROBIOLOGY
(2021)
Editorial Material
Biochemistry & Molecular Biology
Alexis R. Barr, Sarah E. McClelland
Summary: Recent studies have revealed that prolonged use of Cdk4/6 inhibitors can induce cellular senescence, thereby enhancing anti-tumor effects and reducing therapy-induced side effects. This finding is of great significance in improving the efficacy of cancer treatment.
Article
Biophysics
Jacob B. Swadling, Tobias Warnecke, Kyle L. Morris, Alexis R. Barr
Summary: Balanced proliferation-quiescence decisions are crucial for normal development and tissue homeostasis, but dysregulation can lead to tumorigenesis. Cyclin/Cyclin-dependent kinases (Cdks) play a key role in driving cell proliferation cycles. Cdk inhibitors (CKIs) p21(Cip1)(/Waf1), p27(Ki)(p1), and p57(Kip2) bind to Cyclin/Cdks and inhibit Cdk activity. Tyrosine phosphorylation of CKIs, in response to mitogenic signaling, affects the activation of specific Cyclin/Cdks. However, the impact of CKI tyrosine phosphorylation on Cdk activity varies among different CKIs.
BIOPHYSICAL JOURNAL
(2022)
Article
Biology
Fern A. Hughes, Alexis R. Barr, Philipp Thomas, Arvind Murugan
Summary: This article investigates how the time of cell division is influenced by inherited factors and identifies three different correlation patterns in interdivision time. The study finds that cell cycle factors are commonly driven by circadian rhythms, but their period may differ in cancer.
Article
Multidisciplinary Sciences
Benjamin G. Wiggins, Yi-Fang Wang, Alice Burke, Nil Grunberg, Julia M. Vlachaki Walker, Marian Dore, Catherine Chahrour, Betheney R. Pennycook, Julia Sanchez-Garrido, Santiago Vernia, Alexis R. Barr, Gad Frankel, Graeme M. Birdsey, Anna M. Randi, Chris Schiering
Summary: Endothelial cells in the intestine actively sense and integrate dietary metabolites through the aryl hydrocarbon receptor (AHR), which plays a critical role in maintaining tissue homeostasis and protecting against enteric infection. The AHR signaling promotes quiescence and restrains activation of endothelial cells in response to environmental cues, and deficiency in AHR leads to dysregulated inflammatory responses and the initiation of proliferative pathways.
Article
Biochemical Research Methods
Sam Cooper, Alexis R. Barr, Robert Glen, Chris Bakal